Published in J Exp Med on January 19, 1998
Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc Natl Acad Sci U S A (1999) 5.66
Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity (2011) 3.58
Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nat Immunol (2009) 3.19
Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J Immunol (2001) 2.64
Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cells. J Exp Med (2007) 1.99
The initial phase of an immune response functions to activate regulatory T cells. J Immunol (2009) 1.88
Antibody is required for protection against virulent but not attenuated Salmonella enterica serovar typhimurium. Infect Immun (2000) 1.88
Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferation. J Exp Med (2003) 1.87
Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin. Immunity (2009) 1.84
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nat Immunol (2008) 1.73
Evolution of antigen-specific T cell receptors in vivo: preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs. J Exp Med (1999) 1.58
Interleukin-2-Dependent Allergen-Specific Tissue-Resident Memory Cells Drive Asthma. Immunity (2015) 1.56
Interleukin 2: from immunostimulation to immunoregulation and back again. EMBO Rep (2007) 1.31
mTOR at the crossroads of T cell proliferation and tolerance. Semin Immunol (2007) 1.22
Glycoprotein 96 can chaperone both MHC class I- and class II-restricted epitopes for in vivo presentation, but selectively primes CD8+ T cell effector function. J Immunol (2004) 1.21
Prevention of peripheral tolerance by a dendritic cell growth factor: flt3 ligand as an adjuvant. J Exp Med (1998) 1.20
Anti-interleukin 10 receptor monoclonal antibody is an adjuvant for T helper cell type 1 responses to soluble antigen only in the presence of lipopolysaccharide. J Exp Med (2000) 1.20
CD28 co-signaling in the adaptive immune response. Self Nonself (2010) 1.08
Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T-cell anergy in vivo. Eur J Immunol (2009) 1.03
Abrogating Cbl-b in effector CD8(+) T cells improves the efficacy of adoptive therapy of leukemia in mice. J Clin Invest (2010) 1.02
Antigen-specific T helper cell function: differential cytokine expression in primary and memory responses. J Exp Med (2000) 0.98
Construction and evaluation of a novel recombinant T cell epitope-based vaccine against Coccidioidomycosis. Infect Immun (2012) 0.97
Immunization with an apoptotic cell-binding protein recapitulates the nephritis and sequential autoantibody emergence of systemic lupus erythematosus. J Immunol (2006) 0.96
Understanding how lipopolysaccharide impacts CD4 T-cell immunity. Crit Rev Immunol (2008) 0.96
Lipopolysaccharide potentiates effector T cell accumulation into nonlymphoid tissues through TRIF. J Immunol (2009) 0.93
Cell cycle progression following naive T cell activation is independent of Jak3/common gamma-chain cytokine signals. J Immunol (2009) 0.89
Costimulation via lymphocyte function-associated antigen 1 in the absence of CD28 ligation promotes anergy of naive CD4+ T cells. Proc Natl Acad Sci U S A (2001) 0.89
Differential regulation of macrophage interleukin-1 (IL-1), IL-12, and CD80-CD86 by two bacterial toxins. Infect Immun (1999) 0.88
Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells. Proc Natl Acad Sci U S A (2015) 0.87
Advances in swine immunology help move vaccine technology forward. Vet Immunol Immunopathol (2014) 0.86
Naive T-cell receptor transgenic T cells help memory B cells produce antibody. Immunology (2006) 0.85
A novel model for IFN-γ-mediated autoinflammatory syndromes. J Immunol (2015) 0.84
Defining the heterogeneity of skeletal muscle-derived side and main population cells isolated immediately ex vivo. J Cell Physiol (2010) 0.84
Casitas B-lineage lymphoma b inhibits antigen recognition and slows cell cycle progression at late times during CD4+ T cell clonal expansion. J Immunol (2008) 0.84
CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs. J Immunol (2012) 0.82
Nasal delivery of antigen with the B subunit of Escherichia coli heat-labile enterotoxin augments antigen-specific T-cell clonal expansion and differentiation. Infect Immun (2004) 0.82
CD8 T cells require Bcl-3 for maximal gamma interferon production upon secondary exposure to antigen. Infect Immun (2006) 0.81
Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells. Proc Natl Acad Sci U S A (2014) 0.81
