Published in J Allergy Clin Immunol on October 01, 1997
PDE4 inhibitors: current status. Br J Pharmacol (2008) 2.23
Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D. Proc Natl Acad Sci U S A (2000) 1.47
Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies. Biochem J (2006) 1.31
Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP. Am J Physiol Heart Circ Physiol (2008) 1.22
Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B. Br J Pharmacol (1999) 1.01
New era of biologic therapeutics in atopic dermatitis. Expert Opin Biol Ther (2013) 0.88
Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects. Br J Pharmacol (2001) 0.83
Cyclic nucleotides and phosphodiesterases in monocytic differentiation. Handb Exp Pharmacol (2011) 0.79
The novel distribution of phosphodiesterase-4 subtypes within the rat retina. Neuroscience (2009) 0.77
Effects of inactivated Bordetella pertussis on phosphodiesterase in the lung of ovalbumin sensitized and challenged rats. Pulm Med (2014) 0.75
A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest (1992) 4.39
Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha requires transcriptional arrest. J Immunol (1994) 2.87
Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. Br J Cancer (2008) 2.67
Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol (1995) 2.55
Effect of filgrastim treatment on inflammatory cytokines and lymphocyte functions. Clin Pharmacol Ther (1999) 2.33
Glutathione peroxidase. Methods Enzymol (1981) 2.07
The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution. Eur J Biochem (1983) 2.05
Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro. J Pharmacol Exp Ther (2001) 1.93
Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice. Biochem Pharmacol (1989) 1.87
Granulocyte colony-stimulating factor treatment protects rodents against lipopolysaccharide-induced toxicity via suppression of systemic tumor necrosis factor-alpha. J Immunol (1992) 1.60
In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis. Eur J Immunol (1997) 1.53
Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers. Blood (1995) 1.52
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity. Br J Pharmacol (1999) 1.47
The fate of extracellular glutathione in the rat. Biochim Biophys Acta (1978) 1.45
Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. J Immunol (1995) 1.45
In vivo efficacy in airway disease models of roflumilast, a novel orally active PDE4 inhibitor. J Pharmacol Exp Ther (2001) 1.42
Improved innate immunity of endotoxin-tolerant mice increases resistance to Salmonella enterica serovar typhimurium infection despite attenuated cytokine response. Infect Immun (2001) 1.40
Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma. Br J Cancer (2004) 1.39
High expression of RelA/p65 is associated with activation of nuclear factor-kappaB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis. Br J Cancer (2007) 1.37
Hyperventilation induces release of cytokines from perfused mouse lung. Am J Respir Crit Care Med (1998) 1.36
A novel biologically active seleno-organic compound--II. Activity of PZ 51 in relation to glutathione peroxidase. Biochem Pharmacol (1984) 1.34
In vitro differentiation of human monocytes to macrophages: change of PDE profile and its relationship to suppression of tumour necrosis factor-alpha release by PDE inhibitors. Br J Pharmacol (1997) 1.34
The amino-acid sequence of bovine glutathione peroxidase. Hoppe Seylers Z Physiol Chem (1984) 1.31
(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha 1-adrenoceptors. Eur J Pharmacol (1989) 1.28
Granulocyte-macrophage colony-stimulating factor and IFN-gamma restore the systemic TNF-alpha response to endotoxin in lipopolysaccharide-desensitized mice. J Immunol (1997) 1.26
Influence of selective phosphodiesterase inhibitors on human neutrophil functions and levels of cAMP and Cai. Naunyn Schmiedebergs Arch Pharmacol (1991) 1.23
The level and half-life of glutathione in human plasma. FEBS Lett (1980) 1.21
Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo. Biochem Pharmacol (1979) 1.20
Selenium and drug metabolism--I. Multiple modulations of mouse liver enzymes. Biochem Pharmacol (1983) 1.18
The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure. Mol Med (1996) 1.16
Drug-induced lipid peroxidation in mice--I. Modulation by monooxygenase activity, glutathione and selenium status. Biochem Pharmacol (1981) 1.15
Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors. Am J Physiol (1994) 1.14
Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6. Immunogenetics (1989) 1.14
Human monocytes express functional receptors for granulocyte colony-stimulating factor that mediate suppression of monokines and interferon-gamma. Blood (2000) 1.13
Lipopolysaccharide-induced interleukin-10 in mice: role of endogenous tumor necrosis factor-alpha. Eur J Immunol (1995) 1.13
[Glutathion peroxidase. I. Isolation and determinations of molecular weight]. Hoppe Seylers Z Physiol Chem (1971) 1.11
Metabolic depletion of ATP by fructose inversely controls CD95- and tumor necrosis factor receptor 1-mediated hepatic apoptosis. J Exp Med (2000) 1.11
DNA fragmentation in mouse organs during endotoxic shock. Am J Pathol (1996) 1.10
Susceptibility of multidrug-resistant human leukemia cell lines to human interleukin 2-activated killer cells. Cancer Res (1990) 1.08
Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins. Gastroenterology (1997) 1.05
Concanavalin A hepatotoxicity in mice: tumor necrosis factor-mediated organ failure independent of caspase-3-like protease activation. Hepatology (1999) 1.05
