Published in Nature on September 12, 1996
Brain-derived neurotrophic factor. Growth Factors (2004) 3.66
Programmed Cell Death in Plants. Plant Cell (1997) 3.64
Neurotrophin regulation of neural circuit development and function. Nat Rev Neurosci (2013) 3.53
Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nat Cell Biol (2008) 2.56
The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. J Cell Biol (1998) 1.90
NMR structure of the death domain of the p75 neurotrophin receptor. EMBO J (1997) 1.84
Analysis of apoptosis during hair follicle regression (catagen) Am J Pathol (1997) 1.82
Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling? Proc Natl Acad Sci U S A (1998) 1.73
Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR. EMBO J (1999) 1.70
Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease. J Clin Invest (1997) 1.66
Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification. Proc Natl Acad Sci U S A (2004) 1.57
Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch. Development (2007) 1.47
POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression. Development (1999) 1.41
A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA. Proc Natl Acad Sci U S A (1997) 1.40
Activity- and Ca(2+)-dependent modulation of surface expression of brain-derived neurotrophic factor receptors in hippocampal neurons. J Cell Biol (2000) 1.37
Understanding proneurotrophin actions: Recent advances and challenges. Dev Neurobiol (2010) 1.35
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation. J Cell Biol (2002) 1.28
The neurotrophin receptor p75NTR modulates long-term depression and regulates the expression of AMPA receptor subunits in the hippocampus. Proc Natl Acad Sci U S A (2005) 1.24
The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons. J Neurosci (2004) 1.21
Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival. PLoS One (2011) 1.20
Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. J Neurosci (2008) 1.19
Regulation of neuronal survival and death by extracellular signals during development. EMBO J (2003) 1.16
Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx. J Cell Biol (2003) 1.16
Chronic upregulation of activated microglia immunoreactive for galectin-3/Mac-2 and nerve growth factor following diffuse axonal injury. J Neuroinflammation (2010) 1.15
Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis. Antioxid Redox Signal (2009) 1.14
Guidance molecules in axon pruning and cell death. Cold Spring Harb Perspect Biol (2010) 1.13
Nuclear localization of the p75 neurotrophin receptor intracellular domain. J Biol Chem (2009) 1.11
p75(NTR) mediates neurotrophin-induced apoptosis of vascular smooth muscle cells. Am J Pathol (2000) 1.10
Dynamic plasticity: the role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors. Neuroscience (2012) 1.10
TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal. J Cell Biol (2001) 1.09
Expression of neurotrophins and their receptors in human bone marrow. Am J Pathol (1999) 1.08
Inositol polyphosphate multikinase is a coactivator of p53-mediated transcription and cell death. Sci Signal (2013) 1.06
Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines. J Exp Med (2002) 1.06
Endogenous brain-derived neurotrophic factor and neurotrophin-3 antagonistically regulate survival of axotomized corticospinal neurons in vivo. J Neurosci (2001) 1.04
Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves: axon-dependent removal of newly generated Schwann cells by apoptosis. Mol Cell Neurosci (2008) 1.03
Transient receptor potential channels as novel effectors of brain-derived neurotrophic factor signaling: potential implications for Rett syndrome. Pharmacol Ther (2006) 1.03
Astrogliosis in amyotrophic lateral sclerosis: role and therapeutic potential of astrocytes. Neurotherapeutics (2010) 1.02
The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E. J Cell Biol (2004) 1.01
Relationship between neural alteration and perineural invasion in pancreatic cancer patients with hyperglycemia. PLoS One (2011) 1.01
Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor. Proc Natl Acad Sci U S A (1999) 1.01
Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction. Ann Neurol (2009) 0.97
Studies of neurotrophin biology in the developing trigeminal system. J Anat (1997) 0.96
Neurotrophins role in depression neurobiology: a review of basic and clinical evidence. Curr Neuropharmacol (2011) 0.96
Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor. Proc Natl Acad Sci U S A (2009) 0.95
Neurogenic inflammation in stress-induced termination of murine hair growth is promoted by nerve growth factor. Am J Pathol (2004) 0.95
Neurotrophin-3 promotes the cholinergic differentiation of sympathetic neurons. Proc Natl Acad Sci U S A (2000) 0.95
Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor. Glia (2009) 0.92
Inflammatory cytokines IL-1β and TNF-α regulate p75NTR expression in CNS neurons and astrocytes by distinct cell-type-specific signalling mechanisms. ASN Neuro (2009) 0.91
p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease. Mol Psychiatry (2015) 0.88
TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor. Proc Natl Acad Sci U S A (2013) 0.88
Astrocyte apoptosis induced by HIV-1 transactivation of the c-kit protooncogene. Proc Natl Acad Sci U S A (1997) 0.88
Proneurotrophins, seizures, and neuronal apoptosis. Neuroscientist (2010) 0.88
Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme. Psychopharmacology (Berl) (2008) 0.86
Nociceptive Sensitizers Are Regulated in Damaged Joint Tissues, Including Articular Cartilage, When Osteoarthritic Mice Display Pain Behavior. Arthritis Rheumatol (2016) 0.85
Sortilin participates in light-dependent photoreceptor degeneration in vivo. PLoS One (2012) 0.84
TrkA activation in the rat visual cortex by antirat trkA IgG prevents the effect of monocular deprivation. Eur J Neurosci (1999) 0.84
The pro-peptide of proNGF: structure formation and intramolecular association with NGF. Protein Sci (2007) 0.84
Nerve growth factor is expressed by postmitotic avian retinal horizontal cells and supports their survival during development in an autocrine mode of action. Development (2001) 0.84
Effect of nerve growth factor and its transforming tyrosine kinase protein and low-affinity nerve growth factor receptors on apoptosis of notochordal cells. Int Orthop (2012) 0.83
Activation of EP2 prostanoid receptors in human glial cell lines stimulates the secretion of BDNF. Neurochem Int (2009) 0.83
Disruption of antigen-induced airway inflammation and airway hyper-responsiveness in low affinity neurotrophin receptor p75 gene deficient mice. Br J Pharmacol (2001) 0.83
Apoptosis in neural development and disease. Arch Dis Child Fetal Neonatal Ed (1997) 0.83
Molecular evolution of vertebrate neurotrophins: co-option of the highly conserved nerve growth factor gene into the advanced snake venom arsenalf. PLoS One (2013) 0.82
Nerve growth factor receptor TrkA is expressed by horizontal and amacrine cells during chicken retinal development. J Comp Neurol (1998) 0.81
The neurotrophin receptor p75NTR mediates early anti-inflammatory effects of estrogen in the forebrain of young adult rats. BMC Neurosci (2005) 0.81
Brain-derived neurotrophic factor-dependent cdk1 inhibition prevents G2/M progression in differentiating tetraploid neurons. PLoS One (2013) 0.81
Chronic nerve growth factor exposure increases apoptosis in a model of in vitro induced conjunctival myofibroblasts. PLoS One (2012) 0.80
p75 neurotrophin receptor and pro-BDNF promote cell survival and migration in clear cell renal cell carcinoma. Oncotarget (2016) 0.80
Role for calcium/calmodulin-dependent protein kinase II in the p75-mediated regulation of sympathetic cholinergic transmission. Proc Natl Acad Sci U S A (2006) 0.80
Constitutive expression of the low-affinity neurotrophin receptor and changes during axotomy-induced death of sensory neurones in the neonatal rat dorsal root ganglion. J Anat (2003) 0.80
Ligand-induced dynamics of neurotrophin receptors investigated by single-molecule imaging approaches. Int J Mol Sci (2015) 0.80
A role for the p75 neurotrophin receptor in axonal degeneration and apoptosis induced by oxidative stress. J Biol Chem (2014) 0.79
Relative expression of type II MAGE genes during retinoic acid-induced neural differentiation of mouse embryonic carcinoma P19 cells: a comparative real-time PCR analysis. Cell Mol Neurobiol (2012) 0.79
Neuroprotection, Growth Factors and BDNF-TrkB Signalling in Retinal Degeneration. Int J Mol Sci (2016) 0.78
Comparison of nerve growth factor receptor binding models using heterodimeric muteins. J Neurosci Res (2012) 0.78
Reciprocal regulation of axonal Filopodia and outgrowth during neuromuscular junction development. PLoS One (2012) 0.78
