Published in Nucleic Acids Res on April 01, 1997
Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance. EMBO J (2000) 1.40
Replication defect of moloney murine leukemia virus with a mutant reverse transcriptase that can incorporate ribonucleotides and deoxyribonucleotides. J Virol (1998) 1.33
Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase. Proc Natl Acad Sci U S A (2000) 1.30
Mutation rates and intrinsic fidelity of retroviral reverse transcriptases. Viruses (2009) 1.19
Second-site reversion of a human immunodeficiency virus type 1 reverse transcriptase mutant that restores enzyme function and replication capacity. J Virol (1999) 1.03
A mutation in the primer grip region of HIV-1 reverse transcriptase that confers reduced fidelity of DNA synthesis. Nucleic Acids Res (2001) 1.02
Effects of amino acid substitutions at position 115 on the fidelity of human immunodeficiency virus type 1 reverse transcriptase. J Virol (2000) 0.99
Development of an in vivo assay to identify structural determinants in murine leukemia virus reverse transcriptase important for fidelity. J Virol (2000) 0.97
The cost of replication fidelity in human immunodeficiency virus type 1. Proc Biol Sci (2007) 0.96
Role of murine leukemia virus reverse transcriptase deoxyribonucleoside triphosphate-binding site in retroviral replication and in vivo fidelity. J Virol (2000) 0.87
Thymidine analogue excision and discrimination modulated by mutational complexes including single amino acid deletions of Asp-67 or Thr-69 in HIV-1 reverse transcriptase. J Biol Chem (2011) 0.87
Increased G-->A transition frequencies displayed by primer grip mutants of human immunodeficiency virus type 1 reverse transcriptase. J Virol (2004) 0.87
Interrelationship between HIV-1 fitness and mutation rate. J Mol Biol (2012) 0.85
Nucleotide specificity of HIV-1 reverse transcriptases with amino acid substitutions affecting Ala-114. Biochem J (2005) 0.82
Rapid incorporation kinetics and improved fidelity of a novel class of 3'-OH unblocked reversible terminators. Nucleic Acids Res (2012) 0.80
Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis. Nucleic Acids Res (2013) 0.80
Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication. J Virol (2014) 0.78
Pre-steady state kinetic analysis of HIV-1 reverse transcriptase for non-canonical ribonucleoside triphosphate incorporation and DNA synthesis from ribonucleoside-containing DNA template. Antiviral Res (2014) 0.78
The role of phenylalanine-119 of the reverse transcriptase of mouse mammary tumour virus in DNA synthesis, ribose selection and drug resistance. Biochem J (2002) 0.75
Complete nucleotide sequence of the AIDS virus, HTLV-III. Nature (1985) 30.62
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science (1992) 14.70
Nucleotide sequence of the filamentous bacteriophage M13 DNA genome: comparison with phage fd. Gene (1980) 10.77
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. Proc Natl Acad Sci U S A (1993) 9.47
The accuracy of reverse transcriptase from HIV-1. Science (1988) 8.24
Fidelity of HIV-1 reverse transcriptase. Science (1988) 8.08
Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase. Science (1996) 5.08
Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations. Proc Natl Acad Sci U S A (1990) 4.72
Infectious potential of human immunodeficiency virus type 1 reverse transcriptase mutants with altered inhibitor sensitivity. Proc Natl Acad Sci U S A (1989) 4.15
Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase. J Biol Chem (1990) 3.38
Reverse transcriptases and genomic variability: the accuracy of DNA replication is enzyme specific and sequence dependent. EMBO J (1990) 2.64
Fidelity of HIV-1 reverse transcriptase copying RNA in vitro. Biochemistry (1992) 2.27
Comparison of HIV-1 and avian myeloblastosis virus reverse transcriptase fidelity on RNA and DNA templates. J Biol Chem (1992) 1.96
Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase. Biochemistry (1995) 1.93
Unequal human immunodeficiency virus type 1 reverse transcriptase error rates with RNA and DNA templates. Proc Natl Acad Sci U S A (1992) 1.93
Role of methionine 184 of human immunodeficiency virus type-1 reverse transcriptase in the polymerase function and fidelity of DNA synthesis. Biochemistry (1996) 1.83
Extension of mismatched 3' termini of DNA is a major determinant of the infidelity of human immunodeficiency virus type 1 reverse transcriptase. Proc Natl Acad Sci U S A (1989) 1.71
Mutational analysis of two conserved sequence motifs in HIV-1 reverse transcriptase. FEBS Lett (1991) 1.69
Mutational analysis of the fingers and palm subdomains of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase. J Mol Biol (1994) 1.64