Adenosine receptor-blocking xanthines as inhibitors of phosphodiesterase isozymes. Biochem Pharmacol (1993) 1.04
Structure analysis and molecular model of the selenoenzyme glutathione peroxidase at 2.8 A resolution. J Mol Biol (1979) 1.04
Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro. Br J Pharmacol (2012) 1.03
Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase via the peroxide tone. J Biol Chem (1993) 1.03
Leukotriene-mediated liver injury. Biochem Pharmacol (1988) 1.03
Leukocyte alterations do not account for hepatitis induced by endotoxin or TNF alpha in galactosamine-sensitized mice. Biochem Pharmacol (1990) 1.02
Cryofixation of monolayer cell cultures for freeze-fracturing without chemical pre-treatments. J Microsc (1981) 1.01
Insulin action on glucose transport and calcium fluxes in developing muscle cells in vitro. Eur J Biochem (1976) 1.01
Novel selective PDE4 inhibitors. 2. Synthesis and structure-activity relationships of 4-aryl-substituted cis-tetra- and cis-hexahydrophthalazinones. J Med Chem (2001) 1.01
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization. Am J Physiol (1993) 1.01
Influence of temperature, cholesterol, dipalmitoyllecithin and Ca2+ on the rate of muscle cell fusion. Exp Cell Res (1973) 1.01
ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha. Immunol Lett (1997) 1.01
Control of fecal peritoneal infection in mice by colony-stimulating factors. J Infect Dis (1996) 1.00
Quantitative investigation on Ca++-and pH-dependence of muscle cell fusion in vitro. Biochem Biophys Res Commun (1972) 1.00
Selenium and drug metabolism--III. Relation of glutathione-peroxidase and other hepatic enzyme modulations to dietary supplements. Biochem Pharmacol (1985) 1.00
Role of phosphodiesterases in the regulation of endothelial permeability in vitro. J Clin Invest (1993) 1.00
Phospholipid hydroperoxide glutathione peroxidase in various mouse organs during selenium deficiency and repletion. Biochim Biophys Acta (1990) 1.00
PDE isoenzymes as targets for anti-asthma drugs. Eur Respir J (1995) 1.00
Pharmacological evidence for selective inhibition of gastric acid secretion by telenzepine, a new antimuscarinic drug. Eur J Pharmacol (1985) 1.00
The physiological consequences of glutathione variations. Life Sci (1992) 0.99
In vitro prevention and reversal of lipopolysaccharide desensitization by IFN-gamma, IL-12, and granulocyte-macrophage colony-stimulating factor. J Immunol (1997) 0.98
Selenium and drug metabolism--II. Independence of glutathione peroxidase and reversibility of hepatic enzyme modulations in deficient mice. Biochem Pharmacol (1984) 0.98
CD95-Mediated murine hepatic apoptosis requires an intact glutathione status. Hepatology (1999) 0.97
Cystic renal cell carcinoma is cured by resection: a study of 24 cases with long-term followup. J Urol (1999) 0.97
Drug-induced lipid peroxidation in mice--II. Protection against paracetamol-induced liver necrosis by intravenous liposomally entrapped glutathione. Biochem Pharmacol (1982) 0.96
Oxygen dependent regulation of DNA synthesis and growth of Ehrlich ascites tumor cells in vitro and in vivo. Cancer Res (1988) 0.96
Hormonal regulation of glucokinase in primary cultures of rat hepatocytes. Eur J Biochem (1979) 0.96
Replicon initiation frequency and intracellular levels of ATP, ADP, AMP and of diadenosine 5',5'''-P1,P4-tetraphosphate in ehrlich ascites cells cultured aerobically and anaerobically. Biochem Biophys Res Commun (1983) 0.96
Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury. Br J Pharmacol (2009) 0.96
Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability. Br J Pharmacol (2007) 0.95
Structural requirements for activity of propafenone-type modulators in P-glycoprotein-mediated multidrug resistance. Mol Pharmacol (1996) 0.95
Modulation of cytokine release in ex vivo-stimulated blood from borreliosis patients. Infect Immun (2001) 0.95
Prevention of endotoxin-induced lethality, but not of liver apoptosis in poly(ADP-ribose) polymerase-deficient mice. Biochem Biophys Res Commun (1999) 0.95
Potentiation by granulocyte macrophage colony-stimulating factor of lipopolysaccharide toxicity in mice. J Clin Invest (1994) 0.95
Cyclic nucleotide phosphodiesterases from purified human CD4+ and CD8+ T lymphocytes. Clin Exp Allergy (1995) 0.94
Cyclic nucleotide phosphodiesterase isoenzyme activities in human alveolar macrophages. Clin Exp Allergy (1995) 0.94
Substrate-induced redox change of selenium in glutathione peroxidase studied by x-ray photoelectron spectroscopy. Biochim Biophys Acta (1975) 0.94
Hydrocarbon exhalation. Methods Enzymol (1981) 0.94
The activity of the peroxide-metabolizing system in human colon carcinoma. J Cancer Res Clin Oncol (1980) 0.94
Novel pyrogen tests based on the human fever reaction. The report and recommendations of ECVAM Workshop 43. European Centre for the Validation of Alternative Methods. European Centre for the Validation of Alternative Methods. Altern Lab Anim (2001) 0.94
Cellular recognition by rat liver cells of neuraminidase-treated erythrocytes. Demonstration and analysis of cell contacts. Exp Cell Res (1978) 0.93
The binding of a K+ competitive ligand, 2-methyl,8-(phenylmethoxy)imidazo(1,2-a)pyridine 3-acetonitrile, to the gastric (H+ + K+)-ATPase. J Biol Chem (1989) 0.93
Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation. Br J Pharmacol (1998) 0.92
Functional and fine structural changes in isolated rat lungs challenged with endotoxin ex vivo and in vitro. Am J Pathol (1995) 0.92