The role of DNA methylation in cancer genetic and epigenetics.

PubWeight™: 2.63‹?› | Rank: Top 1%

🔗 View Article (PMID 8982461)

Published in Annu Rev Genet on January 01, 1996

Authors

P W Laird1, R Jaenisch

Author Affiliations

1: Department of Surgery, University of Southern California, School of Medicine/Norris Comprehensive Cancer Center, Los Angeles 90033, USA. laird_p@froggy.hsc.usc.edu

Articles citing this

High-throughput DNA methylation profiling using universal bead arrays. Genome Res (2006) 8.05

Multiple mutations and cancer. Proc Natl Acad Sci U S A (2003) 4.21

Methylation matters. J Med Genet (2001) 3.00

DNA methylation of the first exon is tightly linked to transcriptional silencing. PLoS One (2011) 2.80

Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome. PLoS One (2010) 2.54

A DNA methyltransferase homolog with a chromodomain exists in multiple polymorphic forms in Arabidopsis. Genetics (1998) 2.47

Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci U S A (2003) 2.44

Enzymatic properties of de novo-type mouse DNA (cytosine-5) methyltransferases. Nucleic Acids Res (2001) 2.36

Genomic imprinting: implications for human disease. Am J Pathol (1999) 2.26

Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. Nucleic Acids Res (1998) 2.17

Initiation of DNA replication at CpG islands in mammalian chromosomes. EMBO J (1998) 2.13

DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas. Br J Cancer (1999) 1.86

Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML. Blood (2011) 1.85

DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer. Genome Res (2011) 1.85

Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation. Proc Natl Acad Sci U S A (2002) 1.77

Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks. Mol Cell Biol (2003) 1.65

DNA methyltransferases: a novel target for prevention and therapy. Front Oncol (2014) 1.62

DNA methylation-based biomarkers for early detection of non-small cell lung cancer: an update. Mol Cancer (2008) 1.55

The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands. Genome Res (2009) 1.32

Position-dependent and promoter-specific regulation of gene expression in Trypanosoma brucei. EMBO J (1997) 1.31

Drosophila proteins related to vertebrate DNA (5-cytosine) methyltransferases. Proc Natl Acad Sci U S A (1999) 1.30

DNA methylation: an alternative pathway to cancer. Ann Surg (2001) 1.24

Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer. Mol Cancer (2008) 1.24

Tissue-specific variation in DNA methylation levels along human chromosome 1. Epigenetics Chromatin (2009) 1.19

Detection and quantification of methylation in DNA using solid-state nanopores. Sci Rep (2013) 1.19

Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells. Mol Cell Biol (2001) 1.17

Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors. Mod Pathol (2008) 1.15

CD133: to be or not to be, is this the real question? Am J Transl Res (2013) 1.12

Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells. Mol Cancer (2010) 1.11

Investigating the target recognition of DNA cytosine-5 methyltransferase HhaI by library selection using in vitro compartmentalisation. Nucleic Acids Res (2002) 1.07

Aberrant DNA hypermethylation patterns lead to transcriptional silencing of tumor suppressor genes in UVB-exposed skin and UVB-induced skin tumors of mice. Carcinogenesis (2010) 1.07

Enhanced gene repair mediated by methyl-CpG-modified single-stranded oligonucleotides. Nucleic Acids Res (2009) 1.05

Methylation patterns and mathematical models reveal dynamics of stem cell turnover in the human colon. Proc Natl Acad Sci U S A (2001) 1.05

Mapping the new molecular landscape: social dimensions of epigenetics. New Genet Soc (2013) 1.04

Evaluation of global DNA hypomethylation in human colon cancer tissues by immunohistochemistry and image analysis. Gut (2000) 1.04

Epigenetic transgenerational effects of endocrine disruptors on male reproduction. Semin Reprod Med (2009) 0.98

Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese population. Cancer Causes Control (2007) 0.97

Transcriptional repression by Drosophila methyl-CpG-binding proteins. Mol Cell Biol (2000) 0.95

Epigenetic alterations in ultraviolet radiation-induced skin carcinogenesis: interaction of bioactive dietary components on epigenetic targets. Photochem Photobiol (2011) 0.95

CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter. Oncotarget (2016) 0.93

Vitamin B12 deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse. Nutr Metab (Lond) (2012) 0.92

Nutrients in folate-mediated, one-carbon metabolism and the risk of rectal tumors in men and women. Nutr Cancer (2011) 0.92