Differential extension of 3' mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-alpha. J Biol Chem (1989) 1.63
Fidelity of human immunodeficiency virus type I reverse transcriptase in copying natural DNA. Nucleic Acids Res (1989) 1.61
Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain. J Biol Chem (1995) 1.57
Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesis. EMBO J (1996) 1.44
Fidelity of human immunodeficiency virus type I reverse transcriptase in copying natural RNA. J Mol Biol (1992) 1.41
Reactions at the polymerase active site that contribute to the fidelity of Escherichia coli DNA polymerase I (Klenow fragment). J Biol Chem (1992) 1.29
Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase. Biochemistry (1995) 1.26
E. coli DNA polymerase I as a reverse transcriptase. EMBO J (1993) 1.22
Structure/function studies of human immunodeficiency virus type 1 reverse transcriptase. Alanine scanning mutagenesis of an alpha-helix in the thumb subdomain. J Biol Chem (1994) 1.20
Misincorporation and mispaired primer extension by human immunodeficiency virus reverse transcriptase. J Biol Chem (1994) 1.20
Human immunodeficiency virus type-1 reverse transcriptase. Contribution of Met-184 to binding of nucleoside 5'-triphosphate. J Biol Chem (1996) 1.12
Increased polymerase fidelity of E89G, a nucleoside analog-resistant variant of human immunodeficiency virus type 1 reverse transcriptase. J Virol (1996) 1.09
Mutational studies of human immunodeficiency virus type 1 reverse transcriptase: the involvement of residues 183 and 184 in the fidelity of DNA synthesis. FEBS Lett (1996) 1.06
Role of the "helix clamp" in HIV-1 reverse transcriptase catalytic cycling as revealed by alanine-scanning mutagenesis. J Biol Chem (1996) 0.99
A possible role for cysteine residues in the fidelity of DNA synthesis exhibited by the reverse transcriptases of human immunodeficiency viruses type 1 and type 2. FEBS Lett (1992) 0.85
Human immunodeficiency virus type 1 reverse transcriptase tG:T mispair formation on RNA and DNA templates with mismatched primers: a kinetic and thermodynamic study. EMBO J (1995) 0.83
Enzymatic properties of two mutants of reverse transcriptase of human immunodeficiency virus type 1 (tyrosine 181-->isoleucine and tyrosine 188-->leucine), resistant to nonnucleoside inhibitors. AIDS Res Hum Retroviruses (1994) 0.81
An active recombinant p15 RNase H domain is functionally distinct from the RNase H domain associated with human immunodeficiency virus type 1 reverse transcriptase. J Biol Chem (1994) 0.78
Nucleotide sequence heterogeneity of an RNA phage population. Cell (1978) 5.55
Rapid fitness losses in mammalian RNA virus clones due to Muller's ratchet. Proc Natl Acad Sci U S A (1992) 4.22
Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol Mol Biol Rev (2006) 4.13
The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance--a review. Gene (1985) 3.42
Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis. J Virol (1990) 3.11
Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus in cell culture. Virology (1983) 3.04
The proportion of revertant and mutant phage in a growing population, as a function of mutation and growth rate. Gene (1976) 2.77
Pol gene quasispecies of human immunodeficiency virus: mutations associated with drug resistance in virus from patients undergoing no drug therapy. J Virol (1995) 2.68
Exponential increases of RNA virus fitness during large population transmissions. Proc Natl Acad Sci U S A (1995) 2.60
Genetic bottlenecks and population passages cause profound fitness differences in RNA viruses. J Virol (1993) 2.55
Nucleotide sequence heterogeneity of the RNA from a natural population of foot-and-mouth-disease virus. Gene (1980) 2.44
Genetic lesions associated with Muller's ratchet in an RNA virus. J Mol Biol (1996) 2.41
Lack of evolutionary stasis during alternating replication of an arbovirus in insect and mammalian cells. J Mol Biol (1999) 2.28
Virus mutation frequencies can be greatly underestimated by monoclonal antibody neutralization of virions. J Virol (1989) 2.27
Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity. J Virol (2000) 2.26
Lack of evidence for proofreading mechanisms associated with an RNA virus polymerase. Gene (1992) 2.20
Size of genetic bottlenecks leading to virus fitness loss is determined by mean initial population fitness. J Virol (1995) 2.18
Evolution of cell recognition by viruses. Science (2001) 2.14
Subclonal components of consensus fitness in an RNA virus clone. J Virol (1994) 2.09
RNA virus quasispecies: significance for viral disease and epidemiology. Infect Agents Dis (1994) 2.08
KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression. Oncogene (2006) 2.07
