Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways.

PubWeight™: 4.58‹?› | Rank: Top 1%

🔗 View Article (PMC 452249)

Published in EMBO J on September 16, 1996

Authors

S J Boulton1, S P Jackson

Author Affiliations

1: Wellcome/CRC Institute, Cambridge, UK.

Articles citing this

(truncated to the top 100)

Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol Mol Biol Rev (1999) 19.25

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43

Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol Mol Biol Rev (2002) 8.50

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J (1998) 7.36

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J (1998) 5.79

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res (1996) 4.37

The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol Cell Biol (1999) 4.32

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev (1999) 4.08

CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature (2008) 3.96

DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol Cell Biol (2001) 3.78

Ku80 is required for immunoglobulin isotype switching. EMBO J (1998) 3.67

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J Exp Med (1998) 3.37

Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair. EMBO J (1997) 3.29

DNA end-joining catalyzed by human cell-free extracts. Proc Natl Acad Sci U S A (1998) 3.11

Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids. Nucleic Acids Res (1998) 3.11

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc Natl Acad Sci U S A (1999) 3.06

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes. Proc Natl Acad Sci U S A (1999) 2.97

Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination. EMBO J (1998) 2.94

Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation. Mol Cell Biol (1998) 2.93

A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks. Genes Dev (1997) 2.61

Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks. EMBO J (1998) 2.52

The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.51

Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair. Genes Dev (2005) 2.47

Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae. Mol Biol Cell (2000) 2.44

The Rad51 paralog Rad51B promotes homologous recombinational repair. Mol Cell Biol (2000) 2.39

Ku is associated with the telomere in mammals. Proc Natl Acad Sci U S A (1999) 2.36

Non-homologous DNA end joining in plant cells is associated with deletions and filler DNA insertions. Nucleic Acids Res (1997) 2.34

DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining. Nucleic Acids Res (2000) 2.29

Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe. EMBO J (2001) 2.15

End-joining, translocations and cancer. Nat Rev Cancer (2013) 2.13

Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4. EMBO J (1998) 2.03

DNA double-strand-break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1997) 2.00

Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle. Genes Dev (2004) 1.98

Protection of telomeres by the Ku protein in fission yeast. Mol Biol Cell (2000) 1.94

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway. Nat Struct Mol Biol (2010) 1.92

The nature of telomere fusion and a definition of the critical telomere length in human cells. Genes Dev (2007) 1.88

ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Mol Cell Biol (2008) 1.88

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med (2010) 1.85

Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A (2010) 1.84

Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair. Proc Natl Acad Sci U S A (2004) 1.79

Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle. Mol Cell Biol (1997) 1.79

The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv Immunol (2010) 1.77

RAD51 is required for the repair of plasmid double-stranded DNA gaps from either plasmid or chromosomal templates. Mol Cell Biol (2000) 1.71

An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells. Nucleic Acids Res (2002) 1.70

The function of DNA polymerase alpha at telomeric G tails is important for telomere homeostasis. Mol Cell Biol (2000) 1.65

Ku-dependent and Ku-independent end-joining pathways lead to chromosomal rearrangements during double-strand break repair in Saccharomyces cerevisiae. Genetics (2003) 1.64

Microarray-based genetic screen defines SAW1, a gene required for Rad1/Rad10-dependent processing of recombination intermediates. Mol Cell (2008) 1.56

Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction. Nucleic Acids Res (2002) 1.52

Rejoining of DNA double-strand breaks as a function of overhang length. Mol Cell Biol (2005) 1.52

Impact of DNA ligase IV on the fidelity of end joining in human cells. Nucleic Acids Res (2003) 1.52

Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity. Genetics (2005) 1.48

A mechanism of palindromic gene amplification in Saccharomyces cerevisiae. Genes Dev (2005) 1.45

Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination. Genetics (2007) 1.41

Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions. Genetics (2001) 1.38

Is non-homologous end-joining really an inherently error-prone process? PLoS Genet (2014) 1.37

Developmental modulation of nonhomologous end joining in Caenorhabditis elegans. Genetics (2006) 1.33

Homologous recombinational repair of double-strand breaks in yeast is enhanced by MAT heterozygosity through yKU-dependent and -independent mechanisms. Genetics (2001) 1.33

Involvement of DNA end-binding protein Ku in Ty element retrotransposition. Mol Cell Biol (1999) 1.33

Multimeric threading-based prediction of protein-protein interactions on a genomic scale: application to the Saccharomyces cerevisiae proteome. Genome Res (2003) 1.32

Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proc Natl Acad Sci U S A (2012) 1.31

The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination. Mol Cell Biol (1997) 1.29

Trypanosoma brucei homologous recombination is dependent on substrate length and homology, though displays a differential dependence on mismatch repair as substrate length decreases. Nucleic Acids Res (2007) 1.29

The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini. Mol Cell Biol (2003) 1.28

Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. J Cell Biol (2008) 1.26

Non-homologous end joining often uses microhomology: implications for alternative end joining. DNA Repair (Amst) (2014) 1.24

The RING finger ATPase Rad5p of Saccharomyces cerevisiae contributes to DNA double-strand break repair in a ubiquitin-independent manner. Nucleic Acids Res (2005) 1.23

Repair of endonuclease-induced double-strand breaks in Saccharomyces cerevisiae: essential role for genes associated with nonhomologous end-joining. Genetics (1999) 1.21

Requirement for end-joining and checkpoint functions, but not RAD52-mediated recombination, after EcoRI endonuclease cleavage of Saccharomyces cerevisiae DNA. Mol Cell Biol (1998) 1.21

Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly. Mol Biol Cell (2009) 1.20

Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements. Nucleic Acids Res (2009) 1.19

Choosing the right path: does DNA-PK help make the decision? Mutat Res (2011) 1.18

Microhomology-dependent end joining and repair of transposon-induced DNA hairpins by host factors in Saccharomyces cerevisiae. Mol Cell Biol (2004) 1.16

Telomere dynamics and fusion of critically shortened telomeres in plants lacking DNA ligase IV. Nucleic Acids Res (2007) 1.15

The RAD5 gene product is involved in the avoidance of non-homologous end-joining of DNA double strand breaks in the yeast Saccharomyces cerevisiae. Nucleic Acids Res (1997) 1.15

The Drosophila melanogaster DmRAD54 gene plays a crucial role in double-strand break repair after P-element excision and acts synergistically with Ku70 in the repair of X-ray damage. Mol Cell Biol (1999) 1.14

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway? Trends Biochem Sci (2015) 1.13

Alternative end-joining mechanisms: a historical perspective. Front Genet (2013) 1.13

Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks. Nucleic Acids Res (2011) 1.12

DNA binding by the KP repressor protein inhibits P-element transposase activity in vitro. EMBO J (1998) 1.11

Subtelomeric repeat amplification is associated with growth at elevated temperature in yku70 mutants of Saccharomyces cerevisiae. Genetics (2000) 1.11

Telomerase subunit overexpression suppresses telomere-specific checkpoint activation in the yeast yku80 mutant. EMBO Rep (2001) 1.10

The Gam protein of bacteriophage Mu is an orthologue of eukaryotic Ku. EMBO Rep (2003) 1.07

Ku heterodimer-independent end joining in Trypanosoma brucei cell extracts relies upon sequence microhomology. Eukaryot Cell (2007) 1.06

A new Saccharomyces cerevisiae strain with a mutant Smt3-deconjugating Ulp1 protein is affected in DNA replication and requires Srs2 and homologous recombination for its viability. Mol Cell Biol (2004) 1.06

Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer. Cancer Discov (2015) 1.06

The non-homologous end-joining protein Nej1p is a target of the DNA damage checkpoint. DNA Repair (Amst) (2006) 1.04

The Drosophila melanogaster DNA Ligase IV gene plays a crucial role in the repair of radiation-induced DNA double-strand breaks and acts synergistically with Rad54. Genetics (2003) 1.04

The formation of double-strand breaks at multiply damaged sites is driven by the kinetics of excision/incision at base damage in eukaryotic cells. Nucleic Acids Res (2009) 1.02

DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates. PLoS One (2013) 1.02

Ionizing radiation and restriction enzymes induce microhomology-mediated illegitimate recombination in Saccharomyces cerevisiae. Nucleic Acids Res (2007) 1.01

End joining at Caenorhabditis elegans telomeres. Genetics (2008) 1.01

Lig4 and rad54 are required for repair of DNA double-strand breaks induced by P-element excision in Drosophila. Genetics (2004) 1.00

The spatial organization of non-homologous end joining: from bridging to end joining. DNA Repair (Amst) (2014) 0.99

Different mating-type-regulated genes affect the DNA repair defects of Saccharomyces RAD51, RAD52 and RAD55 mutants. Genetics (2006) 0.98

Mismatch tolerance by DNA polymerase Pol4 in the course of nonhomologous end joining in Saccharomyces cerevisiae. Genetics (2006) 0.97

