Published in Curr Biol on February 01, 1997
Rho GTPases and their effector proteins. Biochem J (2000) 8.89
Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK. EMBO J (2000) 4.39
Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol Mol Biol Rev (1999) 3.61
A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1. Mol Cell Biol (1998) 2.92
p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. J Cell Biol (1999) 2.84
Pak protein kinases and their role in cancer. Cancer Metastasis Rev (2009) 2.44
PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation. Biochem J (2005) 2.19
Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. EMBO J (1998) 2.18
Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol Cell Biol (1998) 2.13
The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL). J Cell Biol (2001) 2.10
Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Mol Cell Biol (1997) 1.94
PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis. J Cell Biol (1999) 1.89
The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol (2003) 1.86
Temporal and spatial distribution of activated Pak1 in fibroblasts. J Cell Biol (2000) 1.82
Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. Mol Biol Cell (1998) 1.81
P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium. EMBO J (2002) 1.75
Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway. Mol Biol Cell (2002) 1.72
Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness. Mol Biol Cell (2005) 1.69
Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation. Mol Cell Biol (2000) 1.66
Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis. J Cell Biol (2007) 1.62
Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1. Proc Natl Acad Sci U S A (2001) 1.49
Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration. Mol Cell Biol (2003) 1.44
Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation. Mol Cell Biol (2000) 1.38
A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK. EMBO J (1998) 1.31
p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep (2002) 1.30
Sns and Kirre, the Drosophila orthologs of Nephrin and Neph1, direct adhesion, fusion and formation of a slit diaphragm-like structure in insect nephrocytes. Development (2009) 1.29
Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb. Mol Cell Biol (2000) 1.24
Role of the SH3-ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaques. J Virol (1998) 1.23
Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak. EMBO J (2001) 1.23
Association of PI-3 kinase with PAK1 leads to actin phosphorylation and cytoskeletal reorganization. Mol Biol Cell (2002) 1.21
Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Mol Cell Biol (2005) 1.21
Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts. J Virol (2004) 1.20
P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration. J Cell Biol (2002) 1.17
A role for Pak protein kinases in Schwann cell transformation. Proc Natl Acad Sci U S A (1998) 1.14
GIT1 activates p21-activated kinase through a mechanism independent of p21 binding. Mol Cell Biol (2004) 1.13
Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts. Mol Cell Biol (1999) 1.07
Interaction with the SH3 domain protein Bem1 regulates signaling by the Saccharomyces cerevisiae p21-activated kinase Ste20. Mol Cell Biol (2005) 1.04
Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions. Mol Biol Cell (2004) 1.03
Inhibition of the motility and growth of B16F10 mouse melanoma cells by dominant negative mutants of Dok-1. Mol Cell Biol (2001) 0.99
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3. Mol Cell Biol (2001) 0.99
Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts. J Virol (2004) 0.97
Expression of mutated Nck SH2/SH3 adaptor respecifies mesodermal cell fate in Xenopus laevis development. Proc Natl Acad Sci U S A (1997) 0.94
XPak3 promotes cell cycle withdrawal during primary neurogenesis in Xenopus laevis. EMBO J (2002) 0.94
PAK1-Nck regulates cyclin D1 promoter activity in response to prolactin. Mol Endocrinol (2011) 0.94
EphA4 signaling regulates blastomere adhesion in the Xenopus embryo by recruiting Pak1 to suppress Cdc42 function. Mol Biol Cell (2007) 0.93
Regulation of neurotrophin-induced axonal responses via Rho GTPases. J Comp Neurol (2001) 0.93
Neutrophils stimulated with a variety of chemoattractants exhibit rapid activation of p21-activated kinases (Paks): separate signals are required for activation and inactivation of paks. Mol Cell Biol (1998) 0.90
