Published in Nature on October 17, 1996
Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci U S A (2000) 10.88
Genetic influence on neurogenesis in the dentate gyrus of adult mice. Proc Natl Acad Sci U S A (1997) 2.96
From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci U S A (2001) 2.66
The astrocyte odyssey. Prog Neurobiol (2008) 2.58
Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc Natl Acad Sci U S A (2000) 2.35
Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex. Proc Natl Acad Sci U S A (1997) 2.20
Adult neurogenesis and the olfactory system. Prog Neurobiol (2009) 2.12
Migration and differentiation of neural precursor cells can be directed by microglia. Proc Natl Acad Sci U S A (2003) 2.05
Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI. Proc Natl Acad Sci U S A (2007) 2.03
IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. J Cell Biol (2004) 2.02
Development of neural stem cell in the adult brain. Curr Opin Neurobiol (2008) 2.02
BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis. Proc Natl Acad Sci U S A (2001) 2.01
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain. Philos Trans R Soc Lond B Biol Sci (2008) 1.91
Heterogeneity of neural progenitor cells revealed by enhancers in the nestin gene. Dev Biol (1999) 1.81
In vitro-generated neural precursors participate in mammalian brain development. Proc Natl Acad Sci U S A (1997) 1.73
Adult neural stem cells in the mammalian central nervous system. Cell Res (2009) 1.64
Signaling mechanisms regulating adult neural stem cells and neurogenesis. Biochim Biophys Acta (2012) 1.50
Signaling in adult neurogenesis. Curr Opin Neurobiol (2010) 1.45
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells. Philos Trans R Soc Lond B Biol Sci (2006) 1.44
Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind. Neurobiol Dis (2010) 1.26
Lack of extracellular superoxide dismutase (EC-SOD) in the microenvironment impacts radiation-induced changes in neurogenesis. Free Radic Biol Med (2007) 1.18
Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension. EMBO J (2004) 1.14
Neurogenesis and brain injury: managing a renewable resource for repair. J Clin Invest (2003) 1.08
Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A (2004) 1.05
Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain. Development (2013) 1.04
ASK1 inhibits astroglial development via p38 mitogen-activated protein kinase and promotes neuronal differentiation in adult hippocampus-derived progenitor cells. Mol Cell Biol (2004) 0.98
The molecular profiles of neural stem cell niche in the adult subventricular zone. PLoS One (2012) 0.97
Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis. Proc Natl Acad Sci U S A (1997) 0.97
Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCgamma1 activation for self-renewal of adult neural stem cells. Mol Brain (2009) 0.97
Anatomical perspectives on adult neural stem cells. J Anat (2005) 0.96
Stem cells: cross-talk and developmental programs. Philos Trans R Soc Lond B Biol Sci (2004) 0.93
Restricted nature of adult neural stem cells: re-evaluation of their potential for brain repair. Front Neurosci (2014) 0.92
CXCL12-mediated guidance of migrating embryonic stem cell-derived neural progenitors transplanted into the hippocampus. PLoS One (2010) 0.92
Developmental profiling of postnatal dentate gyrus progenitors provides evidence for dynamic cell-autonomous regulation. Hippocampus (2011) 0.91
The repair of complex neuronal circuitry by transplanted and endogenous precursors. NeuroRx (2004) 0.90
Current concept in neural regeneration research: NSCs isolation, characterization and transplantation in various neurodegenerative diseases and stroke: A review. J Adv Res (2013) 0.88
Clusterin secreted by astrocytes enhances neuronal differentiation from human neural precursor cells. Cell Death Differ (2011) 0.88
Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and Genome-wide expression analysis. Glia (2015) 0.88
A global transcriptome analysis reveals molecular hallmarks of neural stem cell death, survival, and differentiation in response to partial FGF-2 and EGF deprivation. PLoS One (2013) 0.86
Neural stem cells: brain building blocks and beyond. Ups J Med Sci (2012) 0.85
