Published in Am J Hum Genet on September 01, 1996
Transmission-disequilibrium tests for quantitative traits. Am J Hum Genet (1997) 7.10
The genetics of Tourette syndrome: a review. J Psychosom Res (2009) 1.46
A complete genome screen in sib pairs affected by Gilles de la Tourette syndrome. The Tourette Syndrome Association International Consortium for Genetics. Am J Hum Genet (1999) 1.35
Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. Neurosci Biobehav Rev (2011) 1.00
Indications of linkage and association of Gilles de la Tourette syndrome in two independent family samples: 17q25 is a putative susceptibility region. Am J Hum Genet (2004) 0.98
Open-label study comparing the efficacy and tolerability of aripiprazole and haloperidol in the treatment of pediatric tic disorders. Eur Child Adolesc Psychiatry (2010) 0.89
Tourette Syndrome: Bridging the Gap between Genetics and Biology. Mol Neuropsychiatry (2015) 0.87
D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects. Am J Hum Genet (1997) 0.86
Genetic and environmental factors in complex neurodevelopmental disorders. Curr Genomics (2007) 0.84
The role of D4 receptor gene exon III polymorphisms in shaping human altruism and prosocial behavior. Front Hum Neurosci (2013) 0.84
The polymorphic nature of the human dopamine D4 receptor gene: a comparative analysis of known variants and a novel 27 bp deletion in the promoter region. BMC Genet (2005) 0.83
Genetics of impulse control disorders in Parkinson's disease. J Neural Transm (Vienna) (2012) 0.83
Nonreplication of linkage disequilibrium between the dopamine D4 receptor locus and Tourette syndrome. Am J Hum Genet (1997) 0.78
Parent-child DRD4 genotype as a potential biomarker for oppositional, anxiety, and repetitive behaviors in children with autism spectrum disorder. Prog Neuropsychopharmacol Biol Psychiatry (2010) 0.78
The Genetic Etiology of Tourette Syndrome: Large-Scale Collaborative Efforts on the Precipice of Discovery. Front Neurosci (2016) 0.77
From Genetics to Epigenetics: New Perspectives in Tourette Syndrome Research. Front Neurosci (2016) 0.77
Association between DRD2/ANKK1 TaqIA Polymorphism and Susceptibility with Tourette Syndrome: A Meta-Analysis. PLoS One (2015) 0.76
Genetic susceptibility and neurotransmitters in Tourette syndrome. Int Rev Neurobiol (2013) 0.76
Support of positive association in family-based genetic analysis between COL27A1 and Tourette syndrome. Sci Rep (2015) 0.76
Quest for the elusive genetic basis of Tourette syndrome. Am J Hum Genet (1996) 0.75
Structural signatures of DRD4 mutants revealed using molecular dynamics simulations: Implications for drug targeting. J Mol Model (2015) 0.75
Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet (1993) 51.42
The transmission/disequilibrium test: history, subdivision, and admixture. Am J Hum Genet (1995) 24.52
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature (1991) 16.77
The affected-pedigree-member method of linkage analysis. Am J Hum Genet (1988) 13.67
A note on the application of the transmission disequilibrium test when a parent is missing. Am J Hum Genet (1995) 7.79
A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res (1991) 6.26
Mapping disease genes: family-based association studies. Am J Hum Genet (1995) 5.82
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature (1991) 4.36
Multiple dopamine D4 receptor variants in the human population. Nature (1992) 4.08
Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature (1993) 3.19
Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem (1995) 3.08
Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nat Genet (1996) 2.92
The inheritance of Gilles de la Tourette's syndrome and associated behaviors. Evidence for autosomal dominant transmission. N Engl J Med (1986) 2.30
Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nat Genet (1996) 2.18
The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus. Hum Genet (1996) 2.13
A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Hum Mol Genet (1993) 2.09
