Comparative properties of arginases.

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Arginase: an emerging key player in the mammalian immune system. Br J Pharmacol (2009) 2.59

Recent advances in arginine metabolism: roles and regulation of the arginases. Br J Pharmacol (2009) 2.24

Mouse model for human arginase deficiency. Mol Cell Biol (2002) 1.88

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment. Blood (2013) 1.79

Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy. Eur J Immunol (2007) 1.76

Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene. Mol Cell Biol (2001) 1.63

Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation. Proc Natl Acad Sci U S A (2001) 1.58

Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat. Cancer Res (2004) 1.52

Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesis. J Hepatol (2014) 1.48

The human arginases and arginase deficiency. J Inherit Metab Dis (1998) 1.46

Arginase I expression and activity in human mononuclear cells after injury. Ann Surg (2001) 1.25

Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype. PLoS One (2011) 1.21

Arginase and pulmonary diseases. Naunyn Schmiedebergs Arch Pharmacol (2008) 1.16

Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives. Br J Pharmacol (2009) 1.16

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages. Front Immunol (2014) 1.15

Arginase and autoimmune inflammation in the central nervous system. Immunology (2003) 1.15

Arginase activity mediates retinal inflammation in endotoxin-induced uveitis. Am J Pathol (2009) 1.12

Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis. J Am Heart Assoc (2012) 1.10

Evolution of the arginase fold and functional diversity. Cell Mol Life Sci (2008) 1.09

Arginine de novo and nitric oxide production in disease states. Am J Physiol Endocrinol Metab (2012) 1.06

Arginase is inoperative in developing soybean embryos. Plant Physiol (1999) 1.06

Long-term survival of the juvenile lethal arginase-deficient mouse with AAV gene therapy. Mol Ther (2012) 1.02

Local arginase 1 activity is required for cutaneous wound healing. J Invest Dermatol (2013) 1.02

Leishmania major lacking arginase (ARG) are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice. Mol Biochem Parasitol (2009) 1.01

Characterization of Bacillus anthracis arginase: effects of pH, temperature, and cell viability on metal preference. BMC Biochem (2008) 0.99

Glucocorticoids inhibit lipopolysaccharide-induced up-regulation of arginase in rat alveolar macrophages. Br J Pharmacol (2001) 0.99

Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection. PLoS One (2012) 0.99

AAV-based gene therapy prevents neuropathology and results in normal cognitive development in the hyperargininemic mouse. Gene Ther (2013) 0.97

Hypoxic upregulation of arginase II in human lung endothelial cells. Am J Physiol Cell Physiol (2010) 0.97

Myocyte-mediated arginase expression controls hyperargininemia but not hyperammonemia in arginase-deficient mice. Mol Ther (2014) 0.97

A novel blood-based biomarker for detection of autism spectrum disorders. Transl Psychiatry (2012) 0.97

Modulation of cholinergic airway reactivity and nitric oxide production by endogenous arginase activity. Br J Pharmacol (2000) 0.96

Thrombin induces endothelial arginase through AP-1 activation. Am J Physiol Cell Physiol (2009) 0.95

ADP-ribosylation of human defensin HNP-1 results in the replacement of the modified arginine with the noncoded amino acid ornithine. Proc Natl Acad Sci U S A (2009) 0.95

2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I. J Med Chem (2010) 0.93

Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis. Biochem J (2002) 0.93

Arginine depletion as a mechanism for the immune privilege of corneal allografts. Eur J Immunol (2011) 0.93

Localization and differential expression of arginase II in the kidney of male and female mice. Pflugers Arch (2004) 0.92

Evolutionary roots of arginase expression and regulation. Front Immunol (2014) 0.92

In-depth identification of pathways related to cisplatin-induced hepatotoxicity through an integrative method based on an informatics-assisted label-free protein quantitation and microarray gene expression approach. Mol Cell Proteomics (2011) 0.90

Role of arginase in vessel wall remodeling. Front Immunol (2013) 0.90

Arginases and arginine deficiency syndromes. Curr Opin Clin Nutr Metab Care (2012) 0.90

Arginase 1 mediates increased blood pressure and contributes to vascular endothelial dysfunction in deoxycorticosterone acetate-salt hypertension. Front Immunol (2013) 0.89

