Published in Dev Biol on October 01, 1997
Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci (2001) 11.40
A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci (2008) 2.36
Merkel cells are essential for light-touch responses. Science (2009) 2.24
Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron (2009) 1.88
Atonal homolog 1 is a tumor suppressor gene. PLoS Biol (2009) 1.76
Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Implications for paracrine and target-derived Neurotrophic functions. Am J Pathol (1999) 1.37
Neurotrophic modulation of myelinated cutaneous innervation and mechanical sensory loss in diabetic mice. Neuroscience (2006) 1.20
Rodents rely on Merkel cells for texture discrimination tasks. J Neurosci (2012) 1.19
Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice. J Comp Neurol (2008) 1.10
Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice. Proc Natl Acad Sci U S A (2000) 1.10
Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis. J Neurosci (2012) 1.05
Etv1 inactivation reveals proprioceptor subclasses that reflect the level of NT3 expression in muscle targets. Neuron (2013) 1.04
Diverse dependencies of developing Merkel innervation on the trkA and both full-length and truncated isoforms of trkC. Development (2002) 1.00
TrkC kinase expression in distinct subsets of cutaneous trigeminal innervation and nonneuronal cells. J Comp Neurol (2004) 0.95
Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation. Neural Dev (2010) 0.92
Differential effects of NGF and NT-3 on embryonic trigeminal axon growth patterns. J Comp Neurol (2000) 0.91
Anterograde tracing method using DiI to label vagal innervation of the embryonic and early postnatal mouse gastrointestinal tract. J Neurosci Methods (2007) 0.91
BDNF promotes target innervation of Xenopus mandibular trigeminal axons in vivo. BMC Dev Biol (2007) 0.89
Factors regulating vagal sensory development: potential role in obesities of developmental origin. Physiol Behav (2007) 0.89
The anatomy, function, and development of mammalian Aβ low-threshold mechanoreceptors. Front Biol (Beijing) (2013) 0.88
Peripheral somatosensation: a touch of genetics. Curr Opin Genet Dev (2011) 0.87
Merkel cells as putative regulatory cells in skin disorders: an in vitro study. PLoS One (2009) 0.85
Overexpression of neurotrophin 4 in skin enhances myelinated sensory endings but does not influence sensory neuron number. J Comp Neurol (2006) 0.84
Organization of sensory input to the nociceptive-specific cutaneous trunk muscle reflex in rat, an effective experimental system for examining nociception and plasticity. J Comp Neurol (2014) 0.83
A role for NT-3 in the hyperinnervation of neonatally wounded skin. Pain (2012) 0.81
Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermis. Development (2015) 0.80
High abundances of neurotrophin 3 in atopic dermatitis mast cell. J Occup Med Toxicol (2009) 0.80
Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes. J Neurosci (2016) 0.79
Mice lacking the p75 receptor fail to acquire a normal complement of taste buds and geniculate ganglion neurons by adulthood. Anat Rec A Discov Mol Cell Evol Biol (2006) 0.78
The p75NTR signaling cascade mediates mechanical hyperalgesia induced by nerve growth factor injected into the rat hind paw. Neuroscience (2013) 0.78
Dual innervation of neonatal Merkel cells in mouse touch domes. PLoS One (2014) 0.78
Neurotrophin-4 is more potent than brain-derived neurotrophic factor in promoting, attracting and suppressing geniculate ganglion neurite outgrowth. Dev Neurosci (2012) 0.78
Target specific differentiation of peripheral trigeminal axons in rat-chick chimeric explant cocultures. Brain Res Dev Brain Res (2001) 0.78
Reduced intestinal brain-derived neurotrophic factor increases vagal sensory innervation of the intestine and enhances satiation. J Neurosci (2014) 0.77
Elaboration and Innervation of the Vibrissal System in the Rock Hyrax (Procavia capensis). Brain Behav Evol (2015) 0.75
Null mutations of NT-3 and Bax affect trigeminal ganglion cell number but not brainstem barrelette pattern formation. Somatosens Mot Res (2013) 0.75
Dynamic expression of transcription factor Brn3b during mouse cranial nerve development. J Comp Neurol (2015) 0.75
The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor. Neuroscience (2016) 0.75
The specification and wiring of mammalian cutaneous low-threshold mechanoreceptors. Wiley Interdiscip Rev Dev Biol (2016) 0.75
Tunicamycin-induced cell death in the trigeminal ganglion is suppressed by nerve growth factor in the mouse embryo. Cell Mol Neurobiol (2009) 0.75
ras genes. Annu Rev Biochem (1987) 22.59
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature (1993) 15.70
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science (1997) 15.48
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell (1996) 13.95
Identification of ubiquitin ligases required for skeletal muscle atrophy. Science (2001) 12.98
A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene. Nature (1982) 11.92
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol (2001) 10.85
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell (1991) 9.54
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science (1999) 9.18
Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell (1996) 9.10
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet (1999) 8.53
Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science (1999) 6.96
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol (2001) 6.71
Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J (1984) 6.67
Essential role for oncogenic Ras in tumour maintenance. Nature (1999) 6.51
Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell (1985) 6.21
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature (1986) 5.88
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature (1984) 5.75
Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med (2000) 5.58