Dissecting activation of the PAK1 kinase at protrusions in living cells. J Biol Chem (2009) 0.89
Adaptive responses to dasatinib-treated lung squamous cell cancer cells harboring DDR2 mutations. Cancer Res (2014) 0.89
Altered nitric oxide production mediates matrix-specific PAK2 and NF-κB activation by flow. Mol Biol Cell (2012) 0.88
Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites. J Cell Biol (2002) 0.88
Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics. Nat Commun (2013) 0.87
Regulation of process retraction and cell migration by EphA3 is mediated by the adaptor protein Nck1. Biochemistry (2009) 0.87
A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling. BMC Cell Biol (2002) 0.87
Phosphatase of regenerating liver 3 (PRL3) provokes a tyrosine phosphoproteome to drive prometastatic signal transduction. Mol Cell Proteomics (2013) 0.86
Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation. Mol Cell Biol (2002) 0.85
Untangling the complexity of PAK1 dynamics: The future challenge. Cell Logist (2012) 0.85
Roles of P21-activated kinases and associated proteins in epithelial wound healing. Int Rev Cell Mol Biol (2008) 0.85
Integration of signaling and cytoskeletal remodeling by Nck in directional cell migration. Bioarchitecture (2013) 0.83
p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor. J Biol Chem (2011) 0.83
Evidence for a novel mechanism of the PAK1 interaction with the Rho-GTPases Cdc42 and Rac. PLoS One (2013) 0.83
EphB2 receptor forward signaling controls cortical growth cone collapse via Nck and Pak. Mol Cell Neurosci (2012) 0.83
The role of p21-activated kinases in hepatocellular carcinoma metastasis. J Mol Signal (2014) 0.81
Dexamethasone increases the phosphorylation of nephrin in cultured podocytes. Clin Exp Nephrol (2011) 0.81
Increased SHP-1 protein expression by high glucose levels reduces nephrin phosphorylation in podocytes. J Biol Chem (2014) 0.80
Phosphorylation status of nephrin in human membranous nephropathy. Clin Exp Nephrol (2009) 0.79
Angiotensin II stimulates serine phosphorylation of the adaptor protein Nck: physical association with the serine/threonine kinases Pak1 and casein kinase I. Biochem J (1999) 0.78
Protein kinase CK2 phosphorylates and activates p21-activated kinase 1. Mol Biol Cell (2013) 0.78
Coordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol. Nat Commun (2013) 0.77
p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix. Blood (2016) 0.77
The Role of the Pleckstrin Homology Domain-containing Protein CKIP-1 in Activation of p21-activated Kinase 1 (PAK1). J Biol Chem (2015) 0.77
Multiple cytoskeletal pathways and PI3K signaling mediate CDC-42-induced neuronal protrusion in C. elegans. Small GTPases (2013) 0.77
Recruitment of the adaptor protein Nck to PECAM-1 couples oxidative stress to canonical NF-κB signaling and inflammation. Sci Signal (2015) 0.75
Specification of Dendritogenesis Site in Drosophila aCC Motoneuron by Membrane Enrichment of Pak1 through Dscam1. Dev Cell (2015) 0.75
p27(Kip1) promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway. Elife (2017) 0.75
Dock8 interacts with Nck1 in mediating Schwann cell precursor migration. Biochem Biophys Rep (2016) 0.75
The phylogeny of prokaryotes. Science (1980) 24.57
Detailed analysis of the higher-order structure of 16S-like ribosomal ribonucleic acids. Microbiol Rev (1983) 23.08
Progress in development of the index of ADL. Gerontologist (1970) 15.21
Timing the ancestor of the HIV-1 pandemic strains. Science (2000) 10.42
Secondary structure model for bacterial 16S ribosomal RNA: phylogenetic, enzymatic and chemical evidence. Nucleic Acids Res (1980) 9.50
A measure of primary sociobiological functions. Int J Health Serv (1976) 8.93
Identification of a ten-amino acid proline-rich SH3 binding site. Science (1993) 8.05
Ecology. Synthesizing U.S. river restoration efforts. Science (2005) 7.26
Secondary structure model for 23S ribosomal RNA. Nucleic Acids Res (1981) 7.12
Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (TIPS): a phase II, double-blind, randomised trial. Lancet (2009) 6.83
Active life expectancy. N Engl J Med (1983) 6.36
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature (1995) 6.20
Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. J Am Geriatr Soc (1983) 6.17
Sex differences in the management of coronary artery disease. Survival and Ventricular Enlargement Investigators. N Engl J Med (1991) 6.16