The two species of the foot-and-mouth disease virus leader protein, expressed individually, exhibit the same activities. Virology (1993) 2.05
Multiple molecular pathways for fitness recovery of an RNA virus debilitated by operation of Muller's ratchet. J Mol Biol (1999) 2.00
Genetic variability of Hong Kong (H3N2) influenza viruses: spontaneous mutations and their location in the viral genome. Gene (1980) 1.95
Rapid selection of genetic and antigenic variants of foot-and-mouth disease virus during persistence in cattle. J Virol (1988) 1.92
Coevolution of cells and viruses in a persistent infection of foot-and-mouth disease virus in cell culture. J Virol (1988) 1.90
Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies. J Virol (1991) 1.89
Efficient virus extinction by combinations of a mutagen and antiviral inhibitors. J Virol (2001) 1.86
Drastic fitness loss in human immunodeficiency virus type 1 upon serial bottleneck events. J Virol (1999) 1.85
Establishment of cell lines persistently infected with foot-and-mouth disease virus. Virology (1985) 1.84
Extreme fitness differences in mammalian and insect hosts after continuous replication of vesicular stomatitis virus in sandfly cells. J Virol (1995) 1.84
The red queen reigns in the kingdom of RNA viruses. Proc Natl Acad Sci U S A (1994) 1.83
Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas. Gastroenterology (2010) 1.83
The structure and antigenicity of a type C foot-and-mouth disease virus. Structure (1994) 1.82
RNA virus evolution and the control of viral disease. Prog Drug Res (1989) 1.74
In vitro site-directed mutagenesis: generation and properties of an infectious extracistronic mutant of bacteriophage Qbeta. Gene (1976) 1.72
Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades. J Virol (1992) 1.72
Implications of a quasispecies genome structure: effect of frequent, naturally occurring amino acid substitutions on the antigenicity of foot-and-mouth disease virus. Proc Natl Acad Sci U S A (1989) 1.71
Memory in viral quasispecies. J Virol (2000) 1.70
Evolution of the nucleotide sequence of influenza virus RNA segment 7 during drift of the H3N2 subtype. Gene (1983) 1.64
Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity. Proc Natl Acad Sci U S A (2002) 1.60
Exponential fitness gains of RNA virus populations are limited by bottleneck effects. J Virol (1999) 1.60
A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C. J Gen Virol (1990) 1.57
Origin and evolution of viruses. Virus Genes (1998) 1.56
Fixation of mutations in the viral genome during an outbreak of foot-and-mouth disease: heterogeneity and rate variations. Gene (1986) 1.53
Multiple virulence determinants of foot-and-mouth disease virus in cell culture. J Virol (1998) 1.52
Foot-and-mouth disease virus lacking the VP1 G-H loop: the mutant spectrum uncovers interactions among antigenic sites for fitness gain. Virology (2001) 1.50
A single nucleotide substitution in the internal ribosome entry site of foot-and-mouth disease virus leads to enhanced cap-independent translation in vivo. J Virol (1993) 1.50
The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: validation in the VICTOR trial. Ann Oncol (2012) 1.46
Negative effects of chemical mutagenesis on the adaptive behavior of vesicular stomatitis virus. J Virol (1997) 1.45
Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesis. EMBO J (1996) 1.44
Extensive antigenic heterogeneity of foot-and-mouth disease virus of serotype C. Virology (1988) 1.42
Modifications of the 5' untranslated region of foot-and-mouth disease virus after prolonged persistence in cell culture. Virus Res (1992) 1.40
[The usefulness of Doppler echocardiography in the preoperative assessment of valvulopathies. A comparison with the hemodynamic and surgical findings]. Rev Esp Cardiol (1993) 1.40
Many-trillionfold amplification of single RNA virus particles fails to overcome the Muller's ratchet effect. J Virol (1993) 1.40
Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance. EMBO J (2000) 1.40
Uncomplicated first myocardial infarction: strategy for comprehensive prognostic studies. J Am Coll Cardiol (1991) 1.38
Evolution subverting essentiality: dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus. Proc Natl Acad Sci U S A (1997) 1.37
A large-scale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of escape mutants. J Virol (1997) 1.36
Unique amino acid substitutions in the capsid proteins of foot-and-mouth disease virus from a persistent infection in cell culture. J Virol (1990) 1.35
Intracellular transport of the murine leukemia virus during acute infection of NIH 3T3 cells: nuclear import of nucleocapsid protein and integrase. J Cell Sci (1995) 1.35