The A1 allele at the D2 dopamine receptor gene and alcoholism. A reappraisal. JAMA (1993) 1.83
Familial relationship between Gilles de la Tourette's syndrome, attention deficit disorder, learning disabilities, speech disorders, and stuttering. J Am Acad Child Adolesc Psychiatry (1993) 1.69
Exacerbation of Gilles de la Tourette's syndrome associated with thermal stress: a family study. Neurology (1991) 1.52
Familial pattern of Gilles de la Tourette syndrome. Arch Gen Psychiatry (1980) 1.30
A controlled study of Tourette syndrome. I. Attention-deficit disorder, learning disorders, and school problems. Am J Hum Genet (1987) 1.15
Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes. Mol Pharmacol (1994) 1.14
The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS. Genomics (1992) 1.12
Controlled study of haloperidol, pimozide and placebo for the treatment of Gilles de la Tourette's syndrome. Arch Gen Psychiatry (1989) 1.09
Intermediate inheritance of Tourette syndrome, assuming assortative mating. Am J Hum Genet (1995) 1.07
Effects of dopamine agonists and antagonists in Tourette's disease. Arch Gen Psychiatry (1979) 1.06
Tourette's syndrome: current concepts. Neurology (1989) 1.06
Cerebrospinal fluid biogenic amines in obsessive compulsive disorder, Tourette's syndrome, and healthy controls. Neuropsychopharmacology (1995) 1.05
Associations of disease with genetic markers: déjà vu all over again. Am J Med Genet (1993) 1.05
[123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder. Am J Psychiatry (1995) 1.03
Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette's syndrome. Ann Neurol (1991) 0.98
Dopamine receptor gene expression in the human medial temporal lobe. Neuropsychopharmacology (1994) 0.97
An ordered NotI fragment map of human chromosome band 11p15. Genomics (1994) 0.97
Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients. Biol Psychiatry (1993) 0.96
Human dopamine D4 receptor gene: frequent occurrence of a null allele and observation of homozygosity. Hum Mol Genet (1994) 0.95
Complex traits on the map. Nature (1996) 0.93
Familial Tourette's syndrome: report of a large pedigree and potential for linkage analysis. Neurology (1986) 0.92
Gilles de la Tourette syndrome is not linked to D2-dopamine receptor. Arch Gen Psychiatry (1990) 0.89
Progress in the search for genetic linkage with Tourette syndrome: an exclusion map covering more than 50% of the autosomal genome. Am J Hum Genet (1991) 0.85
Gilles de la Tourette's syndrome: effects of stimulant drugs. Neurology (1985) 0.84
Effect of tetrabenazine on tics and sleep of Gilles de la Tourette's syndrome. Neurology (1984) 0.84
Steroid hormones and CNS sexual dimorphisms modulate symptom expression in Tourette's syndrome. Psychoneuroendocrinology (1992) 0.84
Developmental psychopathology and neurobiology of Tourette's syndrome. J Am Acad Child Adolesc Psychiatry (1994) 0.80
Dopamine D4 receptor variant, D4GLYCINE194, in Africans, but not in Caucasians: no association with schizophrenia. Am J Med Genet (1994) 0.80
Presynaptic catecholamine antagonists as treatment for Tourette syndrome. Effects of alpha methyl para tyrosine and tetrabenazine. Arch Gen Psychiatry (1974) 0.79
The dopamine transporter protein gene (SLC6A3): primary linkage mapping and linkage studies in Tourette syndrome. Genomics (1995) 0.79
Exclusion of close linkage of Tourette's syndrome to D1 dopamine receptor. Am J Psychiatry (1993) 0.78
Tourette-like symptoms following chronic neuroleptic therapy. Adv Neurol (1982) 0.78
Methylphenidate treatment of attention-deficit hyperactivity disorder in boys with Tourette's syndrome. J Am Acad Child Adolesc Psychiatry (1989) 0.77
Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine. Arch Gen Psychiatry (1994) 0.77
HAPLO: a program using the EM algorithm to estimate the frequencies of multi-site haplotypes. J Hered (1995) 13.52
Global patterns of linkage disequilibrium at the CD4 locus and modern human origins. Science (1996) 8.25