Community-based treatment of advanced HIV disease: introducing DOT-HAART (directly observed therapy with highly active antiretroviral therapy). Bull World Health Organ (2001) 6.07
Sequence of the 16S Ribosomal RNA from Halobacterium volcanii, an Archaebacterium. Science (1983) 5.66
Designing the national resident assessment instrument for nursing homes. Gerontologist (1990) 5.49
Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management. J Assoc Physicians India (2009) 5.45
The phylogeny of purple bacteria: the alpha subdivision. Syst Appl Microbiol (1984) 4.96
Speaking the same language: treatment outcome definitions for multidrug-resistant tuberculosis. Int J Tuberc Lung Dis (2005) 4.57
Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho. Science (1992) 4.57
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature (1992) 4.46
12. Index of ADL. Med Care (1976) 4.27
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell (2000) 4.21
Screening for Down's syndrome: effects, safety, and cost effectiveness of first and second trimester strategies. BMJ (2001) 4.15
Were the original eubacteria thermophiles? Syst Appl Microbiol (1987) 4.06
Mianserin hydrochloride: a novel antidepressant. Br J Psychiatry (1976) 3.92
Etanercept for active Crohn's disease: a randomized, double-blind, placebo-controlled trial. Gastroenterology (2001) 3.85
Rooting the archaebacterial tree: the pivotal role of Thermococcus celer in archaebacterial evolution. Syst Appl Microbiol (1988) 3.76
Factors affecting uptake of antenatal HIV testing in London: results of a multicentre study. BMJ (1998) 3.72
Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins. Science (1990) 3.67
Putative introns in tRNA genes of prokaryotes. Proc Natl Acad Sci U S A (1983) 3.60
A prospective study of functional status among community elders. Am J Public Health (1984) 3.51
Analgesic efficacy of pre-operative stellate ganglion block on postoperative pain relief: a randomised controlled trial. Anaesthesia (2014) 3.30
Halobacterium volcanii tRNAs. Identification of 41 tRNAs covering all amino acids, and the sequences of 33 class I tRNAs. J Biol Chem (1984) 3.25
Chronic-disease classification in evaluation of medical care programs. Med Care (1969) 3.23
Sequence of the 16S rRNA gene from the thermoacidophilic archaebacterium Sulfolobus solfataricus and its evolutionary implications. J Mol Evol (1985) 3.20
Risk of functional decline among well elders. J Clin Epidemiol (1989) 3.17
A putative modular domain present in diverse signaling proteins. Cell (1993) 2.90
Adverse events in the treatment of multidrug-resistant tuberculosis: results from the DOTS-Plus initiative. Int J Tuberc Lung Dis (2004) 2.87
Antimicrobial susceptibility and frequency of occurrence of clinical blood isolates in Europe from the SENTRY antimicrobial surveillance program, 1997 and 1998. Clin Infect Dis (2000) 2.87
Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway. J Biol Chem (2001) 2.85
The hierarchical relationship between activities of daily living and instrumental activities of daily living. J Chronic Dis (1987) 2.81
Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA. Cell (2000) 2.73
Prediction of human protein function according to Gene Ontology categories. Bioinformatics (2003) 2.54
Transcription and excision of a large intron in the tRNATrp gene of an archaebacterium, Halobacterium volcanii. J Biol Chem (1985) 2.45
Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins. Mol Cell Biol (1995) 2.44
Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Nat Genet (1998) 2.34
Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Curr Biol (2000) 2.19
Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease. Dig Dis Sci (1996) 2.15
Blood pressure cuffs: friend or foe? J Hosp Infect (2006) 2.15
Anticipation in Crohn's disease may be influenced by gender and ethnicity of the transmitting parent. Am J Gastroenterol (1998) 2.14
Itopride in functional dyspepsia: results of two phase III multicentre, randomised, double-blind, placebo-controlled trials. Gut (2007) 2.11
Lymphatic manifestations of lymphangioleiomyomatosis. Lymphology (2014) 2.06
With a pinch of salt. Clin Med (2010) 2.06
Prediction of human protein function from post-translational modifications and localization features. J Mol Biol (2002) 2.05
NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling. Proc Natl Acad Sci U S A (1999) 2.03
Surgical decisions in the elderly: the importance of biological age. J R Soc Med (2001) 2.02
