Published in Am J Physiol on January 01, 1996
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci U S A (2001) 1.61
20-hydroxyeicosatetraeonic acid: a new target for the treatment of hypertension. J Cardiovasc Pharmacol (2010) 1.55
A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid. Biochem J (2002) 1.33
Increased blood pressure in mice lacking cytochrome P450 2J5. FASEB J (2008) 1.30
Cat cerebral arterial smooth muscle cells express cytochrome P450 4A2 enzyme and produce the vasoconstrictor 20-HETE which enhances L-type Ca2+ current. J Physiol (1998) 1.24
20-HETE-mediated cytotoxicity and apoptosis in ischemic kidney epithelial cells. Am J Physiol Renal Physiol (2008) 1.22
Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness. Br J Pharmacol (1999) 1.20
Renal autoregulation in health and disease. Physiol Rev (2015) 1.18
Epoxyeicosatrienoic acids mediate adenosine-induced vasodilation in rat preglomerular microvessels (PGMV) via A2A receptors. Br J Pharmacol (2004) 1.14
Altered release of cytochrome p450 metabolites of arachidonic acid in renovascular disease. Hypertension (2008) 1.12
Heme oxygenase: the key to renal function regulation. Am J Physiol Renal Physiol (2009) 1.12
The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension. Hypertension (2008) 1.11
Renal renin-angiotensin system. Contrib Nephrol (2004) 1.09
Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transport. Am J Physiol Renal Physiol (2000) 1.07
Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. Am J Physiol Renal Physiol (2008) 1.06
20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells. Am J Physiol Heart Circ Physiol (2009) 1.05
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism. Am J Physiol Renal Physiol (2009) 1.05
20-HETE and blood pressure regulation: clinical implications. Cardiol Rev (2013) 1.02
Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury. Kidney Int (2010) 1.00
Eicosanoid excretion in hepatic cirrhosis. Predominance of 20-HETE. J Clin Invest (1997) 1.00
Postmenopausal hypertension: role of 20-HETE. Am J Physiol Regul Integr Comp Physiol (2011) 0.98
A new class of lipid mediators: cytochrome P450 arachidonate metabolites. Thorax (2000) 0.96
Endothelium-derived Relaxing Factors of Small Resistance Arteries in Hypertension. Toxicol Res (2014) 0.95
20-Hydroxyeicosatetraenoic acid potentiates stretch-induced contraction of canine basilar artery via PKC alpha-mediated inhibition of KCa channel. Br J Pharmacol (2002) 0.94
20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice. PLoS One (2010) 0.94
Calibration of the channel that determines the omega-hydroxylation regiospecificity of cytochrome P4504A1: catalytic oxidation of 12-HALODOdecanoic acids. J Biol Chem (2005) 0.92
Molecular mechanisms of renal blood flow autoregulation. Curr Vasc Pharmacol (2014) 0.92
Epoxyeicosatrienoic acids, 20-hydroxyeicosatetraenoic acid, and renal microvascular function. Prostaglandins Other Lipid Mediat (2013) 0.92
Contribution of cytochrome P450 4A isoforms to renal functional response to inhibition of nitric oxide production in the rat. J Physiol (2003) 0.89
Influence of Ca(2+)-activated K(+) channels on rat renal arteriolar responses to depolarizing agonists. Am J Physiol Renal Physiol (2001) 0.88
Potassium channel contributions to afferent arteriolar tone in normal and diabetic rat kidney. Am J Physiol Renal Physiol (2008) 0.87
20-Hydroxyeicosatetraenoic acid contributes to the inhibition of K+ channel activity and vasoconstrictor response to angiotensin II in rat renal microvessels. PLoS One (2013) 0.87
Astrocyte regulation of blood flow in the brain. Cold Spring Harb Perspect Biol (2015) 0.86
Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes. Auton Autacoid Pharmacol (2009) 0.86
Vascular actions of 20-HETE. Prostaglandins Other Lipid Mediat (2015) 0.85
Endogenously produced 20-HETE modulates myogenic and TGF response in microperfused afferent arterioles. Prostaglandins Other Lipid Mediat (2013) 0.84
Oxidative status in the macula densa modulates tubuloglomerular feedback responsiveness in angiotensin II-induced hypertension. Acta Physiol (Oxf) (2014) 0.81
Sodium reabsorption in the thick ascending limb in relation to blood pressure: a clinical perspective. Hypertension (2011) 0.81
20-HETE in acute kidney injury. Kidney Int (2011) 0.80
Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney. Mol Pharmacol (2013) 0.79
Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat. Am J Physiol Regul Integr Comp Physiol (2014) 0.79
Afferent Arteriolar Responses to β,γ-methylene ATP and 20-HETE are not Blocked by ENaC Inhibition. Physiol Rep (2013) 0.76
Epoxyeicosatrienoic Acids and 20-Hydroxyeicosatetraenoic Acid on Endothelial and Vascular Function. Adv Pharmacol (2016) 0.76
Clinical Implications of 20-Hydroxyeicosatetraenoic Acid in the Kidney, Liver, Lung and Brain: An Emerging Therapeutic Target. Pharmaceutics (2017) 0.75
Dietary Omega-3 Polyunsaturated Fatty Acids Prevent Vascular Dysfunction and Attenuate Cytochrome P4501A1 Expression by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin. Toxicol Sci (2016) 0.75
Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology. Front Biosci (Landmark Ed) (2016) 0.75
An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature (1996) 7.86
Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res (1996) 5.77
Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature (1999) 4.47
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science (1998) 4.41
The scavenger cell pathway for lipoprotein degradation: specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages. J Supramol Struct (1980) 3.10
Visualization of acidic organelles in intact cells by electron microscopy. Proc Natl Acad Sci U S A (1984) 3.09
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. J Biol Chem (1994) 3.08
Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. J Biol Chem (1996) 2.95
High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity. J Biol Chem (1997) 2.88
Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells. Mol Pharmacol (1998) 2.81
Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res (2000) 2.70
Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circ Res (2000) 2.67
Pressure-dependent membrane depolarization in cat middle cerebral artery. Circ Res (1984) 2.33
Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current. Am J Physiol (1999) 2.12
A genomic-systems biology map for cardiovascular function. Science (2001) 2.09
14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. Circ Res (2002) 2.09
Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase. J Biol Chem (1993) 2.03
Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat. Hypertension (2001) 1.99
Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes. J Biol Chem (1997) 1.92
Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding. EMBO J (1999) 1.86
Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. I. Use of inhibitors. J Biol Chem (1987) 1.86
Cytochrome P450 and the arachidonate cascade. FASEB J (1992) 1.85
Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors. J Pharmacol Exp Ther (1998) 1.84
The role of the kidney in hypertension. JAMA (1996) 1.80
Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle. Am J Physiol (1992) 1.80
Heme oxygenase-1 protects against radiocontrast-induced acute kidney injury by regulating anti-apoptotic proteins. Kidney Int (2007) 1.80
Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. J Vasc Res (1995) 1.76
Endothelium-derived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of tone. Circ Res (1999) 1.75
Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. Stroke (1996) 1.68
Differential effects of adenosine and nitroglycerin on the action potentials of large and small coronary arteries. Circ Res (1979) 1.65
Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells. Mol Pharmacol (2001) 1.64
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci U S A (2001) 1.61
Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiol Genomics (1999) 1.60
Functional hyperemia in the brain: hypothesis for astrocyte-derived vasodilator metabolites. Stroke (1998) 1.58
A functional phosphatidylinositol 3,4,5-trisphosphate/phosphoinositide binding domain in the clathrin adaptor AP-2 alpha subunit. Implications for the endocytic pathway. J Biol Chem (1996) 1.58
Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels. Am J Physiol (1994) 1.57
The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase. Arch Biochem Biophys (1983) 1.55
Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet. J Clin Invest (1994) 1.53
