Published in J Biol Chem on February 21, 1997
RecQ helicases: suppressors of tumorigenesis and premature aging. Biochem J (2003) 3.71
Mechanisms of accurate translesion synthesis by human DNA polymerase eta. EMBO J (2000) 3.46
Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity. EMBO J (1999) 3.31
Neighboring-nucleotide effects on the rates of germ-line single-base-pair substitution in human genes. Am J Hum Genet (1998) 3.12
Physical and functional interactions of human DNA polymerase eta with PCNA. Mol Cell Biol (2001) 2.84
Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae. Mol Cell Biol (2004) 2.49
The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo. PLoS Genet (2009) 2.32
Saccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nuclease. Mol Cell Biol (1999) 2.29
Characterization of molecular recognition features, MoRFs, and their binding partners. J Proteome Res (2007) 2.23
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity. EMBO J (2001) 2.21
The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability. Proc Natl Acad Sci U S A (2001) 2.16
Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA. Mol Cell Biol (2002) 2.15
Triplet repeats form secondary structures that escape DNA repair in yeast. Proc Natl Acad Sci U S A (1999) 1.83
An interaction between DNA ligase I and proliferating cell nuclear antigen: implications for Okazaki fragment synthesis and joining. Proc Natl Acad Sci U S A (1997) 1.82
Two modes of FEN1 binding to PCNA regulated by DNA. EMBO J (2000) 1.77
Advances in mechanisms of genetic instability related to hereditary neurological diseases. Nucleic Acids Res (2005) 1.77
Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27. Mol Cell Biol (1999) 1.73
Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1. Proc Natl Acad Sci U S A (2001) 1.61
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork. Mol Biol Cell (2003) 1.61
Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage. Mol Cell Biol (2003) 1.59
A role for FEN-1 in nonhomologous DNA end joining: the order of strand annealing and nucleolytic processing events. Proc Natl Acad Sci U S A (1999) 1.59
Unlocking the sugar "steric gate" of DNA polymerases. Biochemistry (2011) 1.56
Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair. EMBO J (2001) 1.55
Links between replication and recombination in Saccharomyces cerevisiae: a hypersensitive requirement for homologous recombination in the absence of Rad27 activity. Proc Natl Acad Sci U S A (2001) 1.54
Mutational spectrum analysis of RNase H(35) deficient Saccharomyces cerevisiae using fluorescence-based directed termination PCR. Nucleic Acids Res (2000) 1.50
CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation. EMBO J (2003) 1.45
Genetic analyses of Schizosaccharomyces pombe dna2(+) reveal that dna2 plays an essential role in Okazaki fragment metabolism. Genetics (2000) 1.45
Pif1 helicase directs eukaryotic Okazaki fragments toward the two-nuclease cleavage pathway for primer removal. J Biol Chem (2008) 1.43
Okazaki fragment maturation: nucleases take centre stage. J Mol Cell Biol (2011) 1.42
Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility. Mol Cell Biol (2003) 1.41
The endonuclease activity of the yeast Dna2 enzyme is essential in vivo. Nucleic Acids Res (2000) 1.40
Molecular architecture of the mouse DNA polymerase alpha-primase complex. Mol Cell Biol (1999) 1.39
Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex. Nucleic Acids Res (2008) 1.39
Functional regulation of FEN1 nuclease and its link to cancer. Nucleic Acids Res (2010) 1.35
Bimodal interaction between replication-protein A and Dna2 is critical for Dna2 function both in vivo and in vitro. Nucleic Acids Res (2003) 1.31
Junction ribonuclease: an activity in Okazaki fragment processing. Proc Natl Acad Sci U S A (1998) 1.31
Human DNA ligase I efficiently seals nicks in nucleosomes. EMBO J (2000) 1.30
Genetic and biochemical analyses of Pfh1 DNA helicase function in fission yeast. Nucleic Acids Res (2004) 1.28
