Published in Genetics on August 01, 1997
The serine protease Corin is a novel modifier of the Agouti pathway. Development (2007) 1.69
Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein. Biochem J (2003) 1.49
Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo. Genes Dev (1998) 1.25
Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides (2009) 1.16
Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system. Proc Natl Acad Sci U S A (2001) 1.09
Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. Proc Natl Acad Sci U S A (2008) 1.06
Molecular and phenotypic analysis of 25 recessive, homozygous-viable alleles at the mouse agouti locus. Genetics (2002) 1.02
Abnormal regulation of TSG101 in mice with spongiform neurodegeneration. Biochim Biophys Acta (2009) 0.98
The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. J Clin Invest (2002) 0.97
Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas. J Biol Chem (2009) 0.95
Molecular and phenotypic analysis of Attractin mutant mice. Genetics (2001) 0.94
Mitochondrial dysfunction precedes neurodegeneration in mahogunin (Mgrn1) mutant mice. Neurobiol Aging (2007) 0.94
Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein. J Biol Chem (2011) 0.93
Transgenic analysis of the physiological functions of Mahogunin Ring Finger-1 isoforms. Genesis (2009) 0.89
Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti. Proc Natl Acad Sci U S A (1998) 0.89
Melanocortin 1 Receptor: Structure, Function, and Regulation. Front Genet (2016) 0.88
The ubiquitin-proteasome system in spongiform degenerative disorders. Biochim Biophys Acta (2008) 0.86
60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH. J Mol Endocrinol (2016) 0.79
Mouse models for the central melanocortin system. Genes Nutr (2009) 0.79
An agouti mutation lacking the basic domain induces yellow pigmentation but not obesity in transgenic mice. Proc Natl Acad Sci U S A (1999) 0.79
Functional conservation between mammalian MGRN1 and plant LOG2 ubiquitin ligases. FEBS Lett (2013) 0.79
Confirmation of sable QTL that modifies the effects of the A(y) allele on yellow coat color on mouse chromosome 1. Proc Jpn Acad Ser B Phys Biol Sci (2006) 0.75
Alteration of sheep coat color pattern by disruption of ASIP gene via CRISPR Cas9. Sci Rep (2017) 0.75
Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell (1997) 11.35
The cloning of a family of genes that encode the melanocortin receptors. Science (1992) 4.64
Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell (1993) 3.84
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature (1994) 3.70
Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene. FASEB J (1994) 2.27
The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype Sl-Sld. Blood (1965) 2.14
Molecular and developmental genetics of mouse coat color. Annu Rev Genet (1994) 2.04
Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci U S A (1994) 1.77
A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation. Proc Natl Acad Sci U S A (1994) 1.67
Expression and transgenic studies of the mouse agouti gene provide insight into the mechanisms by which mammalian coat color patterns are generated. Development (1995) 1.55
The agouti gene: turned on to yellow. Trends Genet (1994) 1.43
Structure and function of ASP, the human homolog of the mouse agouti gene. Hum Mol Genet (1995) 1.25
Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice. Proc Natl Acad Sci U S A (1995) 1.18
Effects of recombinant agouti-signaling protein on melanocortin action. Mol Endocrinol (1997) 1.12
Aggregation chimeras demonstrate that the primary defect responsible for aganglionic megacolon in lethal spotted mice is not neuroblast autonomous. Development (1993) 1.03
Proopiomelanocortin, its derived peptides, and the skin. J Invest Dermatol (1996) 0.96
Agouti structure and function: characterization of a potent alpha-melanocyte stimulating hormone receptor antagonist. Biochemistry (1995) 0.95
Upregulation of adipocyte metabolism by agouti protein: possible paracrine actions in yellow mouse obesity. Am J Physiol (1996) 0.94
Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol (1975) 0.94
Effects of MSH on food intake, body weight and coat color of the yellow obese mouse. Life Sci (1989) 0.86
DK/Lm: a strain of laboratory mouse with an unusual expression of the lethal yellow (Ay) phenotype. Genet Res (1986) 0.83
Central nervous system control of food intake and body weight. Nature (2006) 11.89
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet (2013) 9.46
Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet (1998) 7.89
