Published in J Cell Biol on February 23, 1998
Biochemical and genetic conservation of fission yeast Dsk1 and human SR protein-specific kinase 1. Mol Cell Biol (2000) 9.92
Sorting out the complexity of SR protein functions. RNA (2000) 9.25
Prp8 protein: at the heart of the spliceosome. RNA (2005) 2.89
A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers. EMBO J (1998) 2.71
Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. J Cell Biol (1998) 2.60
Transportin-SR, a nuclear import receptor for SR proteins. J Cell Biol (1999) 2.31
A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Mol Cell (2008) 2.29
Sequential entry of components of the gene expression machinery into daughter nuclei. Mol Biol Cell (2003) 2.15
The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing. Mol Cell Biol (1999) 2.09
Functional characterization of SR and SR-related genes in Caenorhabditis elegans. EMBO J (2000) 2.05
Phosphorylation regulates in vivo interaction and molecular targeting of serine/arginine-rich pre-mRNA splicing factors. J Cell Biol (1999) 2.00
Conserved SR protein kinase functions in nuclear import and its action is counteracted by arginine methylation in Saccharomyces cerevisiae. J Cell Biol (2000) 1.96
Plant and animal pathogen recognition receptors signal through non-RD kinases. PLoS Pathog (2006) 1.87
The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus. Mol Cell (2012) 1.83
Conservation in budding yeast of a kinase specific for SR splicing factors. Proc Natl Acad Sci U S A (1999) 1.82
Transportin-SR2 mediates nuclear import of phosphorylated SR proteins. Proc Natl Acad Sci U S A (2001) 1.80
ICP27 interacts with SRPK1 to mediate HSV splicing inhibition by altering SR protein phosphorylation. EMBO J (2003) 1.79
Processive phosphorylation of alternative splicing factor/splicing factor 2. Proc Natl Acad Sci U S A (2003) 1.75
Death, autoantigen modifications, and tolerance. Arthritis Res (2000) 1.75
Reversible phosphorylation differentially affects nuclear and cytoplasmic functions of splicing factor 2/alternative splicing factor. Proc Natl Acad Sci U S A (2005) 1.74
Phosphorylation by Sky1p promotes Npl3p shuttling and mRNA dissociation. RNA (2001) 1.69
Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis. J Biol Chem (2009) 1.68
Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes Dev (2009) 1.65
Pre-mRNA splicing in the absence of an SR protein RS domain. Genes Dev (2000) 1.58
Substrate and docking interactions in serine/threonine protein kinases. Chem Rev (2007) 1.55
Regulation of splicing by SR proteins and SR protein-specific kinases. Chromosoma (2013) 1.53
The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor. Genes Dev (1999) 1.49
Regulated cellular partitioning of SR protein-specific kinases in mammalian cells. Mol Biol Cell (2005) 1.42
Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein. J Virol (2002) 1.40
Tau exon 10 alternative splicing and tauopathies. Mol Neurodegener (2008) 1.38
Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation. Structure (2009) 1.36
Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing. J Cell Biol (2002) 1.34
Phosphorylation mechanism and structure of serine-arginine protein kinases. FEBS J (2011) 1.30
Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCbetaII messenger ribonucleic acid. Endocrinology (2008) 1.24
The plant U1 small nuclear ribonucleoprotein particle 70K protein interacts with two novel serine/arginine-rich proteins. Plant Cell (1998) 1.23
Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin. EMBO J (2010) 1.23
Regulation and substrate specificity of the SR protein kinase Clk/Sty. Mol Cell Biol (2003) 1.20
A syn-anti conformational difference allows SRSF2 to recognize guanines and cytosines equally well. EMBO J (2011) 1.18
Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. J Mol Biol (2008) 1.17
Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions. Mol Biol Cell (2001) 1.14
Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev (2005) 1.13
Major phosphorylation of SF1 on adjacent Ser-Pro motifs enhances interaction with U2AF65. FEBS J (2006) 1.13
Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. J Biol Chem (2009) 1.10
Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1. Cancer Res (2008) 1.10
Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell (2014) 1.06
Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway. J Exp Med (2002) 1.04
Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. Mol Cell Biol (2000) 1.04
Evidence for a role of Sky1p-mediated phosphorylation in 3' splice site recognition involving both Prp8 and Prp17/Slu4. RNA (2001) 1.01
