Published in N Engl J Med on November 17, 1977
The unpredictability paradox: review of empirical comparisons of randomised and non-randomised clinical trials. BMJ (1998) 5.05
Sexual health education interventions for young people: a methodological review. BMJ (1995) 4.18
Clinical effects of anticoagulant therapy in suspected acute myocardial infarction: systematic overview of randomised trials. BMJ (1996) 2.90
Tacrolimus versus cyclosporin for immunosuppression in renal transplantation: meta-analysis of randomised trials. BMJ (1999) 2.65
Long-term follow-up after bariatric surgery: a systematic review. JAMA (2014) 2.56
Which clinical studies provide the best evidence? The best RCT still trumps the best observational study. BMJ (2000) 2.06
An historical perspective on meta-analysis: dealing quantitatively with varying study results. J R Soc Med (2007) 1.68
Two cheers for meta-analysis: problems and opportunities in aggregating results of clinical trials. CMAJ (1988) 1.49
Retention of orthodontic brackets bonded with resin-modified GIC versus composite resin adhesives--a quantitative systematic review of clinical trials. Clin Oral Investig (2011) 1.46
Therapeutic ranges in anticoagulant administration. Br Med J (Clin Res Ed) (1985) 1.40
The effects of changes in smoking habits on coronary heart disease mortality. Am J Public Health (1979) 1.30
Atraumatic restorative treatment versus amalgam restoration longevity: a systematic review. Clin Oral Investig (2009) 1.29
Comparison of effects in randomized controlled trials with observational studies in digestive surgery. Ann Surg (2006) 1.19
Sample size: how many patients are necessary? Br J Cancer (1995) 1.15
Meta-analysis in medical research. Hippokratia (2010) 1.14
Unbiased research and the human spirit: the challenges of randomized controlled trials. CMAJ (1995) 1.14
Caries-preventive effect of glass ionomer and resin-based fissure sealants on permanent teeth: An update of systematic review evidence. BMC Res Notes (2011) 1.12
Clinical review articles. BMJ (1992) 0.98
Statistics and ethics in medical research. VII--Interpreting results. Br Med J (1980) 0.95
Absence of carious lesions at margins of glass-ionomer cement and amalgam restorations: An update of systematic review evidence. BMC Res Notes (2011) 0.90
Assessing observational studies of medical treatments. Emerg Themes Epidemiol (2005) 0.88
The modified Blalock-Taussig shunt versus the right ventricle-to-pulmonary artery conduit for the Norwood procedure. Pediatr Cardiol (2007) 0.83
Accuracy of the Berger-Exner test for detecting third-order selection bias in randomised controlled trials: a simulation-based investigation. BMC Med Res Methodol (2014) 0.81
Statistics in question. Assessing clinical trials--trial size. Br Med J (Clin Res Ed) (1981) 0.79
Research gaps identified during systematic reviews of clinical trials: glass-ionomer cements. BMC Oral Health (2012) 0.79
Meta-analysis in clinical medicine. Trans Am Clin Climatol Assoc (1988) 0.79
Are more observational studies being included in Cochrane Reviews? BMC Res Notes (2012) 0.75
Access to primary care. J R Coll Gen Pract (1979) 0.75
How to assess new treatments. West J Med (2001) 0.75
Thrombosis: its role and prevention in cardiovascular events-Part II. West J Med (1981) 0.75
Systematic Review With Meta-analysis: Prompt Endoscopy As the Initial Management Strategy for Uninvestigated Dyspepsia in Asi (Aliment Pharmacol Ther 2015;41:239-252). J Neurogastroenterol Motil (2015) 0.75
Twenty year follow up of patients in the Medical Research Council trial of anticoagulants in acute myocardial infarction. Br Heart J (1987) 0.75
Risk factors, interventions and therapeutic agents in the prevention of atherosclerosis-related ischaemic diseases. Drugs (1991) 0.75
Beta-blockers in portal hypertension. An overview. Drugs (1989) 0.75
Direct Comparison of Aspirin Plus Hirudin, Aspirin Plus Heparin, and Aspirin Alone Among 12,000 Patients with Acute Myocardial Infarction Not Receiving Thrombolysis: Rationale and Design of the First American Study of Infarct Survival (ASIS-1). J Thromb Thrombolysis (1995) 0.75
Meta-analyses in cancer clinical trials: principles and pitfalls. World J Surg (2006) 0.75
A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarction. JAMA (1992) 22.27
Cumulative meta-analysis of therapeutic trials for myocardial infarction. N Engl J Med (1992) 17.33
The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial. Survey of 71 "negative" trials. N Engl J Med (1978) 15.13