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol (1994) 5.02
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science (1995) 4.90
To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer (2001) 4.86
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. Science (1990) 4.63
T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes. Nature (1982) 4.54
The trk proto-oncogene encodes a receptor for nerve growth factor. Cell (1991) 4.54
Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature (1985) 4.40
Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations. Nature (1984) 4.38
Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature (1996) 4.37
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci U S A (2007) 4.27
Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science (1997) 4.26
Development of the primary antibody repertoire. Science (1987) 4.19
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature (1984) 4.18
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron (1996) 4.12
gag Gene of mammalian type-C RNA tumour viruses. Nature (1976) 4.11
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science (1999) 4.10
Regulation of the assembly and expression of variable-region genes. Annu Rev Immunol (1986) 4.09
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2000) 4.07
The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo. Cell (1996) 3.81
Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. Circ Res (1998) 3.79
Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature (1987) 3.74
Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature (1994) 3.73
vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J (1989) 3.67
Increased vascularization in mice overexpressing angiopoietin-1. Science (1998) 3.67
Regulation of genome rearrangement events during lymphocyte differentiation. Immunol Rev (1986) 3.65
Requirement of FGF-4 for postimplantation mouse development. Science (1995) 3.64
GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science (1994) 3.63
Differential expression of myc family genes during murine development. Nature (1986) 3.57
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science (1994) 3.53
Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell (1986) 3.51
Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes Dev (1997) 3.45
New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene (1999) 3.45
Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev (1999) 3.35
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation. Proc Natl Acad Sci U S A (1991) 3.31
The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell (1990) 3.21
NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron (1990) 3.12
Molecular and biochemical characterization of the human trk proto-oncogene. Mol Cell Biol (1989) 3.10
PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron (1998) 3.09
VEGF-initiated blood-retinal barrier breakdown in early diabetes. Invest Ophthalmol Vis Sci (2001) 3.08
Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. Science (1989) 3.03
Development of sensory neurons in the absence of NGF/TrkA signaling in vivo. Neuron (2000) 3.01
Oncogenes in solid human tumours. Nature (1982) 3.00
trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell (1991) 2.97
Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates. Nature (1992) 2.97
Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient. Science (1984) 2.97
LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science (1993) 2.93
Biochemical and immunological characterization of polyproteins coded for by the McDonough, Gardner-Arnstein, and Snyder-Theilen strains of feline sarcoma virus. J Virol (1980) 2.92
Characterization of a multicomponent receptor for GDNF. Nature (1996) 2.92
Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science (1990) 2.91
An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Mol Cell (1997) 2.89
Origin and functional properties of the major gene product of the Snyder-Theilen strain of feline sarcoma virus. Proc Natl Acad Sci U S A (1980) 2.83
Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria. Oncogene (2007) 2.82
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands. Nature (1996) 2.81
Agrin acts via a MuSK receptor complex. Cell (1996) 2.81
Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci U S A (1992) 2.78
A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature (1995) 2.75
Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons. Proc Natl Acad Sci U S A (1997) 2.75
The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell (1988) 2.71
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature (1991) 2.70
Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. EMBO J (1986) 2.62
Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature (1994) 2.61
The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell (1991) 2.56
Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells. Proc Natl Acad Sci U S A (1982) 2.55
Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell (1993) 2.52
Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. Immunity (1998) 2.46
Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev Biol (2001) 2.46
Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone. Nat Neurosci (2000) 2.45
The alphas, betas, and kinases of cytokine receptor complexes. Cell (1993) 2.45
The receptor for ciliary neurotrophic factor. Science (1991) 2.39
The trichodermin group of antibiotics, inhibitors of peptide bond formation by eukaryotic ribosomes. Biochim Biophys Acta (1973) 2.36
Structure and expression of the murine N-myc gene. Proc Natl Acad Sci U S A (1986) 2.36
N-myc can cooperate with ras to transform normal cells in culture. Proc Natl Acad Sci U S A (1985) 2.33
The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. Genes Dev (1987) 2.33
Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors. Lab Invest (1999) 2.32