Apoptosis of purified CD4+ T cell subsets is dominated by cytokine deprivation and absence of other cells in new onset diabetic NOD mice. PLoS One (2010) 0.81
T cells demonstrate a Th1-biased response to native beta2-glycoprotein I in a murine model of anti-phospholipid antibody induction. Autoimmunity (2009) 0.81
Adjuvant activity of naturally occurring monophosphoryl lipopolysaccharide preparations from mucosa-associated bacteria. Infect Immun (2013) 0.79
Anti-IL-2 treatment impairs the expansion of T(reg) cell population during acute malaria and enhances the Th1 cell response at the chronic disease. PLoS One (2012) 0.77
IL-15 enhances the antitumor effect of human antigen-specific CD8(+) T cells by cellular senescence delay. Oncoimmunology (2016) 0.75
BATF Modulates the Th2 Locus Control Region and Regulates CD4+ T Cell Fate during Antihelminth Immunity. J Immunol (2016) 0.75
NADPH Oxidase-Derived Superoxide Provides a Third Signal for CD4 T Cell Effector Responses. J Immunol (2016) 0.75
Lipopolysaccharide enhances in vivo interleukin-2 production and proliferation by naive antigen-specific CD4 T cells via a Toll-like receptor 4-dependent mechanism. Immunology (2007) 0.75
Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science (1990) 12.13
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell (1993) 11.95
Immunological memory and protective immunity: understanding their relation. Science (1996) 10.02
Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol (1993) 9.97
Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol (1989) 7.69
Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity (1994) 7.22
Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity (1995) 7.08
Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature (1991) 5.80
The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol (1993) 5.65
Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature (1991) 5.51
Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J Exp Med (1996) 4.70
Interleukin 2. Annu Rev Immunol (1984) 4.37
Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J Exp Med (1995) 4.12
In vivo detection of dendritic cell antigen presentation to CD4(+) T cells. J Exp Med (1997) 3.75
The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J Exp Med (1994) 3.66
Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. J Immunol Methods (1995) 3.54
Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur J Immunol (1995) 3.34
Constructing polycompetitor cDNAs for quantitative PCR. J Immunol Methods (1993) 2.62
Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells. J Immunol (1997) 2.33
Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements. J Exp Med (1992) 2.30
Lipopolysaccharide interferes with the induction of peripheral T cell death. Immunity (1995) 2.29
Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cell for the study of T-cell activation in vivo. Immunol Rev (1997) 1.79
Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur J Immunol (1995) 1.62
Microbial induction of co-stimulatory activity for CD4 T-cell growth. Int Immunol (1991) 1.54
CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo. J Immunol (1997) 1.44
Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor. J Immunol (1997) 1.32
Memory T cell development in the absence of specific antigen priming. J Immunol (1996) 1.30
Human dendritic cells activate T lymphocytes via a CD40: CD40 ligand-dependent pathway. Eur J Immunol (1996) 1.21
Autocrine feedback death and the regulation of mature T lymphocyte antigen responses. Int Rev Immunol (1995) 1.09
Surface proteins involved in T cell costimulation. J Leukoc Biol (1994) 1.09
Visualization of antigen-specific T cell activation and cytokine expression in vivo. J Immunol (1997) 1.02
Activation of CD4+ T lymphocytes form interleukin 2-deficient mice by costimulatory B7 molecules. Proc Natl Acad Sci U S A (1996) 0.86
Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol (1989) 7.69
Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity (1994) 7.22
Visualizing the generation of memory CD4 T cells in the whole body. Nature (2001) 7.07
Helper T cell differentiation is controlled by the cell cycle. Immunity (1998) 5.71
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science (2001) 5.58
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med (1987) 5.48
Visualization of specific B and T lymphocyte interactions in the lymph node. Science (1998) 5.04
In vivo detection of dendritic cell antigen presentation to CD4(+) T cells. J Exp Med (1997) 3.75
