Published in Proc Natl Acad Sci U S A on March 17, 1998
Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu Rev Biochem (2009) 8.83
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry. Mol Cell (2007) 4.54
Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Mol Cell (2008) 3.49
The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death. Proc Natl Acad Sci U S A (1998) 2.40
Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and activation of the 26 S proteasome. J Biol Chem (2008) 1.93
Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation. EMBO J (2008) 1.65
Proteasome activators. Mol Cell (2011) 1.62
The proteasome activator 11 S REG (PA28) and class I antigen presentation. Biochem J (2000) 1.62
Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome-ATPase interactions. EMBO J (2009) 1.60
Regulated protein turnover: snapshots of the proteasome in action. Nat Rev Mol Cell Biol (2014) 1.57
The pore of activated 20S proteasomes has an ordered 7-fold symmetric conformation. EMBO J (2003) 1.50
Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening. Mol Cell (2010) 1.36
Structural models for interactions between the 20S proteasome and its PAN/19S activators. J Biol Chem (2009) 1.17
Lysine 188 substitutions convert the pattern of proteasome activation by REGgamma to that of REGs alpha and beta. EMBO J (2001) 1.02
The dominant temperature-sensitive lethal DTS7 of Drosophila melanogaster encodes an altered 20S proteasome beta-type subunit. Genetics (1999) 0.97
The molecular basis of wound healing processes induced by lithospermi radix: a proteomics and biochemical analysis. Evid Based Complement Alternat Med (2012) 0.87
Structural insights into proteasome activation by the 19S regulatory particle. Biochemistry (2013) 0.87
PA28γ is a novel corepressor of HTLV-1 replication and controls viral latency. Blood (2012) 0.84
Potential allosteric modulators of the proteasome activity. Biopolymers (2010) 0.83
Molecular and cellular roles of PI31 (PSMF1) protein in regulation of proteasome function. J Biol Chem (2014) 0.82
PA28αβ: the enigmatic magic ring of the proteasome? Biomolecules (2014) 0.81
Characterization of a REG/PA28 proteasome activator homolog in Dictyostelium discoideum indicates that the ubiquitin- and ATP-independent REGgamma proteasome is an ancient nuclear protease. Eukaryot Cell (2009) 0.80
Regulation of c-Myc protein stability by proteasome activator REGγ. Cell Death Differ (2014) 0.80
Upregulation of GSK3β Contributes to Brain Disorders in Elderly REGγ-knockout Mice. Neuropsychopharmacology (2015) 0.75
Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein. PLoS One (2015) 0.75
The 11S Proteasomal Activator REGγ Impacts Polyglutamine-Expanded Androgen Receptor Aggregation and Motor Neuron Viability through Distinct Mechanisms. Front Mol Neurosci (2017) 0.75
Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci U S A (1985) 68.48
Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol (1987) 66.52
Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution. Science (1995) 12.94
Structure of 20S proteasome from yeast at 2.4 A resolution. Nature (1997) 12.73
Randomization of genes by PCR mutagenesis. PCR Methods Appl (1992) 6.76
Proteasome from Thermoplasma acidophilum: a threonine protease. Science (1995) 3.62
Cell biology of antigen processing and presentation to major histocompatibility complex class I molecule-restricted T lymphocytes. Adv Immunol (1992) 2.77
Generation, translocation, and presentation of MHC class I-restricted peptides. Annu Rev Biochem (1995) 2.76
Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain). J Biol Chem (1992) 2.48
Purification of an 11 S regulator of the multicatalytic protease. J Biol Chem (1992) 2.35
A role for the proteasome regulator PA28alpha in antigen presentation. Nature (1996) 2.30
Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm. J Biol Chem (1994) 2.23
Identification, purification, and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20 S proteasome. J Biol Chem (1994) 2.15
Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit reticulocyte lysate. J Biol Chem (1992) 1.81
Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands. Cell (1996) 1.76
Peptide antigen production by the proteasome: complexity provides efficiency. Immunol Today (1996) 1.65
Structure of the proteasome activator REGalpha (PA28alpha). Nature (1997) 1.56
Characterization of recombinant REGalpha, REGbeta, and REGgamma proteasome activators. J Biol Chem (1997) 1.47
KEKE motifs. Proposed roles in protein-protein association and presentation of peptides by MHC class I receptors. FEBS Lett (1994) 1.37
Proteasomes and antigen processing. Adv Immunol (1997) 1.20
Purification and characterization of a multiprotein component of the Drosophila 26 S (1500 kDa) proteolytic complex. J Biol Chem (1993) 1.20
Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease. J Biol Chem (1994) 1.16
Kinetically coordinated induction of TAP1 and HLA class I by IFN-gamma: the rapid induction of TAP1 by IFN-gamma is mediated by Stat1 alpha. J Immunol (1996) 1.07
Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science (1986) 15.84
Recognition of the polyubiquitin proteolytic signal. EMBO J (2000) 10.12
Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid. Cell (1996) 6.74
Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein. Science (1997) 6.10
Image reconstructions of helical assemblies of the HIV-1 CA protein. Nature (2000) 5.60
A 26 S protease subunit that binds ubiquitin conjugates. J Biol Chem (1994) 4.93
Molecular recognition in the HIV-1 capsid/cyclophilin A complex. J Mol Biol (1997) 3.50
MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity. Proc Natl Acad Sci U S A (1997) 3.42
Structural basis for the activation of 20S proteasomes by 11S regulators. Nature (2000) 3.04
Structural basis for the specificity of ubiquitin C-terminal hydrolases. EMBO J (1999) 2.79
Introduction of macromolecules into cultured mammalian cells by osmotic lysis of pinocytic vesicles. Cell (1982) 2.79
Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution. Acta Crystallogr D Biol Crystallogr (1999) 2.77
Purification of two high molecular weight proteases from rabbit reticulocyte lysate. J Biol Chem (1987) 2.54
Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting. Proc Natl Acad Sci U S A (1996) 2.50
Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a. J Biol Chem (1998) 2.47
Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. J Biol Chem (1998) 2.44
Purification of an 11 S regulator of the multicatalytic protease. J Biol Chem (1992) 2.35
Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution. EMBO J (1997) 2.29
Generalization and maintenance of the reduction of self-injurious behavior maintained by two types of reinforcement. Behav Res Ther (1984) 2.23
Penicillin acylase has a single-amino-acid catalytic centre. Nature (1995) 2.18
Intracellular localization of proteasomal degradation of a viral antigen. J Cell Biol (1999) 2.04
Identification of the long ubiquitin extension as ribosomal protein S27a. Nature (1989) 1.93
Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit reticulocyte lysate. J Biol Chem (1992) 1.81
Structure of the C-terminal domain of FliG, a component of the rotor in the bacterial flagellar motor. Nature (1999) 1.76
Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates. J Biol Chem (1986) 1.70
The hydrophobic effect contributes to polyubiquitin chain recognition. Biochemistry (1998) 1.68
Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family. J Biol Chem (1992) 1.63
The proteasome activator 11 S REG (PA28) and class I antigen presentation. Biochem J (2000) 1.62
Arabidopsis MBP1 gene encodes a conserved ubiquitin recognition component of the 26S proteasome. Proc Natl Acad Sci U S A (1996) 1.58
Structure of the proteasome activator REGalpha (PA28alpha). Nature (1997) 1.56
Microinjection of ubiquitin: changes in protein degradation in HeLa cells subjected to heat-shock. J Cell Biol (1987) 1.52
Proteasome activator 11S REG or PA28: recombinant REG alpha/REG beta hetero-oligomers are heptamers. Biochemistry (1999) 1.49
Characterization of recombinant REGalpha, REGbeta, and REGgamma proteasome activators. J Biol Chem (1997) 1.47
Conjugation of ubiquitin to denatured hemoglobin is proportional to the rate of hemoglobin degradation in HeLa cells. Proc Natl Acad Sci U S A (1982) 1.44
The C terminus of mouse ornithine decarboxylase confers rapid degradation on dihydrofolate reductase. Support for the pest hypothesis. J Biol Chem (1991) 1.44
Microinjection of the nonhistone chromosomal protein HMG1 into bovine fibroblasts and HeLa cells. Cell (1979) 1.43
Ubiquitin-lysozyme conjugates. Purification and susceptibility to proteolysis. J Biol Chem (1986) 1.42
KEKE motifs. Proposed roles in protein-protein association and presentation of peptides by MHC class I receptors. FEBS Lett (1994) 1.37
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein. Protein Sci (1997) 1.36
Degradation of microinjected proteins: effects of lysosomotropic agents and inhibitors of autophagy. J Cell Physiol (1983) 1.32
Degradation of proteins microinjected into cultured mammalian cells. J Cell Physiol (1979) 1.32
Structure of a new crystal form of tetraubiquitin. Acta Crystallogr D Biol Crystallogr (2001) 1.28
Crystal structure of human uroporphyrinogen decarboxylase. EMBO J (1998) 1.26
Comparison of the NMR and X-ray structures of the HIV-1 matrix protein: evidence for conformational changes during viral assembly. Protein Sci (1996) 1.26
Inhibition of ubiquitin-mediated proteolysis by the Arabidopsis 26 S protease subunit S5a. J Biol Chem (1995) 1.25
Peptide sequencing identifies MSS1, a modulator of HIV Tat-mediated transactivation, as subunit 7 of the 26 S protease. FEBS Lett (1993) 1.24
Crystal structure of human uroporphyrinogen III synthase. EMBO J (2001) 1.23
Ubiquitin metabolism in cycling Xenopus egg extracts. J Biol Chem (1993) 1.22
