Humanization of a mouse monoclonal antibody that blocks the epidermal growth factor receptor: recovery of antagonistic activity.

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🔗 View Article (PMID 9154469)

Published in Immunotechnology on March 01, 1997

Authors

C Mateo1, E Moreno, K Amour, J Lombardero, W Harris, R Pérez

Author Affiliations

1: Centro de Immunología Molecular, Habana, Cuba. cristina@ict.sld.cu

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Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes. Infect Immun (1998) 3.92

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Visualization of gene expression in living adult Drosophila. Science (1996) 2.92

A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence. Mol Microbiol (1998) 2.60

Correlation of the highest-energy cosmic rays with nearby extragalactic objects. Science (2007) 2.57

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Imaging protein kinase Calpha activation in cells. Science (1999) 2.37

Controlling the maturation of pathogen-containing vacuoles: a matter of life and death. Nat Cell Biol (1999) 2.17

Biological activities of Brucella abortus lipopolysaccharides. Infect Immun (1981) 2.13

A high-dose preparation of lactobacilli and bifidobacteria in the prevention of antibiotic-associated and Clostridium difficile diarrhoea in older people admitted to hospital: a multicentre, randomised, double-blind, placebo-controlled, parallel arm trial (PLACIDE). Health Technol Assess (2013) 2.09

Nucleotide sequence of the 16S rRNA from Brucella abortus. Nucleic Acids Res (1989) 2.05

Comparative genomic hybridization of breast tumors stratified by histological grade reveals new insights into the biological progression of breast cancer. Cancer Res (1999) 2.02

Immunochemical characterization of Brucella lipopolysaccharides and polysaccharides. Infect Immun (1981) 1.96

Propranolol in prevention of recurrent bleeding from severe portal hypertensive gastropathy in cirrhosis. Lancet (1991) 1.88

The outer membranes of Brucella spp. are resistant to bactericidal cationic peptides. Infect Immun (1995) 1.82

The two-component system BvrR/BvrS essential for Brucella abortus virulence regulates the expression of outer membrane proteins with counterparts in members of the Rhizobiaceae. Proc Natl Acad Sci U S A (2002) 1.77

"Threshold-level" multipulse transcranial electrical stimulation of motor cortex for intraoperative monitoring of spinal motor tracts: description of method and comparison to somatosensory evoked potential monitoring. J Neurosurg (1998) 1.76

Low predictive value of polymerase chain reaction for diagnosis of cytomegalovirus disease in liver transplant recipients. J Clin Microbiol (1992) 1.74

[Validity of the protocol for evaluating the inappropriate use of hospitalization]. Med Clin (Barc) (1996) 1.70

Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity. J Med Chem (1992) 1.58

Monochromatic aberrations and point-spread functions of the human eye across the visual field. J Opt Soc Am A Opt Image Sci Vis (1998) 1.56

Xotch, the Xenopus homolog of Drosophila notch. Science (1990) 1.55

Comparative study of the clinical efficacy of two different coumarin dosages in the management of arm lymphedema after treatment for breast cancer. Lymphology (1999) 1.51

Evaluation of a radial immunodiffusion test with polysaccharide B antigen for diagnosis of bovine brucellosis. J Clin Microbiol (1980) 1.50

Characterization of Brucella abortus and Brucella melitensis native haptens as outer membrane O-type polysaccharides independent from the smooth lipopolysaccharide. J Bacteriol (1996) 1.49

Pathogenicity island markers in commensal and uropathogenic Escherichia coli isolates. Clin Microbiol Infect (2006) 1.49

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Immunochemical characterization of rough Brucella lipopolysaccharides. Infect Immun (1984) 1.45

A new species of Leishmania parasite from the Venezuelan Andes region. Trans R Soc Trop Med Hyg (1979) 1.43

MR findings in primary antiphospholipid syndrome. AJNR Am J Neuroradiol (1991) 1.43

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Ciliary Neuralgia and its Treatment. Br Med J (1936) 1.12

