hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6.

PubWeight™: 3.60‹?› | Rank: Top 1%

🔗 View Article (PMC 19374)

Published in Proc Natl Acad Sci U S A on November 26, 1996

Authors

S Acharya1, T Wilson, S Gradia, M F Kane, S Guerrette, G T Marsischky, R Kolodner, R Fishel

Author Affiliations

1: Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Articles citing this

(truncated to the top 100)

Microsatellite instability in colorectal cancer. Gastroenterology (2010) 7.39

Mechanisms in eukaryotic mismatch repair. J Biol Chem (2006) 3.55

Mismatch repair proficiency and in vitro response to 5-fluorouracil. Gastroenterology (1999) 3.06

The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations. Proc Natl Acad Sci U S A (1998) 2.77

MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev (2000) 2.49

Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part I. The utility of immunohistochemistry. J Mol Diagn (2008) 2.30

Molecular and clinical characteristics of MSH6 variants: an analysis of 25 index carriers of a germline variant. Am J Hum Genet (2002) 2.17

ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair. Nucleic Acids Res (1998) 2.09

A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy. J Natl Cancer Inst (2012) 2.07

The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus. Mol Biol Cell (2006) 2.01

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J Exp Med (1998) 2.00

Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer. Cancer Res (2008) 1.81

exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair. Mol Cell Biol (2001) 1.79

The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome: from bench to bedside. Fam Cancer (2007) 1.76

A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination. J Exp Med (2004) 1.76

Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations. Mol Cell Biol (1997) 1.74

Beta clamp directs localization of mismatch repair in Bacillus subtilis. Mol Cell (2008) 1.73

Photoaffinity isolation and identification of proteins in cancer cell extracts that bind to platinum-modified DNA. Chembiochem (2009) 1.71

DNA replication fidelity and cancer. Semin Cancer Biol (2010) 1.69

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents. Proc Natl Acad Sci U S A (1999) 1.69

Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells. Mol Cell Biol (2001) 1.68

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice. J Exp Med (1998) 1.63

Replication errors: cha(lle)nging the genome. EMBO J (1998) 1.62

Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management. Mol Oncol (2009) 1.61

hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha. EMBO J (1998) 1.60

DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. Proc Natl Acad Sci U S A (1997) 1.58

Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes. Neurobiol Dis (2008) 1.58

Molecular pathways: microsatellite instability in colorectal cancer: prognostic, predictive, and therapeutic implications. Clin Cancer Res (2012) 1.57

Penetrance and expressivity of MSH6 germline mutations in seven kindreds not ascertained by family history. Am J Hum Genet (2004) 1.57

Mismatch repair deficiency associated with overexpression of the MSH3 gene. Proc Natl Acad Sci U S A (1998) 1.56

Msh3 is a limiting factor in the formation of intergenerational CTG expansions in DM1 transgenic mice. Hum Genet (2006) 1.55

Base composition of mononucleotide runs affects DNA polymerase slippage and removal of frameshift intermediates by mismatch repair in Saccharomyces cerevisiae. Mol Cell Biol (2002) 1.49

Removal of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiae. Mol Cell Biol (1999) 1.47

Evidence that hMLH3 functions primarily in meiosis and in hMSH2-hMSH3 mismatch repair. Cancer Biol Ther (2009) 1.46

Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease. DNA Repair (Amst) (2008) 1.37

Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repair. Mol Cell Biol (1998) 1.33

Mismatch repair proteins are activators of toxic responses to chromium-DNA damage. Mol Cell Biol (2005) 1.32

Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene. Proc Natl Acad Sci U S A (1999) 1.32

Arabidopsis MutS homologs-AtMSH2, AtMSH3, AtMSH6, and a novel AtMSH7-form three distinct protein heterodimers with different specificities for mismatched DNA. Plant Cell (2000) 1.32

Evolutionary origin, diversification and specialization of eukaryotic MutS homolog mismatch repair proteins. Nucleic Acids Res (2000) 1.25

Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer. Mol Cell Biol (1998) 1.25

The nucleotide binding dynamics of human MSH2-MSH3 are lesion dependent. Nat Struct Mol Biol (2009) 1.25

Physical interaction between components of DNA mismatch repair and nucleotide excision repair. Proc Natl Acad Sci U S A (1998) 1.24

Mononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer. J Med Genet (1999) 1.23

Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross-links by both MutS dimers. Cancer Res (2009) 1.21

Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part II. The utility of microsatellite instability testing. J Mol Diagn (2008) 1.21