Down-regulation of interferon regulatory factor 4 gene expression in leukemic cells due to hypermethylation of CpG motifs in the promoter region. Nucleic Acids Res (2005) 0.91

DNA methylation in gastric cancer, related to Helicobacter pylori and Epstein-Barr virus. World J Gastroenterol (2014) 0.91

Imprinted genes as potential genetic and epigenetic toxicologic targets. Environ Health Perspect (2000) 0.88

Quantitation of cellular metabolic fluxes of methionine. Anal Chem (2014) 0.87

miR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1. Oncotarget (2015) 0.87

Loss of expression of HDAC-recruiting methyl-CpG-binding domain proteins in human cancer. Br J Cancer (2001) 0.87

Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations. Int J Mol Epidemiol Genet (2010) 0.85

Structural biology-based insights into combinatorial readout and crosstalk among epigenetic marks. Biochim Biophys Acta (2014) 0.85

Studying human telomerase gene transcription by a chromatinized reporter generated by recombinase-mediated targeting of a bacterial artificial chromosome. Nucleic Acids Res (2009) 0.85

Retinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complex. Am J Pathol (2007) 0.84

Claudin-7 expression induces mesenchymal to epithelial transformation (MET) to inhibit colon tumorigenesis. Oncogene (2014) 0.84

Mycoplasma CG- and GATC-specific DNA methyltransferases selectively and efficiently methylate the host genome and alter the epigenetic landscape in human cells. Epigenetics (2015) 0.83

Pattern of nonspecific (or global) DNA methylation in oral carcinogenesis. Head Neck (2005) 0.83

Correlation between the DNA global methylation status and progesterone receptor expression in normal endometrium, endometrioid adenocarcinoma and precursors. Virchows Arch (2004) 0.83

Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer susceptibility. World J Gastroenterol (2014) 0.83

Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract. Gene Expr Patterns (2013) 0.82

TNF-α inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation. J Cell Mol Med (2012) 0.82

The MethDet: a technology for biomarker development. Expert Rev Mol Diagn (2011) 0.82

A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4. Aging Cell (2010) 0.82

DAP kinase and DAP-3: novel positive mediators of apoptosis. Ann Rheum Dis (1999) 0.81

Epigenetics and the overhealing wound: the role of DNA methylation in fibrosis. Fibrogenesis Tissue Repair (2015) 0.81

Role of loss of o⁶-methylguanine dna methyltransferase (MGMT) expression in non-small cell lung carcinomas (NSCLCs): with reference to the relationship with p53 overexpression. Cancer Res Treat (2010) 0.81

The tendency to recreate ancestral CG dinucleotides in the human genome. BMC Evol Biol (2011) 0.80

Are the somatic mutation and tissue organization field theories of carcinogenesis incompatible? Cancer Inform (2013) 0.79

ConteXt of change--X inactivation and disease. EMBO Mol Med (2010) 0.79

Hypermethylation of CpG islands is more prevalent than hypomethylation across the entire genome in breast carcinogenesis. Clin Exp Med (2012) 0.78

Biological Basis of Differential Susceptibility to Hepatocarcinogenesis among Mouse Strains. J Toxicol Pathol (2009) 0.78

Is the fungus Magnaporthe losing DNA methylation? Genetics (2013) 0.78

PIWIL2 promotes progression of non-small cell lung cancer by inducing CDK2 and Cyclin A expression. J Transl Med (2015) 0.78

Decreased DNA Methylation in the Shati/Nat8l Promoter in Both Patients with Schizophrenia and a Methamphetamine-Induced Murine Model of Schizophrenia-Like Phenotype. PLoS One (2016) 0.77

An Integrated Analysis of the Genome-Wide Profiles of DNA Methylation and mRNA Expression Defining the Side Population of a Human Malignant Mesothelioma Cell Line. J Cancer (2016) 0.77

Mechanisms of epigenetic regulation of leukemia onset and progression. Adv Immunol (2013) 0.77

Epigenetic modulation of the muscarinic type 3 receptor in salivary epithelial cells. Lab Invest (2014) 0.77

Non-methylated Genomic Sites Coincidence Cloning (NGSCC): an approach to large scale analysis of hypomethylated CpG patterns at predetermined genomic loci. Mol Genet Genomics (2003) 0.77

A Novel Combinatorial Epigenetic Therapy Using Resveratrol and Pterostilbene for Restoring Estrogen Receptor-α (ERα) Expression in ERα-Negative Breast Cancer Cells. PLoS One (2016) 0.76