Neurotrophin blood-based gene expression and social cognition analysis in patients with autism spectrum disorder. Neurogenetics (2014) 0.78
The interaction of neurotrophins with the p75NTR common neurotrophin receptor: a comprehensive molecular modeling study. Protein Sci (1999) 0.77
BDNF pro-peptide regulates dendritic spines via caspase-3. Cell Death Dis (2016) 0.77
Neuronal programmed cell death-1 ligand expression regulates retinal ganglion cell number in neonatal and adult mice. J Neuroophthalmol (2012) 0.77
Death of injured neurons caused by the precursor of nerve growth factor. Proc Natl Acad Sci U S A (2004) 0.77
The neurotrophin receptor p75 regulates gustatory axon branching and promotes innervation of the tongue during development. Neural Dev (2014) 0.77
Somatic tetraploidy in vertebrate neurons: Implications in physiology and pathology. Commun Integr Biol (2010) 0.76
Interleukin-1β enhances neuronal vulnerability to proNGF-mediated apoptosis by increasing surface expression of p75(NTR) and sortillin. Neuroscience (2013) 0.76
Nerve growth factor (NGF) and lenses: effects of NGF in an in vitro rat model of cataract. Graefes Arch Clin Exp Ophthalmol (2003) 0.76
Functional Diversity of Neurotrophin Actions on the Oculomotor System. Int J Mol Sci (2016) 0.76
Transsynaptic activity-dependent regulation of axon branching and neurotrophin expression in vivo. J Neurosci (2011) 0.76
Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Front Mol Neurosci (2017) 0.75
Cytokine/neurotrophin interaction in the aged central nervous system. J Anat (2000) 0.75
Proneurotrophin-3 promotes cell cycle withdrawal of developing cerebellar granule cell progenitors via the p75 neurotrophin receptor. Elife (2016) 0.75
Computational Studies of Beta Amyloid (Aβ42) with p75NTR Receptor: A Novel Therapeutic Target in Alzheimer's Disease. Adv Bioinformatics (2014) 0.75
Immunosympathectomy as the first phenotypic knockout with antibodies. Proc Natl Acad Sci U S A (2013) 0.75
Time-Dependent Nerve Growth Factor Signaling Changes in the Rat Retina During Optic Nerve Crush-Induced Degeneration of Retinal Ganglion Cells. Int J Mol Sci (2017) 0.75
p75(NTR) antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa. Cell Death Dis (2017) 0.75
Physiology of the neurotrophins. Annu Rev Neurosci (1996) 4.82
Physiology of nerve growth factor. Physiol Rev (1980) 4.58
Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev (2000) 4.07
Neurotrophins are required for nerve growth during development. Nat Neurosci (2001) 3.96
Molecular cloning and expression of brain-derived neurotrophic factor. Nature (1989) 3.90
Purification of a new neurotrophic factor from mammalian brain. EMBO J (1982) 3.68
Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J (1990) 2.77
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature (1991) 2.70
Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature (1990) 2.69
Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Nature (1994) 2.57
Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth. Neuron (1999) 2.26
Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75. Science (1996) 2.15
Binding of brain-derived neurotrophic factor to the nerve growth factor receptor. Neuron (1990) 2.02
Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture. Neuron (1990) 1.77
Relative contribution of endogenous neurotrophins in hippocampal long-term potentiation. J Neurosci (1999) 1.74
Brain-derived neurotrophic factor prevents neuronal death in vivo. Nature (1988) 1.74
Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section. Nature (1993) 1.71
Activity of penicillin-binding protein 3 from Escherichia coli. J Bacteriol (1986) 1.71
Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR. EMBO J (1999) 1.70
Sensory neurons in culture: changing requirements for survival factors during embryonic development. Proc Natl Acad Sci U S A (1980) 1.69
Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells. J Neurosci (1986) 1.64
A crucial role for neurotrophin-3 in oligodendrocyte development. Nature (1994) 1.60
Nerve growth factor in mouse and rat serum: correlation between bioassay and radioimmunoassay determinations. Proc Natl Acad Sci U S A (1978) 1.59
Placode and neural crest-derived sensory neurons are responsive at early developmental stages to brain-derived neurotrophic factor. Dev Biol (1985) 1.57