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science (1997) 6.23
High-throughput variation detection and genotyping using microarrays. Genome Res (2001) 5.24
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol (2001) 4.05
Neomorphic agouti mutations in obese yellow mice. Nat Genet (1994) 3.92
Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol (1998) 3.01
Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences. Nat Genet (1994) 2.97
DNA and chromatin structure of the human alpha 1 (I) collagen gene. J Biol Chem (1984) 2.85
Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev (1993) 2.67
Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet (1999) 2.57
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature (1995) 2.51
Type I osteogenesis imperfecta: a nonfunctional allele for pro alpha 1 (I) chains of type I procollagen. Proc Natl Acad Sci U S A (1982) 2.45
Reduced secretion of structurally abnormal type I procollagen in a form of osteogenesis imperfecta. Proc Natl Acad Sci U S A (1981) 2.28
Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene. FASEB J (1994) 2.27
WNT signaling in the control of hair growth and structure. Dev Biol (1999) 2.13
Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects. Proc Natl Acad Sci U S A (1996) 2.02
Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice. Cell (1993) 1.95
TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers. Neurology (2010) 1.93
Genome-wide association study of Alzheimer's disease. Transl Psychiatry (2012) 1.88
The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor. Cell (1994) 1.85
Melanocortin 1 receptor variation in the domestic dog. Mamm Genome (2000) 1.83
The human growth hormone gene family: structure and evolution of the chromosomal locus. Nucleic Acids Res (1983) 1.81
Allele frequency distributions in pooled DNA samples: applications to mapping complex disease genes. Genome Res (1998) 1.81
Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain. J Neurosci (1999) 1.80
Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block. Proc Natl Acad Sci U S A (1997) 1.78
Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci U S A (1994) 1.77
Regulation of mouse lens fiber cell development and differentiation by the Maf gene. Development (2000) 1.75
Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c. Science (1996) 1.59
Expression and transgenic studies of the mouse agouti gene provide insight into the mechanisms by which mammalian coat color patterns are generated. Development (1995) 1.55
Intron-mediated recombination may cause a deletion in an alpha 1 type I collagen chain in a lethal form of osteogenesis imperfecta. Proc Natl Acad Sci U S A (1985) 1.53
Cardiovascular indexes in the mouse at rest and with exercise: new tools to study models of cardiac disease. Am J Physiol (1997) 1.50
A biochemical function for attractin in agouti-induced pigmentation and obesity. Nat Genet (2001) 1.49
Altered secretion of type III procollagen in a form of type IV Ehlers-Danlos syndrome. Biochemical studies in cultured fibroblasts. Lab Invest (1981) 1.46
Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3. Cell (2001) 1.40
Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice. The yellow mouse syndrome. J Hered (1986) 1.40
Genomic, transcriptional and mutational analysis of the mouse microphthalmia locus. Genetics (2000) 1.37
The mouse mahogany locus encodes a transmembrane form of human attractin. Nature (1999) 1.37
Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG. Proc Natl Acad Sci U S A (1989) 1.36
Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition. Diabetologia (2005) 1.33
Opposite orientations of an inverted duplication and allelic variation at the mouse agouti locus. Genetics (1996) 1.27
Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to alpha-melanotropin. J Invest Dermatol (1997) 1.26
Structure and function of ASP, the human homolog of the mouse agouti gene. Hum Mol Genet (1995) 1.25
Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo. Genes Dev (1998) 1.25
Physiological and anatomical circuitry between Agouti-related protein and leptin signaling. Endocrinology (1999) 1.22
Peptide mapping of collagen chains using CNBr cleavage of proteins within polyacrylamide gels. Coll Relat Res (1981) 1.21
Isolation, chromosomal mapping, and expression of the mouse tyrosinase gene. J Invest Dermatol (1989) 1.20
Segmental regulation of Hoxb-3 by kreisler. Nature (1997) 1.19
A mouse model for vitiligo. J Invest Dermatol (1986) 1.19
