Complex subunit assembly of neuronal voltage-gated K+ channels. Basis for high-affinity toxin interactions and pharmacology.

PubWeight™: 1.35‹?› | Rank: Top 10%

🔗 View Article (PMID 9346893)

Published in J Biol Chem on October 31, 1997

Authors

R O Koch1, S G Wanner, A Koschak, M Hanner, C Schwarzer, G J Kaczorowski, R S Slaughter, M L Garcia, H G Knaus

Author Affiliations

1: Institute for Biochemical Pharmacology, Neuropharmacology Unit, University Innsbruck, Peter-Mayr Strasse 1, A-6020 Innsbruck, Austria.

Articles citing this

Localization and targeting of voltage-dependent ion channels in mammalian central neurons. Physiol Rev (2008) 2.90

Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol (2005) 2.08

The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. Proc Natl Acad Sci U S A (2005) 1.69

Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3. J Neurosci (2011) 1.46

Voltage-gated K+ channels in rat small cerebral arteries: molecular identity of the functional channels. J Physiol (2003) 1.44

Expression and biophysical properties of Kv1 channels in supragranular neocortical pyramidal neurones. J Physiol (2005) 1.43

Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis. J Invest Dermatol (2007) 1.41

Identification of a trafficking determinant localized to the Kv1 potassium channel pore. Proc Natl Acad Sci U S A (2001) 1.25

Structural consequences of Kcna1 gene deletion and transfer in the mouse hippocampus. Epilepsia (2007) 1.19

A new Kv1.2 channelopathy underlying cerebellar ataxia. J Biol Chem (2010) 1.08

Expression and function of native potassium channel [K(V)alpha1] subunits in terminal arterioles of rabbit. J Physiol (2001) 1.04

KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels. Biophys J (2003) 1.03

Kv1.5 association modifies Kv1.3 traffic and membrane localization. J Biol Chem (2008) 1.03

Function and mechanism of axonal targeting of voltage-sensitive potassium channels. Prog Neurobiol (2011) 1.01

The 'functional' dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels. Biochem J (2004) 0.98

Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K. FASEB J (2006) 0.96

Kv1 channels selectively prevent dendritic hyperexcitability in rat Purkinje cells. J Physiol (2005) 0.96

Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells. Mol Pharmacol (2012) 0.96

Antibody-based validation of CNS ion channel drug targets. J Gen Physiol (2008) 0.95

Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons. J Comp Neurol (2010) 0.94

Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic beta-cells. J Physiol (2005) 0.93

Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics. J Neurosci (2013) 0.89

A-type potassium currents active at subthreshold potentials in mouse cerebellar Purkinje cells. J Physiol (2002) 0.87

Role of Kv1 potassium channels in regulating dopamine release and presynaptic D2 receptor function. PLoS One (2011) 0.86

Cellular mechanisms and behavioral consequences of Kv1.2 regulation in the rat cerebellum. J Neurosci (2012) 0.85

Regulation of action potential delays via voltage-gated potassium Kv1.1 channels in dentate granule cells during hippocampal epilepsy. Front Cell Neurosci (2013) 0.81

Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium. J Gen Physiol (2010) 0.81

Mature and precursor brain-derived neurotrophic factor have individual roles in the mouse olfactory bulb. PLoS One (2012) 0.81

Effect of synthetic aβ peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance. PLoS One (2012) 0.80

Cerebellar secretin modulates eyeblink classical conditioning. Learn Mem (2014) 0.77

KV1 and KV3 Potassium Channels Identified at Presynaptic Terminals of the Corticostriatal Synapses in Rat. Neural Plast (2016) 0.75

Intracerebellar infusion of the protein kinase M zeta (PKMζ) inhibitor zeta-inhibitory peptide (ZIP) disrupts eyeblink classical conditioning. Behav Neurosci (2016) 0.75

Mutations underlying Episodic Ataxia type-1 antagonize Kv1.1 RNA editing. Sci Rep (2017) 0.75