Methylation kinetics and CpG-island methylator phenotype status in colorectal cancer cell lines. Biol Direct (2013) 0.76

The Structural Determinants behind the Epigenetic Role of Histone Variants. Genes (Basel) (2015) 0.76

Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway. PLoS One (2017) 0.76

NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compounds. Acta Pharmacol Sin (2016) 0.75

Epigenetic alteration of the purinergic type 7 receptor in salivary epithelial cells. Biochem Biophys Res Commun (2015) 0.75

Genome-Wide Scan for Methylation Profiles in Keloids. Dis Markers (2015) 0.75

Tumoral environment triggers transcript anomalies in established tumors: induction of altered gene expression and of aberrant, truncated and B2 repeat-containing gene transcripts. Neoplasia (1999) 0.75

Structure, genetics and function of the pulmonary associated surfactant proteins A and D: The extra-pulmonary role of these C type lectins. Ann Anat (2017) 0.75

Articles by these authors

(truncated to the top 100)

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell (1992) 27.80

Epigenetic memory in induced pluripotent stem cells. Nature (2010) 14.31

Role for DNA methylation in genomic imprinting. Nature (1993) 12.65

Simplified mammalian DNA isolation procedure. Nucleic Acids Res (1991) 12.56

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity (2001) 9.45

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet (2001) 8.64

Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells. Nature (1990) 8.57

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc Natl Acad Sci U S A (2000) 8.12

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development (1996) 7.98

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. Nature (1992) 7.66

MyoD or Myf-5 is required for the formation of skeletal muscle. Cell (1993) 7.14

WT-1 is required for early kidney development. Cell (1993) 7.05

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat Genet (2001) 6.92

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development. Cell (1992) 5.98

Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc Natl Acad Sci U S A (2001) 5.76

Xist-deficient mice are defective in dosage compensation but not spermatogenesis. Genes Dev (1997) 4.90

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell (1995) 4.73

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci U S A (2001) 4.60

Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells. J Exp Med (1991) 4.49

Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature (1989) 4.46

Chromosomal position and activation of retroviral genomes inserted into the germ line of mice. Cell (1981) 4.42

De novo methylation and expression of retroviral genomes during mouse embryogenesis. Nature (1982) 4.42

Replicating SV40 molecules containing closed circular template DNA strands. Nat New Biol (1971) 4.36

Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol (2001) 4.34

Chromosomal position or virus mutation permits retrovirus expression in embryonal carcinoma cells. Cell (1986) 4.32

A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation. Mol Cell (2000) 4.26

Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. Development (1996) 4.20

Suppression of intestinal neoplasia by DNA hypomethylation. Cell (1995) 4.16

Embryonic lethal mutation in mice induced by retrovirus insertion into the alpha 1(I) collagen gene. Nature (1983) 4.14

Epigenetic instability in ES cells and cloned mice. Science (2001) 4.08

Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus. Proc Natl Acad Sci U S A (1976) 4.07

MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity. Science (1991) 3.93

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell (1992) 3.91

Nuclear cloning and epigenetic reprogramming of the genome. Science (2001) 3.79

De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells. Proc Natl Acad Sci U S A (1982) 3.77

ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Curr Biol (1998) 3.77

DNA methylation and gene expression: endogenous retroviral genome becomes infectious after molecular cloning. Proc Natl Acad Sci U S A (1981) 3.70

Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death. Cell (1992) 3.65

Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature (1994) 3.64

DNA hypomethylation leads to elevated mutation rates. Nature (1998) 3.60

DNA methylation in Drosophila melanogaster. Nature (2000) 3.46

Retrovirus integration and chromatin structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites. J Virol (1987) 3.45

Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infectious. Nature (1983) 3.43

Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice. Nature (1991) 3.36

Delayed clearance of Sendai virus in mice lacking class I MHC-restricted CD8+ T cells. J Immunol (1992) 3.31

Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes. Genes Dev (1996) 3.29

Transcription factor AP-2 essential for cranial closure and craniofacial development. Nature (1996) 3.27

Retroviral expression in embryonic stem cells and hematopoietic stem cells. Mol Cell Biol (2000) 3.20

Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation. J Cell Biol (2001) 2.94

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci U S A (1994) 2.92

DNA methylation and cancer. Hum Mol Genet (1994) 2.84

A generic intron increases gene expression in transgenic mice. Mol Cell Biol (1991) 2.75

DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J Neurosci (2001) 2.75

Infectivity and methylation of retroviral genomes is correlated with expression in the animal. Cell (1981) 2.73

Functional analysis of activins during mammalian development. Nature (1995) 2.71

Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell (1994) 2.65

Infection of preimplantation mouse embryos and of newborn mice with leukemia virus: tissue distribution of viral DNA and RNA and leukemogenesis in the adult animal. Proc Natl Acad Sci U S A (1975) 2.64

Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation. Nat Genet (1999) 2.62

Long-range cis effects of ectopic X-inactivation centres on a mouse autosome. Nature (1997) 2.62

X chromosome inactivation is mediated by Xist RNA stabilization. Cell (1997) 2.60

X-Chromosome inactivation in cloned mouse embryos. Science (2000) 2.59

A 450 kb transgene displays properties of the mammalian X-inactivation center. Cell (1996) 2.52

DNA hypomethylation can activate Xist expression and silence X-linked genes. Genes Dev (1996) 2.51

Perinatal lethal osteogenesis imperfecta in transgenic mice bearing an engineered mutant pro-alpha 1(I) collagen gene. Nature (1988) 2.49

alpha3beta1 Integrin is required for normal development of the epidermal basement membrane. J Cell Biol (1997) 2.46

Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A (1997) 2.37

Generation of mice from wild-type and targeted ES cells by nuclear cloning. Nat Genet (2000) 2.36

The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. Cell (1991) 2.33

Germline integration of moloney murine leukemia virus at the Mov13 locus leads to recessive lethal mutation and early embryonic death. Cell (1983) 2.33

Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice. Proc Natl Acad Sci U S A (1984) 2.30

A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J Cell Biol (1995) 2.30

Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron (1995) 2.27

Retroviruses as probes for mammalian development: allocation of cells to the somatic and germ cell lineages. Cell (1986) 2.26

Simian virus 40 DNA sequences in DNA of healthy adult mice derived from preimplantation blastocysts injected with viral DNA. Proc Natl Acad Sci U S A (1974) 2.26

Retrovirus-induced de novo methylation of flanking host sequences correlates with gene inactivity. Nature (1985) 2.26

Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice. Oncogene (2007) 2.22

Mice lacking major histocompatibility complex class I and class II molecules. Proc Natl Acad Sci U S A (1993) 2.18

Integration of Moloney leukaemia virus into the germ line of mice: correlation between site of integration and virus activation. Nature (1980) 2.18

Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes. Diabetes (1994) 2.16

Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells. Cancer Res (2000) 2.13

RNA and the epigenetic regulation of X chromosome inactivation. Cell (1998) 2.10

Loss of methylation activates Xist in somatic but not in embryonic cells. Genes Dev (1995) 2.08

Retroviruses and embryogenesis: microinjection of Moloney leukemia virus into midgestation mouse embryos. Cell (1980) 2.05

Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn (1997) 2.05

The MyoD family of transcription factors and skeletal myogenesis. Bioessays (1995) 2.05

Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death. Cell (1984) 2.03

Low-multiplicity infection of Moloney murine leukemia virus in mouse cells: effect on number of viral DNA copies and virus production in producer cells. J Virol (1978) 1.99

Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila. Nat Genet (1999) 1.98

Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease. Proc Natl Acad Sci U S A (1994) 1.96

Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice. Proc Natl Acad Sci U S A (1992) 1.93

Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal. Nature (1981) 1.91

Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev (1994) 1.91

Retrovirus-induced lethal mutation in collagen I gene of mice is associated with an altered chromatin structure. Cell (1984) 1.91

Two distinct sequence elements mediate retroviral gene expression in embryonal carcinoma cells. J Virol (1987) 1.90

Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A (1994) 1.88

Chromosomal deletion complexes in mice by radiation of embryonic stem cells. Nat Genet (1997) 1.87

The integration sites of endogenous and exogenous Moloney murine leukemia virus. Cell (1979) 1.87

Dnmt1 expression in pre- and postimplantation embryogenesis and the maintenance of IAP silencing. Mol Cell Biol (2004) 1.86

Antisense transcription through the Xist locus mediates Tsix function in embryonic stem cells. Mol Cell Biol (2001) 1.86

Abrogation of resistance to Theiler's virus-induced demyelination in H-2b mice deficient in beta 2-microglobulin. J Immunol (1993) 1.85