Published in Nature on February 24, 1977
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Sequence data handling by computer. Nucleic Acids Res (1977) 45.33
Compilation and analysis of Escherichia coli promoter DNA sequences. Nucleic Acids Res (1983) 38.72
Computer analysis of nucleic acid regulatory sequences. Proc Natl Acad Sci U S A (1977) 20.96
Statistical characterization of nucleic acid sequence functional domains. Nucleic Acids Res (1983) 20.31
A strategy of DNA sequencing employing computer programs. Nucleic Acids Res (1979) 19.82
Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc Natl Acad Sci U S A (1978) 19.34
Hybridization of synthetic oligodeoxyribonucleotides to phi chi 174 DNA: the effect of single base pair mismatch. Nucleic Acids Res (1979) 14.12
Computer programs for the assembly of DNA sequences. Nucleic Acids Res (1979) 13.36
pBR322 restriction map derived from the DNA sequence: accurate DNA size markers up to 4361 nucleotide pairs long. Nucleic Acids Res (1978) 13.22
Codon catalog usage and the genome hypothesis. Nucleic Acids Res (1980) 11.97
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The first Korean genome sequence and analysis: full genome sequencing for a socio-ethnic group. Genome Res (2009) 7.87
Nucleotide sequence of bacteriophage fd DNA. Nucleic Acids Res (1978) 7.25
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Properties of the translocatable tetracycline-resistance element Tn10 in Escherichia coli and bacteriophage lambda. Genetics (1978) 6.73
Viral integration and excision: structure of the lambda att sites. Science (1977) 6.66
Diagnosing the decline in pharmaceutical R&D efficiency. Nat Rev Drug Discov (2012) 5.55
Regions of broad-host-range plasmid RK2 which are essential for replication and maintenance. J Bacteriol (1980) 5.45
Unique DNA associated with mitochondria in the "S"-type cytoplasm of male-sterile maize. Proc Natl Acad Sci U S A (1977) 5.05
Overlapping genes at the cheA locus of Escherichia coli. Proc Natl Acad Sci U S A (1980) 4.82
A computer algorithm for testing potential prokaryotic terminators. Nucleic Acids Res (1984) 4.73
Nucleotide sequence divergence and functional constraint in mRNA evolution. Proc Natl Acad Sci U S A (1980) 4.71
Exceptional convergent evolution in a virus. Genetics (1997) 4.69
Synthesis and deposition of zein in protein bodies of maize endosperm. Plant Physiol (1978) 4.62
Structure of the joint region and the termini of the DNA of herpes simplex virus type 1. J Virol (1978) 4.62
phiX174 cistron A protein is a multifunctional enzyme in DNA replication. Proc Natl Acad Sci U S A (1977) 4.31
A restriction enzyme Tha I from the thermophilic mycoplasma Thermoplasma acidophilum. Nucleic Acids Res (1978) 4.25
Efficient correction of a mutation by use of chemically synthesized DNA. Proc Natl Acad Sci U S A (1978) 4.13
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Improved methods for the formation and stabilization of R-loops. Nucleic Acids Res (1979) 3.73
Complete sequence of IS3. Nucleic Acids Res (1985) 3.27
New map of bacteriophage lambda DNA. J Virol (1980) 3.21
The maize cytochrome c oxidase subunit I gene: sequence, expression and rearrangement in cytoplasmic male sterile plants. EMBO J (1985) 3.21
The DNA sequence at the T7 C promoter. Nucleic Acids Res (1979) 3.10
Human RNA "rumor" viruses: the search for novel human retroviruses in chronic disease. Microbiol Mol Biol Rev (2008) 3.07
A computer aided oligonucleotide analysis provides a model sequence for RNA polymerase-promoter recognition in E.coli. Nucleic Acids Res (1978) 3.01
Characterization of a new type of human papillomavirus that causes skin warts. J Virol (1977) 2.94
Sequence-specific DNA uptake in Haemophilus transformation. Proc Natl Acad Sci U S A (1979) 2.94
Head morphogenesis of complex double-stranded deoxyribonucleic acid bacteriophages. Microbiol Rev (1978) 2.82
Cloning, mapping and expression of the genetic determinant that encodes for the K88ab antigen. Nucleic Acids Res (1979) 2.80
Identification of the tetracycline resistance promoter and repressor in transposon Tn10. J Bacteriol (1981) 2.77
Molecular evolution of human and rabbit beta-globin mRNAs. Proc Natl Acad Sci U S A (1977) 2.70