Mechanism of functional interaction between potassium channel Kv1.3 and sodium channel NavBeta1 subunit. Sci Rep (2017) 0.75

Articles by these authors

Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science (2003) 6.35

GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience (2000) 5.81

Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J Biol Chem (1990) 3.98

Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci U S A (1996) 3.39

Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release. Neuron (1993) 3.07

A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies. Trends Pharmacol Sci (1999) 2.71

Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle. J Biol Chem (1994) 2.62

Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release. J Neurosci (2001) 2.48

High-conductance calcium-activated potassium channels; structure, pharmacology, and function. J Bioenerg Biomembr (1996) 2.31

GABA(A) receptor subunits in the rat hippocampus I: immunocytochemical distribution of 13 subunits. Neuroscience (1997) 2.27

Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium. Receptors Channels (1995) 2.24

Molecular constituents of maxi KCa channels in human coronary smooth muscle: predominant alpha + beta subunit complexes. J Physiol (1997) 2.23

Mechanism of lactose translocation in membrane vesicles from Escherichia coli. 1. Effect of pH on efflux, exchange, and counterflow. Biochemistry (1979) 2.07

Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology. J Gen Physiol (1997) 1.99

Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3. Science (2000) 1.97

Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels. J Biol Chem (1993) 1.94

Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels. Proc Natl Acad Sci U S A (1988) 1.92

Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle, a representative of the mSlo and slowpoke family of potassium channels. J Biol Chem (1994) 1.89

Mode of action of iberiotoxin, a potent blocker of the large conductance Ca(2+)-activated K+ channel. Biophys J (1992) 1.86

Mechanism of lactose translocation in membrane vesicles from Escherichia coli. 2. Effect of imposed delata psi, delta pH, and Delta mu H+. Biochemistry (1979) 1.85

Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle. J Pharmacol Exp Ther (1989) 1.82

Oxaliplatin added to the simplified bimonthly leucovorin and 5-fluorouracil regimen as second-line therapy for metastatic colorectal cancer (FOLFOX6). GERCOR. Eur J Cancer (1999) 1.72

Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminals. J Neurosci (1996) 1.71

Use of toxins to study potassium channels. J Bioenerg Biomembr (1991) 1.70

Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation. J Exp Med (1993) 1.67

Selective blockers of voltage-gated K+ channels depolarize human T lymphocytes: mechanism of the antiproliferative effect of charybdotoxin. Proc Natl Acad Sci U S A (1992) 1.65

Enhancement of neutrophils function as a result of prior exposure to chemotactic factor. J Clin Invest (1980) 1.64

Active transport in membrane vesicles from Escherichia coli: the electrochemical proton gradient alters the distribution of the lac carrier between two different kinetic states. Biochemistry (1980) 1.60

Anomalous fluorescence enhancement of Cy3 and cy3.5 versus anomalous fluorescence loss of Cy5 and Cy7 upon covalent linking to IgG and noncovalent binding to avidin. Bioconjug Chem (2000) 1.56

An activator of calcium-dependent potassium channels isolated from a medicinal herb. Biochemistry (1993) 1.55

Purification and reconstitution of the high-conductance, calcium-activated potassium channel from tracheal smooth muscle. J Biol Chem (1994) 1.54

Oxidative regulation of large conductance calcium-activated potassium channels. J Gen Physiol (2001) 1.54

Purified reconstituted lac carrier protein from Escherichia coli is fully functional. Proc Natl Acad Sci U S A (1984) 1.40

Mechanism of iberiotoxin block of the large-conductance calcium-activated potassium channel from bovine aortic smooth muscle. Biochemistry (1992) 1.40

Inhibition of Na+/Ca2+ exchange in membrane vesicle and papillary muscle preparations from guinea pig heart by analogs of amiloride. Proc Natl Acad Sci U S A (1984) 1.39

Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli. 1. Effect of pH and imposed membrane potential on efflux, exchange, and counterflow. Biochemistry (1983) 1.37