Promoted neuronal differentiation after activation of alpha4/beta2 nicotinic acetylcholine receptors in undifferentiated neural progenitors. PLoS One (2012) 0.84
Insights into neurogenesis and aging: potential therapy for degenerative disease? Future Neurol (2010) 0.84
Endothelium-induced proliferation and electrophysiological differentiation of human embryonic stem cell-derived neuronal precursors. Stem Cells Dev (2008) 0.82
Potential of Neural Stem Cell-Based Therapy for Parkinson's Disease. Parkinsons Dis (2015) 0.82
Promotion of both proliferation and neuronal differentiation in pluripotent P19 cells with stable overexpression of the glutamine transporter slc38a1. PLoS One (2012) 0.82
Temporal features of adult neurogenesis: differences and similarities across mammalian species. Front Neurosci (2013) 0.81
Engineering the CNS stem cell microenvironment. Regen Med (2009) 0.80
Transplantation and magnetic resonance imaging of canine neural progenitor cell grafts in the postnatal dog brain. J Neuropathol Exp Neurol (2008) 0.80
The bone morphogenetic protein type Ib receptor is a major mediator of glial differentiation and cell survival in adult hippocampal progenitor cell culture. Mol Biol Cell (2004) 0.80
Cultured subventricular zone progenitor cells transduced with neurogenin-2 become mature glutamatergic neurons and integrate into the dentate gyrus. PLoS One (2012) 0.79
Age-related changes in the oligodendrocyte progenitor pool influence brain remodeling after injury. Dev Neurosci (2010) 0.78
Cell origin and culture history determine successful integration of neural precursor transplants into the dentate gyrus of the adult rat. PLoS One (2011) 0.78
Sustained survival and maturation of adult neural stem/progenitor cells after transplantation into the injured brain. J Neurotrauma (2011) 0.78
Region-specific differentiation potential of adult rat spinal cord neural stem/precursors and their plasticity in response to in vitro manipulation. J Histochem Cytochem (2009) 0.78
Human embryonic stem cells: a potential source of transplantable neural progenitor cells. Neurosurg Focus (2008) 0.78
Postnatal age governs the extent of differentiation of hippocampal CA1 and CA3 subfield neural stem/progenitor cells into neurons and oligodendrocytes. Int J Dev Neurosci (2013) 0.78
Novel treatment strategies for malignant gliomas using neural stem cells. Neurotherapeutics (2009) 0.77
Cell replacement therapies for nervous system regeneration. Dev Neurobiol (2012) 0.77
Stem cell therapy for central nerve system injuries: glial cells hold the key. Neural Regen Res (2014) 0.77
Transcription-Factor-Dependent Control of Adult Hippocampal Neurogenesis. Cold Spring Harb Perspect Biol (2015) 0.76
Potential of adult neural stem cells for cellular therapy. Biologics (2007) 0.76
Heterotopically transplanted CVO neural stem cells generate neurons and migrate with SVZ cells in the adult mouse brain. Neurosci Lett (2010) 0.76
Versatile stem cells, young and old. A review. Cytotechnology (2001) 0.76
Epigallocatechin-3-gallate rescues LPS-impaired adult hippocampal neurogenesis through suppressing the TLR4-NF-κB signaling pathway in mice. Korean J Physiol Pharmacol (2015) 0.75
Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications. Cancer Sci (2017) 0.75
Establishment and characterization of immortalized hippocampal neural precursor cell lines. Cytotechnology (2000) 0.75
Regeneration strategies after the adult mammalian central nervous system injury-biomaterials. Regen Biomater (2016) 0.75
A rat model for studying neural stem cell transplantation. Acta Pharmacol Sin (2009) 0.75
Differential fate and functional outcome of lithium chloride primed adult neural progenitor cell transplants in a rat model of Huntington disease. Stem Cell Res Ther (2010) 0.75
Function of mouse embryonic stem cell-derived supporting cells in neural progenitor cell maturation and long term expansion. PLoS One (2013) 0.75
Glutamate triggers elevation of intracellular Ca(2+) concentration in neural precursor cells. Cytotechnology (2000) 0.75
The dynamics of adult neurogenesis in human hippocampus. Neural Regen Res (2016) 0.75
Analyses of distribution and dosimetry of brain metastases in small cell lung cancer with relation to the neural stem cell regions: feasibility of sparing the hippocampus in prophylactic cranial irradiation. Radiat Oncol (2017) 0.75