Alternatively spliced tissue factor promotes breast cancer growth in a β1 integrin-dependent manner. Proc Natl Acad Sci U S A (2013) 1.00
Phosphorylation-mediated regulation of alternative splicing in cancer. Int J Cell Biol (2013) 1.00
Differential effects of hyperphosphorylation on splicing factor SRp55. Biochem J (2003) 0.99
Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1. J Mol Biol (2009) 0.99
A kinase chaperones hepatitis B virus capsid assembly and captures capsid dynamics in vitro. PLoS Pathog (2011) 0.98
Structural basis for nuclear import of splicing factors by human Transportin 3. Proc Natl Acad Sci U S A (2014) 0.98
Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A. Nucleic Acids Res (2011) 0.95
Induced transcription and stability of CELF2 mRNA drives widespread alternative splicing during T-cell signaling. Proc Natl Acad Sci U S A (2015) 0.94
Therapeutic potential of manipulating VEGF splice isoforms in oncology. Future Oncol (2009) 0.93
Identification of a nuclear localization motif in the serine/arginine protein kinase PSRPK of physarum polycephalum. BMC Biochem (2009) 0.93
Bruchpilot in ribbon-like axonal agglomerates, behavioral defects, and early death in SRPK79D kinase mutants of Drosophila. PLoS Genet (2009) 0.91
A novel role for PA28gamma-proteasome in nuclear speckle organization and SR protein trafficking. Mol Biol Cell (2008) 0.91
Applying the brakes to multisite SR protein phosphorylation: substrate-induced effects on the splicing kinase SRPK1. Biochemistry (2011) 0.91
Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles. Biochem Pharmacol (2014) 0.90
Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease. J Biol Chem (2011) 0.89
Phosphorylation by SR kinases regulates the binding of PTB-associated splicing factor (PSF) to the pre-mRNA polypyrimidine tract. FEBS Lett (2006) 0.89
Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Antimicrob Agents Chemother (2010) 0.88
VEGF gene alternative splicing: pro- and anti-angiogenic isoforms in cancer. J Cancer Res Clin Oncol (2011) 0.87
Characterization of mammalian Par 6 as a dual-location protein. Mol Cell Biol (2007) 0.86
Interactions between two fission yeast serine/arginine-rich proteins and their modulation by phosphorylation. Biochem J (2002) 0.86
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion. J Biol Chem (2012) 0.86
DAP-like kinase interacts with the rat homolog of Schizosaccharomyces pombe CDC5 protein, a factor involved in pre-mRNA splicing and required for G2/M phase transition. Nucleic Acids Res (2002) 0.86
Multiple roles for SR proteins in trans splicing. Mol Cell Biol (2002) 0.84
PSKH1, a novel splice factor compartment-associated serine kinase. Nucleic Acids Res (2002) 0.84
SRPK1 Dissimilarly Impacts on the Growth, Metastasis, Chemosensitivity and Angiogenesis of Glioma in Normoxic and Hypoxic Conditions. J Cancer (2013) 0.83
The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2. Mol Biol Cell (2012) 0.83
Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening. PLoS One (2009) 0.83
Suppression of HPV-16 late L1 5'-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs. Nucleic Acids Res (2013) 0.83
SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease. J Neurosci (2012) 0.81
Characterization of nuclear localization signals (NLSs) and function of NLSs and phosphorylation of serine residues in subcellular and subnuclear localization of transformer-2β (Tra2β). J Biol Chem (2013) 0.81
Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing. Mol Cell (2016) 0.80
The N-terminal fragment from caspase-cleaved serine/arginine protein-specific kinase2 (SRPK2) translocates into the nucleus and promotes apoptosis. J Biol Chem (2010) 0.80
Paraquat modulates alternative pre-mRNA splicing by modifying the intracellular distribution of SRPK2. PLoS One (2013) 0.79
Splicing-factor alterations in cancers. RNA (2016) 0.78
Connecting the speckles: Splicing kinases and their role in tumorigenesis and treatment response. Nucleus (2015) 0.78
Dysregulation of splicing proteins in head and neck squamous cell carcinoma. Cancer Biol Ther (2016) 0.77
A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones. Elife (2015) 0.76
Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma. Hepatology (2015) 0.76
Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340). PLoS One (2015) 0.76
Nuclear protein kinase CLK1 uses a non-traditional docking mechanism to select physiological substrates. Biochem J (2015) 0.76
SF1 Phosphorylation Enhances Specific Binding to U2AF(65) and Reduces Binding to 3'-Splice-Site RNA. Biophys J (2016) 0.75