The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity. J Lipid Res (2004) 1.52
Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. J Biol Chem (2007) 1.52
Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding. J Biol Chem (2000) 1.51
EDHF mediates flow-induced dilation in skeletal muscle arterioles of female eNOS-KO mice. Am J Physiol Heart Circ Physiol (2001) 1.50
Actions of epoxygenase metabolites on the preglomerular vasculature. J Am Soc Nephrol (1996) 1.50
Consomic rat model systems for physiological genomics. Acta Physiol Scand (2004) 1.50
20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. Circ Res (1993) 1.48
Genetic contamination of Dahl SS/Jr rats. Impact on studies of salt-sensitive hypertension. Hypertension (1994) 1.48
The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3. J Biol Chem (1996) 1.48
The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C. J Biol Chem (1997) 1.47
The renal medulla and hypertension. Hypertension (1995) 1.46
20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. Am J Physiol (1996) 1.46
Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels. Circulation (2003) 1.46
Liquid chromatographic-electrospray ionization-mass spectrometric analysis of cytochrome P450 metabolites of arachidonic acid. Anal Biochem (2001) 1.45
Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. J Biol Chem (2008) 1.44
Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism. Arch Biochem Biophys (1988) 1.43
Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension. Kidney Int (2007) 1.39
Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats. J Pharmacol Exp Ther (1994) 1.38
An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. J Biol Chem (2002) 1.37
Endotoxin augments cerebral hyperemic response to halothane by inducing nitric oxide synthase and cyclooxygenase. Anesth Analg (2000) 1.37
20-HETE agonists and antagonists in the renal circulation. Am J Physiol (1999) 1.37
Characterization of epoxyeicosatrienoic acid binding site in U937 membranes using a novel radiolabeled agonist, 20-125i-14,15-epoxyeicosa-8(Z)-enoic acid. J Pharmacol Exp Ther (2008) 1.35
Stimulation of rat erythrocyte P2X7 receptor induces the release of epoxyeicosatrienoic acids. Br J Pharmacol (2007) 1.34
Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity. Am J Physiol (1996) 1.33
Regulation of AP-3 function by inositides. Identification of phosphatidylinositol 3,4,5-trisphosphate as a potent ligand. J Biol Chem (1997) 1.33
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat Chem Biol (2011) 1.33
Inhibition of renal vascular 20-HETE production impairs autoregulation of renal blood flow. Am J Physiol (1994) 1.32
Effect of cytochrome P450 arachidonate metabolites on ion transport in rabbit kidney loop of Henle. Science (1991) 1.32
Role of P-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats. Stroke (1997) 1.32
Identification of a putative microvascular oxygen sensor. Circ Res (1996) 1.30
Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis. Arch Biochem Biophys (1995) 1.29
Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta. Am J Physiol (1991) 1.26
Role of nitric oxide in renal papillary blood flow and sodium excretion. Hypertension (1992) 1.26
Pressure-induced myogenic activation of cat cerebral arteries is dependent on intact endothelium. Circ Res (1987) 1.25
Role of tyrosine kinase and PKC in the vasoconstrictor response to 20-HETE in renal arterioles. Hypertension (1999) 1.24
Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow. Am J Physiol (1996) 1.24
Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity. J Biol Chem (2000) 1.24
Cat cerebral arterial smooth muscle cells express cytochrome P450 4A2 enzyme and produce the vasoconstrictor 20-HETE which enhances L-type Ca2+ current. J Physiol (1998) 1.24
Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells. J Biol Chem (1998) 1.24
Gender-specific compensation for the lack of NO in the mediation of flow-induced arteriolar dilation. Am J Physiol Heart Circ Physiol (2001) 1.23
The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol (2003) 1.22
Cerebral microvascular endothelial cell tube formation: role of astrocytic epoxyeicosatrienoic acid release. Am J Physiol Heart Circ Physiol (2000) 1.21
Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma. Biochem Biophys Res Commun (1992) 1.21