Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation.

PubWeight™: 1.66‹?› | Rank: Top 3%

🔗 View Article (PMID 9212230)

Published in Int J Cancer on July 03, 1997

Authors

R P Huang1, Y Fan, I de Belle, C Niemeyer, M M Gottardis, D Mercola, E D Adamson

Author Affiliations

1: Department of Molecular Medicine, Northwest Hospital, Seattle, WA 98125, USA.

Articles citing this

The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin. Cancer Gene Ther (2006) 2.24

Re-employment of developmental transcription factors in adult heart disease. Semin Cell Dev Biol (2006) 1.82

PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J (2008) 1.58

Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence. Proc Natl Acad Sci U S A (2003) 1.30

Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. PLoS Genet (2013) 1.24

ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells. Mol Cancer Ther (2008) 1.19

Expression profiling of Galectin-3-depleted melanoma cells reveals its major role in melanoma cell plasticity and vasculogenic mimicry. Am J Pathol (2008) 1.17

Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms. Cancer Res (2006) 1.13

APE1/Ref-1 regulates PTEN expression mediated by Egr-1. Free Radic Res (2008) 1.13

Inhibition of human breast carcinoma proliferation, migration, chemoinvasion and solid tumour growth by DNAzymes targeting the zinc finger transcription factor EGR-1. Nucleic Acids Res (2004) 1.11

CDK6 as a key regulator of hematopoietic and leukemic stem cell activation. Blood (2014) 1.09

Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma. Cancer Cell Int (2004) 1.08

Transcription factor EGR-1 inhibits growth of hepatocellular carcinoma and esophageal carcinoma cell lines. World J Gastroenterol (2002) 1.03

Effect of insulin analogues on insulin/IGF1 hybrid receptors: increased activation by glargine but not by its metabolites M1 and M2. PLoS One (2012) 1.03

Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras. EMBO J (2006) 1.01

Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice. Am J Respir Cell Mol Biol (2009) 1.00

Transcriptional Regulation of EGR1 by EGF and the ERK Signaling Pathway in Prostate Cancer Cells. Genes Cancer (2011) 0.98

Taxane-mediated gene induction is independent of microtubule stabilization: induction of transcription regulators and enzymes that modulate inflammation and apoptosis. Proc Natl Acad Sci U S A (1998) 0.94

An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer. Mol Cell Biol (2007) 0.93

Experimental and clinicopathologic study on the relationship between transcription factor Egr-1 and esophageal carcinoma. World J Gastroenterol (2001) 0.93

Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway. J Mol Med (Berl) (2007) 0.92

Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation. Cell Signal (2011) 0.90

Relationship between Egr-1 gene expression and apoptosis in esophageal carcinoma and precancerous lesions. World J Gastroenterol (2002) 0.89

EGR1 decreases the malignancy of human non-small cell lung carcinoma by regulating KRT18 expression. Sci Rep (2014) 0.88

Decreased EGR3 expression is related to poor prognosis in patients with gastric cancer. J Mol Histol (2013) 0.87

Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1. PLoS One (2011) 0.86

Role of INK4a/Arf locus-encoded senescent checkpoints activated in normal and psoriatic keratinocytes. Am J Pathol (2003) 0.86

Heparin inhibits Hepatocyte Growth Factor induced motility and invasion of hepatocellular carcinoma cells through early growth response protein 1. PLoS One (2012) 0.86

Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase. Oncotarget (2016) 0.85

Cancers of unknown primary origin (CUP) are characterized by chromosomal instability (CIN) compared to metastasis of know origin. BMC Cancer (2015) 0.84

pH modulates the binding of early growth response protein 1 transcription factor to DNA. FEBS J (2013) 0.83

Identification of modulated genes by three classes of chemopreventive agents at preneoplastic stages in a p53-null mouse mammary tumor model. Cancer Prev Res (Phila) (2009) 0.83

Desmin regulates airway smooth muscle hypertrophy through early growth-responsive protein-1 and microRNA-26a. J Biol Chem (2011) 0.82

O-GlcNAcylation-inducing treatments inhibit estrogen receptor α expression and confer resistance to 4-OH-tamoxifen in human breast cancer-derived MCF-7 cells. PLoS One (2013) 0.82

