Published in Proc Natl Acad Sci U S A on November 12, 1996
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Mol Cell Biol (2013) 5.33
Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. Genes Dev (1998) 5.20
p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol (2003) 4.36
The mouse homolog of Drosophila Vasa is required for the development of male germ cells. Genes Dev (2000) 3.93
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat Struct Mol Biol (2011) 3.10
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
Telomeres, stem cells, senescence, and cancer. J Clin Invest (2004) 2.87
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet (2009) 2.68
ATM is required for efficient recombination between immunoglobulin switch regions. J Exp Med (2004) 2.30
Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis. Sci Transl Med (2016) 2.19
The controlling role of ATM in homologous recombinational repair of DNA damage. EMBO J (2000) 2.17
Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs. Mol Oncol (2011) 2.07
Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. Proc Natl Acad Sci U S A (2005) 2.03
Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. PLoS One (2008) 1.94
Phosphorylation of serine 18 regulates distinct p53 functions in mice. Mol Cell Biol (2004) 1.85
Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. Proc Natl Acad Sci U S A (2000) 1.83
Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice. Proc Natl Acad Sci U S A (1997) 1.79
Chromatin remodeling finds its place in the DNA double-strand break response. Nucleic Acids Res (2009) 1.66
Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J Cell Biol (2009) 1.66
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair. EMBO J (2002) 1.64
Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality. Mol Cell Biol (2004) 1.63
ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci U S A (2006) 1.58
Focus on histone variant H2AX: to be or not to be. FEBS Lett (2010) 1.56
Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice. Mol Cell Biol (1998) 1.49
ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation. Proc Natl Acad Sci U S A (2000) 1.46
Replication stress and cancer. Nat Rev Cancer (2015) 1.43
Host cell DNA repair pathways in adeno-associated viral genome processing. J Virol (2006) 1.43
Sensing of intermediates in V(D)J recombination by ATM. Genes Dev (2002) 1.42
Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proc Natl Acad Sci U S A (2008) 1.42
Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53. EMBO J (2011) 1.42
Cell division in the CNS: protective response or lethal event in post-mitotic neurons? Biochim Biophys Acta (2006) 1.41
Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion. Proc Natl Acad Sci U S A (2000) 1.40
MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem (2009) 1.39
ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. J Exp Med (2010) 1.36
Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma. Genes Dev (1999) 1.35
Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR. Genetics (2003) 1.33
Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. Mol Cell Biol (2005) 1.31
Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes. J Exp Med (2007) 1.29
DNA strand breaks, neurodegeneration and aging in the brain. Mech Ageing Dev (2008) 1.27
Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development. Mol Cell Biol (2001) 1.25
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J Cell Biol (2008) 1.24
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination. J Exp Med (2009) 1.24
Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition. BMC Mol Biol (2007) 1.23
Loss of ATM kinase activity leads to embryonic lethality in mice. J Cell Biol (2012) 1.23
Atm inactivation results in aberrant telomere clustering during meiotic prophase. Mol Cell Biol (1999) 1.22
A role for AID in chromosome translocations between c-myc and the IgH variable region. J Exp Med (2007) 1.22
A peek into the complex realm of histone phosphorylation. Mol Cell Biol (2011) 1.22
Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression. PLoS One (2009) 1.22
Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice. Mol Cell Biol (2000) 1.19
Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction. Mol Cell Biol (1999) 1.19
Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia-telangiectasia. Proc Natl Acad Sci U S A (1997) 1.18
Ataxia telangiectasia gene mutations in leukaemia and lymphoma. J Clin Pathol (2001) 1.17
Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice. Proc Natl Acad Sci U S A (2000) 1.17
Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice. Proc Natl Acad Sci U S A (2013) 1.12
Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors p18(Ink4c) and p19(Ink4d). Mol Cell Biol (2001) 1.10
The cellular control of DNA double-strand breaks. J Cell Biochem (2006) 1.10
Self-organization of meiotic recombination initiation: general principles and molecular pathways. Annu Rev Genet (2014) 1.10
G2E3 is a dual function ubiquitin ligase required for early embryonic development. J Biol Chem (2008) 1.08
