Published in Nature on June 12, 1997
GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron (1998) 2.34
The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors. Br J Pharmacol (2013) 2.29
Protein tyrosine phosphatase alpha (PTPalpha) and contactin form a novel neuronal receptor complex linked to the intracellular tyrosine kinase fyn. J Cell Biol (1999) 1.35
The Caenorhabditis elegans odr-2 gene encodes a novel Ly-6-related protein required for olfaction. Genetics (2001) 1.10
Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure. Mol Biol Cell (2007) 1.09
Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation. J Biol Chem (2010) 1.07
Signaling through sphingolipid microdomains of the plasma membrane: the concept of signaling platform. Glycoconj J (2001) 1.05
GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc Natl Acad Sci U S A (1998) 1.04
A Drosophila model of multiple endocrine neoplasia type 2. Genetics (2005) 1.03
Journey to the skin: Somatosensory peripheral axon guidance and morphogenesis. Cell Adh Migr (2013) 0.98
Urokinase receptor-dependent and -independent p56/59(hck) activation state is a molecular switch between myelomonocytic cell motility and adherence. EMBO J (1999) 0.96
Development of a maturing T-cell-mediated immune response in patients with idiopathic Parkinson's disease receiving r-metHuGDNF via continuous intraputaminal infusion. J Clin Immunol (2007) 0.96
Shc and Enigma are both required for mitogenic signaling by Ret/ptc2. Mol Cell Biol (1998) 0.96
Coordinate regulation of cadherin and integrin function by the chondroitin sulfate proteoglycan neurocan. J Cell Biol (2000) 0.96
Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor. Proc Natl Acad Sci U S A (1998) 0.94
Glial cell line-derived neurotrophic factor family ligands enhance capsaicin-stimulated release of calcitonin gene-related peptide from sensory neurons. Neuroscience (2009) 0.93
The ret-Activating Ligand GDNF Is Differentiative and Not Mitogenic for Normal and Neoplastic Human Chromaffin Cells In Vitro. Endocr Pathol (1998) 0.93
Mutations in the extracellular domain cause RET loss of function by a dominant negative mechanism. Mol Cell Biol (1998) 0.92
Structure and physiology of the RET receptor tyrosine kinase. Cold Spring Harb Perspect Biol (2013) 0.90
CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. J Neurosci (2008) 0.88
New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control. Am J Pathol (2000) 0.87
Ape1/Ref-1 induces glial cell-derived neurotropic factor (GDNF) responsiveness by upregulating GDNF receptor alpha1 expression. Mol Cell Biol (2009) 0.86
Investigation of germline GFR alpha-1 mutations in Hirschsprung disease. J Med Genet (1999) 0.85
Characterisation of the human GFRalpha-3 locus and investigation of the gene in Hirschsprung disease. J Med Genet (2000) 0.84
Oncological implications of RET gene mutations in Hirschsprung's disease. Gut (1998) 0.83
Huntington's Disease: From Mutant Huntingtin Protein to Neurotrophic Factor Therapy. Int J Biomed Sci (2011) 0.82
A Mutation in the Catalytic Subunit of the Glycosylphosphatidylinositol Transamidase Disrupts Growth, Fertility, and Stomata Formation. Plant Physiol (2016) 0.79
Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors. Elife (2015) 0.78
Receptor tyrosine kinase signaling: regulating neural crest development one phosphate at a time. Curr Top Dev Biol (2015) 0.77
Different requirements for GFRα2-signaling in three populations of cutaneous sensory neurons. PLoS One (2014) 0.77
Activation by GDNF of a transcriptional program repressing neurite growth in dorsal root ganglia. Proc Natl Acad Sci U S A (2001) 0.77
Internalization of glial cell-derived neurotrophic factor receptor GFR alpha 1 in the absence of the ret tyrosine kinase coreceptor. Cell Mol Neurobiol (2003) 0.77
Molecular fingerprinting delineates progenitor populations in the developing zebrafish enteric nervous system. Dev Dyn (2016) 0.75
Mutation and deletion analysis of GFR alpha-1, encoding the co-receptor for the GDNF/RET complex, in human brain tumours. Br J Cancer (1999) 0.75
Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model. Cell Death Dis (2016) 0.75
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature (1993) 15.70
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun (1999) 14.25
A physical map of the human genome. Nature (2001) 12.39
The DNA sequence of human chromosome 21. Nature (2000) 10.66
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol (2000) 9.85
The genome of the social amoeba Dictyostelium discoideum. Nature (2005) 9.18
Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet (1988) 8.76
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science (1999) 7.75
The action of sulphites on the cystine disulphide linkages in wool: The influence of pH values on the reaction. Biochem J (1938) 7.61
Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature (1998) 7.43
Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1. DNA Res (1999) 7.39
Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation (2000) 6.96
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron (2000) 6.92
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene (2008) 6.82
Molecular basis of symbiosis between Rhizobium and legumes. Nature (1997) 6.66
Development of a self-inactivating lentivirus vector. J Virol (1998) 6.60
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature (1998) 6.49
Human tumor necrosis factor. Production, purification, and characterization. J Biol Chem (1985) 6.28
The Analysis of Proteins. III. Estimation of Histidine and Tyrosine by Bromination. Biochem J (1924) 5.91
Bisulfite genomic sequencing: systematic investigation of critical experimental parameters. Nucleic Acids Res (2001) 5.89
A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki syndrome. N Engl J Med (1991) 5.76
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature (1996) 5.69
Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity. Nature (1985) 5.41
Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation (2000) 5.36
Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection. Clin Infect Dis (2001) 5.27
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes (2001) 5.18
Risk of congenital anomalies near hazardous-waste landfill sites in Europe: the EUROHAZCON study. Lancet (1998) 5.08
Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome. Nat Genet (1997) 4.95
Cloning and structural analyses of hepatitis B virus DNAs, subtype adr. Nucleic Acids Res (1983) 4.94
Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging (1999) 4.94
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell (1998) 4.72
The action of alkalis on wool: 1. The subdivision of the combined cystine into two fractions differing in their rate and mode of reaction with alkalis. Biochem J (1945) 4.64
Comparison of MB-Check, BACTEC, and egg-based media for recovery of mycobacteria. J Clin Microbiol (1992) 4.55
Race-ethnicity and determinants of intracranial atherosclerotic cerebral infarction. The Northern Manhattan Stroke Study. Stroke (1995) 4.54
The treatment of Kawasaki syndrome with intravenous gamma globulin. N Engl J Med (1986) 4.49
A randomized trial of a program to reduce the use of psychoactive drugs in nursing homes. N Engl J Med (1992) 4.49
DNA sequences required for regulated expression of beta-globin genes in murine erythroleukemia cells. Cell (1984) 4.42
Renal and neuronal abnormalities in mice lacking GDNF. Nature (1996) 4.06
Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell (1993) 4.04
Detection of Mycobacterium tuberculosis in clinical specimens by polymerase chain reaction and Gen-Probe Amplified Mycobacterium Tuberculosis Direct Test. J Clin Microbiol (1993) 4.04
Positional cloning of the gene for X-linked retinitis pigmentosa 2. Nat Genet (1998) 4.01
Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell (1985) 3.86
Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc Natl Acad Sci U S A (1991) 3.76
A cost-benefit analysis of demand for food. J Exp Anal Behav (1988) 3.74
A second serine protease associated with mannan-binding lectin that activates complement. Nature (1997) 3.64
GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science (1994) 3.63
The action of sulphites on the cystine disulphide linkages of wool: 4. Methylation of the thiol groups of bisulphited wools. Biochem J (1944) 3.55
Redundant regulation of meristem identity and plant architecture by FRUITFULL, APETALA1 and CAULIFLOWER. Development (2000) 3.47
K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem Biophys Res Commun (1987) 3.46
Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet (2000) 3.42
Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci U S A (1997) 3.40
FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell (1998) 3.33
The action of sulphites on the cystine disulphide linkages of wool: The subdivision of the combined cystine into four fractions differing in their reactivity towards sodium bisulphite. Biochem J (1942) 3.26
Live vaccine used to prevent the spread of varicella in children in hospital. Lancet (1974) 3.24
The methylation of wool with methyl sulphate and methyl halides. Biochem J (1941) 3.24
Sequence requirements for the transcription of the rabbit beta-globin gene in vivo: the -80 region. Nucleic Acids Res (1982) 3.11
Switching of Candida albicans during successive episodes of recurrent vaginitis. J Clin Microbiol (1989) 3.10
Access to coronary artery bypass surgery by race/ethnicity and gender among patients who are appropriate for surgery. Med Care (1999) 3.07
Cardiovascular effects of implanted acrylic bone cement. Br Med J (1971) 3.05
Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med (1996) 3.02
Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Mol Psychiatry (2002) 3.01
Topical ketorolac tromethamine 0.5% ophthalmic solution in ocular inflammation after cataract surgery. Ophthalmology (2001) 3.01
Complete genome sequence of an aerobic thermoacidophilic crenarchaeon, Sulfolobus tokodaii strain7. DNA Res (2001) 2.99
Characterization of a multicomponent receptor for GDNF. Nature (1996) 2.92
Herpesviridae. Definition, provisional nomenclature, and taxonomy. The Herpesvirus Study Group, the International Committee on Taxonomy of Viruses. Intervirology (1981) 2.92
Molecular architecture of membranes involved in excitation-contraction coupling of cardiac muscle. J Cell Biol (1995) 2.88
Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants. J Biol Chem (2000) 2.87
Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc Natl Acad Sci U S A (1999) 2.84
Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects. Pharmacol Biochem Behav (2000) 2.83
Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83
An Epstein-Barr virus-producer line Akata: establishment of the cell line and analysis of viral DNA. Virus Genes (1991) 2.77
The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis. Science (1993) 2.77
The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency. J Biol Chem (1996) 2.75
Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J Biol Chem (2000) 2.73
THE FILTRATION RATE, EFFECTIVE RENAL BLOOD FLOW, TUBULAR EXCRETORY MASS AND PHENOL RED CLEARANCE IN SPECIFIC TOXEMIA OF PREGANANCY. J Clin Invest (1942) 2.65
Overexpression of transforming growth factor alpha in psoriatic epidermis. Science (1989) 2.63
An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm Metab Res (2000) 2.59
Seroepidemiology of human herpesvirus 6 infection in normal children and adults. J Clin Microbiol (1989) 2.58
Expression of T cell antigen receptor heterodimers in a lipid-linked form. Science (1990) 2.56
Human lymphotoxin. Production by a lymphoblastoid cell line, purification, and initial characterization. J Biol Chem (1984) 2.55