Getting to grips with Archie Cochrane's agenda. BMJ (1992) 14.05
General practitioner's perceptions of the route to evidence based medicine: a questionnaire survey. BMJ (1998) 13.39
Antibodies to ribosomes in chronic active hepatitis. Gastroenterology (1979) 12.78
Measuring the quality of medical care. A clinical method. N Engl J Med (1976) 11.68
Meta-analyses of randomized controlled trials. N Engl J Med (1987) 10.37
Randomized versus historical controls for clinical trials. Am J Med (1982) 7.53
Performance indicators for primary care groups: an evidence based approach. BMJ (1998) 6.97
A method for assessing the quality of a randomized control trial. Control Clin Trials (1981) 6.63
Perusing the literature: comparison of MEDLINE searching with a perinatal trials database. Control Clin Trials (1985) 6.60
Microbial surfaces in relation to pathogenicity. Bacteriol Rev (1977) 5.79
Guidelines for meta-analyses evaluating diagnostic tests. Ann Intern Med (1994) 5.72
Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann Intern Med (2000) 5.68
A study of manufacturer-supported trials of nonsteroidal anti-inflammatory drugs in the treatment of arthritis. Arch Intern Med (1994) 5.04
Bias in treatment assignment in controlled clinical trials. N Engl J Med (1983) 4.78
Randomization of the first patient. Med Clin North Am (1975) 4.69
Effectiveness of five different approaches in management of urinary tract infection: randomised controlled trial. BMJ (2010) 4.53
Publication bias and clinical trials. Control Clin Trials (1987) 4.34
Large trials vs meta-analysis of smaller trials: how do their results compare? JAMA (1996) 3.88
Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J Clin Invest (1996) 3.74
MR imaging and T2 mapping of femoral cartilage: in vivo determination of the magic angle effect. AJR Am J Roentgenol (2001) 3.69
Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. JAMA (1995) 3.48
Giardia and Cryptosporidium join the 'Neglected Diseases Initiative'. Trends Parasitol (2006) 3.34
Future provision of out of hours primary medical care: a survey with two general practitioner research networks. BMJ (1996) 3.34
The comparative effects of postoperative analgesic therapies on pulmonary outcome: cumulative meta-analyses of randomized, controlled trials. Anesth Analg (1998) 3.32
Paediatric intensive care transfers. Anaesthesia (2000) 3.32
Clinical outcomes and costs of transcatheter as compared with surgical closure of patent ductus arteriosus. The Patient Ductus Arteriosus Closure Comparative Study Group. N Engl J Med (1993) 3.27
Meta-analysis of effects of intensive blood-glucose control on late complications of type I diabetes. Lancet (1993) 3.24
Evaluating the quality of articles published in journal supplements compared with the quality of those published in the parent journal. JAMA (1994) 3.15
The effect of dietary protein restriction on the progression of diabetic and nondiabetic renal diseases: a meta-analysis. Ann Intern Med (1996) 3.15
Early or deferred zidovudine therapy in HIV-infected patients without an AIDS-defining illness. Ann Intern Med (1995) 3.14
A quality assessment of randomized control trials of primary treatment of breast cancer. J Clin Oncol (1986) 3.14
Vitamin A supplementation and child mortality. A meta-analysis. JAMA (1993) 3.09
Association of adrenocorticosteroid therapy and peptic-ulcer disease. N Engl J Med (1983) 3.04
Appropriateness of use of emergency ambulances. J Accid Emerg Med (1998) 3.02
Rate of regeneration of peripheral nerves in man. J Physiol (1943) 3.02
Transgene-mediated auxin overproduction in Arabidopsis: hypocotyl elongation phenotype and interactions with the hy6-1 hypocotyl elongation and axr1 auxin-resistant mutants. Plant Mol Biol (1995) 3.01
Infection and diabetes: the case for glucose control. Am J Med (1982) 2.90
Is perinatal mortality still a good indicator of perinatal care? Paediatr Perinat Epidemiol (1988) 2.87
Chlorination, chlorination by-products, and cancer: a meta-analysis. Am J Public Health (1992) 2.86
Pathogenicity of influenza virus. Microbiol Rev (1980) 2.80
Cumulative meta-analysis of clinical trials builds evidence for exemplary medical care. J Clin Epidemiol (1995) 2.74
An empirical study of the possible relation of treatment differences to quality scores in controlled randomized clinical trials. Control Clin Trials (1990) 2.71
Drug surveillance utilizing nurse monitors. An epidemiological approach. Lancet (1966) 2.69
