Published in Science on September 12, 1997
Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci U S A (1999) 14.16
Antiviral actions of interferons. Clin Microbiol Rev (2001) 13.06
Role of platelet-derived growth factors in physiology and medicine. Genes Dev (2008) 8.89
Interferon signaling and treatment outcome in chronic hepatitis C. Proc Natl Acad Sci U S A (2008) 8.56
Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7. EMBO J (1998) 7.20
A comprehensive pathway map of epidermal growth factor receptor signaling. Mol Syst Biol (2005) 5.68
Stat proteins and oncogenesis. J Clin Invest (2002) 4.79
A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. EMBO J (1999) 4.66
The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell (2009) 4.47
DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection. J Virol (2001) 4.22
slender rice, a constitutive gibberellin response mutant, is caused by a null mutation of the SLR1 gene, an ortholog of the height-regulating gene GAI/RGA/RHT/D8. Plant Cell (2001) 4.22
Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol Mol Biol Rev (2006) 4.13
Inhibition of Stat1-mediated gene activation by PIAS1. Proc Natl Acad Sci U S A (1998) 4.12
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J (1999) 3.77
Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells. Mol Cell Biol (2004) 3.76
Epigenetic regulation of the alternatively activated macrophage phenotype. Blood (2009) 3.76
Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol (2002) 3.57
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A (2003) 3.46
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A (2000) 3.44
Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation. EMBO J (2000) 3.35
Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis. Proc Natl Acad Sci U S A (2001) 3.29
Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms. J Clin Invest (2003) 3.02
Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded. Nat Rev Microbiol (2008) 3.01
Sendai virus C proteins counteract the interferon-mediated induction of an antiviral state. J Virol (1999) 2.99
Essential role of STAT3 for embryonic stem cell pluripotency. Proc Natl Acad Sci U S A (1999) 2.74
Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation. J Virol (2002) 2.68
Targeting STAT3 in cancer: how successful are we? Expert Opin Investig Drugs (2009) 2.58
Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells. PLoS One (2008) 2.51
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc Natl Acad Sci U S A (1998) 2.48
Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway. Genes Dev (1998) 2.47
STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res (2008) 2.46
Targeting the interleukin-6/Jak/stat pathway in human malignancies. J Clin Oncol (2012) 2.46
Sex differences in the expression of hepatic drug metabolizing enzymes. Mol Pharmacol (2009) 2.45
Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells. J Biol Chem (2008) 2.42
STAT3 is required for the gp130-mediated full activation of the c-myc gene. J Exp Med (1999) 2.36
Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proc Natl Acad Sci U S A (2003) 2.35
STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3. Proc Natl Acad Sci U S A (2005) 2.32
Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer. Breast Cancer Res (2007) 2.32
Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice. Proc Natl Acad Sci U S A (1998) 2.31
The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. J Natl Cancer Inst (2009) 2.30
Simulation-based model selection for dynamical systems in systems and population biology. Bioinformatics (2009) 2.27
Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Proc Natl Acad Sci U S A (2004) 2.25
Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor. EMBO J (2000) 2.24
Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J Exp Med (2002) 2.23
Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain. Proc Natl Acad Sci U S A (2000) 2.20
Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Proc Natl Acad Sci U S A (2000) 2.20
Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity. Blood (2007) 2.19
Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function. Immunity (2012) 2.16
Functional analysis of transcription factor binding sites in human promoters. Genome Biol (2012) 2.12
Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways. EMBO J (2000) 2.11
Premature expression of the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase. Mol Cell Biol (1999) 2.11
Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells. EMBO J (1999) 2.10
Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins. EMBO J (1999) 2.09
Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha/beta interferon signal transduction. J Virol (2002) 2.08
A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1. Proc Natl Acad Sci U S A (1999) 2.07
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells. J Biol Chem (2001) 2.07
Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc Natl Acad Sci U S A (1999) 2.04
Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon. J Virol (2000) 2.03
Constitutive and IFN-gamma-induced nuclear import of STAT1 proceed through independent pathways. EMBO J (2002) 2.01
Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha. EMBO J (2002) 2.01
Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis. Cell (2016) 1.99
Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively. J Virol (2004) 1.98
Stat1-independent regulation of gene expression in response to IFN-gamma. Proc Natl Acad Sci U S A (2001) 1.96
STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling. J Virol (2003) 1.95
FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Genes Dev (1999) 1.94
Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress. Mol Cell Biol (2001) 1.93
Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors. J Clin Pathol (2005) 1.90
Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. Immunity (2010) 1.90
Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proc Natl Acad Sci U S A (2001) 1.89
Chk2 activation and phosphorylation-dependent oligomerization. Mol Cell Biol (2002) 1.88
Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion. J Biol Chem (2009) 1.86
Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. Clin Cancer Res (2008) 1.83
Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein. Mol Cell Biol (1999) 1.80
Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2. Proc Natl Acad Sci U S A (1999) 1.79
Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B. Proc Natl Acad Sci U S A (2001) 1.78
Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivo. J Virol (2007) 1.77
Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation. Mol Cell Biol (1999) 1.76
MicroRNA-513 regulates B7-H1 translation and is involved in IFN-gamma-induced B7-H1 expression in cholangiocytes. J Immunol (2009) 1.76
Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol (2004) 1.74
Transcriptional factors that promote formation of white adipose tissue. Mol Cell Endocrinol (2009) 1.74
An essential role of the JAK-STAT pathway in ischemic preconditioning. Proc Natl Acad Sci U S A (2001) 1.73
Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation. EMBO J (1998) 1.71
STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells. Biochem J (2005) 1.70
Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma. Am J Pathol (2001) 1.69
A cytomegaloviral protein reveals a dual role for STAT2 in IFN-{gamma} signaling and antiviral responses. J Exp Med (2005) 1.68
DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1. Genes Dev (2003) 1.68
Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation. EMBO J (1998) 1.68
DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites. Mol Cell Biol (2000) 1.68
TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. Mol Biol Cell (1998) 1.67
Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells. Oncogene (2011) 1.67
Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets. Gut (2003) 1.67
The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3. EMBO J (2000) 1.67
Lambda interferon is the predominant interferon induced by influenza A virus infection in vivo. J Virol (2010) 1.66
Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action. Clin Exp Immunol (2003) 1.65
Protein tyrosine phosphatases in the JAK/STAT pathway. Front Biosci (2008) 1.63
A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway. Genetics (2003) 1.63
The significance of tetramerization in promoter recruitment by Stat5. Mol Cell Biol (1999) 1.62