Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains.

PubWeight™: 7.87‹?› | Rank: Top 0.1%

🔗 View Article (PMID 9299439)

Published in Biochem Biophys Res Commun on August 28, 1997

Authors

R Feil1, J Wagner, D Metzger, P Chambon

Author Affiliations

1: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, C.U. de Strasbourg, France.

Articles citing this

(truncated to the top 100)

Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature (2008) 7.03

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell (2007) 6.02

Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell (2008) 5.76

A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature (2009) 5.65

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature (2010) 4.85

Controlled expression of transgenes introduced by in vivo electroporation. Proc Natl Acad Sci U S A (2007) 4.57

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev (2003) 4.40

Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell (2011) 4.29

Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration. Development (2011) 3.97

Activating ESR1 mutations in hormone-resistant metastatic breast cancer. Nat Genet (2013) 3.96

The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell (2012) 3.91

Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements. Nature (2009) 3.72

Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A (2007) 3.51

Multiple layers of B cell memory with different effector functions. Nat Immunol (2009) 3.33

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest (2005) 3.29

Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum Mol Genet (2008) 3.14

A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo. J Neurosci (2012) 3.13

Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells. Genesis (2010) 3.12

Generation of an inducible and optimized piggyBac transposon system. Nucleic Acids Res (2007) 3.09

Rapid generation of inducible mouse mutants. Nucleic Acids Res (2003) 2.77

Characterization of Nkx6-2-derived neocortical interneuron lineages. Cereb Cortex (2009) 2.61

Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy. Mol Cell Biol (2004) 2.58

The distinct temporal origins of olfactory bulb interneuron subtypes. J Neurosci (2008) 2.54

Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia. Dev Biol (2007) 2.48

Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature (2010) 2.46

Harnessing transposons for cancer gene discovery. Nat Rev Cancer (2010) 2.44

A high-resolution enhancer atlas of the developing telencephalon. Cell (2013) 2.34

The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes. Neuron (2008) 2.33

Experience dictates stem cell fate in the adult hippocampus. Neuron (2011) 2.18

Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. Proc Natl Acad Sci U S A (2008) 2.13

Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish. Development (2011) 2.11

Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity. Nat Commun (2013) 2.08

The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis. Mol Cell Biol (2007) 2.07

Genomewide production of multipurpose alleles for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A (2005) 2.07

Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis (2007) 2.01

Secondary replicative function of CD8+ T cells that had developed an effector phenotype. Science (2009) 1.96

Molecular neuroanatomy's "Three Gs": a primer. Neuron (2007) 1.91

Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas. Development (2011) 1.89

Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia. Gastroenterology (2009) 1.89

Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron (2009) 1.88

Fate-restricted neural progenitors in the mammalian cerebral cortex. Science (2012) 1.77

Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo. Mol Cell Biol (2007) 1.76

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proc Natl Acad Sci U S A (2006) 1.67

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. Genes Dev (2010) 1.66

Astrocytes contribute to gamma oscillations and recognition memory. Proc Natl Acad Sci U S A (2014) 1.65

Temporally-controlled site-specific recombination in zebrafish. PLoS One (2009) 1.64

Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. Dev Biol (2009) 1.63

The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis. Epigenetics Chromatin (2009) 1.59

Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth. Dev Biol (2008) 1.59

Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells. PLoS Biol (2008) 1.55

Pet-1 is required across different stages of life to regulate serotonergic function. Nat Neurosci (2010) 1.48

Distinct requirements of microRNAs in NK cell activation, survival, and function. J Immunol (2010) 1.48

Frequent coinfection of cells explains functional in vivo complementation between cytomegalovirus variants in the multiply infected host. J Virol (2005) 1.46

Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas. BMC Dev Biol (2010) 1.45

In vivo fate mapping identifies mesenchymal progenitor cells. Stem Cells (2012) 1.44

De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination. Proc Natl Acad Sci U S A (2003) 1.43

Single-neuron labeling with inducible Cre-mediated knockout in transgenic mice. Nat Neurosci (2008) 1.43

A critical role for Neurofascin in regulating action potential initiation through maintenance of the axon initial segment. Neuron (2011) 1.41

Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning. J Clin Invest (2012) 1.41

Genetic inducible fate mapping in larval zebrafish reveals origins of adult insulin-producing β-cells. Development (2011) 1.36

Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells. Cancer Res (2006) 1.36

Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populations. Neuron (2013) 1.33

Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. Front Neural Circuits (2014) 1.32

Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei. Neural Dev (2011) 1.32

Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular program. Development (2009) 1.31

Inducible site-specific recombination in neural stem/progenitor cells. Genesis (2009) 1.31

Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels. Nat Commun (2012) 1.30

Notch signalling via RBP-J promotes myeloid differentiation. EMBO J (2000) 1.28

Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis. Carcinogenesis (2008) 1.26

Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma. Proc Natl Acad Sci U S A (2008) 1.26

Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice. PLoS One (2011) 1.24

Postnatally induced inactivation of Osterix in osteoblasts results in the reduction of bone formation and maintenance. Bone (2009) 1.23

A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB. Mol Cell (2014) 1.22

Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus. Cancer Cell (2014) 1.22

Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling. Proc Natl Acad Sci U S A (2011) 1.20

A requirement for nuclear factor-kappaB in developmental and plasticity-associated synaptogenesis. J Neurosci (2011) 1.19

Inducible gene inactivation in neurons of the adult mouse forebrain. BMC Neurosci (2007) 1.19

Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors. Proc Natl Acad Sci U S A (2009) 1.17

MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival. Cancer Res (2010) 1.16

Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes. Cancer Res (2008) 1.14

Lost in transgenesis: a user's guide for genetically manipulating the mouse in cardiac research. Circ Res (2012) 1.14

Conditional gene expression and lineage tracing of tuba1a expressing cells during zebrafish development and retina regeneration. J Comp Neurol (2010) 1.13

Mice expressing GFP and CreER in osteochondro progenitor cells in the periosteum. Biochem Biophys Res Commun (2009) 1.12

Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia. Mol Endocrinol (2009) 1.12

Transgenic mice expressing a ligand-inducible cre recombinase in osteoblasts and odontoblasts: a new tool to examine physiology and disease of postnatal bone and tooth. Am J Pathol (2004) 1.11

Early patterning and specification of cardiac progenitors in gastrulating mesoderm. Elife (2014) 1.11

The Engrailed homeobox genes determine the different foliation patterns in the vermis and hemispheres of the mammalian cerebellum. Development (2010) 1.09

Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre-LoxP system. Nucleic Acids Res (2004) 1.08

The a"MAZE"ing world of lung-specific transgenic mice. Am J Respir Cell Mol Biol (2011) 1.07

Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses. Eur J Immunol (2011) 1.07

Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development (2013) 1.07

Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons. Development (2010) 1.07

A new era for functional labeling of neurons: activity-dependent promoters have come of age. Front Neural Circuits (2014) 1.07

Systolic dysfunction in cardiac-specific ligand-inducible MerCreMer transgenic mice. Am J Physiol Heart Circ Physiol (2011) 1.06

An efficient system for conditional gene expression in embryonic stem cells and in their in vitro and in vivo differentiated derivatives. Proc Natl Acad Sci U S A (2001) 1.05

The duration of Fgf8 isthmic organizer expression is key to patterning different tectal-isthmo-cerebellum structures. Development (2009) 1.05

Beyond knockouts: cre resources for conditional mutagenesis. Mamm Genome (2012) 1.04

Activation of postnatal neural stem cells requires nuclear receptor TLX. J Neurosci (2011) 1.04

The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitalia. Endocrinology (2011) 1.03

Temporal and spatial delineation of mouse Otx2 functions by conditional self-knockout. EMBO Rep (2006) 1.03

Articles by these authors

Organization and expression of eucaryotic split genes coding for proteins. Annu Rev Biochem (1981) 49.46

The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics (2003) 32.92

The Fifth Edition of the Addiction Severity Index. J Subst Abuse Treat (1992) 29.45

In vivo sequence requirements of the SV40 early promotor region. Nature (1981) 25.00

The nuclear receptor superfamily: the second decade. Cell (1995) 24.99

Isolation of high-molecular-weight DNA from mammalian cells. Eur J Biochem (1973) 24.38

Promoter sequences of eukaryotic protein-coding genes. Science (1980) 19.96

The ovalbumin gene-sequence of putative control regions. Nucleic Acids Res (1980) 18.04

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity (2000) 16.03

A reliable method for the recovery of DNA fragments from agarose and acrylamide gels. Anal Biochem (1981) 15.38

The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants. Nucleic Acids Res (1981) 15.12

Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc Natl Acad Sci U S A (1978) 14.82

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature (1986) 11.35

Specific in vitro transcription of conalbumin gene is drastically decreased by single-point mutation in T-A-T-A box homology sequence. Proc Natl Acad Sci U S A (1980) 10.27

Specific in vitro initiation of transcription on conalbumin and ovalbumin genes and comparison with adenovirus-2 early and late genes. Nature (1980) 10.22

DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor. Science (1993) 9.94

Folding of the DNA double helix in chromatin-like structures from simian virus 40. Proc Natl Acad Sci U S A (1975) 9.70

Organisation and sequences at the 5' end of a cloned complete ovalbumin gene. Nature (1979) 9.30

A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature (1988) 9.07

Electron microscopic and biochemical evidence that chromatin structure is a repeating unit. Cell (1975) 8.90

Deletions covering the putative promoter region of early mRNAs of simian virus 40 do not abolish T-antigen expression. Proc Natl Acad Sci U S A (1980) 7.77

Multiple sequence motifs are involved in SV40 enhancer function. EMBO J (1986) 7.76