An L-Glutamine Transporter Isoform for Neurogenesis Facilitated by L-Theanine. Neurochem Res (2017) 0.75
Heterogeneous populations of neural stem cells contribute to myelin repair. Neural Regen Res (2017) 0.75
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science (1996) 28.95
Neurogenesis in the adult human hippocampus. Nat Med (1998) 17.53
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci (1999) 12.50
Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci U S A (2000) 10.88
More hippocampal neurons in adult mice living in an enriched environment. Nature (1997) 10.06
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci (1996) 9.84
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci U S A (1996) 9.15
Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci U S A (1999) 8.83
Gene therapy restores vision in a canine model of childhood blindness. Nat Genet (2001) 7.88
Vascular niche for adult hippocampal neurogenesis. J Comp Neurol (2000) 7.19
Neural consequences of environmental enrichment. Nat Rev Neurosci (2000) 6.79
A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science (2009) 6.62
Development of a self-inactivating lentivirus vector. J Virol (1998) 6.60
Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci (1997) 4.92
Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet (1997) 4.26
The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci (1997) 4.07
Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain. Proc Natl Acad Sci U S A (1995) 3.89
Structure and expression of an ethylene-related mRNA from tomato. Nucleic Acids Res (1987) 3.80
Experience-induced neurogenesis in the senescent dentate gyrus. J Neurosci (1998) 3.71
Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci (1999) 3.61
Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J Neurosci (1997) 3.61
Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci U S A (1997) 3.40
Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. J Neurosci (2000) 3.40
Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J Virol (1997) 3.37
Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability. Virology (1992) 3.22
Multipotent progenitor cells in the adult dentate gyrus. J Neurobiol (1998) 3.15
Hepatitis C virus infection in post-transfusion hepatitis. An analysis with first- and second-generation assays. N Engl J Med (1991) 3.02
Sequencing and identification of a cDNA clone for tomato polygalacturonase. Nucleic Acids Res (1986) 3.00
Genetic influence on neurogenesis in the dentate gyrus of adult mice. Proc Natl Acad Sci U S A (1997) 2.96
Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. Proc Natl Acad Sci U S A (1997) 2.89
Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol Psychiatry (2000) 2.87
Regenerating the damaged central nervous system. Nature (2000) 2.85
Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience (2004) 2.81
Nucleus basalis and thalamic control of neocortical activity in the freely moving rat. J Neurosci (1988) 2.73
Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature (1998) 2.72
Cell culture. Progenitor cells from human brain after death. Nature (2001) 2.63
Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction. J Neurochem (1997) 2.62
Isolation, characterization, and use of stem cells from the CNS. Annu Rev Neurosci (1995) 2.52
Expression of a truncated tomato polygalacturonase gene inhibits expression of the endogenous gene in transgenic plants. Mol Gen Genet (1990) 2.49
Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting in vivo. Proc Natl Acad Sci U S A (2001) 2.48
FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain. Mol Cell Neurosci (1995) 2.45
Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature (1987) 2.33
The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell (1996) 2.26
Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci (2000) 2.24
Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise. Proc Natl Acad Sci U S A (2010) 2.22
Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles. J Comp Neurol (1999) 2.21
The EPIC nutrient database project (ENDB): a first attempt to standardize nutrient databases across the 10 European countries participating in the EPIC study. Eur J Clin Nutr (2007) 2.21
Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. J Neurosci (1998) 2.17
Can stem cells cross lineage boundaries? Nat Med (2001) 2.08
Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats. Mol Cell Neurosci (2000) 2.07
Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J Neurosci (1997) 2.07
Retracted The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens. Immunity (1998) 2.02
Proliferation, differentiation, and long-term culture of primary hippocampal neurons. Proc Natl Acad Sci U S A (1993) 2.00
Transcriptional profiling reveals strict boundaries between hippocampal subregions. J Comp Neurol (2001) 1.98
A structurally flexible and antigenically variable N-terminal domain of the hepatitis C virus E2/NS1 protein: implication for an escape from antibody. Virology (1993) 1.90
Long-chain acyl-coenzyme A esters and fatty acids directly link metabolism to K(ATP) channels in the heart. Circ Res (2001) 1.88
Treatment process and outcomes for managed care patients receiving new antidepressant prescriptions from psychiatrists and primary care physicians. Arch Gen Psychiatry (2001) 1.79
Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. J Neurobiol (1999) 1.79
Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection. Proc Natl Acad Sci U S A (1986) 1.77
Expression and site-specific mutagenesis of the poliovirus 3C protease in Escherichia coli. Proc Natl Acad Sci U S A (1986) 1.76
Avian reticuloendotheliosis virus (strain T): V. DNA polymerase. Virology (1972) 1.75
Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Development (1999) 1.73
Essential role of neocortical acetylcholine in spatial memory. Nature (1995) 1.68
Characterization of the ileal microbiota in rejecting and nonrejecting recipients of small bowel transplants. Am J Transplant (2011) 1.67
Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task. Eur J Neurosci (2002) 1.67
Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer. J Virol (1999) 1.64
A physician-pharmacist model for the surveillance of blood pressure in the community: a feasibility study. J Hum Hypertens (2001) 1.63
Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina. Mol Cell Neurosci (1998) 1.62
Spatial learning and motor deficits in aged rats. Neurobiol Aging (1984) 1.60
An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression. Neuron (1998) 1.58
Hippocampal connections and spatial discrimination. Brain Res (1978) 1.54
Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations. Proc Natl Acad Sci U S A (1999) 1.54
A mutation altering the function of a carbohydrate binding protein blocks cell-cell cohesion in developing Dictyostelium discoideum. Nature (1979) 1.53
Control and manipulation of gene expression during tomato fruit ripening. Plant Mol Biol (1989) 1.53
Environmental stimulation of 129/SvJ mice causes increased cell proliferation and neurogenesis in the adult dentate gyrus. Curr Biol (1998) 1.51
FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor. Neuron (2000) 1.50
A packaging cell line for lentivirus vectors. J Virol (1999) 1.48
New nerve cells for the adult brain. Sci Am (1999) 1.47
Cutting edge: hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation. J Immunol (2000) 1.44
Voriconazole concentrations and outcome of invasive fungal infections. Clin Microbiol Infect (2009) 1.43
Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression. J Cell Biol (2001) 1.42
Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression. Science (1988) 1.42
Nicotinic receptor-induced apoptotic cell death of hippocampal progenitor cells. J Neurosci (1998) 1.42
Gestational diseases -- a workshop report. Placenta (2007) 1.41
Alzheimer's disease and spirochetes; a questionable relationship. Neuroreport (1993) 1.41
Effect of chlorine treatment on infectivity of hepatitis A virus. Appl Environ Microbiol (1983) 1.41
Lentiviral vectors: regulated gene expression. Mol Ther (2000) 1.39
Hyaluronan secretion into the synovial cavity of rabbit knees and comparison with albumin turnover. J Physiol (1997) 1.38
Flecainide: what are we measuring? Ther Drug Monit (1990) 1.38
Ataxia telangiectasia mutated is essential during adult neurogenesis. Genes Dev (2001) 1.35