Physiological implications of arginine metabolism in plants. Front Plant Sci (2015) 0.89

Transgenic manipulation of the metabolism of polyamines in poplar cells. Plant Physiol (2001) 0.88

Insights into the arginine paradox: evidence against the importance of subcellular location of arginase and eNOS. Am J Physiol Heart Circ Physiol (2013) 0.88

Vascular dysfunction in retinopathy-an emerging role for arginase. Brain Res Bull (2009) 0.88

Binding of α,α-disubstituted amino acids to arginase suggests new avenues for inhibitor design. J Med Chem (2011) 0.88

The subcellular compartmentalization of arginine metabolizing enzymes and their role in endothelial dysfunction. Front Immunol (2013) 0.87

Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanism. Proc Natl Acad Sci U S A (2006) 0.87

Functions of arginase isoforms in macrophage inflammatory responses: impact on cardiovascular diseases and metabolic disorders. Front Immunol (2014) 0.87

Arginine dependence of tumor cells: targeting a chink in cancer's armor. Oncogene (2016) 0.86

Pharmacologic agents elevating cAMP prevent arginase II expression and proliferation of pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol (2012) 0.86

Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity. Cancer Res (2015) 0.86

Effects of L-arginine pretreatment on nitric oxide metabolism and hepatosplanchnic perfusion during porcine endotoxemia. Am J Clin Nutr (2011) 0.84

Nonimmune Cells Contribute to Crosstalk between Immune Cells and Inflammatory Mediators in the Innate Response to Trypanosoma cruzi Infection. J Parasitol Res (2011) 0.84

Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine. Circ Cardiovasc Genet (2014) 0.83

Vasomotor regulation of coronary microcirculation by oxidative stress: role of arginase. Front Immunol (2013) 0.83

Increased endothelial inflammation, sTie-2 and arginase activity in umbilical cords obtained from gestational diabetic mothers. PLoS One (2013) 0.82

Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity. Int J Parasitol (2008) 0.82

Arginase II is a target of miR-17-5p and regulates miR-17-5p expression in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2014) 0.82

Assessment of serum arginase I as a type 2 diabetes mellitus diagnosis biomarker in patients. Exp Ther Med (2014) 0.81

The physiology and evolution of urea transport in fishes. J Membr Biol (2007) 0.81

Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma. J Hematol Oncol (2008) 0.81

Regulation of the urea cycle enzyme genes in nitric oxide synthesis. J Inherit Metab Dis (1998) 0.81

Urea transporter UT-B deletion induces DNA damage and apoptosis in mouse bladder urothelium. PLoS One (2013) 0.81

Selective up-regulation of arginase-1 in coronary arteries of diabetic patients. Front Immunol (2013) 0.81

Biomarkers for Presymptomatic Doxorubicin-Induced Cardiotoxicity in Breast Cancer Patients. PLoS One (2016) 0.80

Role of myeloid-derived suppressor cells in autoimmune disease. World J Immunol (2014) 0.80

Distribution and properties of arginase in the salivary glands of four species of laboratory mammals. J Comp Physiol B (2004) 0.80

Periodontal therapy reduces arginase activity in saliva of patients with chronic periodontitis. Clin Oral Investig (2007) 0.80

L-Arginine modulates neonatal lymphocyte proliferation through an interleukin-2 independent pathway. Immunology (2014) 0.80

Unique hepatic cytosolic arginase evolved independently in ureogenic freshwater air-breathing teleost, Heteropneustes fossilis. PLoS One (2013) 0.78

Arginase 2 deficiency prevents oxidative stress and limits hyperoxia-induced retinal vascular degeneration. PLoS One (2014) 0.78

Partial purification of a liver-derived tumor cell growth inhibitor that differentially inhibits poorly-liver metastasizing cell lines: identification as an active subunit of arginase. Clin Exp Metastasis (2000) 0.78

Traumatic Brain Injury Causes Endothelial Dysfunction in the Systemic Microcirculation through Arginase-1-Dependent Uncoupling of Endothelial Nitric Oxide Synthase. J Neurotrauma (2016) 0.78