Formation of stable preinitiation complexes between eukaryotic class B transcription factors and promoter sequences. Nature (1983) 7.22

Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription. Nature (1985) 7.14

Ovalbumin gene is split in chicken DNA. Nature (1977) 7.05

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell (1988) 6.59

Functional domains of the human estrogen receptor. Cell (1987) 6.52

Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci U S A (1996) 6.48

Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science (1995) 6.37

Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res (1999) 6.35

The human estrogen receptor has two independent nonacidic transcriptional activation functions. Cell (1989) 6.24

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. Mol Cell (2000) 6.14

Localisation of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor. EMBO J (1986) 6.08

Nuclear receptors enhance our understanding of transcription regulation. Trends Genet (1988) 5.95

The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements. Cell (1983) 5.67

Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science (1996) 5.55

Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor. Nature (1987) 5.47

The SV40 early region TATA box is required for accurate in vitro initiation of transcription. Nature (1981) 5.43

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha. Nature (1995) 5.40

Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat Genet (1999) 5.31

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J (2001) 5.29

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci U S A (1997) 5.24

Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. Nucleic Acids Res (1982) 5.14

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. Nature (1991) 5.13

Identification of a second human retinoic acid receptor. Nature (1988) 5.11

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J (1990) 5.05

Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development (2000) 5.03

Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions. Science (1985) 5.00

TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J (1996) 4.96

The repeated GC-rich motifs upstream from the TATA box are important elements of the SV40 early promoter. Nucleic Acids Res (1983) 4.93

DNA methylation: organ specific variations in the methylation pattern within and around ovalbumin and other chicken genes. Nucleic Acids Res (1979) 4.81

Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid. Nature (1995) 4.79

Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter. Nature (1986) 4.77

The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J (1995) 4.72

A canonical structure for the ligand-binding domain of nuclear receptors. Nat Struct Biol (1996) 4.69

A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J (1996) 4.65

Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell (1995) 4.64

A new measure of substance abuse treatment. Initial studies of the treatment services review. J Nerv Ment Dis (1992) 4.64

The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors. EMBO J (1986) 4.47

Organization and sequence studies of the 17-piece chicken conalbumin gene. Nature (1979) 4.36

Sequences upstream from the T-A-T-A box are required in vivo and in vitro for efficient transcription from the adenovirus serotype 2 major late promoter. Proc Natl Acad Sci U S A (1982) 4.30

Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. EMBO J (1992) 4.30

Stimulation of in vitro transcription from the SV40 early promoter by the enhancer involves a specific trans-acting factor. EMBO J (1984) 4.28

The yeast UASG is a transcriptional enhancer in human HeLa cells in the presence of the GAL4 trans-activator. Cell (1988) 4.22

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell (1988) 4.17

Alpha-amanitin: a specific inhibitor of one of two DNA-pendent RNA polymerase activities from calf thymus. Biochem Biophys Res Commun (1970) 4.16

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J Biol Chem (2000) 4.15

The ovalbumin gene family: structure of the X gene and evolution of duplicated split genes. Cell (1980) 4.14

Cooperativity and hierarchical levels of functional organization in the SV40 enhancer. Cell (1988) 4.03

A trans-acting factor is responsible for the simian virus 40 enhancer activity in vitro. Nature (1985) 4.01

Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase. Proc Natl Acad Sci U S A (1995) 3.94

Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity (2000) 3.84

Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. EMBO J (1999) 3.81

MEDTAG: tag-like semantics for medical document indexing. Proc AMIA Symp (1999) 3.75

Distinct classes of transcriptional activating domains function by different mechanisms. Cell (1990) 3.75

A third human retinoic acid receptor, hRAR-gamma. Proc Natl Acad Sci U S A (1989) 3.74

Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature (1989) 3.72

Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1. Cell (1991) 3.71

Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins. Mol Cell (2001) 3.70

Induction of altered chromatin structures by simian virus 40 enhancer and promoter elements. Nature (1984) 3.68

The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J (1998) 3.64

Multiplicity generates diversity in the retinoic acid signalling pathways. Trends Biochem Sci (1992) 3.63

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen. EMBO J (1990) 3.59

Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development (1994) 3.53

Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression. Cell (1991) 3.53

Steroid hormone receptors compete for factors that mediate their enhancer function. Cell (1989) 3.50

Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor. Cell (1994) 3.46

The HeLa cell protein TEF-1 binds specifically and cooperatively to two SV40 enhancer motifs of unrelated sequence. Cell (1988) 3.41

Isolation by molecular cloning of a fragment in the split ovalbumin gene. Nature (1978) 3.40

The human oestrogen receptor functions in yeast. Nature (1988) 3.32

Molecular cloning of extensive sequences of the in vitro synthesized chicken ovalbumin structural gene. Nucleic Acids Res (1977) 3.32

Cell-type specific protein binding to the enhancer of simian virus 40 in nuclear extracts. Nature (1986) 3.25

Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7. Proc Natl Acad Sci U S A (1984) 3.25