Specific location of penicillin-binding proteins within the cell envelope of Escherichia coli. J Bacteriol (1986) 1.53
Microglia-derived nerve growth factor causes cell death in the developing retina. Neuron (1998) 1.47
ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons. Neuron (1989) 1.46
Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor. EMBO J (1992) 1.36
Genetic evidence for cell death mediated by nerve growth factor and the neurotrophin receptor p75 in the developing mouse retina and spinal cord. Development (1999) 1.36
Reduced size of retinal ganglion cell axons and hypomyelination in mice lacking brain-derived neurotrophic factor. Mol Cell Neurosci (1997) 1.33
Nerve growth factor: two receptors, multiple functions. Bioessays (1998) 1.27
Selective binding and internalisation by truncated receptors restrict the availability of BDNF during development. Development (1995) 1.27
In vivo effect of brain-derived neurotrophic factor on the survival of developing dorsal root ganglion cells. EMBO J (1987) 1.25
New factor released by cultured glioma cells supporting survival and growth of sensory neurones. Nature (1978) 1.23
The response of chick sensory neurons to brain-derived neurotrophic factor. J Neurosci (1986) 1.23
Down-regulation of the neurotrophin receptor TrkB following ligand binding. Evidence for an involvement of the proteasome and differential regulation of TrkA and TrkB. J Biol Chem (2000) 1.23
The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death. EMBO J (1999) 1.20
Subpopulations of cultured chick sympathetic neurones differ in their requirements for survival factors. Nature (1981) 1.19
Brain-derived neurotrophic factor levels in the nervous system of wild-type and neurotrophin gene mutant mice. J Neurochem (1999) 1.19
Location of some proteins involved in peptidoglycan synthesis and cell division in the inner and outer membranes of Escherichia coli. J Bacteriol (1985) 1.16
New neurotrophic factors. Annu Rev Physiol (1983) 1.13
Signalling through the neurotrophin receptor p75NTR. Curr Opin Neurobiol (1997) 1.08
A splice variant of the neurotrophin receptor trkB with increased specificity for brain-derived neurotrophic factor. EMBO J (1996) 1.07
Characterisation of neurotrophin dimers and monomers. Eur J Biochem (1994) 1.04
Specific high-affinity receptors for neurotrophin-3 on sympathetic neurons. J Neurosci (1993) 1.03
Binding characteristics of brain-derived neurotrophic factor to its receptors on neurons from the chick embryo. J Neurosci (1988) 1.01
Presence and disappearance of nerve growth factor receptors on sensory neurons in culture. Dev Biol (1982) 1.00
Control of early cell death by BDNF in the chick retina. Development (1997) 1.00
Help from within for damaged axons. Nature (1997) 0.99
cDNA cloning and complete sequence of porcine choline acetyltransferase: in vitro translation of the corresponding RNA yields an active protein. Proc Natl Acad Sci U S A (1987) 0.98
Production and characterization of recombinant mouse neurotrophin-3. Eur J Biochem (1992) 0.97
Identification of genes differentially expressed by nerve growth factor- and neurotrophin-3-dependent sensory neurons. Proc Natl Acad Sci U S A (1997) 0.97
Differential regulation of p21ras activation in neurons by nerve growth factor and brain-derived neurotrophic factor. J Biol Chem (1995) 0.96
The survival of chick retinal ganglion cells in response to brain-derived neurotrophic factor depends on their embryonic age. Dev Biol (1989) 0.96
Altered balance of glutamatergic/GABAergic synaptic input and associated changes in dendrite morphology after BDNF expression in BDNF-deficient hippocampal neurons. J Neurosci (2006) 0.95
Different factors from the central nervous system and periphery regulate the survival of sensory neurones. Nature (1986) 0.94
Sensory ganglia require neurotrophin-3 early in development. Development (1994) 0.93
Expression of the BDNF gene in the developing visual system of the chick. Development (1994) 0.92
Brain derived neurotrophic factor. Prog Brain Res (1987) 0.91
Expression and binding characteristics of the BDNF receptor chick trkB. Development (1993) 0.91
The autoregulation of retinal ganglion cell number. Development (2001) 0.90
Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons. J Cell Biol (1993) 0.90