Role of Dot1 in the response to alkylating DNA damage in Saccharomyces cerevisiae: regulation of DNA damage tolerance by the error-prone polymerases Polzeta/Rev1. Genetics (2008) 0.96

Capture of extranuclear DNA at fission yeast double-strand breaks. Genetics (2005) 0.94

KARP-1: a novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity. EMBO J (1997) 0.94

Genome wide distribution of illegitimate recombination events in Kluyveromyces lactis. Nucleic Acids Res (2006) 0.94

Noncanonical views of homology-directed DNA repair. Genes Dev (2016) 0.92

Articles cited by this

High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier. Curr Genet (1989) 31.80

Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol Cell Biol (1996) 7.33

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell (1993) 7.17

The primary structure of the Saccharomyces cerevisiae gene for alcohol dehydrogenase. J Biol Chem (1982) 7.03

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell (1995) 5.58

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science (1994) 4.99

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell (1995) 4.64

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science (1995) 4.54

Mechanism of interaction between Ku protein and DNA. J Biol Chem (1986) 4.22

Integration of DNA fragments by illegitimate recombination in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1991) 4.18

Semidominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA proteins. Mol Cell Biol (1992) 4.04

GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase. Cell (1990) 4.04

Dominant negative alleles of RAD52 reveal a DNA repair/recombination complex including Rad51 and Rad52. Genes Dev (1993) 3.60

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II. Proc Natl Acad Sci U S A (1992) 3.58

Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science (1994) 3.47

In vivo biochemistry: physical monitoring of recombination induced by site-specific endonucleases. Bioessays (1995) 3.44

Two different types of double-strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52-independent, nonhomologous recombination events. Mol Cell Biol (1994) 3.40

Homologous recombination and the roles of double-strand breaks. Trends Biochem Sci (1995) 3.10

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK. Trends Biochem Sci (1995) 3.01

Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc Natl Acad Sci U S A (1995) 2.99

A DNA-activated protein kinase from HeLa cell nuclei. Mol Cell Biol (1990) 2.95

RAD1 and RAD10, but not other excision repair genes, are required for double-strand break-induced recombination in Saccharomyces cerevisiae. Mol Cell Biol (1995) 2.90

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc Natl Acad Sci U S A (1995) 2.87

Menage à trois: double strand break repair, V(D)J recombination and DNA-PK. Bioessays (1995) 2.86

The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination. Genetics (1996) 2.79

Analysis of the mechanism of interaction of simian Ku protein with DNA. Nucleic Acids Res (1991) 2.76

HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex. J Mol Biol (1989) 2.73

A putative homologue of the human autoantigen Ku from Saccharomyces cerevisiae. J Biol Chem (1993) 2.72

Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap. J Clin Invest (1981) 2.68

V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair. Mol Cell Biol (1993) 2.66

ATM-related genes: what do they tell us about functions of the human gene? Cell (1995) 2.65

Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks. Proc Natl Acad Sci U S A (1994) 2.58

EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA. J Biol Chem (1993) 2.34

Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant. J Biol Chem (1994) 2.30

Homotypic and heterotypic protein associations control Rad51 function in double-strand break repair. Genes Dev (1994) 2.18

Transformation of Saccharomyces cerevisiae with nonhomologous DNA: illegitimate integration of transforming DNA into yeast chromosomes and in vivo ligation of transforming DNA to mitochondrial DNA sequences. Mol Cell Biol (1993) 2.12

X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining. Mutat Res (1985) 2.10

A mechanism for deletion formation in DNA by human cell extracts: the involvement of short sequence repeats. Nucleic Acids Res (1992) 2.03

Homologous, homeologous, and illegitimate repair of double-strand breaks during transformation of a wild-type strain and a rad52 mutant strain of Saccharomyces cerevisiae. Mol Cell Biol (1994) 1.92

Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen. Proc Natl Acad Sci U S A (1995) 1.72

Mammalian mutants defective in the response to ionizing radiation-induced DNA damage. Mutat Res (1995) 1.59

Purification of an 86-70 kDa nuclear DNA-associated protein complex. Biochim Biophys Acta (1985) 1.54

Involvement of the Saccharomyces cerevisiae HDF1 gene in DNA double-strand break repair and recombination. J Biol Chem (1996) 1.52

Identification of Ki (Ku, p70/p80) autoantigens and analysis of anti-Ki autoantibody reactivity. J Immunol (1986) 1.49