Sustained conditional knockdown reveals intracellular bone sialoprotein as essential for breast cancer skeletal metastasis. Oncotarget (2014) 0.80

Cross-species hybridization of woodchuck hepatitis virus-induced hepatocellular carcinoma using human oligonucleotide microarrays. World J Gastroenterol (2006) 0.80

Analysis of prolactin-modulated gene expression profiles during the Nb2 cell cycle using differential screening techniques. Genome Biol (2000) 0.80

RUNX3, EGR1 and SOX9B form a regulatory cascade required to modulate BMP-signaling during cranial cartilage development in zebrafish. PLoS One (2012) 0.78

A Positive Feed-forward Loop Associating EGR1 and PDGFA Promotes Proliferation and Self-renewal in Glioblastoma Stem Cells. J Biol Chem (2016) 0.78

Identification of STAT3-independent regulatory effects for protein inhibitor of activated STAT3 by binding to novel transcription factors. Cancer Biol Ther (2011) 0.78

ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line. Brain Res (2009) 0.78

The transcription factor EGR1 localizes to the nucleolus and is linked to suppression of ribosomal precursor synthesis. PLoS One (2014) 0.77

Evidence of EGR1 as a differentially expressed gene among proliferative skin diseases. Genomic Med (2007) 0.77

hEGR1 is induced by EGF, inhibited by gefitinib in bladder cell lines and related to EGF receptor levels in bladder tumours. Br J Cancer (2007) 0.77

Δ(9)-Tetrahydrocannabinol disrupts estrogen-signaling through up-regulation of estrogen receptor β (ERβ). Chem Res Toxicol (2013) 0.76

Role of promoter DNA sequence variations on the binding of EGR1 transcription factor. Arch Biochem Biophys (2014) 0.76

Trisomy 12 CLLs progress through NOTCH1 mutations. Leukemia (2012) 0.76

Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice. Endocr Relat Cancer (2016) 0.76

Enthalpic factors override the polyelectrolyte effect in the binding of EGR1 transcription factor to DNA. J Mol Recognit (2014) 0.75

A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignancies. Oncotarget (2015) 0.75

Revealing potential molecular targets bridging colitis and colorectal cancer based on multidimensional integration strategy. Oncotarget (2015) 0.75

The expression of B23 and EGR1 proteins is functionally linked in tumor cells under stress conditions. BMC Cell Biol (2015) 0.75

Single-channel quantitative multiplex reverse transcriptase-polymerase chain reaction for large numbers of gene products differentiates nondemented from neuropathological Alzheimer's disease. Am J Pathol (2004) 0.75

New approaches for cancer treatment: antitumor drugs based on gene-targeted nucleic acids. Acta Naturae (2009) 0.75

Development and application of molecular biomarkers for characterizing Caribbean Yellow Band Disease in Orbicella faveolata. PeerJ (2015) 0.75

Mechanisms of dietary response in mice and primates: a role for EGR1 in regulating the reaction to human-specific nutritional content. PLoS One (2012) 0.75

Radiation Induced Apoptosis of Murine Bone Marrow Cells Is Independent of Early Growth Response 1 (EGR1). PLoS One (2017) 0.75

Articles by these authors

Comparison of human genetic and sequence-based physical maps. Nature (2001) 4.97

Vinculin knockout results in heart and brain defects during embryonic development. Development (1998) 3.44

Sequential Monte Carlo without likelihoods. Proc Natl Acad Sci U S A (2007) 3.42

An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci U S A (2000) 3.13

Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group. Blood (2000) 3.13

Classifying spatial patterns of brain activity with machine learning methods: application to lie detection. Neuroimage (2005) 2.92

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme. Biochim Biophys Acta (1998) 2.83

Long-term results of five consecutive trials in childhood acute lymphoblastic leukemia performed by the ALL-BFM study group from 1981 to 2000. Leukemia (2009) 2.78

alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells. J Cell Biol (1998) 2.74

The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling. Nat Cell Biol (2001) 2.71

Current insights into the regulation of programmed cell death by NF-kappaB. Oncogene (2006) 2.60