DNA base excision repair: a mechanism of trinucleotide repeat expansion. Trends Biochem Sci (2012) 1.27
Pif1 helicase lengthens some Okazaki fragment flaps necessitating Dna2 nuclease/helicase action in the two-nuclease processing pathway. J Biol Chem (2009) 1.27
The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair. EMBO J (2002) 1.23
EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiae. Genetics (2000) 1.23
Cuts can kill: the roles of apoptotic nucleases in cell death and animal development. Chromosoma (2006) 1.22
The impact of lagging strand replication mutations on the stability of CAG repeat tracts in yeast. Genetics (2000) 1.20
Architecture of the replication fork stalled at the 3' end of yeast ribosomal genes. Mol Cell Biol (2000) 1.19
Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage. Mol Cell Biol (2001) 1.19
Mutator phenotype induced by aberrant replication. Mol Cell Biol (1999) 1.18
Okazaki fragment metabolism. Cold Spring Harb Perspect Biol (2013) 1.17
Instability of the human minisatellite CEB1 in rad27Delta and dna2-1 replication-deficient yeast cells. EMBO J (2002) 1.12
Eukaryotic lagging strand DNA replication employs a multi-pathway mechanism that protects genome integrity. J Biol Chem (2010) 1.08
Replication proteins influence the maintenance of telomere length and telomerase protein stability. Mol Cell Biol (2003) 1.06
The Fen1 extrahelical 3'-flap pocket is conserved from archaea to human and regulates DNA substrate specificity. Nucleic Acids Res (2004) 1.05
Complex minisatellite rearrangements generated in the total or partial absence of Rad27/hFEN1 activity occur in a single generation and are Rad51 and Rad52 dependent. Mol Cell Biol (2006) 1.03
Novel function of Rad27 (FEN-1) in restricting short-sequence recombination. Mol Cell Biol (2001) 1.00
Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota. Nucleic Acids Res (2002) 1.00
A novel function of adenomatous polyposis coli (APC) in regulating DNA repair. Cancer Lett (2008) 0.99
Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes. Clin Interv Aging (2008) 0.99
Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer. Cell Res (2011) 0.98
The MPH1 gene of Saccharomyces cerevisiae functions in Okazaki fragment processing. J Biol Chem (2009) 0.97
An alternative pathway for Okazaki fragment processing: resolution of fold-back flaps by Pif1 helicase. J Biol Chem (2010) 0.97
Mechanism of adenomatous polyposis coli (APC)-mediated blockage of long-patch base excision repair. Biochemistry (2006) 0.97
Saccharomyces cerevisiae exonuclease-1 plays a role in UV resistance that is distinct from nucleotide excision repair. Nucleic Acids Res (1998) 0.96
A single domain in human DNA polymerase iota mediates interaction with PCNA: implications for translesion DNA synthesis. Mol Cell Biol (2005) 0.96
Analysis of single nucleotide polymorphisms with solid phase invasive cleavage reactions. Nucleic Acids Res (2001) 0.95
In vivo and in vitro studies of Mgs1 suggest a link between genome instability and Okazaki fragment processing. Nucleic Acids Res (2005) 0.95
ATP-dependent structural change of the eukaryotic clamp-loader protein, replication factor C. Proc Natl Acad Sci U S A (2000) 0.94
Interactions among DNA ligase I, the flap endonuclease and proliferating cell nuclear antigen in the expansion and contraction of CAG repeat tracts in yeast. Genetics (2005) 0.94
Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method. Mol Cell Biol (2004) 0.93
Msh2-Msh3 interferes with Okazaki fragment processing to promote trinucleotide repeat expansions. Cell Rep (2012) 0.92
Enzymatic properties of the Caenorhabditis elegans Dna2 endonuclease/helicase and a species-specific interaction between RPA and Dna2. Nucleic Acids Res (2005) 0.92
The Rad27 (Fen-1) nuclease inhibits Ty1 mobility in Saccharomyces cerevisiae. Genetics (2003) 0.92
Distinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA. PLoS One (2010) 0.92