Checkpoints take the next step. Science (1996) 1.40

Cancer predisposition. Ataxia-telangiectasia at the crossroads. Curr Biol (1995) 1.20

Noncomplementary DNA double-strand-break rejoining in bacterial and human cells. Nucleic Acids Res (1993) 1.16

Double-strand break repair and G2 block in Chinese hamster ovary cells and their radiosensitive mutants. Mutat Res (1985) 1.07

Articles by these authors

(truncated to the top 100)

DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet (2001) 10.77

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell (1993) 7.17

The DNA-dependent protein kinase. Genes Dev (1999) 5.80

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J (1998) 5.79

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell (1995) 5.58

A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature (2001) 5.28

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science (1994) 4.99

DNA end-joining: from yeast to man. Trends Biochem Sci (1998) 4.94

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell (1995) 4.64

Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Cell (1989) 4.49

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res (1996) 4.37

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr Biol (1997) 3.67

The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol Cell (2000) 3.64

Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription. Cell (1991) 3.46

Identification of a yeast snRNP protein and detection of snRNP-snRNP interactions. Cell (1987) 3.46

Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair. EMBO J (1997) 3.29

Regulation of p53 in response to DNA damage. Oncogene (1999) 3.23

The FHA domain is a modular phosphopeptide recognition motif. Mol Cell (1999) 3.16

The TATA-binding protein: a general transcription factor in eukaryotes and archaebacteria. Science (1994) 3.06

Repression of RNA polymerase III transcription by the retinoblastoma protein. Nature (1996) 3.04

Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Curr Biol (1999) 2.98

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr Opin Cell Biol (2001) 2.93

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc Natl Acad Sci U S A (1995) 2.87

Menage à trois: double strand break repair, V(D)J recombination and DNA-PK. Bioessays (1995) 2.86

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc Natl Acad Sci U S A (1996) 2.77

The yeast Xrs2 complex functions in S phase checkpoint regulation. Genes Dev (2001) 2.75

Developmental expression of Sp1 in the mouse. Mol Cell Biol (1991) 2.73

DNA looping and Sp1 multimer links: a mechanism for transcriptional synergism and enhancement. Proc Natl Acad Sci U S A (1991) 2.51

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. Immunity (1998) 2.43

Human cell senescence as a DNA damage response. Mech Ageing Dev (2005) 2.26

Mechanism and regulation of transcription in archaea. Curr Opin Microbiol (2001) 2.25

LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae. EMBO J (2000) 2.22

Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr Biol (2001) 2.21

Ku, a DNA repair protein with multiple cellular functions? Mutat Res (1999) 2.16

Transcription and translation in Archaea: a mosaic of eukaryal and bacterial features. Trends Microbiol (1998) 2.08

Crystal structure of an Xrcc4-DNA ligase IV complex. Nat Struct Biol (2001) 2.07

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J (1996) 1.97

Polar overdominance at the ovine callipyge locus. Science (1996) 1.96

Conserved functional domains of the RNA polymerase III general transcription factor BRF. Genes Dev (1994) 1.90

A role for the TATA-box-binding protein component of the transcription factor IID complex as a general RNA polymerase III transcription factor. Proc Natl Acad Sci U S A (1992) 1.85

Orientation of the transcription preinitiation complex in archaea. Proc Natl Acad Sci U S A (1999) 1.84

Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I. Development (1998) 1.81

Factor requirements for transcription in the Archaeon Sulfolobus shibatae. EMBO J (1997) 1.78

Mechanism of TATA-binding protein recruitment to a TATA-less class III promoter. Cell (1992) 1.76

Competitive and noncompetitive inhibition of the DNA-dependent protein kinase. Cancer Res (1999) 1.74

Mapping of protein-protein interactions within the DNA-dependent protein kinase complex. Nucleic Acids Res (1999) 1.72

Sequence-specific DNA binding by the S. shibatae TFIIB homolog, TFB, and its effect on promoter strength. Mol Cell (1998) 1.71

Characterization of the residues phosphorylated in vitro by different C-terminal domain kinases. J Biol Chem (1998) 1.70

SV40 stimulates expression of the transacting factor Sp1 at the mRNA level. Genes Dev (1990) 1.70

Mitotic regulation of a TATA-binding-protein-containing complex. Mol Cell Biol (1995) 1.69

Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer. Cold Spring Harb Symp Quant Biol (2005) 1.67

DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p. Curr Biol (1999) 1.64

The crystal structure of a hyperthermophilic archaeal TATA-box binding protein. J Mol Biol (1996) 1.63