Non-homologous end joining in class switch recombination: the beginning of the end. Philos Trans R Soc Lond B Biol Sci (2009) 1.08
The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain. J Biol Chem (2010) 1.04
Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia. Genes Dev (2008) 1.03
Identification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouse. Proc Natl Acad Sci U S A (1998) 1.02
Selective loss of dopaminergic nigro-striatal neurons in brains of Atm-deficient mice. Proc Natl Acad Sci U S A (1998) 1.01
Atm heterozygous mice are more sensitive to radiation-induced cataracts than are their wild-type counterparts. Proc Natl Acad Sci U S A (2002) 1.00
High-resolution melting curve analysis for rapid detection of mutations in a Medaka TILLING library. BMC Mol Biol (2010) 1.00
RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice. Mol Cell Biol (2002) 1.00
The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease. Cell Cycle (2012) 1.00
Genetic evidence that synaptonemal complex axial elements govern recombination pathway choice in mice. Genetics (2011) 0.99
T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice. Mutagenesis (2013) 0.96
The control of mammalian female meiosis: factors that influence chromosome segregation. J Assist Reprod Genet (1998) 0.95
Functional overlaps between XLF and the ATM-dependent DNA double strand break response. DNA Repair (Amst) (2014) 0.94
Stable brain ATM message and residual kinase-active ATM protein in ataxia-telangiectasia. J Neurosci (2011) 0.93
Tug of war between survival and death: exploring ATM function in cancer. Int J Mol Sci (2014) 0.92
Induced pluripotent stem cells from ataxia-telangiectasia recapitulate the cellular phenotype. Stem Cells Transl Med (2012) 0.92
Mouse models of DNA double-strand break repair and neurological disease. DNA Repair (Amst) (2008) 0.92
Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis. PLoS Genet (2010) 0.90
Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks. J Exp Med (2000) 0.90
DNA damage response in plants: conserved and variable response compared to animals. Biology (Basel) (2013) 0.90
c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency. Proc Natl Acad Sci U S A (2000) 0.89
Ataxia telangiectasia: a review. Orphanet J Rare Dis (2016) 0.88
Endoplasmic reticulum stress and unfolded protein response in Atm-deficient thymocytes and thymic lymphoma cells are attributable to oxidative stress. Neoplasia (2008) 0.88
Lymphocyte development: integration of DNA damage response signaling. Adv Immunol (2012) 0.87
53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response. J Cell Biol (2012) 0.86
Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis. Mol Cancer Res (2010) 0.86
Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy. Mol Cell Oncol (2015) 0.86
Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice. EMBO J (2001) 0.85
The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage. Mol Cell Biol (2007) 0.85
A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis. Hum Mol Genet (2010) 0.85
Emerging issues in radiogenic cataracts and cardiovascular disease. J Radiat Res (2014) 0.85
Effects of antioxidants on cancer prevention and neuromotor performance in Atm deficient mice. Food Chem Toxicol (2007) 0.84
Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling. Am J Pathol (2011) 0.84
Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency. Cell Death Dis (2014) 0.84
Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling. PLoS Genet (2014) 0.84
Tcrδ translocations that delete the Bcl11b haploinsufficient tumor suppressor gene promote atm-deficient T cell acute lymphoblastic leukemia. Cell Cycle (2014) 0.83
The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase. Mol Cell Biol (2000) 0.83
Creation of non-human primate neurogenetic disease models by gene targeting and nuclear transfer. Reprod Biol Endocrinol (2004) 0.82
Restrictions limiting the generation of DNA double strand breaks during chromosomal V(D)J recombination. J Exp Med (2002) 0.81
Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum. J Biol Chem (2011) 0.81
Impaired skin and mammary gland development and increased gamma-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1. Cancer Res (2009) 0.81
A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science (1995) 15.20
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell (1991) 14.23
Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell (1996) 10.40
Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell (1996) 7.70
Breast and other cancers in families with ataxia-telangiectasia. N Engl J Med (1987) 3.86
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum Mol Genet (1995) 3.05
Ataxia-telangiectasia and cellular responses to DNA damage. Cancer Res (1995) 2.89
Relative increase of T cells expressing the gamma/delta rather than the alpha/beta receptor in ataxia-telangiectasia. N Engl J Med (1990) 2.69
Leukemia and lymphoma in ataxia telangiectasia. Blood (1996) 2.65
