Heterogeneous nuclear expression of the promyelocytic leukemia (PML) protein in normal and neoplastic human tissues.

PubWeight™: 1.11‹?› | Rank: Top 10%

🔗 View Article (PMC 1865355)

Published in Am J Pathol on December 01, 1996

Authors

M Gambacorta1, L Flenghi, M Fagioli, S Pileri, L Leoncini, B Bigerna, R Pacini, L N Tanci, L Pasqualucci, S Ascani, A Mencarelli, A Liso, P G Pelicci, B Falini

Author Affiliations

1: Institute of Pathology, Ospedale Niguarda, Milan, Italy.

Articles citing this

Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1. J Cell Biol (1997) 2.98

ALK expression defines a distinct group of T/null lymphomas ("ALK lymphomas") with a wide morphological spectrum. Am J Pathol (1998) 1.64

PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool. Proc Natl Acad Sci U S A (2009) 1.01

The herpesvirus associated ubiquitin specific protease, USP7, is a negative regulator of PML proteins and PML nuclear bodies. PLoS One (2011) 1.00

PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies. Proc Natl Acad Sci U S A (2013) 1.00

Progressive multifocal leukoencephalopathy and promyelocytic leukemia nuclear bodies: a review of clinical, neuropathological, and virological aspects of JC virus-induced demyelinating disease. Acta Neuropathol (2010) 0.98

SUMO interaction motifs in Sizn1 are required for promyelocytic leukemia protein nuclear body localization and for transcriptional activation. J Biol Chem (2009) 0.97

PML promotes MHC class II gene expression by stabilizing the class II transactivator. J Cell Biol (2012) 0.95

Oxidative stress-induced assembly of PML nuclear bodies controls sumoylation of partner proteins. J Cell Biol (2014) 0.94

The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence. Mol Cell Biol (2014) 0.90

Role of the promyelocytic leukaemia protein in cell death regulation. Cell Death Dis (2012) 0.90

Interleukin 6 signaling regulates promyelocytic leukemia protein gene expression in human normal and cancer cells. J Biol Chem (2012) 0.86

PML: An emerging tumor suppressor and a target with therapeutic potential. Cancer Ther (2009) 0.86

Promyelocytic leukemia protein induces apoptosis due to caspase-8 activation via the repression of NFkappaB activation in glioblastoma. Neuro Oncol (2008) 0.83

PML Degradation: Multiple Ways to Eliminate PML. Front Oncol (2013) 0.82

The function, regulation and therapeutic implications of the tumor suppressor protein, PML. Cell Biosci (2015) 0.82

Polymorphisms in microRNA target sites modulate risk of lymphoblastic and myeloid leukemias and affect microRNA binding. J Hematol Oncol (2014) 0.81

Induction of the pro-myelocytic leukaemia gene by type I and type II interferons. Mediators Inflamm (1998) 0.80

Nuclear microenvironment in cancer diagnosis and treatment. J Cell Biochem (2008) 0.77

Immunohistochemical expression of promyelocytic leukemia body in soft tissue sarcomas. J Exp Clin Cancer Res (2008) 0.77

Expression of promyelocytic leukemia protein increases during the differentiation of human neuroblastoma cells. Virchows Arch (2003) 0.76

HO-1, RET and PML as possible markers for risk stratification of acute myelocytic leukemia and prognostic evaluation. Oncol Lett (2015) 0.75

Articles cited by this

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem (1984) 18.48

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell (1991) 9.40

The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell (1991) 8.98

Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem (1991) 8.81

Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection. N Engl J Med (1995) 8.52

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell (1994) 6.52

Antigen unmasking on formalin-fixed, paraffin-embedded tissue sections. J Pathol (1993) 6.15

Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells. Cell (1994) 5.37

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature (1990) 5.24

Acute promyelocytic leukemia. N Engl J Med (1993) 4.63

Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICP0). J Gen Virol (1993) 4.32

The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion. EMBO J (1994) 4.29

Identification of a novel nuclear domain. J Cell Biol (1991) 3.91

A monoclonal antibody recognizing nuclear matrix-associated nuclear bodies. J Cell Sci (1992) 3.91

Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science (1990) 3.34

Updated Kiel classification for lymphomas. Lancet (1988) 3.25

The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell (1993) 2.96

The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML. EMBO J (1995) 2.93

The acute promyelocytic leukaemia-associated PML gene is induced by interferon. Oncogene (1995) 2.80

Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis. J Immunol (1990) 2.73

PML, a growth suppressor disrupted in acute promyelocytic leukemia. Mol Cell Biol (1994) 2.68

CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy. Blood (1995) 2.67

The PML growth-suppressor has an altered expression in human oncogenesis. Oncogene (1995) 2.23

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia. EMBO J (1992) 2.14

Acute promyelocytic leukemia: from genetics to treatment. Blood (1994) 2.09

Nuclear bodies (NBs): a newly "rediscovered" organelle. Exp Cell Res (1992) 1.92

Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment. J Cell Biol (1995) 1.92

Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus. Proc Natl Acad Sci U S A (1991) 1.90

Nuclear dot antigens may specify transcriptional domains in the nucleus. Mol Cell Biol (1993) 1.83

PML protein expression in hematopoietic and acute promyelocytic leukemia cells. Blood (1993) 1.82

Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms. Oncogene (1992) 1.59

PML nuclear bodies are general targets for inflammation and cell proliferation. Cancer Res (1995) 1.54

Inhibition of endogenous tissue alkaline phosphatase with the use of alkaline phosphatase conjugates in immunohistochemistry. J Histochem Cytochem (1981) 1.44

Characterization of a new monoclonal antibody (PG-M3) directed against the aminoterminal portion of the PML gene product: immunocytochemical evidence for high expression of PML proteins on activated macrophages, endothelial cells, and epithelia. Blood (1995) 1.37

Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia. Proc Natl Acad Sci U S A (1992) 1.24

Histological and immunohistological analysis of human lymphomas. Crit Rev Oncol Hematol (1989) 1.22

Expression of cytokine genes, cytokine receptor genes, and transcription factors in cultured Hodgkin and Reed-Sternberg cells. Cancer Res (1992) 0.95

Nucleolar budding and formation of nuclear bodies in cultured thyroid cells stimulated by thyrotropin, dibutyryl cyclic AMP, and prostaglandin E2. J Ultrastruct Res (1980) 0.93

Cell type- and differentiation stage-dependent expression of PML domains in rat, detected by monoclonal antibody HIS55. Exp Cell Res (1995) 0.89

Articles by these authors

A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood (1994) 21.00

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem (1984) 18.48

The tripartite motif family identifies cell compartments. EMBO J (2001) 9.64

The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature (1999) 7.85

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell (1992) 6.86

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J (2001) 6.85

The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood (1985) 6.74

Antigen unmasking on formalin-fixed, paraffin-embedded tissue sections. J Pathol (1993) 6.15

Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia (2006) 5.64

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature (1992) 5.47

Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature (1998) 5.30

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature (2000) 4.90

Hodgkin's disease with monoclonal and polyclonal populations of Reed-Sternberg cells. N Engl J Med (1995) 4.51

Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology (2002) 4.22

CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. Blood (2000) 3.99

Diagnosis of human lymphoma with monoclonal antileukocyte antibodies. N Engl J Med (1983) 3.63

High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein. Cancer Res (1998) 3.56

A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci U S A (1997) 3.20

BCL-6 protein is expressed in germinal-center B cells. Blood (1995) 3.18

Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. Mol Cell Biol (1998) 3.13

A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood (2000) 3.13

Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. Genes Dev (1997) 3.01

The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell (1993) 2.96

Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties. Oncogene (1991) 2.86

Epstein-Barr virus latent membrane protein expression in Hodgkin and Reed-Sternberg cells. Proc Natl Acad Sci U S A (1991) 2.82

The acute promyelocytic leukaemia-associated PML gene is induced by interferon. Oncogene (1995) 2.80

Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells. J Natl Cancer Inst (1998) 2.75

Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences. Blood (1997) 2.72

CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy. Blood (1995) 2.67

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. EMBO J (1997) 2.62

Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells. N Engl J Med (1997) 2.59

Individual differences in intuitive-experiential and analytical-rational thinking styles. J Pers Soc Psychol (1996) 2.55

Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice. Proc Natl Acad Sci U S A (1997) 2.47

The EnVision++ system: a new immunohistochemical method for diagnostics and research. Critical comparison with the APAAP, ChemMate, CSA, LABC, and SABC techniques. J Clin Pathol (1998) 2.44

ALK expression in extranodal anaplastic large cell lymphoma favours systemic disease with (primary) nodal involvement and a good prognosis and occurs before dissemination. J Clin Pathol (2000) 2.43

Immunohistological analysis of human mononuclear phagocytes and dendritic cells by using monoclonal antibodies. Lab Invest (1986) 2.42

ALK-positive lymphoma: a single disease with a broad spectrum of morphology. Blood (1998) 2.41

Peripheral T-cell lymphoma associated with hemophagocytic syndrome. Blood (1990) 2.40

Numb is an endocytic protein. J Cell Biol (2000) 2.39

ALK+ lymphoma: clinico-pathological findings and outcome. Blood (1999) 2.38

Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins. Oncogene (1994) 2.27

Histiocytic necrotizing lymphadenitis without granulocytic infiltration. Virchows Arch A Pathol Anat Histol (1982) 2.22

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia. EMBO J (1992) 2.14

T-cell receptor gene rearrangements as markers of lineage and clonality in T-cell neoplasms. Proc Natl Acad Sci U S A (1985) 2.10

Acute promyelocytic leukemia: from genetics to treatment. Blood (1994) 2.09

Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma. Proc Natl Acad Sci U S A (1986) 2.09

Low versus high cell turnover in diffusely growing non-Hodgkin's lymphomas. J Pathol (1995) 2.03

Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation. Mol Cell (2000) 2.02

Antigen retrieval techniques in immunohistochemistry: comparison of different methods. J Pathol (1997) 2.01

eps15 and eps15R are essential components of the endocytic pathway. Cancer Res (1997) 1.99

Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc. Nature (1994) 1.97

Analysis of MUM1/IRF4 protein expression using tissue microarrays and immunohistochemistry. Mod Pathol (2001) 1.96

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J (1994) 1.94

Use of a two-hybrid assay to study the assembly of a complex multicomponent protein machinery: bacterial septosome differentiation. Microbiology (2003) 1.94

Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases. Proc Natl Acad Sci U S A (1992) 1.93

Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus. Proc Natl Acad Sci U S A (1991) 1.90

Distribution of T cells bearing different forms of the T cell receptor gamma/delta in normal and pathological human tissues. J Immunol (1989) 1.89

A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution. Proc Natl Acad Sci U S A (1995) 1.87

Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc Natl Acad Sci U S A (2001) 1.84

PG-M1: a new monoclonal antibody directed against a fixative-resistant epitope on the macrophage-restricted form of the CD68 molecule. Am J Pathol (1993) 1.81

Evolution of Shc functions from nematode to human. Curr Opin Genet Dev (2000) 1.80

Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases. Oncogene (2011) 1.79

Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes. J Exp Med (1985) 1.79

BER-H2: a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope. Blood (1989) 1.76

Not all Shc's roads lead to Ras. Trends Biochem Sci (1996) 1.74

The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Mol Cell Biol (1998) 1.69

Expression of bcl-6 and CD10 in primary mediastinal large B-cell lymphoma: evidence for derivation from germinal center B cells? Am J Surg Pathol (2001) 1.68

Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin. Leukemia (2005) 1.67

A revised European-American classification of lymphoid neoplasms proposed by the International Lymphoma Study Group. A summary version. Am J Clin Pathol (1995) 1.67

HIV-associated malignant lymphomas in Kenya (Equatorial Africa) Hum Pathol (1998) 1.66

ALK expression defines a distinct group of T/null lymphomas ("ALK lymphomas") with a wide morphological spectrum. Am J Pathol (1998) 1.64