In vivo activation of antigen-specific CD4 T cells. Annu Rev Immunol (2001) 3.65
Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J Immunol (1999) 3.10
Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J Immunol (1995) 3.06
Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4+ T cells. Science (1996) 2.97
CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. J Exp Med (1994) 2.88
Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J Exp Med (1997) 2.81
Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J Immunol (1996) 2.69
Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones. Proc Natl Acad Sci U S A (1987) 2.57
Characterization of CD4+ T cell responses during natural infection with Salmonella typhimurium. J Immunol (2000) 2.48
Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells. J Immunol (1997) 2.33
Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. Mol Cell Biol (1993) 2.25
Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science (1993) 2.20
T-cell unresponsiveness in vivo and in vitro: fine specificity of induction and molecular characterization of the unresponsive state. Immunol Rev (1987) 2.07
Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J Immunol (1991) 2.03
Stat6 regulation of in vivo IL-4 responses. J Immunol (2000) 1.97
T helper phenotype and genetic susceptibility in experimental Lyme disease. J Exp Med (1995) 1.95
Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor. Mol Cell Biol (1993) 1.91
Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines. J Immunol (1991) 1.89
Antibody is required for protection against virulent but not attenuated Salmonella enterica serovar typhimurium. Infect Immun (2000) 1.88
Class II MHC-bearing keratinocytes induce antigen-specific unresponsiveness in hapten-specific Th1 clones. J Immunol (1988) 1.83
Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cell for the study of T-cell activation in vivo. Immunol Rev (1997) 1.79
Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses. J Exp Med (1996) 1.68
Direct evidence that functionally impaired CD4+ T cells persist in vivo following induction of peripheral tolerance. J Immunol (1998) 1.68
Structural analysis of CTLA-4 function in vivo. J Immunol (2000) 1.61
Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J Immunol (1999) 1.58
Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major. Proc Natl Acad Sci U S A (1994) 1.47
Experimental lyme arthritis in the absence of interleukin-4 or gamma interferon. Infect Immun (1999) 1.43
Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J Immunol (1994) 1.43
The anatomy of T-cell activation and tolerance. Proc Natl Acad Sci U S A (1996) 1.42
Genetic control of experimental lyme arthritis in the absence of specific immunity. Infect Immun (1999) 1.40
Cutting edge: in vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cells. J Immunol (2001) 1.37
T-cell clonal anergy. Cold Spring Harb Symp Quant Biol (1989) 1.34
Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells. J Immunol (1995) 1.31
Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing. Immunity (1998) 1.30
Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection. Res Immunol (1991) 1.30
The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells. J Immunol (1992) 1.29
Molecular mechanisms underlying functional T-cell unresponsiveness. Curr Opin Immunol (1995) 1.27
Limited role of CD28-mediated signals in T helper subset differentiation. J Exp Med (1996) 1.21
An accessory cell-derived costimulatory signal acts independently of protein kinase C activation to allow T cell proliferation and prevent the induction of unresponsiveness. J Immunol (1989) 1.20
Antigen-experienced CD4 T cells display a reduced capacity for clonal expansion in vivo that is imposed by factors present in the immune host. J Immunol (2000) 1.20
Induction of cytotoxic T lymphocyte antigen 4 (CTLA-4) restricts clonal expansion of helper T cells. J Exp Med (2001) 1.17
Dendritic cell longevity and T cell persistence is controlled by CD154-CD40 interactions. Eur J Immunol (2001) 1.15
In vivo effects of GK1.5 (anti-L3T4a) monoclonal antibody on induction and expression of delayed-type hypersensitivity. Cell Immunol (1985) 1.15
Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis. J Immunol (1993) 1.13
Molecular requirements for T cell activation by the staphylococcal toxic shock syndrome toxin-1. J Immunol (1990) 1.12
Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation. Surgery (1981) 1.12