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73. Mol Cell Biol (1992) 2.34

The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin. Cancer Gene Ther (2006) 2.24

Transcription of c-onc genes c-rasKi and c-fms during mouse development. Mol Cell Biol (1983) 2.14

Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion. EMBO J (1983) 2.08

Mutations in ribosomal protein S19 gene and diamond blackfan anemia: wide variations in phenotypic expression. Blood (1999) 2.07

Pleuro-pulmonary blastoma: a case report and review of the literature. Med Pediatr Oncol (1995) 2.02

The synthesis and storage of histones during the oogenesis of Xenopus laevis. Dev Biol (1977) 1.99

The Polycomb group in Caenorhabditis elegans and maternal control of germline development. Development (1998) 1.97

Myelodysplasia and acute myelogenous leukemia in Down's syndrome. A report of 40 children of the AML-BFM Study Group. Leukemia (1996) 1.96

Beta-synuclein gene alterations in dementia with Lewy bodies. Neurology (2004) 1.82

Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion. Proc Natl Acad Sci U S A (1995) 1.82

Phenotype and genotype of advanced premalignant head and neck lesions after chemopreventive therapy. J Natl Cancer Inst (1998) 1.78

Structure of insulin in 4-zinc insulin. Nature (1976) 1.78

Suppression of growth and transformation and induction of apoptosis by EGR-1. Cancer Gene Ther (1998) 1.77

UV activates growth factor receptors via reactive oxygen intermediates. J Cell Biol (1996) 1.70

Rescue of the mutant phenotype by reexpression of full-length vinculin in null F9 cells; effects on cell locomotion by domain deleted vinculin. J Cell Sci (1998) 1.69

Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress. Cell Death Differ (2007) 1.64

Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines. Am J Pathol (1995) 1.61

Histone synthesis in early amphibian development: histone and DNA syntheses are not co-ordinated. J Mol Biol (1974) 1.61

Local thrombolysis for severe cerebral venous sinus thrombosis. AJNR Am J Neuroradiol (2012) 1.57

Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43). Cancer Res (1998) 1.53

Tissue and cell type-specific expression of two human c-onc genes. Nature (1983) 1.53

An isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegans. Development (2001) 1.53

Effect of cadmium on estrogen receptor levels and estrogen-induced responses in human breast cancer cells. J Biol Chem (1994) 1.53

Antitumor actions of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model. Cancer Res (1987) 1.52

Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma. Neuropediatrics (2007) 1.52

The localization and synthesis of some collagen types in developing mouse embryos. Cell (1979) 1.51

Epidermal growth factor receptors. Mol Cell Biochem (1981) 1.50

Paraptosis: mediation by MAP kinases and inhibition by AIP-1/Alix. Cell Death Differ (2004) 1.50

Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II. J Biol Chem (1994) 1.49

IFN-gamma knockout mice show Th2-associated delayed-type hypersensitivity and the inflammatory cells fail to localize and control chlamydial infection. Eur J Immunol (1999) 1.48

The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells. Mol Cell Biol (1999) 1.47

Severe combined immunodeficiency due to defective binding of the nuclear factor of activated T cells in T lymphocytes of two male siblings. Eur J Immunol (1996) 1.47

Down's syndrome in childhood acute lymphoblastic leukemia: clinical characteristics and treatment outcome in four consecutive BFM trials. Berlin-Frankfurt-Münster Group. Leukemia (1998) 1.44

An upper limit on the stochastic gravitational-wave background of cosmological origin. Nature (2009) 1.42

Percutaneous vasal sperm aspiration and intrauterine insemination in the treatment of obstructive azoospermia. Fertil Steril (1997) 1.41

Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals. Oncogene (2006) 1.40

The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin. J Biol Chem (1997) 1.39

Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor. Cancer Res (2001) 1.38

Mining and visualizing large anticancer drug discovery databases. J Chem Inf Comput Sci (2000) 1.38

Characterization of the U(L)33 gene product of herpes simplex virus 1. Virology (2000) 1.37

In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor? Br J Pharmacol (2006) 1.37

Biochemical markers of the progress of differentiation in cloned teratocarcinoma cell lines. Eur J Biochem (1977) 1.36