Novel protein kinases associated with calcineurin B-like calcium sensors in Arabidopsis. Plant Cell (1999) 2.02
The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity. Nature (1998) 2.01
Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J Assoc Physicians India (2001) 2.01
The product of the cellular crk gene consists primarily of SH2 and SH3 regions. Cell Growth Differ (1992) 1.94
Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins. Mol Cell Biol (1991) 1.92
Effects and costs of day-care services for the chronically ill: a randomized experiment. Med Care (1980) 1.90
The ras recruitment system, a novel approach to the study of protein-protein interactions. Curr Biol (1998) 1.90
The pleckstrin homology domain of phospholipase C-delta 1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes. Biochemistry (1995) 1.84
Atrial fibrillation detected by mobile cardiac outpatient telemetry in cryptogenic TIA or stroke. Neurology (2008) 1.80
Hyponatremia resulting from apparently inappropriate secretion of antidiuretic hormone in patients with pulmonary tuberculosis. Am Rev Respir Dis (1965) 1.80
Recombination activities of HsDmc1 protein, the meiotic human homolog of RecA protein. Proc Natl Acad Sci U S A (1997) 1.79
The phylogenetic relationships of three sulfur dependent archaebacteria. Syst Appl Microbiol (1984) 1.79
Tyrosine-phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyze Crk-phosphotyrosine-dependent interactions in vitro. J Biol Chem (1992) 1.75
Renal localization of the membrane attack complex in systemic lupus erythematosus nephritis. J Exp Med (1981) 1.74
Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis. EMBO J (2001) 1.74
Bacterial adherence to surgical sutures. A possible factor in suture induced infection. Ann Surg (1981) 1.73
Pseudomonas aeruginosa community-acquired pneumonia in previously healthy adults: case report and review of the literature. Clin Infect Dis (2000) 1.72
Waist circumference cutoff points and action levels for Asian Indians for identification of abdominal obesity. Int J Obes (Lond) (2006) 1.71
Total hip arthroplasty in ankylosing spondylitis: outcome in 340 patients. J Rheumatol (2001) 1.71
Multiple retinal haemorrhages (decompression retinopathy) following paracentesis for macular branch artery occlusion. Eye (Lond) (2005) 1.70
In vitro activity of minocycline, a new tetracycline. Am J Med Sci (1968) 1.70
Improved survival in the treatment of squamous carcinoma of the oral tongue. Am J Surg (1993) 1.69
Amphotericin B lipid complex compared with amphotericin B in the treatment of cryptococcal meningitis in patients with AIDS. Clin Infect Dis (1996) 1.68
Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J Clin Invest (2001) 1.66
Prevalence of tobacco use and awareness of risks among school children in Jaipur. J Assoc Physicians India (2006) 1.66
Distinction between hyperaldosteronism due to bilateral hyperplasia and unilateral aldosteronoma: reliability of CT. Radiology (1992) 1.66
Effect of a chimeric antibody to tumor necrosis factor-alpha on cytokine and physiologic responses in patients with severe sepsis--a randomized, clinical trial. Crit Care Med (1998) 1.65
Genetic lesions involved in temperature sensitivity of the src gene products of four Rous sarcoma virus mutants. J Virol (1986) 1.64
Phenotypic spectrum of neurodegeneration associated with mutations in the PLA2G6 gene (PLAN). Neurology (2008) 1.60
The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers. Carcinogenesis (1998) 1.59
Long term course of 147 patients with fracture of the hip. Surg Gynecol Obstet (1967) 1.59
Posttranscriptional modification of tRNA in thermophilic archaea (Archaebacteria). J Bacteriol (1991) 1.57
Mouse B7-H3 induces antitumor immunity. Gene Ther (2003) 1.57
Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56
The burden of drug-resistant tuberculosis and mechanisms for its control. Ann N Y Acad Sci (2001) 1.55
Assessment of colorectal cancer risk in patients with ulcerative colitis: experience from a private practice. Gastroenterology (1983) 1.55
Reversible leukoencephalopathy associated with cerebral amyloid angiopathy. Neurology (2004) 1.55
Ascitic fluid cholesterol in malignant and tubercular ascites. J Assoc Physicians India (1995) 1.54
Interaction specificity of Arabidopsis calcineurin B-like calcium sensors and their target kinases. Plant Physiol (2000) 1.53
Three-dimensional solution structure of the src homology 2 domain of c-abl. Cell (1992) 1.53