Published in Eur J Biochem on June 01, 1997
Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell (2000) 36.09
Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21
Osmotic stress signaling and osmoadaptation in yeasts. Microbiol Mol Biol Rev (2002) 8.02
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab (2008) 6.60
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci U S A (2002) 5.93
Yeast carbon catabolite repression. Microbiol Mol Biol Rev (1998) 5.91
Sugar sensing and signaling in plants. Plant Cell (2002) 4.05
Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem J (2000) 3.91
The regulation of AMP-activated protein kinase by phosphorylation. Biochem J (2000) 3.76
AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. Biochem J (1998) 3.73
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes (2009) 3.39
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest (2007) 3.32
Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Mol Cell Biol (2000) 3.27
AMPK and cell proliferation--AMPK as a therapeutic target for atherosclerosis and cancer. J Physiol (2006) 3.11
Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol (2006) 3.08
Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol (2008) 3.07
AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge. Biochem J (1999) 2.75
Assessing the potential of glucokinase activators in diabetes therapy. Nat Rev Drug Discov (2009) 2.60
AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress. Mol Cell Biol (2005) 2.56
Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells. Circulation (2008) 2.48
AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem J (1999) 2.46
AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. Biochem J (1998) 2.45
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J (2002) 2.41
Application of independent component analysis to microarrays. Genome Biol (2003) 2.16
AMP-activated kinase regulates cytoplasmic HuR. Mol Cell Biol (2002) 2.14
AMPK alterations in cardiac physiology and pathology: enemy or ally? J Physiol (2006) 2.09
AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance. J Biol Chem (2008) 2.02
Novel protein kinases associated with calcineurin B-like calcium sensors in Arabidopsis. Plant Cell (1999) 2.02
Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem J (2003) 2.02
beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J (2000) 1.92
Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms. Arch Biochem Biophys (2009) 1.91
Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metab (2011) 1.89
Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases. Biochem J (2006) 1.88
Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells. Biochem J (2002) 1.87
Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. J Clin Invest (2000) 1.86
AMP-activated protein kinase: nature's energy sensor. Nat Chem Biol (2011) 1.85
SKP1-SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase. EMBO J (2001) 1.83
The blooming of the French lilac. J Clin Invest (2001) 1.80
A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proc Natl Acad Sci U S A (2007) 1.79
Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J (2003) 1.77
AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation. Mol Endocrinol (2010) 1.75
Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. Eur J Neurosci (2008) 1.74
Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver. Cancer Res (2008) 1.73
Regulatory interaction of PRL1 WD protein with Arabidopsis SNF1-like protein kinases. Proc Natl Acad Sci U S A (1999) 1.73
Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle. EMBO J (1998) 1.72
Mitochondria as signaling organelles in the vascular endothelium. Proc Natl Acad Sci U S A (2006) 1.72
Functions of AMP-activated protein kinase in adipose tissue. J Physiol (2006) 1.70
Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization. Biochem J (2001) 1.69
Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke. Stroke (2007) 1.67
Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle. J Appl Physiol (1985) (2010) 1.67
Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain. J Physiol (2006) 1.67
AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling. J Leukoc Biol (2013) 1.65
Two SNF1-related protein kinases from spinach leaf phosphorylate and inactivate 3-hydroxy-3-methylglutaryl-coenzyme A reductase, nitrate reductase, and sucrose phosphate synthase in vitro. Plant Physiol (1999) 1.64
Activated protein C modulates cardiac metabolism and augments autophagy in the ischemic heart. J Thromb Haemost (2012) 1.63
A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. Am J Physiol Cell Physiol (2012) 1.62
AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes. J Biol Chem (2010) 1.60
Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels. Mol Cell Biol (2011) 1.54
Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes. Diabetes (2008) 1.53
Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity. Proc Natl Acad Sci U S A (2005) 1.52
The fat side of prostate cancer. Biochim Biophys Acta (2013) 1.46
Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression. Proc Natl Acad Sci U S A (2000) 1.46
Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells. J Biol Chem (2008) 1.41
Glucose, exercise and insulin: emerging concepts. J Physiol (2001) 1.40
Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage. J Clin Invest (2007) 1.40
AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply. Proc Natl Acad Sci U S A (2009) 1.40
Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake. Proc Natl Acad Sci U S A (2008) 1.38
Higher skeletal muscle alpha2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exercise. J Physiol (2006) 1.34
AMP-activated protein kinase regulation and biological actions in the heart. Circ Res (2012) 1.33
AMP-activated protein kinase mediates carotid body excitation by hypoxia. J Biol Chem (2006) 1.32
Evidence for new alleles in the protein kinase adenosine monophosphate-activated gamma(3)-subunit gene associated with low glycogen content in pig skeletal muscle and improved meat quality. Genetics (2001) 1.32
Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy. Mol Cancer (2007) 1.31
Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice. Diabetes (2009) 1.31
Bringing light to the dark side of insulin: a journey across the blood-brain barrier. Diabetes (2008) 1.30
AMP-activated protein kinase, stress responses and cardiovascular diseases. Clin Sci (Lond) (2012) 1.29
ARK5 is a tumor invasion-associated factor downstream of Akt signaling. Mol Cell Biol (2004) 1.29
AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function. J Biol Chem (2012) 1.27
Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis. Cell Mol Life Sci (2010) 1.27
Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells. J Physiol (2005) 1.26
Short-term exercise training in humans reduces AMPK signalling during prolonged exercise independent of muscle glycogen. J Physiol (2005) 1.25
Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells. J Biol Chem (2008) 1.25
Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival. Am J Physiol Heart Circ Physiol (2010) 1.25
Adenylate kinase 1 gene deletion disrupts muscle energetic economy despite metabolic rearrangement. EMBO J (2000) 1.23
Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo. Diabetologia (2010) 1.22
The protein kinase SnRK2.6 mediates the regulation of sucrose metabolism and plant growth in Arabidopsis. Plant Physiol (2010) 1.22
Adiponectin and its receptors are expressed in adult ventricular cardiomyocytes and upregulated by activation of peroxisome proliferator-activated receptor gamma. J Mol Cell Cardiol (2007) 1.21
Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice. Proc Natl Acad Sci U S A (2004) 1.21
Sac3, an Snf1-like serine/threonine kinase that positively and negatively regulates the responses of Chlamydomonas to sulfur limitation. Plant Cell (1999) 1.19
Effects of metformin in experimental stroke. Stroke (2010) 1.19
A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis. EMBO Mol Med (2014) 1.19
Malonyl-CoA and the regulation of fatty acid oxidation in soleus muscle. Biochem J (1998) 1.16
Inhibition of acetyl coenzyme A carboxylase activity restores expression of the INO1 gene in a snf1 mutant strain of Saccharomyces cerevisiae. Mol Cell Biol (2001) 1.15
AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction. Aging Cell (2010) 1.14
Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise. J Physiol (2003) 1.13
The prince and the pauper. A tale of anticancer targeted agents. Mol Cancer (2008) 1.12
Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta. J Biol Chem (2009) 1.11
Wired on sugar: the role of the CNS in the regulation of glucose homeostasis. Nat Rev Neurosci (2012) 1.10
The central role of a SNRK2 kinase in sulfur deprivation responses. Plant Physiol (2008) 1.08
A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction. Biochem J (2007) 1.08
Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance. Am J Physiol Endocrinol Metab (2009) 1.08
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med (2002) 14.15
The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem (1998) 8.46
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J Biol Chem (1996) 7.23
Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. Eur J Biochem (1989) 4.65
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature (1989) 4.27
Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem J (2000) 3.91
The regulation of AMP-activated protein kinase by phosphorylation. Biochem J (2000) 3.76
AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. Biochem J (1998) 3.73
5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. J Biol Chem (1995) 3.46
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr Biol (2000) 3.28
Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Mol Cell Biol (2000) 3.27
The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro. FEBS Lett (1996) 3.21
Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. J Biol Chem (1994) 3.18
Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS Lett (1994) 2.65
AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes. J Biol Chem (1998) 2.38
Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets. Eur J Biochem (1992) 2.27
Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro. J Biol Chem (1996) 1.98
Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. J Biol Chem (1998) 1.92
Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism. Eur J Biochem (1989) 1.88
Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase. Eur J Biochem (1988) 1.87
Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle. EMBO J (1998) 1.72
Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure. Eur J Biochem (1994) 1.54
Characterisation of 5'-AMP-activated protein kinase in human liver using specific peptide substrates and the effects of 5'-AMP analogues on enzyme activity. Biochem Biophys Res Commun (1994) 1.37
The regulation and function of mammalian AMPK-related kinases. Acta Physiol (Oxf) (2009) 1.29
Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C alpha. Biochem J (1996) 1.27
Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem Soc Trans (2003) 1.24
Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase. Diabetes (2000) 1.23
The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1. FEBS Lett (1999) 1.23
Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress. Semin Cell Biol (1994) 1.17
AMP-activated protein kinase and the metabolic syndrome. Biochem Soc Trans (2005) 1.15
The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes. J Neurochem (1999) 1.13
The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA. Eur J Biochem (1995) 1.04
Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components. FEBS Lett (1998) 1.00
Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase. FEBS Lett (1997) 0.89
Negative interactions between phosphorylation of acetyl-CoA carboxylase by the cyclic AMP-dependent and AMP-activated protein kinases. FEBS Lett (1988) 0.88
Characterization of the phosphorylation of rat mammary ATP-citrate lyase and acetyl-CoA carboxylase by Ca2+ and calmodulin-dependent multiprotein kinase and Ca2+ and phospholipid-dependent protein kinase. Eur J Biochem (1986) 0.83
Second trial of low dosages of DDS in lepromatous leprosy. Lepr Rev (1969) 0.79
Adenosine monophosphate-activated protein kinase: hydroxymethylglutaryl-CoA reductase kinase. Methods Enzymol (1991) 0.78
Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase. FEBS Lett (1994) 0.78
Bacteriological effect of Lamprene (clofazimine) in lepromatous leprosy (report of one year's treatment of 44 patients with 100 mg of Lamprene daily). Lepr Rev (1971) 0.77
Hepatic lipase gene is transcribed in rat adrenals into a truncated mRNA. J Lipid Res (1994) 0.76
Evidence for involvement of Saccharomyces cerevisiae protein kinase C in glucose induction of HXT genes and derepression of SUC2. FEMS Yeast Res (2002) 0.76
Interaction of AMP-activated protein kinase subunits in the heterotrimeric complex and with their yeast homologues. Biochem Soc Trans (1997) 0.75
Identification of a novel AMPK beta subunit that is highly expressed in skeletal muscle. Biochem Soc Trans (1997) 0.75
Low dosage of DDS. Lepr Rev (1966) 0.75
Relationship between protein kinase C and derepression of different enzymes. FEBS Lett (2002) 0.75