Splicing Regulators and Their Roles in Cancer Biology and Therapy. Biomed Res Int (2015) 0.75
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A (1992) 35.45
Signal transduction by receptors with tyrosine kinase activity. Cell (1990) 22.72
Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science (1991) 9.99
Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods Enzymol (1991) 9.39
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature (1990) 8.79
SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev (1992) 8.60
Identification of a ten-amino acid proline-rich SH3 binding site. Science (1993) 8.05
The superfamily of arginine/serine-rich splicing factors. RNA (1995) 7.96
SR proteins and splicing control. Genes Dev (1996) 7.09
The structure and function of proteins involved in mammalian pre-mRNA splicing. Annu Rev Biochem (1996) 7.08
Cloning and domain structure of the mammalian splicing factor U2AF. Nature (1992) 6.55
A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell (1994) 6.52
Use of an oriented peptide library to determine the optimal substrates of protein kinases. Curr Biol (1994) 6.04
Macromolecular domains within the cell nucleus. Annu Rev Cell Biol (1993) 5.90
A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature (1994) 5.01
The dynamics of a pre-mRNA splicing factor in living cells. Nature (1997) 4.97
Distinct functions of SR proteins in alternative pre-mRNA splicing. Science (1993) 4.79
A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature (1996) 4.65
The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J (1996) 4.65
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol Cell Biol (1996) 4.61
The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. Proc Natl Acad Sci U S A (1995) 4.52
General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proc Natl Acad Sci U S A (1992) 3.97
A monoclonal antibody recognizing nuclear matrix-associated nuclear bodies. J Cell Sci (1992) 3.91
Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes Dev (1997) 3.87
Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains. EMBO J (1993) 3.51
In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism. Cell (1993) 3.13
Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism. EMBO J (1994) 3.11
Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide. Nature (1996) 3.11
Characterization of a novel protein-binding module--the WW domain. FEBS Lett (1995) 3.11
A coactivator of pre-mRNA splicing. Genes Dev (1998) 3.04
Association of nuclear matrix antigens with exon-containing splicing complexes. J Cell Biol (1994) 3.01
Three protein kinase structures define a common motif. Structure (1994) 2.88
The SR protein family: pleiotropic functions in pre-mRNA splicing. Trends Biochem Sci (1996) 2.88
Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit. Proc Natl Acad Sci U S A (1992) 2.82
Structure and function of the WW domain. Prog Biophys Mol Biol (1996) 2.73
Identification of Prp40, a novel essential yeast splicing factor associated with the U1 small nuclear ribonucleoprotein particle. Mol Cell Biol (1996) 2.65
Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing. Nucleic Acids Res (1992) 2.53
Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations. Protein Sci (1993) 2.44
A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. EMBO J (1991) 2.38
Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer. Proc Natl Acad Sci U S A (1997) 2.34
Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors. Proc Natl Acad Sci U S A (1994) 2.34
SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors. J Biol Chem (1996) 2.28
Intron-dependent recruitment of pre-mRNA splicing factors to sites of transcription. J Cell Biol (1996) 2.23
FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. EMBO J (1997) 2.10
Thiophosphorylation of U1-70K protein inhibits pre-mRNA splicing. Nature (1993) 2.09
U2AF homolog required for splicing in vivo. Science (1993) 2.08
Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. EMBO J (1996) 1.98
STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases. Mol Cell Biol (1991) 1.97
Cloning of a yeast U1 snRNP 70K protein homologue: functional conservation of an RNA-binding domain between humans and yeast. EMBO J (1991) 1.97
Evidence for a NIMA-like mitotic pathway in vertebrate cells. Cell (1995) 1.92
A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA. Nature (1997) 1.87
Autoactivation of catalytic (C alpha) subunit of cyclic AMP-dependent protein kinase by phosphorylation of threonine 197. Mol Cell Biol (1993) 1.84