Conformational trapping of mismatch recognition complex MSH2/MSH3 on repair-resistant DNA loops. Proc Natl Acad Sci U S A (2011) 1.21

Novel DNA mismatch-repair activity involving YB-1 in human mitochondria. DNA Repair (Amst) (2009) 1.18

Functional characterization of pathogenic human MSH2 missense mutations in Saccharomyces cerevisiae. Genetics (2007) 1.17

Structural and functional divergence of MutS2 from bacterial MutS1 and eukaryotic MSH4-MSH5 homologs. J Bacteriol (2005) 1.16

Oxidative stress induces nuclear-to-cytosol shift of hMSH3, a potential mechanism for EMAST in colorectal cancer cells. PLoS One (2012) 1.15

Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegans. Genetics (2005) 1.15

Mismatch repair processing of carcinogen-DNA adducts triggers apoptosis. Mol Cell Biol (1999) 1.12

The utility of immunohistochemical detection of DNA mismatch repair gene proteins. Virchows Arch (2004) 1.09

Interaction between the Msh2 and Msh6 nucleotide-binding sites in the Saccharomyces cerevisiae Msh2-Msh6 complex. J Biol Chem (2010) 1.08

Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination. Mol Cell Biol (1999) 1.08

Recognition of DNA alterations by the mismatch repair system. Biochem J (1999) 1.08

Mutation rates of TGFBR2 and ACVR2 coding microsatellites in human cells with defective DNA mismatch repair. PLoS One (2008) 1.08

Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer. J Clin Oncol (2009) 1.08

The msh2 gene of Schizosaccharomyces pombe is involved in mismatch repair, mating-type switching, and meiotic chromosome organization. Mol Cell Biol (1999) 1.07

DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targets. Br J Pharmacol (2009) 1.07

DNA mismatch repair in plants. An Arabidopsis thaliana gene that predicts a protein belonging to the MSH2 subfamily of eukaryotic MutS homologs. Plant Physiol (1997) 1.06

Regulation of the human MSH6 gene by the Sp1 transcription factor and alteration of promoter activity and expression by polymorphisms. Mol Cell Biol (2003) 1.05

Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry. J Biol Chem (2010) 1.05

Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins. Proc Natl Acad Sci U S A (2007) 1.04

Lynch syndrome-associated neoplasms: a discussion on histopathology and immunohistochemistry. Fam Cancer (2013) 1.03

MSH3-deficiency initiates EMAST without oncogenic transformation of human colon epithelial cells. PLoS One (2012) 1.01

Chemotherapeutic implications in microsatellite unstable colorectal cancer. Cancer Biomark (2006) 1.01

Biochemical basis for dominant mutations in the Saccharomyces cerevisiae MSH6 gene. Proc Natl Acad Sci U S A (2006) 1.01

Both hMutSα and hMutSß DNA mismatch repair complexes participate in 5-fluorouracil cytotoxicity. PLoS One (2011) 1.01

'VIT1', a novel gene associated with vitiligo. Pigment Cell Res (2001) 1.01

The effect of different chemotherapeutic agents on the enrichment of DNA mismatch repair-deficient tumour cells. Br J Cancer (1998) 1.00

Mismatch Repair proteins are recruited to replicating DNA through interaction with Proliferating Cell Nuclear Antigen (PCNA). Nucleic Acids Res (2007) 1.00

Dissimilar mispair-recognition spectra of Arabidopsis DNA-mismatch-repair proteins MSH2*MSH6 (MutSalpha) and MSH2*MSH7 (MutSgamma). Nucleic Acids Res (2003) 0.98

DNA mismatch repair complex MutSβ promotes GAA·TTC repeat expansion in human cells. J Biol Chem (2012) 0.97

Mutation rates, spectra, and genome-wide distribution of spontaneous mutations in mismatch repair deficient yeast. G3 (Bethesda) (2013) 0.97

Reconstitution of long and short patch mismatch repair reactions using Saccharomyces cerevisiae proteins. Proc Natl Acad Sci U S A (2013) 0.97

PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair. Mol Cell (2014) 0.97

A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory. J Cell Mol Med (2009) 0.96

Functional significance of concomitant inactivation of hMLH1 and hMSH6 in tumor cells of the microsatellite mutator phenotype. Proc Natl Acad Sci U S A (2001) 0.96

Flanking sequence specificity determines coding microsatellite heteroduplex and mutation rates with defective DNA mismatch repair (MMR). Oncogene (2010) 0.95

Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins. Oncogene (2008) 0.94

Human MSH2 (hMSH2) protein controls ATP processing by hMSH2-hMSH6. J Biol Chem (2011) 0.93

Insights into protein - DNA interactions, stability and allosteric communications: a computational study of mutSα-DNA recognition complexes. J Biomol Struct Dyn (2012) 0.92

hMSH4-hMSH5 adenosine nucleotide processing and interactions with homologous recombination machinery. J Biol Chem (2007) 0.91

Aberrant protein expression and frequent allelic loss of MSH3 in colorectal cancer with low-level microsatellite instability. Int J Colorectal Dis (2012) 0.91

MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells. PLoS One (2013) 0.91

Melanocytic dysplastic naevi occupy the middle ground between benign melanocytic naevi and cutaneous malignant melanomas: emerging clues. J Clin Pathol (2005) 0.90

Ectopic expression of human MutS homologue 2 on renal carcinoma cells is induced by oxidative stress with interleukin-18 promotion via p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways. J Biol Chem (2012) 0.90

Functional studies and homology modeling of Msh2-Msh3 predict that mispair recognition involves DNA bending and strand separation. Mol Cell Biol (2010) 0.90

Ectopically expressed human tumor biomarker MutS homologue 2 is a novel endogenous ligand that is recognized by human γδ T cells to induce innate anti-tumor/virus immunity. J Biol Chem (2012) 0.90

Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays. Hered Cancer Clin Pract (2012) 0.89

Application of molecular diagnostics for the detection of Lynch syndrome. Expert Rev Mol Diagn (2010) 0.89

Single-molecule views of MutS on mismatched DNA. DNA Repair (Amst) (2014) 0.88

DNA triplet repeat expansion and mismatch repair. Annu Rev Biochem (2015) 0.88

Exonuclease 1-dependent and independent mismatch repair. DNA Repair (Amst) (2015) 0.88

Biochemical analysis of the human mismatch repair proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D). J Biol Chem (2012) 0.87

Mismatch repair in Schizosaccharomyces pombe requires the mutL homologous gene pms1: molecular cloning and functional analysis. Genetics (1997) 0.86

Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway. PLoS Genet (2013) 0.86

Mispair-specific recruitment of the Mlh1-Pms1 complex identifies repair substrates of the Saccharomyces cerevisiae Msh2-Msh3 complex. J Biol Chem (2014) 0.86

Articles cited by this

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell (1993) 13.54

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell (1993) 9.93

Biochemistry and genetics of eukaryotic mismatch repair. Genes Dev (1996) 9.64

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. Genes Dev (1996) 5.34

Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med (1996) 4.87

Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science (1995) 4.48

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat Genet (1995) 4.01

Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions. Genetics (1992) 3.97

MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair. Genes Dev (1995) 3.88

Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction. Cell (1994) 3.54

GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science (1995) 3.34

Mutations of GTBP in genetically unstable cells. Science (1995) 3.23

Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability. J Biol Chem (1996) 2.72

Dual bidirectional promoters at the mouse dhfr locus: cloning and characterization of two mRNA classes of the divergently transcribed Rep-1 gene. Mol Cell Biol (1989) 2.66

Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins. Genetics (1992) 2.50

hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds. Cancer Res (1994) 2.39

Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res (1995) 2.35

Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1995) 2.29

The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions. Genes Dev (1995) 2.06

Isolation and characterization of cDNA clones derived from the divergently transcribed gene in the region upstream from the human dihydrofolate reductase gene. J Biol Chem (1989) 1.83

The yeast gene MSH3 defines a new class of eukaryotic MutS homologues. Mol Gen Genet (1993) 1.82

Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations. Genomics (1994) 1.63

Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas. Hum Mol Genet (1995) 1.57

Binding of mismatched microsatellite DNA sequences by the human MSH2 protein. Science (1994) 1.41

Purified human MSH2 protein binds to DNA containing mismatched nucleotides. Cancer Res (1994) 1.13

Differential cellular expression of the human MSH2 repair enzyme in small and large intestine. Cancer Res (1995) 1.07

Cloning and chromosomal location of human alpha 1(XVI) collagen. Proc Natl Acad Sci U S A (1992) 1.06

Genomic organization and expression of the human MSH3 gene. Genomics (1996) 0.99

Anchor-ligated cDNA libraries: a technique for generating a cDNA library for the immediate cloning of the 5' ends of mRNAs. Biotechniques (1993) 0.95