Systematic replacement of amino acid residues within an Arg-Gly-Asp-containing loop of foot-and-mouth disease virus and effect on cell recognition. J Biol Chem (1996) 1.33
Cell recognition by foot-and-mouth disease virus that lacks the RGD integrin-binding motif: flexibility in aphthovirus receptor usage. J Virol (2000) 1.32
Reactivity with monoclonal antibodies of viruses from an episode of foot-and-mouth disease. Virus Res (1987) 1.31
Genomic nucleotide sequence of a foot-and-mouth disease virus clone and its persistent derivatives. Implications for the evolution of viral quasispecies during a persistent infection. Virus Res (1999) 1.31
A single amino acid substitution in nonstructural protein 3A can mediate adaptation of foot-and-mouth disease virus to the guinea pig. J Virol (2001) 1.29
Distinct repertoire of antigenic variants of foot-and-mouth disease virus in the presence or absence of immune selection. J Virol (1993) 1.26
Unusual distribution of mutations associated with serial bottleneck passages of human immunodeficiency virus type 1. J Virol (2000) 1.25
Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites. J Virol (1994) 1.23
VP1 of serotype C foot-and-mouth disease viruses: long-term conservation of sequences. J Virol (1988) 1.22
Rapid selection in modified BHK-21 cells of a foot-and-mouth disease virus variant showing alterations in cell tropism. J Virol (1998) 1.21
Viral quasispecies and the problem of vaccine-escape and drug-resistant mutants. Prog Drug Res (1997) 1.21
Schistosomiasis japonica in the Philippines: the long-term impact of population-based chemotherapy on infection, transmission, and morbidity. J Infect Dis (1996) 1.21
Molecular intermediates of fitness gain of an RNA virus: characterization of a mutant spectrum by biological and molecular cloning. J Gen Virol (2001) 1.21
Structure of the complex of an Fab fragment of a neutralizing antibody with foot-and-mouth disease virus: positioning of a highly mobile antigenic loop. EMBO J (1997) 1.20
Ribavirin cures cells of a persistent infection with foot-and-mouth disease virus in vitro. J Virol (1987) 1.18
Long-term, large-population passage of aphthovirus can generate and amplify defective noninterfering particles deleted in the leader protease gene. Virology (1996) 1.18
The sympathetic nervous system modulates perception and reflex responses to gut distention in humans. Gastroenterology (1995) 1.18
APC and the three-hit hypothesis. Oncogene (2008) 1.17
Two mechanisms of antigenic diversification of foot-and-mouth disease virus. Virology (1991) 1.15
Selection of antigenic variants of foot-and-mouth disease virus in the absence of antibodies, as revealed by an in situ assay. J Gen Virol (1989) 1.15
An RNA virus can adapt to the multiplicity of infection. J Gen Virol (1998) 1.14
In vitro synthesis of full-length influenza virus complementary RNA. EMBO J (1985) 1.13
Characterization of the reverse transcriptase of a human immunodeficiency virus type 1 group O isolate. Virology (1997) 1.13
Genetic and immunogenic variations among closely related isolates of foot-and-mouth disease virus. Gene (1988) 1.12
Dilute passage promotes expression of genetic and phenotypic variants of human immunodeficiency virus type 1 in cell culture. J Virol (1993) 1.12
Evolution of fitness in experimental populations of vesicular stomatitis virus. Genetics (1996) 1.11
Sequence of the viral replicase gene from foot-and-mouth disease virus C1-Santa Pau (C-S8). Gene (1985) 1.10
Intravascular ultrasound of the elastic pulmonary arteries: a new approach for the evaluation of primary pulmonary hypertension. Heart (2003) 1.08
Reproducible nonlinear population dynamics and critical points during replicative competitions of RNA virus quasispecies. J Mol Biol (1996) 1.08
Identification of an essential region for internal initiation of translation in the aphthovirus internal ribosome entry site and implications for viral evolution. J Virol (1996) 1.05
Gene encoding capsid protein VP1 of foot-and-mouth disease virus: a quasispecies model of molecular evolution. Proc Natl Acad Sci U S A (1988) 1.05
Evidence for positive selection in the capsid protein-coding region of the foot-and-mouth disease virus (FMDV) subjected to experimental passage regimens. Mol Biol Evol (2001) 1.05
Survival following self-limited left ventricular free wall rupture during myocardial infarction. Management differences between patients with or without pseudoaneurysm formation. Int J Cardiol (2001) 1.04
Second-site reversion of a human immunodeficiency virus type 1 reverse transcriptase mutant that restores enzyme function and replication capacity. J Virol (1999) 1.03