The conserved pre-mRNA splicing factor U2AF from Drosophila: requirement for viability. Science (1993) 1.78
Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors. Mol Biol Cell (1996) 1.72
The WW module competes with the SH3 domain? Trends Biochem Sci (1996) 1.66
Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects. Proc Natl Acad Sci U S A (1996) 1.60
A mitotic role for a novel fission yeast protein kinase dsk1 with cell cycle stage dependent phosphorylation and localization. Mol Biol Cell (1993) 1.49
Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. J Mol Biol (1994) 1.41
Molecular cloning of a novel human cdc2/CDC28-like protein kinase. J Biol Chem (1991) 1.31
Alternative splicing of STY, a nuclear dual specificity kinase. J Biol Chem (1995) 1.30
Protein phosphatase 1 can modulate alternative 5' splice site selection in a HeLa splicing extract. FEBS Lett (1994) 1.23
The structural basis for 14-3-3:phosphopeptide binding specificity. Cell (1997) 10.87
PI3K pathway alterations in cancer: variations on a theme. Oncogene (2008) 9.94
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science (1997) 8.81
Phosphoinositide kinases. Annu Rev Biochem (1998) 8.51
Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science (1997) 8.16
PI3K: downstream AKTion blocks apoptosis. Cell (1997) 7.73
Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature (1997) 7.20
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell (1992) 6.75
A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat Biotechnol (2001) 6.50
PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell (1989) 6.26
Nuclear receptor that identifies a novel retinoic acid response pathway. Nature (1990) 6.23
Use of an oriented peptide library to determine the optimal substrates of protein kinases. Curr Biol (1994) 6.04
Membrane-bound ATPase of intact vacuoles and tonoplasts isolated from mature plant tissue. Biochim Biophys Acta (1977) 5.54
Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science (1997) 5.40
Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. J Biol Chem (1977) 5.16
Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell (1996) 5.10
A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature (1994) 5.01
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science (1999) 4.77
Purification and characterization of phosphoinositide 3-kinase from rat liver. J Biol Chem (1990) 4.75
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat Cell Biol (2001) 4.64
The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem (1999) 4.62
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol Cell Biol (1996) 4.61
TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J (2000) 4.55
Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J Exp Med (1998) 4.52
Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proc Natl Acad Sci U S A (1994) 4.51
ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Mol Cell Biol (1994) 4.49
Pathway of Phloem unloading of sucrose in corn roots. Plant Physiol (1983) 4.41
Associations between distinct pre-mRNA splicing components and the cell nucleus. EMBO J (1991) 4.38
Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell (1995) 4.32
Activation of phosphatidylinositol 3-kinase by insulin. Proc Natl Acad Sci U S A (1990) 4.32
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science (1999) 4.20
Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. Mol Cell (1999) 4.02
Determination of the specific substrate sequence motifs of protein kinase C isozymes. J Biol Chem (1997) 3.86
Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol. Proc Natl Acad Sci U S A (1984) 3.84
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science (1997) 3.73
Immunopathogenic events in acute infection of rhesus monkeys with simian immunodeficiency virus of macaques. J Virol (1994) 3.71
A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications. J Biol Chem (1978) 3.67
Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem (2000) 3.66
The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J (2000) 3.64
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J Cell Biol (2001) 3.63
Vacuolar localization of proteases and degradation of chloroplasts in mesophyll protoplasts from senescing primary wheat leaves. Plant Physiol (1982) 3.57
Rho family GTPases bind to phosphoinositide kinases. J Biol Chem (1995) 3.49
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. Nature (1997) 3.29
Phosphatidylinositol 3-kinase. Bioessays (1994) 3.27
Proto-oncogene PML controls genes devoted to MHC class I antigen presentation. Nature (1998) 3.22
