Published in Nat Genet on August 01, 1997
Phosphorylation of serine 18 regulates distinct p53 functions in mice. Mol Cell Biol (2004) 1.85
A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer. Carcinogenesis (2009) 1.03
Allosteric Interactions by p53 mRNA Govern HDM2 E3 Ubiquitin Ligase Specificity under Different Conditions. Mol Cell Biol (2016) 0.76
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell (1992) 19.87
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev (2001) 15.97
p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (1993) 13.46
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell (1993) 12.02
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature (2001) 10.56
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature (1995) 10.18
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature (1996) 10.14
Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (1995) 8.53
Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell (1992) 7.06
p53 status and the efficacy of cancer therapy in vivo. Science (1994) 6.72
Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. Science (1985) 5.90
Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev (2000) 5.80
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev (1995) 5.63
Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science (1990) 5.47
Sunburn and p53 in the onset of skin cancer. Nature (1995) 5.35
Tumor induction and tissue atrophy in mice lacking E2F-1. Cell (1996) 4.80
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature (1994) 4.52
K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev (1997) 4.24
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet (2001) 4.23
DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell (1994) 4.22
NF1 tumor suppressor gene function: narrowing the GAP. Cell (2001) 4.11
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat Genet (2000) 3.98
Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol (1998) 3.88
Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins. Proc Natl Acad Sci U S A (1987) 3.84
Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature (2000) 3.83
p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell (1994) 3.69
Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev (1996) 3.61
Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev (1993) 3.41
Mouse models of tumor development in neurofibromatosis type 1. Science (1999) 3.40
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications. Oncogene (2001) 3.36
Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet (2001) 3.27
A subset of p53-deficient embryos exhibit exencephaly. Nat Genet (1995) 3.24
Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol Cell Biol (1996) 3.15
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat Genet (1996) 3.08
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nat Cell Biol (2000) 3.07
Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol Cell (1998) 3.05
The retinoblastoma gene family in differentiation and development. Oncogene (1999) 2.95
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ (2006) 2.95
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell (2001) 2.89
p53-independent functions of the p19(ARF) tumor suppressor. Genes Dev (2000) 2.74
Cooperative tumorigenic effects of germline mutations in Rb and p53. Nat Genet (1994) 2.73
Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev (1996) 2.71
Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. J Cell Biol (1996) 2.71
PML, a growth suppressor disrupted in acute promyelocytic leukemia. Mol Cell Biol (1994) 2.68
Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev (1998) 2.66
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J (1999) 2.64
Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J (1996) 2.63
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc Natl Acad Sci U S A (1994) 2.63
The retinoblastoma gene family: cousins with overlapping interests. Trends Genet (1998) 2.59
Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J (1994) 2.57
Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice. Nat Genet (1998) 2.53
Mdm2-mediated ubiquitylation: p53 and beyond. Cell Death Differ (2010) 2.43
Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature (1995) 2.41
Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc Natl Acad Sci U S A (1994) 2.37
PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev (2000) 2.33
Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation. Proc Natl Acad Sci U S A (1998) 2.11
Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation. Proc Natl Acad Sci U S A (1999) 2.10
p53 mutation heterogeneity in cancer. Biochem Biophys Res Commun (2005) 2.03
Modeling human lung cancer in mice: similarities and shortcomings. Oncogene (1999) 1.98
Mutations in the p53 and SCID genes cooperate in tumorigenesis. Genes Dev (1996) 1.89
A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Mol Cell (2001) 1.88
Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev (1997) 1.88
Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system. Mol Cell Biol (2003) 1.86
Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes Dev (1993) 1.84
The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development. J Pathol (2007) 1.83
Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines. J Exp Med (1998) 1.82
NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress. J Biol Chem (1994) 1.73
High metastatic potential in mice inheriting a targeted p53 missense mutation. Proc Natl Acad Sci U S A (2000) 1.73
Analysis of p53 mutants for transcriptional activity. Mol Cell Biol (1991) 1.73
The cell cycle and cancer. Proc Natl Acad Sci U S A (1997) 1.72
A mouse model for the learning and memory deficits associated with neurofibromatosis type I. Nat Genet (1997) 1.71
Tissue-specific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells. J Biol Chem (1992) 1.69
The role of p53 in tumour suppression: lessons from mouse models. Cell Mol Life Sci (1999) 1.68
The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. Genes Dev (1997) 1.67
An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2. Oncogene (2001) 1.66
RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts. Mol Biol Cell (1998) 1.62
Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis. EMBO J (1996) 1.61
p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells. J Cell Biol (1998) 1.59
Nf1 and Gmcsf interact in myeloid leukemogenesis. Mol Cell (2000) 1.58
A genetic mouse model for metastatic lung cancer with gender differences in survival. Oncogene (2007) 1.55
Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli. J Biol Chem (1998) 1.54
Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice. Mol Cell Biol (1998) 1.49
Effective treatment of early endobronchial cancer with regional administration of liposome-p53 complexes. J Natl Cancer Inst (1998) 1.46
Cell-cycle control and its watchman. Nature (1996) 1.44
Isolation and characterization of genomic DNA coding for alpha 2 type I collagen. Nucleic Acids Res (1980) 1.43
mdm2 deletion does not alter growth characteristics of p53-deficient embryo fibroblasts. Oncogene (1996) 1.40
Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1. Proc Natl Acad Sci U S A (2000) 1.39
p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB. Mol Cell Biol (1998) 1.39
Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type II procollagen alpha 1-chain gene. Proc Natl Acad Sci U S A (1991) 1.37
Mouse models of human non-small-cell lung cancer: raising the bar. Cold Spring Harb Symp Quant Biol (2005) 1.37
Sex hormone-induced carcinogenesis in Rb-deficient prostate tissue. Cancer Res (2000) 1.35
Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system. EMBO J (2001) 1.34
Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration. Am J Physiol Lung Cell Mol Physiol (2008) 1.34
Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice. J Pathol (1999) 1.32