Nucleotide sequence and expression of the gene encoding the EcoRII modification enzyme. Nucleic Acids Res (1987) 2.68
Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA. Proc Natl Acad Sci U S A (1983) 2.64
The cleavage site of the restriction endonuclease Ava II. Nucleic Acids Res (1978) 2.60
Landscape of next-generation sequencing technologies. Anal Chem (2011) 2.58
A method for measuring the non-random bias of a codon usage table. Nucleic Acids Res (1984) 2.57
Comparisons of ape and human sequences that regulate mitochondrial DNA transcription and D-loop DNA synthesis. Nucleic Acids Res (1988) 2.54
Restriction enzyme cleavage map of Tn10, a transposon which encodes tetracycline resistance. J Bacteriol (1979) 2.51
Evolutionary reversals during viral adaptation to alternating hosts. Genetics (2000) 2.49
Overlap between ampC and frd operons on the Escherichia coli chromosome. Proc Natl Acad Sci U S A (1982) 2.46
Atomic structure of single-stranded DNA bacteriophage phi X174 and its functional implications. Nature (1992) 2.44
Localization on the viral genome and nucleotide sequence of the gene coding for the two major polypeptides of the hepatitis B surface antigen (HBs Ag). Nucleic Acids Res (1979) 2.42
Nucleotide sequences of the separate origins of synthesis of bacteriophage G4 viral and complementary DNA strands. Proc Natl Acad Sci U S A (1978) 2.41
A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication. J Virol (2004) 2.36
Nucleotide sequence of the three major early promoters of bacteriophage T7. Nucleic Acids Res (1979) 2.32
A computer assisted method for the determination of restriction enzyme recognifion sites. Nucleic Acids Res (1978) 2.32
Restriction enzyme sites on the avian RNA tumor virus genome. J Virol (1978) 2.29
Characterization of two types of human papillomaviruses in lesions of epidermodysplasia verruciformis. Proc Natl Acad Sci U S A (1978) 2.26
DNA sequencing: bench to bedside and beyond. Nucleic Acids Res (2007) 2.25
Interaction of bleomycin with DNA. Proc Natl Acad Sci U S A (1978) 2.17
Evidence for a new hepatitis C virus antigen encoded in an overlapping reading frame. RNA (2001) 2.17
Isolation and localization of herpes simplex virus type 1 mRNA abundant before viral DNA synthesis. J Virol (1979) 2.16
Analysis of the complete nucleotide sequence of the Agrobacterium tumefaciens virB operon. Nucleic Acids Res (1988) 2.13
DNA sequence of the int-xis-Pi region of the bacteriophage lambda; overlap of the int and xis genes. Nucleic Acids Res (1980) 2.12
A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin. Proc Natl Acad Sci U S A (1994) 2.07
Bacteriophage genomics. Curr Opin Microbiol (2008) 2.06
The ;heavy' subunit of the photosynthetic reaction centre from Rhodopseudomonas viridis: isolation of the gene, nucleotide and amino acid sequence. EMBO J (1985) 2.06
Mutagenesis during in vitro DNA synthesis. Proc Natl Acad Sci U S A (1978) 2.05
GATC sequences, DNA nicks and the MutH function in Escherichia coli mismatch repair. EMBO J (1987) 2.05
Properties of overlapping genes are conserved across microbial genomes. Genome Res (2004) 2.01
Chicken ovalbumin is synthesized and secreted by Escherichia coli. Proc Natl Acad Sci U S A (1978) 2.01
Profiles of adaptation in two similar viruses. Genetics (2001) 1.99
The birth of the Epitranscriptome: deciphering the function of RNA modifications. Genome Biol (2012) 1.96
Nucleotide sequence of the region of an origin of replication of the antibiotic resistance plasmid R6K. Proc Natl Acad Sci U S A (1979) 1.95
One hundred years of pleiotropy: a retrospective. Genetics (2010) 1.91
Nucleosomal structure of Epstein-Barr virus DNA in transformed cell lines. J Virol (1979) 1.91
Rearrangements in the chloroplast genomes of mung bean and pea. Proc Natl Acad Sci U S A (1981) 1.89
The apocytochrome b gene in maize mitochondria does not contain introns and is preceded by a potential ribosome binding site. EMBO J (1984) 1.87
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The future of DNA sequence archiving. Gigascience (2012) 1.85
Plasmid-mediated ampicillin resistance in Haemophilus ducreyi. Antimicrob Agents Chemother (1979) 1.85