Nine-bp repeat polymorphism in exon 1 of the hMSH3 gene. Jpn J Hum Genet (1995) 0.87

Articles by these authors

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell (1993) 13.54

inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science (1994) 11.22

The evolution of genes: the chicken preproinsulin gene. Cell (1980) 10.25

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66

The structure and evolution of the two nonallelic rat preproinsulin genes. Cell (1979) 9.25

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res (1997) 8.88

Complexity, leadership, and management in healthcare organisations. BMJ (2001) 8.06

Quality collaboratives: lessons from research. Qual Saf Health Care (2002) 6.78

Method of obtaining optical sectioning by using structured light in a conventional microscope. Opt Lett (1997) 5.73

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. Genes Dev (1996) 5.34

Eukaryotic DNA mismatch repair. Curr Opin Genet Dev (1999) 5.34

The molecular size and conformation of the chloroplast DNA from higher plants. Biochim Biophys Acta (1975) 4.97

Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. Cancer Res (1997) 4.61

Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2. Proc Natl Acad Sci U S A (1997) 3.66

Zea mays chloroplast ribosomal RNA genes are part of a 22,000 base pair inverted repeat. Cell (1977) 3.57

Obliquity-paced Pliocene West Antarctic ice sheet oscillations. Nature (2009) 3.42

Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families. Nat Med (1996) 3.07

Genetic recombination of bacterial plasmid DNA: effect of RecF pathway mutations on plasmid recombination in Escherichia coli. J Bacteriol (1985) 2.92

recA-independent general genetic recombination of plasmids. Nature (1981) 2.89

Promoting patient safety in primary care. BMJ (2001) 2.85

hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA. Mol Cell (1999) 2.85

Germ-line msh6 mutations in colorectal cancer families. Cancer Res (1999) 2.68

Purification and characterization of an activity from Saccharomyces cerevisiae that catalyzes homologous pairing and strand exchange. Proc Natl Acad Sci U S A (1987) 2.67

The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch. Cell (1997) 2.64

Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Nat Genet (1999) 2.62

MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev (2000) 2.49

Interlaboratory comparison of ultrasonic backscatter, attenuation, and speed measurements. J Ultrasound Med (1999) 2.47

Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell (1997) 2.46

Genetic recombination of bacterial plasmid DNA. Physical and genetic analysis of the products of plasmid recombination in Escherichia coli. J Mol Biol (1983) 2.41

Physicochemical characterization of mitochondrial DNA from pea leaves. Proc Natl Acad Sci U S A (1972) 2.38

Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Res (1996) 2.37

Genetic recombination of bacterial plasmid DNA. Analysis of the effect of recombination-deficient mutations on plasmid recombination. J Mol Biol (1982) 2.31

Linkage disequilibrium in domestic sheep. Genetics (2002) 2.29

Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. J Biol Chem (2001) 2.19

BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance. Mol Cell (2001) 2.09

A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. J Biol Chem (2000) 2.08

Characterization of a cDNA encoding the 70-kDa single-stranded DNA-binding subunit of human replication protein A and the role of the protein in DNA replication. J Biol Chem (1991) 2.07

Interaction of wild-type and mutant M protein vesicular stomatitis virus with nucleocapsids in vitro. Biochemistry (1981) 2.06

The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions. Genes Dev (1995) 2.06

Sjögren's syndrome and autoimmunity in a geriatric population. Age Ageing (1972) 2.01

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J Exp Med (1998) 2.00

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. J Biol Chem (1999) 1.96

Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. Gut (2000) 1.95

Chest injuries in a district general hospital. Ann R Coll Surg Engl (1982) 1.92

Mismatch correction catalyzed by cell-free extracts of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1986) 1.89

Intramolecular recombination of linear DNA catalyzed by the Escherichia coli RecE recombination system. J Mol Biol (1985) 1.85

Molecular size and conformation of chloroplast deoxyribonucleic acid from pea leaves. J Biol Chem (1972) 1.81

Gene conversion in Escherichia coli. Resolution of heteroallelic mismatched nucleotides by co-repair. J Mol Biol (1986) 1.80

Size of the detector in confocal imaging systems. Opt Lett (1987) 1.79

The molecular size of the herpes simplex virus type 1 genome. Virology (1974) 1.78

Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein. Mol Cell Biol (1991) 1.77

Partial purification of an enzyme from Saccharomyces cerevisiae that cleaves Holliday junctions. Proc Natl Acad Sci U S A (1985) 1.76