Human RECQL5beta stimulates flap endonuclease 1. Nucleic Acids Res (2010) 0.91
Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions. Proc Natl Acad Sci U S A (2008) 0.91
Telomerase is essential to alleviate pif1-induced replication stress at telomeres. Genetics (2009) 0.90
3' to 5' exonuclease activity of herpes simplex virus type 1 DNA polymerase modulates its strand displacement activity. J Virol (2003) 0.89
Amino acid Asp181 of 5'-flap endonuclease 1 is a useful target for chemotherapeutic development. Biochemistry (2009) 0.85
Kinetics of endogenous mouse FEN1 in base excision repair. Nucleic Acids Res (2012) 0.84
Cloning and characterization of a family B DNA polymerase from the hyperthermophilic crenarchaeon Pyrobaculum islandicum. J Bacteriol (2000) 0.84
The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication. Nucleic Acids Res (2015) 0.84
Components of the secondary pathway stimulate the primary pathway of eukaryotic Okazaki fragment processing. J Biol Chem (2010) 0.83
The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus. Biochem J (2011) 0.80
Methanococcus jannaschii flap endonuclease: expression, purification, and substrate requirements. J Bacteriol (1998) 0.80
Base excision repair in chromatin: Insights from reconstituted systems. DNA Repair (Amst) (2015) 0.80
Regulation of yeast DNA polymerase δ-mediated strand displacement synthesis by 5'-flaps. Nucleic Acids Res (2015) 0.78
Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins. Archaea (2014) 0.77
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat Chem Biol (2016) 0.77
Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis. Life Sci (2015) 0.77
1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells. World J Gastroenterol (2013) 0.77
Association between FEN1 Polymorphisms -69G>A and 4150G>T with Susceptibility in Human Disease: A Meta-Analysis. Iran J Public Health (2015) 0.75
Potential Antitumor Activity and Apoptosis Induction of Glossostemon bruguieri Root Extract against Hepatocellular Carcinoma Cells. Evid Based Complement Alternat Med (2017) 0.75
Mapping the FEN1 interaction domain with hTERT. Biochem Biophys Res Commun (2011) 0.75
A novel possible mechanism for the genesis of genomic duplications and its experimental test. J Mol Evol (2005) 0.75
The application of thermophilic DNA primase TtDnaG2 to DNA amplification. Sci Rep (2017) 0.75
Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One (2017) 0.75
RPA involvement in the damage-recognition and incision steps of nucleotide excision repair. Nature (1995) 3.06
Enzymatic completion of mammalian lagging-strand DNA replication. Proc Natl Acad Sci U S A (1994) 2.11
Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1. J Biol Chem (2000) 1.97
Proteolytic mapping of human replication protein A: evidence for multiple structural domains and a conformational change upon interaction with single-stranded DNA. Biochemistry (1996) 1.63
Junction ribonuclease: an activity in Okazaki fragment processing. Proc Natl Acad Sci U S A (1998) 1.31
Human DNA ligase I efficiently seals nicks in nucleosomes. EMBO J (2000) 1.30
DNA ligase I and proliferating cell nuclear antigen form a functional complex. J Biol Chem (2001) 1.22
Effect of flap modifications on human FEN1 cleavage. Biochemistry (1999) 1.19
Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage. Mol Cell Biol (2001) 1.19
Roles of DNA polymerase zeta and Rev1 protein in eukaryotic mutagenesis and translesion replication. Cold Spring Harb Symp Quant Biol (2000) 1.18
Creation and removal of embedded ribonucleotides in chromosomal DNA during mammalian Okazaki fragment processing. J Biol Chem (1997) 1.15
Role of calf RTH-1 nuclease in removal of 5'-ribonucleotides during Okazaki fragment processing. Biochemistry (1996) 0.94
Cleavage of substrates with mismatched nucleotides by Flap endonuclease-1. Implications for mammalian Okazaki fragment processing. J Biol Chem (1999) 0.85
DNA substrate specificity of DNA helicase E from calf thymus. Nucleic Acids Res (1992) 0.82