Molecular and biochemical characterization of xrs mutants defective in Ku80. Mol Cell Biol (1997) 1.62

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. Nat Genet (1999) 1.56

Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain. Biochem J (1996) 1.55

A revised model of platelet aggregation. J Clin Invest (2000) 1.54

Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. Nat Genet (1997) 1.52

Analysis of the ATM protein in wild-type and ataxia telangiectasia cells. Oncogene (1996) 1.52

Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks. Curr Biol (2000) 1.51

Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM. Proc Natl Acad Sci U S A (1999) 1.50

Extraordinary sequence conservation of the PRP8 splicing factor. Yeast (1995) 1.50

Identification of bacterial homologues of the Ku DNA repair proteins. FEBS Lett (2001) 1.49

Patient attitudes to sternotomy and thoracotomy scars. Thorac Cardiovasc Surg (2005) 1.47

The TATA-binding protein: a central role in transcription by RNA polymerases I, II and III. Trends Genet (1992) 1.47

Cell cycle regulation of RNA polymerase III transcription. Mol Cell Biol (1995) 1.44

The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53. Oncogene (1999) 1.41

Mechanistic analysis of RNA polymerase III regulation by the retinoblastoma protein. EMBO J (1997) 1.41

Chromosomal localization of the callipyge gene in sheep (Ovis aries) using bovine DNA markers. Proc Natl Acad Sci U S A (1994) 1.38

Improving tenderness of normal and callipyge lambs with calcium chloride. J Anim Sci (1997) 1.36

Transcriptional regulation of an archaeal operon in vivo and in vitro. Mol Cell (1999) 1.36

DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I. Genes Dev (1995) 1.34

ATM, a central controller of cellular responses to DNA damage. Cell Death Differ (2001) 1.33

Involvement of DNA end-binding protein Ku in Ty element retrotransposition. Mol Cell Biol (1999) 1.33

DNA double-strand break repair. Curr Biol (1999) 1.31

Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. Genes Dev (1998) 1.31

Differential regulation of RNA polymerases I, II, and III by the TBP-binding repressor Dr1. Science (1994) 1.31

Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20. Nucleic Acids Res (1998) 1.30

Basal and regulated transcription in Archaea. Biochem Soc Trans (2001) 1.29

Transcription: new insights from studies on Archaea. Trends Genet (1995) 1.29

Molecular cloning of the transcription factor TFIIB homolog from Sulfolobus shibatae. Proc Natl Acad Sci U S A (1995) 1.28

Cleavage and inactivation of ATM during apoptosis. Mol Cell Biol (1999) 1.27

Identification and characterization of the phosphatidylinositol-(4, 5)-bisphosphate 5-phosphatase in human platelets. J Biol Chem (1994) 1.26

DNA repair: how Ku makes ends meet. Curr Biol (2001) 1.25

Mechanism of autoregulation by an archaeal transcriptional repressor. J Biol Chem (2000) 1.24

The archaeal TFIIEalpha homologue facilitates transcription initiation by enhancing TATA-box recognition. EMBO Rep (2001) 1.23

Expression and nuclear localization of BLM, a chromosome stability protein mutated in Bloom's syndrome, suggest a role in recombination during meiotic prophase. J Cell Sci (2000) 1.23

The role of transcription factor B in transcription initiation and promoter clearance in the archaeon Sulfolobus acidocaldarius. J Biol Chem (2000) 1.22

Cloning and functional analysis of the TATA binding protein from Sulfolobus shibatae. Nucleic Acids Res (1995) 1.22

Temperature, template topology, and factor requirements of archaeal transcription. Proc Natl Acad Sci U S A (1998) 1.20

Fanconi anemia C gene product plays a role in the fidelity of blunt DNA end-joining. J Mol Biol (1998) 1.19

DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D. Genes Dev (1998) 1.16

The association of ATR protein with mouse meiotic chromosome cores. Chromosoma (1999) 1.14

An archaebacterial homologue of the essential eubacterial cell division protein FtsZ. Proc Natl Acad Sci U S A (1996) 1.14

Transcription in Archaea. Cold Spring Harb Symp Quant Biol (1998) 1.13

DNA-dependent protein kinase and related proteins. Biochem Soc Symp (1999) 1.13

Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. Proc Natl Acad Sci U S A (1995) 1.13

Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8. Proc Natl Acad Sci U S A (1995) 1.11

Telomerase subunit overexpression suppresses telomere-specific checkpoint activation in the yeast yku80 mutant. EMBO Rep (2001) 1.10

Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clots. J Biol Chem (1997) 1.10