Brucella lipopolysaccharides and polysaccharides. Ann Inst Pasteur Microbiol (1987) 1.11

Invasion and intracellular trafficking of Brucella abortus in nonphagocytic cells. Microbes Infect (2000) 1.11

DIFFERENTIAL RATES OF DEVELOPMENT OF HETEROTIC AND NONHETEROTIC YOUNG MAIZE SEEDLINGS, I. CORRELATION OF DIFFERENTIAL MORPHOLOGICAL DEVELOPMENT WITH PHYSIOLOGICAL DIFFERENCES IN GERMINATING SEEDS. Proc Natl Acad Sci U S A (1964) 1.10

Induction of immune and adjuvant immunoglobulin G responses in mice by Brucella lipopolysaccharide. Infect Immun (1984) 1.10

The outer membrane of Brucella ovis shows increased permeability to hydrophobic probes and is more susceptible to cationic peptides than are the outer membranes of mutant rough Brucella abortus strains. Infect Immun (1999) 1.09

BB and pellet guns--toys or deadly weapons? J Trauma (1983) 1.09

New vaccines require potent adjuvants like AFPL1 and AFCo1. Scand J Immunol (2007) 1.07

[Invasive fungal infections in liver transplant recipients: analysis of 21 cases]. Med Clin (Barc) (1998) 1.07

Chromosomal variation and genome size support existence of cryptic species of Triatoma dimidiata with different epidemiological importance as Chagas disease vectors. Trop Med Int Health (2006) 1.06

Modulation of endocytosis in nuclear factor IL-6(-/-) macrophages is responsible for a high susceptibility to intracellular bacterial infection. J Immunol (1999) 1.05

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Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction. J Med Chem (1993) 1.05

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Neutralizing interaction between heparins and myotoxin II, a lysine 49 phospholipase A2 from Bothrops asper snake venom. Identification of a heparin-binding and cytolytic toxin region by the use of synthetic peptides and molecular modeling. J Biol Chem (1994) 1.04

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Behavioural and neuroendocrine effects of cannabinoids in critical developmental periods. Behav Pharmacol (2005) 1.03

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Heterogeneity of Brucella abortus lipopolysaccharides. Res Microbiol (1995) 1.01

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Images in cardiology: Right atrial lithomyxoma with extramedullary hematopoiesis. Heart (2002) 1.00

Complete disruption of the main pancreatic duct: endoscopic management. Gastrointest Endosc (1995) 0.99

Evaluation of conventional therapy versus cyclosporine A in Behçet's syndrome. Transplant Proc (1988) 0.99

Right-sided Extra-cerebellar Tumour. Proc R Soc Med (1908) 0.98

Histological diagnosis of cytomegalovirus hepatitis in liver allografts. J Clin Pathol (1995) 0.98

Clinical significance of donor-unrecognized bacteremia in the outcome of solid-organ transplant recipients. Clin Infect Dis (2001) 0.97

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Toxic effects of dissolved heavy metals on Desulfovibrio vulgaris and Desulfovibrio sp. strains. J Hazard Mater (2006) 0.96

Perception of random dot interference patterns. Nature (1973) 0.96

Syngeneic anti-idiotypic monoclonal antibodies to an anti-NeuGc-containing ganglioside monoclonal antibody. Hybridoma (1998) 0.95

Inappropriate treatment in children with bloody diarrhea: clinical and microbiological studies. Arch Med Res (1995) 0.95

Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J Pharmacol Exp Ther (1994) 0.94

Sex differences in the platelet response to aspirin. Thromb Res (1982) 0.94

Diaphragmatic or transdiaphragmatic thoracic involvement in hepatic hydatid disease: surgical trends and classification. World J Surg (1995) 0.94

BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease. Gene Ther (2010) 0.94

Efficacy and tolerability of prolonged linezolid therapy in the treatment of orthopedic implant infections. Eur J Clin Microbiol Infect Dis (2007) 0.94