Drift, admixture, and selection in human evolution: a study with DNA polymorphisms. Proc Natl Acad Sci U S A (1991) 8.14
Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med (2013) 7.51
Best estimate of lifetime psychiatric diagnosis: a methodological study. Arch Gen Psychiatry (1982) 7.37
Children's Yale-Brown Obsessive Compulsive Scale: reliability and validity. J Am Acad Child Adolesc Psychiatry (1997) 7.10
The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Adolesc Psychiatry (1989) 6.98
Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci U S A (2001) 6.68
Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA (2000) 6.55
Report of the Committee on Methods of Linkage Analysis and Reporting. Cytogenet Cell Genet (1985) 5.61
Report of the DNA committee and catalogs of cloned and mapped genes and DNA polymorphisms. Cytogenet Cell Genet (1989) 5.48
Bipolar affective disorders linked to DNA markers on chromosome 11. Nature (1987) 4.64
Insertional polymorphisms of full-length endogenous retroviruses in humans. Curr Biol (2001) 4.53
Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome. Arch Gen Psychiatry (2000) 4.49
Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature (1989) 4.18
The accuracy of statistical methods for estimation of haplotype frequencies: an example from the CD4 locus. Am J Hum Genet (2000) 4.07
Study of 47 DNA markers in five populations from four continents. Gene Geogr (1987) 4.04
Molecular haplotyping of genetic markers 10 kb apart by allele-specific long-range PCR. Nucleic Acids Res (1996) 3.92
Intraneuronal Abeta42 accumulation in human brain. Am J Pathol (2000) 3.83
Haplotype of multiple polymorphisms resolved by enzymatic amplification of single DNA molecules. Proc Natl Acad Sci U S A (1990) 3.11
Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. Am J Hum Genet (1999) 3.03
Comparison of two platelet glycoprotein IIb/IIIa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percutaneous coronary revascularization. N Engl J Med (2001) 2.83
A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder. Mol Psychiatry (2006) 2.83
Long-term clinical outcomes after unprotected left main trunk percutaneous revascularization in 279 patients. Circulation (2001) 2.77
A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands. Arch Gen Psychiatry (1982) 2.75
Biphasic amplification of very dilute DNA samples via 'booster' PCR. Nucleic Acids Res (1989) 2.74
Stent thrombosis in the modern era: a pooled analysis of multicenter coronary stent clinical trials. Circulation (2001) 2.73
Effect of transradial access on quality of life and cost of cardiac catheterization: A randomized comparison. Am Heart J (1999) 2.72
Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15. Am J Hum Genet (1997) 2.65
Regional brain and ventricular volumes in Tourette syndrome. Arch Gen Psychiatry (2001) 2.59
Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans. Curr Biol (1999) 2.55
Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkage. Nature (1987) 2.54
Phylogenetic analysis: concepts and methods. Am J Hum Genet (1971) 2.50
Sodium channels SCN1A, SCN2A and SCN3A in familial autism. Mol Psychiatry (2003) 2.48
Transmission/disequilibrium tests using multiple tightly linked markers. Am J Hum Genet (2000) 2.45
A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus. Hum Genet (1998) 2.44
Comparisons of two methods for haplotype reconstruction and haplotype frequency estimation from population data. Am J Hum Genet (2001) 2.44
Haplotypes and linkage disequilibrium at the phenylalanine hydroxylase locus, PAH, in a global representation of populations. Am J Hum Genet (2000) 2.43
The utility of DNA typing in forensic work. Science (1991) 2.34
Coupled amplification and sequencing of genomic DNA. Proc Natl Acad Sci U S A (1991) 2.33
Short tandem repeat polymorphism evolution in humans. Eur J Hum Genet (1998) 2.30
The inheritance of Gilles de la Tourette's syndrome and associated behaviors. Evidence for autosomal dominant transmission. N Engl J Med (1986) 2.30