A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein. Nat Genet (1996) 1.19
The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene. EMBO J (1994) 1.17
Equivalence in the genetic control of hindbrain segmentation in fish and mouse. Development (1998) 1.17
Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues. Brain Res (1999) 1.16
Dexamethasone modulates binding and action of epidermal growth factor in serum-free cell culture. Proc Natl Acad Sci U S A (1978) 1.15
Characterization of Agouti-related protein binding to melanocortin receptors. Mol Endocrinol (1999) 1.13
Effects of recombinant agouti-signaling protein on melanocortin action. Mol Endocrinol (1997) 1.12
The mouse ocular albinism 1 gene product is an endolysosomal protein. Exp Eye Res (2001) 1.11
Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system. Proc Natl Acad Sci U S A (2001) 1.09
Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease. Neurology (2010) 1.08
Genome-wide association analysis of age-at-onset in Alzheimer's disease. Mol Psychiatry (2011) 1.05
Assignment of a novel bifurcated SET domain gene, SETDB1, to human chromosome band 1q21 by in situ hybridization and radiation hybrids. Cytogenet Cell Genet (1999) 1.04
Normal spermatozoa from androgen-resistant germ cells of chimaeric mice and the role of androgen in spermatogenesis. Nature (1975) 1.03
Pleiotropic effects of the mouse lethal yellow (Ay) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs. Development (1994) 1.02
Prenatal diagnosis of lethal perinatal osteogenesis imperfecta (OI type II). J Pediatr (1982) 1.01
Genomic variation in multigenic traits: Hirschsprung disease. Cold Spring Harb Symp Quant Biol (2003) 1.00
Isolation and characterization of a mouse homolog of the X-linked ocular albinism (OA1) gene. Genomics (1996) 1.00
Characterization of genes modulated during pheomelanogenesis using differential display. Proc Natl Acad Sci U S A (1998) 0.99
New regulatory factors for melanogenesis: developmental changes in neonatal mice of various genotypes. Dev Biol (1983) 0.99
Secreted and membrane attractin result from alternative splicing of the human ATRN gene. Proc Natl Acad Sci U S A (2000) 0.99
Inhibition of peripheral NF-kappaB activation by central action of alpha-melanocyte-stimulating hormone. J Neuroimmunol (1999) 0.98
MC1R studies in dogs with melanistic mask or brindle patterns. J Hered (2003) 0.97
The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes. J Cell Sci (2001) 0.96
Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist. Mol Pharmacol (1997) 0.96
Modulation of murine melanocyte function in vitro by agouti signal protein. EMBO J (1997) 0.96
Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr). Development (1993) 0.96
Down-regulation of melanocortin receptor signaling mediated by the amino terminus of Agouti protein in Xenopus melanophores. J Biol Chem (1999) 0.95
Molecular and phenotypic analysis of Attractin mutant mice. Genetics (2001) 0.94
Aberrant regulation of the Agouti pigment pattern in the viable yellow mouse. J Hered (1974) 0.94
Mutational analysis of the modulation of tyrosinase by tyrosinase-related proteins 1 and 2 in vitro. Pigment Cell Res (2000) 0.93
Agouti signaling protein and other factors modulating differentiation and proliferation of immortal melanoblasts. Dev Dyn (2001) 0.93
High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein. Biochemistry (2001) 0.93
Systemically administered alpha-melanocyte-stimulating peptides inhibit NF-kappaB activation in experimental brain inflammation. Brain Res (1999) 0.93
Structure and chromosomal localization of the mouse mitochondrial transcription factor A gene (Tfam). Mamm Genome (1997) 0.92
Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. Genomics (1999) 0.92
Serum-stimulated phosphate uptake and initiation of fibroblast proliferation. J Cell Physiol (1977) 0.92
Multifactorial genetics of exencephaly in SELH/Bc mice. Teratology (2001) 0.91
New ligands for melanocortin receptors. Int J Obes (Lond) (2008) 0.91
Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog. Mol Pharmacol (1995) 0.91
Distribution of Mahogany/Attractin mRNA in the rat central nervous system. FEBS Lett (1999) 0.91
Mechanisms of antiinflammatory action of alpha-MSH peptides. In vivo and in vitro evidence. Ann N Y Acad Sci (1999) 0.91
Spatially restricted hypopigmentation associated with an Ednrbs-modifying locus on mouse chromosome 10. Genome Res (2000) 0.91
Misrouting of tyrosinase with a truncated cytoplasmic tail as a result of the murine platinum (cp) mutation. Exp Eye Res (1995) 0.90