Specific interactions between ATPase subunits of the 26 S protease. J Biol Chem (1997) 1.21
Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7. J Biol Chem (2000) 1.20
Substrate specificity of the human proteasome. Chem Biol (2001) 1.19
Nucleotidase activities of the 26 S proteasome and its regulatory complex. J Biol Chem (1996) 1.18
Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease. J Biol Chem (1994) 1.16
Microinjection of ubiquitin: intracellular distribution and metabolism in HeLa cells maintained under normal physiological conditions. J Cell Biol (1987) 1.13
Red cell-mediated microinjection. Natl Cancer Inst Monogr (1978) 1.11
The selective degradation of injected proteins occurs principally in the cytosol rather than in lysosomes. Cell (1981) 1.11
Effects of temperature on the degradation of proteins in rabbit reticulocyte lysates and after injection into HeLa cells. Proc Natl Acad Sci U S A (1984) 1.11
The pyridine nucleotide cycle. Studies in Escherichia coli and the human cell line D98/AH2. J Biol Chem (1981) 1.11
Subunits of the regulatory complex of the 26S protease. Mol Biol Rep (1995) 1.09
Evidence for a quantum phase transition in Pr2-xCe(x)CuO4-delta from transport measurements. Phys Rev Lett (2004) 1.09
Intracellular distribution and degradation of immunoglobulin G and immunoglobulin G fragments injected into HeLa cells. J Cell Biol (1983) 1.07
Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 A resolution. J Biol Chem (1998) 1.06
Molecular dissection of the 11S REG (PA28) proteasome activators. Biochimie (2001) 1.06
Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex. Biochemistry (1997) 1.05
Ubiquitin-mediated degradation of histone H3 does not require the substrate-binding ubiquitin protein ligase, E3, or attachment of polyubiquitin chains. J Biol Chem (1990) 1.05
Characterization and crystallization of human uroporphyrinogen decarboxylase. Protein Sci (1997) 1.02
Lysine 188 substitutions convert the pattern of proteasome activation by REGgamma to that of REGs alpha and beta. EMBO J (2001) 1.02
Potential immunocompetence of proteolytic fragments produced by proteasomes before evolution of the vertebrate immune system. J Exp Med (1997) 1.00
Molecular cloning and expression of a multiubiquitin chain binding subunit of the human 26S protease. FEBS Lett (1996) 0.98
Extended reading frame of a ubiquitin gene encodes a stable, conserved, basic protein. J Biol Chem (1988) 0.98
Magnitude and significance of NAD turnover in human cell line D98/AH2. Nature (1976) 0.98
Synthesis of peptides as cloned ubiquitin extensions. J Biol Chem (1989) 0.96
Effects of interferon gamma and major histocompatibility complex-encoded subunits on peptidase activities of human multicatalytic proteases. Proc Natl Acad Sci U S A (1995) 0.95
Expression, purification and crystallization of penicillin G acylase from Escherichia coli ATCC 11105. Protein Eng (1990) 0.95
Molecular cloning and expression of a 26 S protease subunit enriched in dileucine repeats. J Biol Chem (1995) 0.94
Ubiquitination of full-length cyclin. FEBS Lett (1995) 0.94
Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani. EMBO J (1999) 0.93
Activation of the multicatalytic protease. The 11 S regulator and 20 S ATPase complexes contain distinct 30-kilodalton subunits. J Biol Chem (1994) 0.93
Molecular cloning and expression of subunit 12: a non-MCP and non-ATPase subunit of the 26 S protease. FEBS Lett (1995) 0.93
Complete optical analysis of an UV laser dye using saturation techniques. Appl Opt (1992) 0.92
Functional consequences of naturally occurring mutations in human uroporphyrinogen decarboxylase. Blood (2001) 0.91
The biosynthesis and turnover of nicotinamide adenine dinucleotide in enucleated culture cells. J Cell Physiol (1974) 0.91
The N terminus of antizyme promotes degradation of heterologous proteins. J Biol Chem (1996) 0.90
Interactions of poly(ADP-ribose) with nuclear proteins. Biochimie (1995) 0.90
Histone shuttle driven by the automodification cycle of poly(ADP-ribose)polymerase. Environ Mol Mutagen (1993) 0.88
Relationship between forward head posture and diagnosed internal derangement of the temporomandibular joint. J Orofac Pain (1993) 0.87
The turnover of tRNAs microinjected into animal cells. Nucleic Acids Res (1978) 0.87
Defining polyubiquitin chain topology. Nat Struct Biol (2001) 0.86
Identification, molecular cloning, and characterization of subunit 11 of the human 26S proteasome. FEBS Lett (1999) 0.86
Proteolysis in heat-stressed HeLa cells. Stabilization of ubiquitin correlates with the loss of proline endopeptidase. J Biol Chem (1989) 0.86
The proteasome activator 11 S REG or PA28: chimeras implicate carboxyl-terminal sequences in oligomerization and proteasome binding but not in the activation of specific proteasome catalytic subunits. J Mol Biol (2000) 0.86
Comparative studies on microinjected high-mobility-group chromosomal proteins, HMG1 and HMG2. J Cell Biol (1981) 0.86
A proteasome activator subunit binds calcium. J Biol Chem (1995) 0.86