ATM-related genes: what do they tell us about functions of the human gene? Cell (1995) 2.65
Predominance of null mutations in ataxia-telangiectasia. Hum Mol Genet (1996) 2.06
Cancer risks in A-T heterozygotes. Int J Radiat Biol (1994) 2.04
Accelerated telomere shortening in ataxia telangiectasia. Nat Genet (1996) 1.82
Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells. Cytogenet Cell Genet (1995) 1.51
Ataxia-telangiectasia: closer to unraveling the mystery. Eur J Hum Genet (1995) 1.51
Mutations revealed by sequencing the 5' half of the gene for ataxia telangiectasia. Hum Mol Genet (1996) 1.33
The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice. Oncogene (1995) 1.30
Unusual sensitivity of ataxia telangiectasia cells to bleomycin. Cancer Res (1979) 1.24
Selective deficiency of CD4+/CD45RA+ lymphocytes in patients with ataxia-telangiectasia. J Clin Immunol (1992) 1.18
Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene. Genomics (1996) 0.99
Deregulated apoptosis in ataxia telangiectasia: association with clinical stigmata and radiosensitivity. Cancer Res (1996) 0.99
Specificity of bleomycin-induced cytotoxic effects on ataxia telangiectasia lymphoid cell lines. Cancer Res (1981) 0.92
Increased level of bleomycin-induced chromosome breakage in ataxia telangiectasia skin fibroblasts. Cancer Res (1983) 0.91
V(D)J recombination and ataxia-telangiectasia: a review. Int J Radiat Biol (1994) 0.91
Defective calcium-dependent signal transduction in T lymphocytes of ataxia-telangiectasia. Scand J Immunol (1993) 0.90
Influence of ataxia telangiectasia gene dosage on bleomycin-induced chromosome breakage and inhibition of replication in human lymphoblastoid cell lines. Exp Cell Res (1982) 0.88
Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc Natl Acad Sci U S A (1972) 83.88
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet (2005) 24.57
Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J (1982) 17.98
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell (1983) 17.87
Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. Proc Natl Acad Sci U S A (1984) 17.51
EK2 derivatives of bacteriophage lambda useful in the cloning of DNA from higher organisms: the lambdagtWES system. Science (1977) 13.24
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell (1995) 12.39
Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics. J Bacteriol (1997) 12.21
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell (1998) 11.54
Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature (2001) 10.96
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci U S A (1982) 10.50
The sequence of the chromosomal mouse beta-globin major gene: homologies in capping, splicing and poly(A) sites. Cell (1978) 9.73
Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene. Proc Natl Acad Sci U S A (1979) 9.31
The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care (1999) 9.16
Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes. Cell (1981) 9.09
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res (1994) 9.00
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell (1991) 8.99
Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments. Cell (1980) 8.77
The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma. Cell (1983) 8.54
Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med (2000) 8.47
The evolution and sequence comparison of two recently diverged mouse chromosomal beta--globin genes. Cell (1979) 8.11
Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science (1997) 7.95
In vitro synthesis of DNA complementary to purified rabbit globin mRNA (RNA-dependent DNA polymerase-reticulocyte-hemoglobin-density gradient centrifugation-oligo(dT) primer). Proc Natl Acad Sci U S A (1972) 7.89
The frequency of chimeric molecules as a consequence of PCR co-amplification of 16S rRNA genes from different bacterial species. Microbiology (1996) 7.78
Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell (1996) 7.70
Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell (1988) 7.50
The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity (1998) 7.35
The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes. J Biol Chem (1981) 7.26
Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron (1996) 7.20
Frequency of formation of chimeric molecules as a consequence of PCR coamplification of 16S rRNA genes from mixed bacterial genomes. Appl Environ Microbiol (1997) 7.09
A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature (1996) 7.04
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science (1999) 6.93
Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell (1984) 6.71
A kappa-immunoglobulin gene is formed by site-specific recombination without further somatic mutation. Nature (1979) 6.54
Protein synthesis directed by encephalomyocarditis virus RNA: properties of a transfer RNA-dependent system. Proc Natl Acad Sci U S A (1971) 6.52
TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. Biochem Biophys Res Commun (1999) 6.33
c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell (1988) 6.24