Medical care costs and quality of life after randomization to coronary angioplasty or coronary bypass surgery. Bypass Angioplasty Revascularization Investigation (BARI) Investigators. N Engl J Med (1997) 2.65
Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule. Nature (1992) 2.61
In vitro and in vivo modification of Neisseria gonorrhoeae lipooligosaccharide epitope structure by sialylation. J Exp Med (1990) 2.61
A survey of clinical trials of antibiotic prophylaxis in colon surgery: evidence against further use of no-treatment controls. N Engl J Med (1981) 2.59
Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized control trials. Circulation (1990) 2.51
A cohort study of summary reports of controlled trials. JAMA (1990) 2.51
Cancer in universal and left-sided ulcerative colitis: factors determining risk. Gastroenterology (1979) 2.48
Renal failure in the patient with cirrhosis. The role of active vasoconstriction. Am J Med (1970) 2.43
Adjuvant therapy of colorectal cancer. Why we still don't know. JAMA (1988) 2.41
Derivatives of 6-aminopenicillanic acid. XI. Alpha-amino-p-hydroxybenzylpenicillin. J Chem Soc Perkin 1 (1971) 2.39
The present status of shunts for portal hypertension in cirrhosis. Gastroenterology (1966) 2.38
Genetic engineering of harvest index in tobacco through overexpression of a phytochrome gene. Nat Biotechnol (1996) 2.36
Dipsticks and diagnostic algorithms in urinary tract infection: development and validation, randomised trial, economic analysis, observational cohort and qualitative study. Health Technol Assess (2009) 2.36
Measuring the quality of medical care: second revision of tables of indexes. N Engl J Med (1980) 2.34
Overnight calls in primary care: randomised controlled trial of management using nurse telephone consultation. BMJ (1999) 2.32
Endoscopic hemostasis. An effective therapy for bleeding peptic ulcers. JAMA (1990) 2.32
Phytochrome and photomorphogenesis in plants. Nature (1970) 2.26
A meta-analysis of alcoholic beverage consumption in relation to risk of colorectal cancer. Cancer Causes Control (1990) 2.25
Paradoxical expansion of intracranial tuberculomas during chemotherapy. Lancet (1984) 2.19
A controlled study of the prophylactic portacaval shunt. A final report. Ann Intern Med (1969) 2.19
Earthquake injuries related to housing in a guatemalan village. Science (1977) 2.18
Postoperative patient-controlled analgesia: meta-analyses of initial randomized control trials. J Clin Anesth (1993) 2.18
Clinical governance in primary care groups: the feasibility of deriving evidence-based performance indicators. Qual Health Care (2000) 2.16
Preventive care for patients following myocardial infarction. The Wessex Research Network (WReN). Fam Pract (1997) 2.15
Biochemical challenge of microbial pathogenicity. Bacteriol Rev (1968) 2.14
Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes. Oncogene (2007) 2.14
Avoiding serious infections associated with abdominal hysterectomy: a meta-analysis of antibiotic prophylaxis. Am J Obstet Gynecol (1993) 2.07
A controlled study of the therapeutic portacaval shunt. Gastroenterology (1974) 2.05
The effect of high-sodium and low-sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertension. Am J Med (1978) 2.05
A comparison of the frequency of hepatitis-B antigen and antibody in hospital and nonhospital personnel. N Engl J Med (1973) 2.05
Women's views about management and cause of urinary tract infection: qualitative interview study. BMJ (2010) 2.03
A meta-analysis of alcohol consumption in relation to risk of breast cancer. JAMA (1988) 2.01
Fulminant hepatic failure. Presumable contribution to halothane. N Engl J Med (1968) 1.99
Cost analysis of nurse telephone consultation in out of hours primary care: evidence from a randomised controlled trial. BMJ (2000) 1.99
Treatment of patients with symptomless left ventricular dysfunction after myocardial infarction. Lancet (1988) 1.98
Physician attitudes toward applications of computer data base systems. JAMA (1983) 1.95
A comparison of statistical methods for combining event rates from clinical trials. Stat Med (1989) 1.95
Groin hernia repair in Scotland. Br J Surg (2000) 1.93
Meta-analysis of clinical trials as a scientific discipline. I: Control of bias and comparison with large co-operative trials. Stat Med (1987) 1.90
Meta-analysis of randomised controlled trials of nicotine chewing-gum. Lancet (1987) 1.90
Food intolerance and the irritable bowel syndrome. Gut (1989) 1.88
Selection from gonococci grown in vitro of a colony type with some virulence properties of organisms adapted in vivo. J Gen Microbiol (1977) 1.85