The protein kinase resource.

CASTp: Computed Atlas of Surface Topography of proteins. Nucleic Acids Res (2003) 4.93

Determinants of protein function revealed by combinatorial entropy optimization. Genome Biol (2007) 3.46

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas. Proc Natl Acad Sci U S A (2005) 2.38

Object-oriented transcription factors database (ooTFD). Nucleic Acids Res (2000) 1.79

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition. Biochem J (2003) 1.22

The repertoire of protein kinases encoded in the draft version of the human genome: atypical variations and uncommon domain combinations. Genome Biol (2002) 1.21

A surface of the kinase domain critical for the allosteric activation of G protein-coupled receptor kinases. J Biol Chem (2009) 1.19

Combining structure and sequence information allows automated prediction of substrate specificities within enzyme families. PLoS Comput Biol (2010) 1.19

Development of a heme protein structure-electrochemical function database. Nucleic Acids Res (2007) 1.18

KinG: a database of protein kinases in genomes. Nucleic Acids Res (2004) 1.13

EpitopeViewer: a Java application for the visualization and analysis of immune epitopes in the Immune Epitope Database and Analysis Resource (IEDB). Immunome Res (2007) 1.10

Protein functional surfaces: global shape matching and local spatial alignments of ligand binding sites. BMC Struct Biol (2008) 1.09

LGICdb: a manually curated sequence database after the genomes. Nucleic Acids Res (2006) 1.07

ProCKSI: a decision support system for Protein (structure) Comparison, Knowledge, Similarity and Information. BMC Bioinformatics (2007) 1.04

Lipopolysaccharide phosphorylating enzymes encoded in the genomes of Gram-negative bacteria are related to the eukaryotic protein kinases. Protein Sci (2002) 1.01

Serum-dependent selective expression of EhTMKB1-9, a member of Entamoeba histolytica B1 family of transmembrane kinases. PLoS Pathog (2010) 0.96

Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication. J Proteome Res (2010) 0.93

Novel molecular imaging platform for monitoring oncological kinases. Cancer Cell Int (2010) 0.87

Expression and function of a family of transmembrane kinases from the protozoan parasite Entamoeba histolytica. Infect Immun (2006) 0.86

Classification of protein kinases on the basis of both kinase and non-kinase regions. PLoS One (2010) 0.82

Clustering of protein domains for functional and evolutionary studies. BMC Bioinformatics (2009) 0.81

Kinannote, a computer program to identify and classify members of the eukaryotic protein kinase superfamily. Bioinformatics (2013) 0.81

Exploring the nonlinear geometry of protein homology. Protein Sci (2003) 0.76

Isofunctional Protein Subfamily Detection Using Data Integration and Spectral Clustering. PLoS Comput Biol (2016) 0.75

The Protein Data Bank. Nucleic Acids Res (2000) 187.10

Profile analysis: detection of distantly related proteins. Proc Natl Acad Sci U S A (1987) 29.26

Protein structure alignment by incremental combinatorial extension (CE) of the optimal path. Protein Eng (1998) 28.09

The genome of black cottonwood, Populus trichocarpa (Torr. & Gray). Science (2006) 21.03

Combining evidence using p-values: application to sequence homology searches. Bioinformatics (1998) 16.51

Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science (1991) 13.85

Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science (1991) 9.99

Identification of a signal for rapid export of proteins from the nucleus. Cell (1995) 9.92

Profile analysis. Methods Enzymol (1990) 9.40

The sigma 70 family: sequence conservation and evolutionary relationships. J Bacteriol (1992) 9.07

Development of Internet-based multimedia applications. Trends Biochem Sci (1999) 7.34

Developing protein documentaries and other multimedia presentations for molecular biology. Pac Symp Biocomput (1999) 7.33

Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins. Nucleic Acids Res (1986) 7.28

Macromolecular structure databases: past progress and future challenges. Acta Crystallogr D Biol Crystallogr (1998) 7.26

The codon preference plot: graphic analysis of protein coding sequences and prediction of gene expression. Nucleic Acids Res (1984) 6.98

Phylogenetic relationships within cation transporter families of Arabidopsis. Plant Physiol (2001) 4.74

Fluorescence ratio imaging of cyclic AMP in single cells. Nature (1991) 4.45

The Protein Data Bank and the challenge of structural genomics. Nat Struct Biol (2000) 4.21

Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. J Biol Chem (1984) 4.20

Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. EMBO J (1989) 4.08

Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites. Nature (1984) 3.91

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry (1993) 3.88

Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proc Natl Acad Sci U S A (2001) 3.77

Protein docking using continuum electrostatics and geometric fit. Protein Eng (2001) 3.48

Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol Cell (1999) 3.46

Use of keyword hierarchies to interpret gene expression patterns. Bioinformatics (2001) 3.41

Score distributions for simultaneous matching to multiple motifs. J Comput Biol (1997) 3.40

Dynamics of cAMP-dependent protein kinase. Chem Rev (2001) 3.18

Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains. Science (1995) 3.18

A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates. J Biol Chem (1994) 3.08