Translocations among antibody genes in human cancer. Science (1983) 6.20
The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. Proc Natl Acad Sci U S A (1978) 6.20
The complete sequence of a chromosomal mouse alpha--globin gene reveals elements conserved throughout vertebrate evolution. Cell (1979) 6.05
Readmission after hospitalization for congestive heart failure among Medicare beneficiaries. Arch Intern Med (1997) 5.93
RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell (1995) 5.73
Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma. Cell (1984) 5.61
A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation. Proc Natl Acad Sci U S A (1992) 5.60
Protein synthesis directed by encephalomyocarditis virus RNA. II. The in vitro synthesis of high molecular weight proteins and elements of the viral capsid. Biochem Biophys Res Commun (1971) 5.60
Organization and complete sequence of identical embryonic and plasmacytoma kappa V-region genes. J Biol Chem (1980) 5.59
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell (1987) 5.57
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem Biol (1997) 5.49
Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science (1992) 5.46
Blood transfusion in elderly patients with acute myocardial infarction. N Engl J Med (2001) 5.43
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res (1998) 5.41
Genetic diversity and disease control in rice. Nature (2000) 5.34
A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function. Nat Cell Biol (2000) 5.29
Racial differences in the use of cardiac catheterization after acute myocardial infarction. N Engl J Med (2001) 5.29
Purification and properties of biologically active messenger RNA for a myeloma light chain. Proc Natl Acad Sci U S A (1972) 5.28
Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences. Proc Natl Acad Sci U S A (1977) 5.28
Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex. Science (2000) 5.27
RNA codewords and protein synthesis, VII. On the general nature of the RNA code. Proc Natl Acad Sci U S A (1965) 5.17
Antibody diversity. Science (1978) 5.06
The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell (1990) 4.91
The arrangement and rearrangement of antibody genes. Nature (1979) 4.88
Clustered arrangement of immunoglobulin lambda constant region genes in man. Nature (1981) 4.87
Splicing and the formation of stable RNA. Cell (1979) 4.71
Differential signaling via the same axon of neocortical pyramidal neurons. Proc Natl Acad Sci U S A (1998) 4.59
Functional role for c-myc in mitogenic response to platelet-derived growth factor. Nature (1984) 4.56
POWER_SAGE: comparing statistical tests for SAGE experiments. Bioinformatics (2000) 4.56
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci (2001) 4.54
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A (1996) 4.45
The kit ligand: a cell surface molecule altered in steel mutant fibroblasts. Cell (1990) 4.43
Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells. Cell (1975) 4.32
Do "America's Best Hospitals" perform better for acute myocardial infarction? N Engl J Med (1999) 4.30
Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing. Nature (1982) 4.14
Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09
Broadly protective vaccine for Staphylococcus aureus based on an in vivo-expressed antigen. Science (1999) 4.08
Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes. Science (1982) 4.05
Globin messenger-RNA induction during erythroid differentiation of cultured leukemia cells. Proc Natl Acad Sci U S A (1972) 4.02
Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene. Proc Natl Acad Sci U S A (1978) 4.02
Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev (1994) 3.97
Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis. Proc Natl Acad Sci U S A (1978) 3.88
Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing. Proc Natl Acad Sci U S A (1994) 3.85
Purification and cloning of a mouse ribosomal gene fragment in coliphage lambda. Gene (1977) 3.79
An eosinophil-dependent mechanism for the antitumor effect of interleukin-4. Science (1992) 3.78
Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness. Nat Genet (1999) 3.73
Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proc Natl Acad Sci U S A (1981) 3.73
Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development. Cell (1986) 3.70
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet (1997) 3.69
The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Neuron (2001) 3.68
Activation and somatic mutation of the translocated c-myc gene in burkitt lymphoma cells. Cell (1984) 3.66
Signal timing across the macaque visual system. J Neurophysiol (1998) 3.66
Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells. Nature (1981) 3.64
Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation. Science (1984) 3.63
Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant. Cell (1991) 3.60
The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells. Proc Natl Acad Sci U S A (1999) 3.53
Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. J Med Genet (2004) 3.45