Longitudinal studies of Sin Nombre virus in deer mouse-dominated ecosystems of Montana. Am J Trop Med Hyg (2001) 1.72

Female embryonic lethality in mice nullizygous for both Msh2 and p53. Nat Genet (1997) 1.71

Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognizes Holliday junctions in DNA. J Mol Biol (1997) 1.71

MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxo-guanine in S. cerevisiae. Mol Cell (1999) 1.69

Subtyping binge eating-disordered women along dieting and negative affect dimensions. Int J Eat Disord (2001) 1.67

The prevention of hepatitis. S Afr Med J (1994) 1.67

Identification and characterization of the Escherichia coli RecT protein, a protein encoded by the recE region that promotes renaturation of homologous single-stranded DNA. J Bacteriol (1993) 1.63

Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations. Genomics (1994) 1.63

Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection. Proc Natl Acad Sci U S A (1998) 1.62

MLH1 promoter methylation and gene silencing is the primary cause of microsatellite instability in sporadic endometrial cancers. Hum Mol Genet (1999) 1.61

Multicentre post-infarction trial of propranolol in 49 hospitals in the United Kingdom, Italy, and Yugoslavia. Br Heart J (1980) 1.60

Extracolonic manifestations of Clostridium difficile infections. Presentation of 2 cases and review of the literature. Medicine (Baltimore) (2001) 1.59

Apoptosis induced by overexpression of hMSH2 or hMLH1. Cancer Res (1999) 1.58

Structure of the human MLH1 locus and analysis of a large hereditary nonpolyposis colorectal carcinoma kindred for mlh1 mutations. Cancer Res (1995) 1.57

Importation of dogs into the United States: risks from rabies and other zoonotic diseases. Zoonoses Public Health (2008) 1.57

Biological properties of poliovirus encapsulated in lipid vesicles: antibody resistance and infectivity in virus-resistant cells. Proc Natl Acad Sci U S A (1977) 1.57

Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas. Hum Mol Genet (1995) 1.57

Genetic recombination of homologous plasmids catalyzed by cell-free extracts of Saccharomyces cerevisiae. Cell (1983) 1.56

Exonuclease VIII of Escherichia coli. II. Mechanism of action. J Biol Chem (1983) 1.56

Human exonuclease I interacts with the mismatch repair protein hMSH2. Cancer Res (1998) 1.53

The preparation of purified carcinoembryonic antigen of the human digestive system from large quantities of tumor tissue. Immunochemistry (1972) 1.48

The interaction of the human MutL homologues in hereditary nonpolyposis colon cancer. J Biol Chem (1999) 1.48

Objective assessment of surgical competency--ENT trainees. Clin Otolaryngol (2007) 1.47

Physical and functional interactions between the herpes simplex virus UL15 and UL28 DNA cleavage and packaging proteins. J Virol (1999) 1.46

Characterizing specimen induced aberrations for high NA adaptive optical microscopy. Opt Express (2004) 1.45

Replication of duplex DNA by bacteriophage T7 DNA polymerase and gene 4 protein is accompanied by hydrolysis of nucleoside 5'-triphosphates. Proc Natl Acad Sci U S A (1977) 1.44

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction. Proc Natl Acad Sci U S A (1996) 1.44

Molecular analysis of the Escherichia coli recO gene. J Bacteriol (1989) 1.43

Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16. Am J Hum Genet (1996) 1.43

Microsatellite instability analysis: a multicenter study for reliability and quality control. Cancer Res (1997) 1.43

Severe attenuation of the B cell immune response in Msh2-deficient mice. J Exp Med (1999) 1.42

The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin. Chem Biol (1996) 1.42

The interaction of DNA mismatch repair proteins with human exonuclease I. J Biol Chem (2001) 1.42

Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin. Oncogene (1996) 1.42

Signaling mismatch repair in cancer. Nat Med (1999) 1.41

The history of urology on postage stamps and cancellations. J Urol (1997) 1.41

Nonhomologous recombination in human cells. Mol Cell Biol (1994) 1.40

MutS homologs in mammalian cells. Curr Opin Genet Dev (1997) 1.40

The human homologous pairing protein HPP-1 is specifically stimulated by the cognate single-stranded binding protein hRP-A. Proc Natl Acad Sci U S A (1991) 1.39

Efficient real-time confocal microscopy with white light sources. Nature (1996) 1.39

Replication of bacteriophage T7 DNA by purified proteins. Cold Spring Harb Symp Quant Biol (1979) 1.38

The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair. J Biol Chem (1998) 1.37