A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains. J Biol Chem (1997) 3.19
Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. J Biol Chem (1993) 3.14
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. J Biol Chem (1994) 3.08
Phosphoinositide kinases. Curr Opin Cell Biol (1996) 3.01
Determination of protease cleavage site motifs using mixture-based oriented peptide libraries. Nat Biotechnol (2001) 2.93
Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts. J Cell Biol (1998) 2.90
In vivo near-infrared fluorescence imaging of osteoblastic activity. Nat Biotechnol (2001) 2.89
Form variation in Escherichia coli K1: determined by O-acetylation of the capsular polysaccharide. J Exp Med (1979) 2.89
Combinatorial expression of three zebrafish genes related to distal-less: part of a homeobox gene code for the head. J Neurosci (1994) 2.88
Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling. Proc Natl Acad Sci U S A (1992) 2.85
Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx. Cell (1985) 2.69
Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation. Methods Enzymol (1991) 2.69
Polyvariant mutant cystic fibrosis transmembrane conductance regulator genes. The polymorphic (Tg)m locus explains the partial penetrance of the T5 polymorphism as a disease mutation. J Clin Invest (1998) 2.68
Interleukin 3-dependent survival by the Akt protein kinase. Proc Natl Acad Sci U S A (1997) 2.64
A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. Cell (1994) 2.64
The erbB3 gene product is a receptor for heregulin. J Biol Chem (1994) 2.63
Phosphoinositide kinases. Biochemistry (1990) 2.56
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell (2001) 2.53
Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts. Mol Cell Biol (1993) 2.47
Utilization of oriented peptide libraries to identify substrate motifs selected by ATM. J Biol Chem (2000) 2.42
Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes. EMBO J (1996) 2.42
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha. Nat Genet (2000) 2.39
Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins. Cell (1995) 2.34
United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. Biochem Soc Trans (2003) 2.34
Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors. Proc Natl Acad Sci U S A (1994) 2.34
Recognition and specificity in protein tyrosine kinase-mediated signalling. Trends Biochem Sci (1995) 2.31
Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. EMBO J (1998) 2.29
Sugar Transport into Protoplasts Isolated from Developing Soybean Cotyledons : II. Sucrose Transport Kinetics, Selectivity, and Modeling Studies. Plant Physiol (1984) 2.29
SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors. J Biol Chem (1996) 2.28
Vanadate inhibits the red cell (Na+, K+) ATPase from the cytoplasmic side. Nature (1978) 2.27
Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation. Science (1993) 2.25
In vivo measurement of blood oxygen saturation using magnetic resonance imaging: a direct validation of the blood oxygen level-dependent concept in functional brain imaging. Hum Brain Mapp (1997) 2.23
Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body. Proc Natl Acad Sci U S A (1998) 2.21
Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development. Neuron (1999) 2.19
Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes. EMBO J (1997) 2.19
The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J Biol Chem (1997) 2.16
Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain. J Biol Chem (1989) 2.15
An updatable holographic three-dimensional display. Nature (2008) 2.14
The use of peptide library for the determination of kinase peptide substrates. Methods Mol Biol (1998) 2.12
Signal transduction and membrane traffic: the PITP/phosphoinositide connection. Cell (1995) 2.11
Early postnatal development of corpus callosum and corticospinal white matter assessed with quantitative tractography. AJNR Am J Neuroradiol (2007) 2.11
The structure of Sky1p reveals a novel mechanism for constitutive activity. Nat Struct Biol (2001) 2.10
Discovery of a Jupiter/Saturn analog with gravitational microlensing. Science (2008) 2.09
Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. EMBO J (1997) 2.09
Ultrastructural analysis of transcription and splicing in the cell nucleus after bromo-UTP microinjection. Mol Biol Cell (1999) 2.08
Temporal and spatial development of axonal maturation and myelination of white matter in the developing brain. AJNR Am J Neuroradiol (2008) 2.08
Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. J Biol Chem (2000) 2.08