Published in J Clin Invest on February 01, 1997
Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation. J Exp Med (1998) 2.89
A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest (1999) 2.65
A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production. J Exp Med (2001) 1.48
Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice. Infect Immun (2000) 1.39
IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease. Proc Natl Acad Sci U S A (2003) 1.06
Association of single nucleotide polymorphisms in the IL-18 gene with production of IL-18 protein by mononuclear cells from healthy donors. Mediators Inflamm (2008) 0.98
Genetic control of severe egg-induced immunopathology and IL-17 production in murine schistosomiasis. J Immunol (2009) 0.94
Elevated interleukin-18 levels correlated with disease activity in systemic lupus erythematosus. Clin Rheumatol (2004) 0.90
IL-18 is required for self-reactive T cell expansion in NOD mice. J Autoimmun (2011) 0.80
Thyrocyte interleukin-18 expression is up-regulated by interferon-γ and may contribute to thyroid destruction in Hashimoto's thyroiditis. Int J Exp Pathol (2010) 0.80
Endogenous interleukin-12 only plays a key pathogenetic role in non-obese diabetic mouse diabetes during the very early stages of the disease. Immunology (1999) 0.80
IL-18 105 A>C polymorphism contributes to renal manifestations in patients with SLE. Rheumatol Int (2009) 0.79
Reduced interleukin-12, interleukin-18, and interferon-gamma production with prolonged rat hepatic allograft survival after donor-specific blood transfusion. Dig Dis Sci (2000) 0.78
Interleukin-12 to interleukin 'infinity': the rationale for future therapeutic cytokine targeting. Springer Semin Immunopathol (2006) 0.78
IFN-gamma, IGIF, and IDDM. J Clin Invest (1997) 0.78
Interleukin-18, rheumatoid arthritis, and tissue destruction. J Clin Invest (1999) 0.76
Absence of significant Th2 response in diabetes-prone non-obese diabetic (NOD) mice. Clin Exp Immunol (1999) 0.75
Pentoxifylline inhibits the synthesis and IFN-gamma-inducing activity of IL-18. Clin Exp Immunol (2001) 0.75
Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature (1995) 10.89
Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J Virol (1982) 6.56
Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice. Science (1987) 6.36
Development and applications of a molecular genetic linkage map of the mouse genome. Trends Genet (1991) 4.17
T helper cell subsets in insulin-dependent diabetes. Science (1995) 3.92
Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J Exp Med (1995) 2.29
Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J Clin Invest (1991) 2.07
Prevention of diabetes in NOD mice treated with antibody to murine IFN gamma. J Autoimmun (1991) 1.71
Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J Autoimmun (1993) 1.50
Crosses of NOD mice with the related NON strain. A polygenic model for IDDM. Diabetes (1995) 1.50
Prevention of diabetes in the NOD mouse: implications for therapeutic intervention in human disease. Immunol Today (1994) 1.05
Interleukin-12 gene expression is associated with rapid development of diabetes mellitus in non-obese diabetic mice. Diabetologia (1996) 1.04
Mouse chromosome 9. Mamm Genome (1994) 0.99
Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene. Genomics (1996) 0.99
Histological study of pancreatic beta-cell loss in relation to the insulitis process in the non-obese diabetic mouse. Histochemistry (1994) 0.94
Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4. Diabetologia (1994) 0.93
Autoimmune diabetes results from genetic defects manifest by antigen presenting cells. FASEB J (1993) 0.93
A role for macrophages in the pathogenesis of type 1 diabetes. Autoimmunity (1989) 0.89
An efficient recombination system for chromosome engineering in Escherichia coli. Proc Natl Acad Sci U S A (2000) 17.30
A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics (2001) 15.03
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell (1993) 13.54
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature (1992) 12.92
Recombineering: a powerful new tool for mouse functional genomics. Nat Rev Genet (2001) 8.35
Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell (1994) 7.23
Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell (1990) 6.94
Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol (2000) 6.57
Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J Virol (1982) 6.56
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron (1997) 6.16
TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell (2000) 6.07
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron (1995) 6.03
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science (1993) 5.50
Self-monitoring of blood glucose in type 2 diabetes and long-term outcome: an epidemiological cohort study. Diabetologia (2005) 5.47
Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron (1995) 5.43
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron (1996) 5.30
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron (1996) 5.14
CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science (1993) 5.04
Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell (1993) 5.00
Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome. Nature (1981) 4.77
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng (2001) 4.64
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron (1997) 4.49
Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol (1991) 4.42
Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron (1997) 4.33
A genetic linkage map of the mouse: current applications and future prospects. Science (1993) 4.24
Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Genes Dev (1994) 4.19
Development and applications of a molecular genetic linkage map of the mouse genome. Trends Genet (1991) 4.17
The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Nat Genet (1998) 4.06
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum Mol Genet (1999) 4.06
Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. Nature (1994) 3.99
Novel myosin heavy chain encoded by murine dilute coat colour locus. Nature (1991) 3.95
Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet (2000) 3.92
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. Development (1995) 3.90
Development of type 1 diabetes despite severe hereditary B-lymphocyte deficiency. N Engl J Med (2001) 3.85
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J (1995) 3.78
Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell (1988) 3.75
The promise of comparative genomics in mammals. Science (1999) 3.67
The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol (1992) 3.66
Excision of the DBA ecotropic provirus in dilute coat-color revertants of mice occurs by homologous recombination involving the viral LTRs. Cell (1983) 3.66
Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med (2000) 3.51
Comparative anchor tagged sequences (CATS) for integrative mapping of mammalian genomes. Nat Genet (1997) 3.47
microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev (1994) 3.44
The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev (1994) 3.42
Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev (1994) 3.40
The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells. Nat Genet (1995) 3.40
Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour. Nature (1984) 3.37
The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform. J Cell Biol (1997) 3.34
Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. Nat Genet (1996) 3.32
Direct interaction of microtubule- and actin-based transport motors. Nature (1999) 3.25
Leukaemia disease genes: large-scale cloning and pathway predictions. Nat Genet (1999) 3.19
Anchored reference loci for comparative genome mapping in mammals. Nat Genet (1993) 3.19
A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet Anal (1996) 3.18
Absence epilepsy in tottering mutant mice is associated with calcium channel defects. Cell (1996) 3.08
A mutation in Rab27a causes the vesicle transport defects observed in ashen mice. Proc Natl Acad Sci U S A (2000) 3.07