Cleavage specificity of the restriction endonuclease isolated from Haemophilus gallinarum (Hga I). Proc Natl Acad Sci U S A (1977) 1.82
Isolation of maxicircle component of kinetoplast DNA from hemoflagellate protozoa. Proc Natl Acad Sci U S A (1979) 1.78
Comparison between the viral transforming gene (src) of recovered avian sarcoma virus and its cellular homolog. Mol Cell Biol (1981) 1.78
Transformation-derived Neisseria gonorrhoeae plasmids with altered structure and function. J Bacteriol (1979) 1.78
Site specific endonuclease from Fusobacterium nucleatum. Nucleic Acids Res (1979) 1.77
Regulation of the OmpA outer membrane protein of Escherichia coli. J Bacteriol (1981) 1.75
Regulation of a new bacteriophage T4 gene, 69, that spans an origin of DNA replication. EMBO J (1984) 1.75
Structure of the dihydrofolate reductase gene in Chinese hamster ovary cells. Nucleic Acids Res (1983) 1.68
Two genes for the major heat-shock protein of Drosophila melanogaster arranged as an inverted repeat. Nucleic Acids Res (1980) 1.67
Restriction cleavage map of SP01 DNA: general location of early, middle, and late genes. J Virol (1979) 1.67
Theoretical melting profiles and denaturation maps of DNA with known sequence: fdDNA. Nucleic Acids Res (1978) 1.65
Promoter recognition by phage SP01-modified RNA polymerase. Proc Natl Acad Sci U S A (1978) 1.61
Adaptive molecular evolution for 13,000 phage generations: a possible arms race. Genetics (2005) 1.59
Structure of a conjugative element in Streptococcus pneumoniae. J Bacteriol (1986) 1.59
Molecular nature of a streptomycin and sulfonamide resistance plasmid (pBP1) prevalent in clinical Escherichia coli strains and integration of an ampicillin resistance transposon (TnA). Antimicrob Agents Chemother (1981) 1.58
A spite specific endonuclease from thermus thermophilus 111, Tth111I. Nucleic Acids Res (1980) 1.57
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase. J Mol Biol (1975) 90.35
Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing. J Mol Biol (1980) 61.16
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature (1998) 60.62
Nucleotide and amino acid sequences of gene G of omegaX174. J Mol Biol (1976) 57.73
Sequence and organization of the human mitochondrial genome. Nature (1981) 57.39
Life with 6000 genes. Science (1996) 41.51
The use of thin acrylamide gels for DNA sequencing. FEBS Lett (1978) 40.52
The minimal gene complement of Mycoplasma genitalium. Science (1995) 32.41
A two-dimensional fractionation procedure for radioactive nucleotides. J Mol Biol (1965) 20.83
Nucleotide sequence of bacteriophage lambda DNA. J Mol Biol (1982) 19.80
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature (2002) 19.35
Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors. Methods Enzymol (1983) 17.47
The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature (2000) 17.14
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Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18. Nature (2001) 15.44
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Genome sequence of Yersinia pestis, the causative agent of plague. Nature (2001) 14.36
The genome sequence of Schizosaccharomyces pombe. Nature (2002) 14.26
The nucleotide sequence of bacteriophage phiX174. J Mol Biol (1978) 13.55
Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA. Nucleic Acids Res (1982) 13.52
A general method for defining restriction enzyme cleavage and recognition sites. Methods Enzymol (1980) 13.26
Massive gene decay in the leprosy bacillus. Nature (2001) 11.98
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Sequence of the gene for iso-1-cytochrome c in Saccharomyces cerevisiae. Cell (1979) 10.86
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Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491. Nature (2000) 9.86
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Report of the Committee on the Genetic Constitution of Chromosomes 7, 8 and 9. Cytogenet Cell Genet (1985) 7.28
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The specific non-symmetrical sequence recognized by restriction endonuclease MboII. J Mol Biol (1980) 6.36
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Complete mutagenesis of the HIV-1 protease. Nature (1989) 5.16
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