The role of anergy in peripheral T cell unresponsiveness. Life Sci (1994) 1.09
Surface proteins involved in T cell costimulation. J Leukoc Biol (1994) 1.09
A role for CD4 in peripheral T cell differentiation. J Exp Med (1997) 1.08
A conformational change in cytochrome c of apoptotic and necrotic cells is detected by monoclonal antibody binding and mimicked by association of the native antigen with synthetic phospholipid vesicles. Biochemistry (1999) 1.08
An intracellular calcium increase and protein kinase C activation fail to initiate T cell proliferation in the absence of a costimulatory signal. J Immunol (1990) 1.07
Cell cycle controlling the silencing and functioning of mammalian activators. Curr Biol (2001) 1.06
Transfected Leishmania expressing biologically active IFN-gamma. J Immunol (1993) 1.06
Clearance of Borrelia burgdorferi may not be required for resistance to experimental lyme arthritis. Infect Immun (1998) 1.05
Primary actinomycosis of an extremity: a case report and review. Rev Infect Dis (1987) 1.03
Single-cell analysis of signal transduction in CD4 T cells stimulated by antigen in vivo. Proc Natl Acad Sci U S A (2001) 1.02
Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells. J Immunol (1996) 1.02
Monocytes provide a novel costimulatory signal to T cells that is not mediated by the CD28/B7 interaction. J Immunol (1994) 1.02
Expression of the costimulatory receptor CD30 is regulated by both CD28 and cytokines. J Immunol (1998) 1.01
A new approach for obtaining total tryptophan recovery in plasma samples deproteinized with sulphosalicylic acid. J Chromatogr (1975) 1.00
Clonal expansion of antigen-specific CD4 T cells following infection with Salmonella typhimurium is similar in susceptible (Itys) and resistant (Ityr) BALB/c mice. Infect Immun (1999) 0.99
A monoclonal antibody specific for a cytochrome c T cell stimulatory peptide inhibits T cell responses and affects the way the peptide associates with antigen-presenting cells. Eur J Immunol (1991) 0.99
Cutting edge: antigen-dependent regulation of telomerase activity in murine T cells. J Immunol (1998) 0.98
Cytokines and T cells in host defense. Curr Opin Immunol (2000) 0.98
Cell and receptor requirements for streptococcal pyrogenic exotoxin T-cell mitogenicity. Infect Immun (1991) 0.98
IL-2 secretion and T cell clonal anergy are induced by distinct biochemical pathways. J Immunol (1991) 0.97
Efficient immunity against Leishmania major in the absence of interleukin-6. Infect Immun (1997) 0.96
Instruction, selection, or tampering with the odds? Science (1999) 0.95
Polarized helper-T-cell responses against Leishmania major in the absence of B cells. Infect Immun (1999) 0.94
Cyclosporin A inhibits positive selection and delays negative selection in alpha beta TCR transgenic mice. J Immunol (1994) 0.94
An improved method of plasma deproteination with sulphosalicylic acid for determining amino acids and related compounds. J Chromatogr (1972) 0.92
Peripheral immune tolerance blocks clonal expansion but fails to prevent the differentiation of Th1 cells. J Immunol (1998) 0.92
Revealing the in vivo behavior of CD4+ T cells specific for an antigen expressed in Escherichia coli. J Immunol (1998) 0.91
Impaired negative selection in CD28-deficient mice. Cell Immunol (1998) 0.89
Activation of natural killer cells in arthritis-susceptible but not arthritis-resistant mouse strains following Borrelia burgdorferi infection. Infect Immun (1998) 0.88
Autoimmunity: when self-tolerance breaks down. Curr Biol (1997) 0.88
Automatic ion-exchange chromatography of amino acids. Experimental studies for optimising resin column dimensions. J Chromatogr (1970) 0.87
Plasma and cerebrospinal fluid tryptophan in multiple sclerosis and degenerative diseases. J Neurol Neurosurg Psychiatry (1979) 0.87
The c-met/HGF receptor in human tumours. Eur J Cancer Prev (1992) 0.86
Bone-marrow chimeras reveal hemopoietic and nonhemopoietic control of resistance to experimental Lyme arthritis. J Immunol (2000) 0.86
Effect of gamma radiation on resting B lymphocytes. II. Functional characterization of the antigen-presentation defect. J Immunol (1988) 0.86
Efficacy of immune therapy in early experimental Naegleria fowleri meningitis. Infect Immun (1987) 0.85
Induction of Th2 responses in infectious diseases. Curr Opin Immunol (1995) 0.85
T helper subset differentiation in the absence of invariant chain. J Exp Med (1997) 0.85