Quantitation and purification of neurotrophic molecules. Cold Spring Harb Symp Quant Biol (1983) 0.90
What, if anything, is a neurotrophic factor? Trends Neurosci (1988) 0.89
Induction of fibre outgrowth and choline acetyltransferase in PC12 pheochromocytoma cells by conditioned media from glial cells and organ extracts. Exp Cell Res (1979) 0.88
Neurotrophic factors and neuronal death. Ciba Found Symp (1987) 0.88
Guinea pig prostate is a rich source of nerve growth factor. Nature (1979) 0.88
Biological and immunological properties of the nerve growth factor from bovine seminal plasma: comparison with the properties of mouse nerve growth factor. Neuroscience (1983) 0.87
Early expression of the nerve growth factor receptor ctrkA in chick sympathetic and sensory ganglia. Mol Cell Neurosci (1995) 0.87
Vitronectin is expressed in the ventral region of the neural tube and promotes the differentiation of motor neurons. Development (1997) 0.87
Production of specific antibodies to choline acetyltransferase purified from pig brain. Neuroscience (1981) 0.86
Purification and characterisation of a brain-derived neurotrophic factor/neurotrophin-3 (BDNF/NT-3) heterodimer. Eur J Biochem (1994) 0.85
Insulin-like growth factor-I stimulates neurogenesis in chick retina by regulating expression of the alpha 6 integrin subunit. Development (1996) 0.85
In vivo effects of neurotrophin-3 during sensory neurogenesis. Development (1996) 0.85
Potassium-induced increase in oxygen consumption of brown adipose tissue from the rat. J Physiol (1975) 0.84
Programmed cell death in the developing somites is promoted by nerve growth factor via its p75(NTR) receptor. Dev Biol (2000) 0.83
Final steps of the maturation of Omp F, a major protein from the outer membrane of Escherichia coli. FEBS Lett (1985) 0.83
Differences and similarities in the neurotrophic growth factor requirements of sensory neurons derived from neural crest and neural placode. J Cell Sci Suppl (1985) 0.83
Role of neurotrophins in the control of neural development: neurotrophin-3 promotes both neuron differentiation and survival of cultured chick retinal cells. Neuroscience (1994) 0.83
Laminin-1 selectively stimulates neuron generation from cultured retinal neuroepithelial cells. Exp Cell Res (1996) 0.83
Neurotrophins and other growth factors in the generation of retinal neurons. Microsc Res Tech (1999) 0.82
The neurotrophin receptor p75 binds neurotrophin-3 on sympathetic neurons with high affinity and specificity. J Neurosci (1997) 0.81
Neurotrophin-3 antibodies disrupt the normal development of the chick retina. J Neurosci (1996) 0.81
Neurotrophin receptors. Prog Neurobiol (1994) 0.81
Neurotrophins: structural relatedness and receptor interactions. Philos Trans R Soc Lond B Biol Sci (1991) 0.80
Strain-specific complementation between NRIF1 and NRIF2, two zinc finger proteins sharing structural and biochemical properties. Gene (2001) 0.80
Labelling and cross-linking of Escherichia coli penicillin-binding proteins with bis-beta-lactam antibiotics. Eur J Biochem (1984) 0.80
Developmentally regulated vitronectin influences cell differentiation, neuron survival and process outgrowth in the developing chicken retina. Neuroscience (1995) 0.78
Roles of neurotrophin-3 during early development of the peripheral nervous system. Philos Trans R Soc Lond B Biol Sci (1996) 0.78
High K+-mediated survival of spinal sensory neurons depends on developmental stage. Exp Cell Res (1987) 0.78
Interaction of beta-lactam antibiotics with penicillin-binding proteins from Bacillus megaterium. Eur J Biochem (1982) 0.78
The role of nerve growth factor (NGF) and related factors for the survival of peripheral neurons. Adv Biochem Psychopharmacol (1981) 0.78
N-terminal sequence of pig brain choline acetyltransferase purified by a rapid procedure. J Neurochem (1987) 0.77
Epithelial-mesenchymal conversion of dermatome progenitors requires neural tube-derived signals: characterization of the role of Neurotrophin-3. Development (1995) 0.77
Expression of depolarizing voltage- and transmitter-activated currents in neuronal precursor cells from the rat brain is preceded by a proton-activated sodium current. Brain Res Dev Brain Res (1989) 0.77
Neurotrophins and their p75 receptor. Cold Spring Harb Symp Quant Biol (1996) 0.77
A novel 7-transmembrane receptor expressed in nerve growth factor-dependent sensory neurons. Mol Cell Neurosci (2001) 0.77