EGR-1, the reluctant suppression factor: EGR-1 is known to function in the regulation of growth, differentiation, and also has significant tumor suppressor activity and a mechanism involving the induction of TGF-beta1 is postulated to account for this suppressor activity. Crit Rev Oncog (1996) 1.35

The early growth response gene EGR-1 behaves as a suppressor gene that is down-regulated independent of ARF/Mdm2 but not p53 alterations in fresh human gliomas. Clin Cancer Res (2001) 1.33

Differences in elasticity of vinculin-deficient F9 cells measured by magnetometry and atomic force microscopy. Exp Cell Res (1998) 1.31

Role of laminin in epithelium formation by F9 aggregates. J Cell Biol (1983) 1.30

Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines. Mol Cell Biol (1998) 1.30

Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy. Proc Natl Acad Sci U S A (1996) 1.30

Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. Development (1999) 1.29

Immunology conformation and biological activity of insulin. Diabetes (1969) 1.28

The heat shock response in HeLa cells is accompanied by elevated expression of the c-fos proto-oncogene. Mol Cell Biol (1987) 1.28

Epidermal growth factor receptors increase during the differentiation of embryonal carcinoma cells. Nature (1979) 1.27

Simultaneous detection of multiple cytokines from conditioned media and patient's sera by an antibody-based protein array system. Anal Biochem (2001) 1.27

Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and EGR-1. J Biol Chem (1996) 1.26

Characterization of the DNA-binding properties of the early growth response-1 (Egr-1) transcription factor: evidence for modulation by a redox mechanism. DNA Cell Biol (1993) 1.26

A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells. Cell Death Differ (2006) 1.26

Functional EGF receptors are present on mouse embryo tissues. Nature (1981) 1.25

Intermediate filament protein synthesis in preimplantation murine embryos. Dev Biol (1983) 1.24

The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251. J Biol Chem (2000) 1.24

c-Jun promotes cellular survival by suppression of PTEN. Cell Death Differ (2006) 1.23

Epithelial layer formation in differentiating aggregates of F9 embryonal carcinoma cells. J Cell Biol (1983) 1.23

Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family. FEBS Lett (1994) 1.23

DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma. Cancer Res (1996) 1.22

In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models. Br J Pharmacol (2007) 1.20

Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1. Dev Biol (1998) 1.20

The transcription factor EGR-1 suppresses transformation of human fibrosarcoma HT1080 cells by coordinated induction of transforming growth factor-beta1, fibronectin, and plasminogen activator inhibitor-1. J Biol Chem (1999) 1.18

Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2. Leukemia (2011) 1.18

White-spot syndrome virus (WSSV) introduction into the Gulf of Mexico and Texas freshwater systems through imported, frozen bait-shrimp. Dis Aquat Organ (2006) 1.18

The ontogeny of expression of murine metallothionein: comparison with the alpha-fetoprotein gene. Dev Biol (1984) 1.18

Inhibition of extracellular signal-regulated protein kinase or c-Jun N-terminal protein kinase cascade, differentially activated by cisplatin, sensitizes human ovarian cancer cell line. J Biol Chem (1999) 1.17

Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1. Proc Natl Acad Sci U S A (1996) 1.16

The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells. J Biol Chem (1997) 1.15

Changes in the rate of histone synthesis during oocyte maturation and very early development of Xenopus laevis. Dev Biol (1977) 1.15

Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development. Mech Dev (2000) 1.15

The proto-oncogene c-fos is over-expressed in the majority of human osteosarcomas. Oncogene (1990) 1.14

p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis. Oncogene (1999) 1.14

Second malignancies after ewing tumor treatment in 690 patients from a cooperative German/Austrian/Dutch study. Ann Oncol (2001) 1.13

Estrogen stimulation and tamoxifen inhibition of leiomyoma cell growth in vitro and in vivo. Endocrinology (1995) 1.13

Egr-1 negatively regulates human tumor cell growth via the DNA-binding domain. Cancer Res (1995) 1.12

Connexin 43 (cx43) enhances chemotherapy-induced apoptosis in human glioblastoma cells. Int J Cancer (2001) 1.12