A functional magnetic resonance imaging study of tic suppression in Tourette syndrome. Arch Gen Psychiatry (1998) 2.27
Silent victims. Children who witness violence. JAMA (1993) 2.26
Report of the committee on human gene mapping by recombinant DNA techniques. Cytogenet Cell Genet (1987) 2.24
A family study of obsessive-compulsive disorder. Am J Psychiatry (1995) 2.24
The 1985 Catalog of Mapped Genes and report of the Nomenclature Committee. Cytogenet Cell Genet (1985) 2.24
A global haplotype analysis of the myotonic dystrophy locus: implications for the evolution of modern humans and for the origin of myotonic dystrophy mutations. Am J Hum Genet (1998) 2.23
The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. Am J Hum Genet (2004) 2.21
Parallelizing genetic linkage analysis: a case study for applying parallel computation in molecular biology. Comput Biomed Res (1991) 2.21
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med (1998) 2.20
Optimum percutaneous transluminal coronary angioplasty compared with routine stent strategy trial (OPUS-1): a randomised trial. Lancet (2000) 2.15
The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus. Hum Genet (1996) 2.13
Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles. Biol Psychiatry (1999) 2.11
Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4. J Biol Chem (2000) 2.11
Studies of three Amerindian populations using nuclear DNA polymorphisms. Hum Biol (1991) 2.09
A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Hum Mol Genet (1993) 2.09
Clinical trials in coronary angiogenesis: issues, problems, consensus: An expert panel summary. Circulation (2000) 2.07
Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence. Hum Mol Genet (2000) 2.05
A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Arch Gen Psychiatry (1996) 2.04
Extravasation of thrombus into the aortic root: a complication following use of an infusion catheter for intragraft thrombolysis. Cathet Cardiovasc Diagn (1996) 2.03
Cyclosporine: a new immunosuppressive agent for organ transplantation. Ann Intern Med (1984) 2.03
Study of an additional 58 DNA markers in five human populations from four continents. Gene Geogr (1991) 1.98
Incidence and treatment of 'no-reflow' after percutaneous coronary intervention. Circulation (1994) 1.98
Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree. Nature (1988) 1.96
Premonitory urges in Tourette's syndrome. Am J Psychiatry (1993) 1.95
A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. Am J Psychiatry (2001) 1.95
A normed study of face recognition in autism and related disorders. J Autism Dev Disord (1999) 1.94
Speech and prosody characteristics of adolescents and adults with high-functioning autism and Asperger syndrome. J Speech Lang Hear Res (2001) 1.91
Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex. J Neurosci (2000) 1.90
Symptoms of obsessive-compulsive disorder. Am J Psychiatry (1997) 1.88
Short tandem-repeat polymorphism/alu haplotype variation at the PLAT locus: implications for modern human origins. Am J Hum Genet (2000) 1.85
Minisatellite diversity supports a recent African origin for modern humans. Nat Genet (1996) 1.84
Gilles de la Tourette's syndrome and obsessive-compulsive disorder. Evidence supporting a genetic relationship. Arch Gen Psychiatry (1986) 1.83
A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus. Am J Hum Genet (2001) 1.80
MSP RFLP for X-linked proteolipid protein gene (PLP) identified with either rat or human PLP cDNA clone. Nucleic Acids Res (1987) 1.80
Mapping the human genome: current status. Science (1990) 1.79
Modeling of heteroduplex formation during PCR from mixtures of DNA templates. PCR Methods Appl (1992) 1.79
A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease. Neurology (2012) 1.77
Consensus conference on best practices in live kidney donation: recommendations to optimize education, access, and care. Am J Transplant (2015) 1.76
X-chromosome markers and manic-depressive illness. Rejection of linkage to Xq28 in nine bipolar pedigrees. Arch Gen Psychiatry (1990) 1.72