Charybdotoxin and its effects on potassium channels. Am J Physiol (1995) 1.35

Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3. Biochemistry (1999) 1.34

Purification and properties of D-amino acid dehydrogenase, an inducible membrane-bound iron-sulfur flavoenzyme from Escherichia coli B. J Biol Chem (1980) 1.32

Interaction of tetrandrine with slowly inactivating calcium channels. Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin. J Biol Chem (1988) 1.31

Effects of charybdotoxin and iberiotoxin on the spontaneous motility and tonus of different guinea pig smooth muscle tissues. J Pharmacol Exp Ther (1991) 1.31

Pharmacology of voltage-gated and calcium-activated potassium channels. Curr Opin Chem Biol (1999) 1.30

Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella (Rochalimaea) henselae infection in immunocompetent patients and patients infected with human immunodeficiency virus type 1. Clin Infect Dis (1995) 1.29

Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli. 2. Deuterium solvent isotope effects. Biochemistry (1983) 1.28

Role of voltage-gated L-type Ca2+ channel isoforms for brain function. Biochem Soc Trans (2006) 1.28

GABA(A) receptor subunits in the rat hippocampus III: altered messenger RNA expression in kainic acid-induced epilepsy. Neuroscience (1997) 1.27

Selective inhibition of relaxation of guinea-pig trachea by charybdotoxin, a potent Ca(++)-activated K+ channel inhibitor. J Pharmacol Exp Ther (1990) 1.27

Identification of a novel 1,4-dihydropyridine- and phenylalkylamine-binding polypeptide in calcium channel preparations. J Biol Chem (1987) 1.25

Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom. J Biol Chem (1988) 1.23

Equilibrium calcium-calcium exchange in cardiac sarcolemmal vesicles. J Biol Chem (1983) 1.22

Two calcium currents in a smooth muscle cell line. Am J Physiol (1986) 1.21

High affinity of sigma 1-binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C8-C7 isomerase. Br J Pharmacol (1997) 1.20

Functional reconstitution of the large-conductance, calcium-activated potassium channel purified from bovine aortic smooth muscle. Biochemistry (1995) 1.20

Inhibition of Na+/Ca2+ exchange in pituitary plasma membrane vesicles by analogues of amiloride. Biochemistry (1985) 1.20

The beta subunit of the high-conductance calcium-activated potassium channel contributes to the high-affinity receptor for charybdotoxin. Proc Natl Acad Sci U S A (1997) 1.20

Synthetic charybdotoxin-iberiotoxin chimeric peptides define toxin binding sites on calcium-activated and voltage-dependent potassium channels. Biochemistry (1993) 1.17

Calcium channels from Cyprinus carpio skeletal muscle. Proc Natl Acad Sci U S A (1991) 1.17

Characterization of a phosphorylated pentasaccharide isolated from Hansenula holstii NRRL Y-2448 phosphomannan. Biochemistry (1973) 1.16

Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom. J Biol Chem (1998) 1.15

Direct measurement of lactose/proton symport in Escherichia coli membrane vesicles: further evidence for the involvement of histidine residue(s). Biochemistry (1982) 1.15

Covalent attachment of charybdotoxin to the beta-subunit of the high conductance Ca(2+)-activated K+ channel. Identification of the site of incorporation and implications for channel topology. J Biol Chem (1994) 1.14

Neuropeptide Y inhibits potassium-stimulated glutamate release through Y2 receptors in rat hippocampal slices in vitro. Br J Pharmacol (1994) 1.14

Lactose-proton symport by purified lac carrier protein. Biochemistry (1982) 1.14

Characterization of the Na+/H+ antiporter of alkalophilic bacilli in vivo: delta psi-dependent 22Na+ efflux from whole cells. J Bacteriol (1983) 1.13

Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse-tubule calcium channel. FEBS Lett (1987) 1.13

Characterization of high affinity binding sites for charybdotoxin in human T lymphocytes. Evidence for association with the voltage-gated K+ channel. J Biol Chem (1991) 1.12

Three new familial hemiplegic migraine mutants affect P/Q-type Ca(2+) channel kinetics. J Biol Chem (2000) 1.12