Methods and statistics for combining motif match scores. J Comput Biol (1998) 2.76

Structural framework for the protein kinase family. Annu Rev Cell Biol (1992) 2.74

A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res (2001) 2.73

A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. J Cell Biol (1999) 2.69

2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor. Acta Crystallogr D Biol Crystallogr (1993) 2.66

CDPKs - a kinase for every Ca2+ signal? Trends Plant Sci (2000) 2.66

cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer. Protein Sci (1994) 2.62

Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria. Proc Natl Acad Sci U S A (1990) 2.61

STAR/mmCIF: an ontology for macromolecular structure. Bioinformatics (2000) 2.51

Affinity labeling of cAMP-dependent protein kinase with p-fluorosulfonylbenzoyl adenosine. Covalent modification of lysine 71. J Biol Chem (1981) 2.48

Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations. Protein Sci (1993) 2.44

A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nat Cell Biol (2000) 2.34

Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence. Nature (1986) 2.32

Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated. J Bacteriol (1995) 2.26

Aneuploid colon cancer cells have a robust spindle checkpoint. EMBO Rep (2001) 2.12

Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. J Biol Chem (1997) 2.10

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. Proc Natl Acad Sci U S A (1998) 2.09

An alternative view of protein fold space. Proteins (2000) 1.95

Overexpression and purification of the sigma subunit of Escherichia coli RNA polymerase. Gene (1983) 1.92

Structural adaptations of lactate dehydrogenase isozymes. Proc Natl Acad Sci U S A (1977) 1.88

Structure-function relationships in lactate dehydrogenase. Proc Natl Acad Sci U S A (1973) 1.87

Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli. J Biol Chem (1989) 1.85

Climate change and the integrity of science. Science (2010) 1.80

D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proc Natl Acad Sci U S A (1997) 1.79

Common EF-hand motifs in cholinesterases and neuroligins suggest a role for Ca2+ binding in cell surface associations. Protein Sci (2000) 1.79

Identification of sequence pattern with profile analysis. Methods Enzymol (1996) 1.71

Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion. Mol Biol Cell (1993) 1.71

Energetic limits of phosphotransfer in the catalytic subunit of cAMP-dependent protein kinase as measured by viscosity experiments. Biochemistry (1992) 1.64

Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit. Structure (2001) 1.59

Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem (1990) 1.57

Role of the glycine triad in the ATP-binding site of cAMP-dependent protein kinase. J Biol Chem (1997) 1.55

Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase. Biochemistry (1995) 1.55

Phosphorylation of histones 1 and 3 and nonhistone high mobility group 14 by an endogenous kinase in HeLa metaphase chromosomes. J Biol Chem (1982) 1.54

Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal growth factor receptor. Proc Natl Acad Sci U S A (1993) 1.53

Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli: multiple isozymes reflect different phosphorylation states. Protein Eng (1993) 1.52

A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility. Structure (1997) 1.51

Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine. Biochemistry (1997) 1.50

Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase. Biochemistry (1996) 1.48

Domain movements in protein kinases. Curr Opin Struct Biol (1994) 1.47

NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum. J Cell Biol (1999) 1.46

Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal. J Biol Chem (1994) 1.43

A new algorithm for the alignment of multiple protein structures using Monte Carlo optimization. Pac Symp Biocomput (2001) 1.43

N-myristylation of the catalytic subunit of cAMP-dependent protein kinase conveys structural stability. J Biol Chem (1993) 1.42

Profile of the disulfide bonds in acetylcholinesterase. J Biol Chem (1986) 1.42

Ribitol dehydrogenase from Klebsiella aerogenes. Purification and subunit structure. Biochem J (1974) 1.39

Serum protein electrophoresis in 147 dogs. Vet Rec (2011) 1.38

Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit. J Biol Chem (1992) 1.37

The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication. Prog Biophys Mol Biol (1999) 1.36

Structural comparisons of cAMP-dependent protein kinases I and II from porcine skeletal muscle. J Biol Chem (1979) 1.36

Dissecting cAMP binding domain A in the RIalpha subunit of cAMP-dependent protein kinase. Distinct subsites for recognition of cAMP and the catalytic subunit. J Biol Chem (1998) 1.34

A database and tools for 3-D protein structure comparison and alignment using the Combinatorial Extension (CE) algorithm. Nucleic Acids Res (2001) 1.34

Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase: effect of MgATP on protein-protein interactions. Biochemistry (1993) 1.33

600 ps molecular dynamics reveals stable substructures and flexible hinge points in cAMP dependent protein kinase. Biopolymers (1999) 1.32

Structural basis of the intrasteric regulation of myosin light chain kinases. Science (1992) 1.31

Design and implementation of a collaborative molecular graphics environment. J Mol Graph Model (2001) 1.30

Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase. Biochemistry (1999) 1.29

Identification of a partially rate-determining step in the catalytic mechanism of cAMP-dependent protein kinase: a transient kinetic study using stopped-flow fluorescence spectroscopy. Biochemistry (1997) 1.27