Enzymes of urea synthesis are expressed at the ocular surface, and decreased urea in the tear fluid is associated with dry-eye syndrome. Graefes Arch Clin Exp Ophthalmol (2013) 0.78

Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-Atherosclerosis. Oxid Med Cell Longev (2015) 0.77

Nitric oxide synthetic pathway in patients with microvascular angina and its relations with oxidative stress. Oxid Med Cell Longev (2014) 0.77

Crystallization and preliminary crystallographic studies of Helicobacter pylori arginase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.77

Labile Low-Molecular-Mass Metal Complexes in Mitochondria: Trials and Tribulations of a Burgeoning Field. Biochemistry (2016) 0.77

Smoking increases salivary arginase activity in patients with dental implants. Clin Oral Investig (2008) 0.77

Human cytomegalovirus may promote tumour progression by upregulating arginase-2. Oncotarget (2016) 0.76

Expression of the Rice Arginase Gene OsARG in Cotton Influences the Morphology and Nitrogen Transition of Seedlings. PLoS One (2015) 0.76

Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state. Rev Bras Hematol Hemoter (2015) 0.76

Effect of rosuvastatin on arginase enzyme activity and polyamine production in experimental breast cancer. Balkan Med J (2015) 0.76

Expression of immune-regulatory genes, arginase-2 and inducible nitric oxide synthase (iNOS), in two rainbow trout (Oncorhynchus mykiss) strains following exposure to Myxobolus cerebralis. Parasitol Res (2009) 0.76

Proteomic Analysis of Responsive Proteins Induced in Japanese Birch Plantlet Treated with Salicylic Acid. Proteomes (2014) 0.75

Cinnamide Derivatives as Mammalian Arginase Inhibitors: Synthesis, Biological Evaluation and Molecular Docking. Int J Mol Sci (2016) 0.75

RNA-seq analyses of the midgut from blood- and serum-fed Ixodes ricinus ticks. Sci Rep (2016) 0.75

Expression of arginase I and inducible nitric oxide synthase in the peripheral blood and lymph nodes of HIV‑positive patients. Mol Med Rep (2015) 0.75

Common and small molecules as the ultimate regulatory and effector mediators of antigen-specific transplantation reactions. World J Transplant (2013) 0.75

Hypoxia-induced proliferation of HeLa cells depends on epidermal growth factor receptor-mediated arginase II induction. Physiol Rep (2017) 0.75

Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2). J Biol Chem (2016) 0.75

l-Arginine metabolism in cardiovascular and renal tissue from hyper- and hypothyroid rats. Exp Biol Med (Maywood) (2015) 0.75

KCl-Dependent Release of Mitochondrial Membrane-Bound Arginase Appears to Be a Novel Variant of Arginase-II. Scientifica (Cairo) (2016) 0.75

Zearalenone (ZEN) and Its Influence on Regulation of Gene Expression in Carp (Cyprinus carpio L.) Liver Tissue. Toxins (Basel) (2017) 0.75

Comprehensive molecular analysis of arginase-encoding genes in common wheat and its progenitor species. Sci Rep (2017) 0.75

Recommended policies for uses of human tissue in research, education, and quality control. Ad Hoc Committee on Stored Tissue, College of American Pathologists. Arch Pathol Lab Med (1999) 1.96

Co-induction of arginase and nitric oxide synthase in murine macrophages activated by lipopolysaccharide. Biochem Biophys Res Commun (1995) 1.57

Polymerase chain reaction-based K-ras mutation detection of pancreatic adenocarcinoma in routine cytology smears. Am J Clin Pathol (1996) 1.54

Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production. Am J Physiol (1996) 1.50

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Targeted massively parallel sequencing provides comprehensive genetic diagnosis for patients with disorders of sex development. Clin Genet (2012) 1.18

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Familial poliodystrophy, mitochondrial myopathy, and lactate acidemia. Neurology (1975) 1.17

The gene for human liver arginase (ARG1) is assigned to chromosome band 6q23. Am J Hum Genet (1986) 1.17

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Cloning of rat liver arginase cDNA and elucidation of regulation of arginase gene expression in H4 rat hepatoma cells. Somat Cell Mol Genet (1986) 1.03

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