Published in Nature on March 12, 1998
Heart valve development: endothelial cell signaling and differentiation. Circ Res (2004) 4.41
NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med (2005) 3.70
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NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells. J Biol Chem (2002) 1.46
Epicardial calcineurin-NFAT signals through Smad2 to direct coronary smooth muscle cell and arterial wall development. Cardiovasc Res (2013) 1.40
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NFAT isoforms control activity-dependent muscle fiber type specification. Proc Natl Acad Sci U S A (2009) 1.33
Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. Biochem J (2003) 1.30
NFAT signaling in neural development and axon growth. Int J Dev Neurosci (2007) 1.30
"String theory" of c-kit(pos) cardiac cells: a new paradigm regarding the nature of these cells that may reconcile apparently discrepant results. Circ Res (2015) 1.29
Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation. Circ Res (2011) 1.28
NFATc1 identifies a population of proximal tubule cell progenitors. J Am Soc Nephrol (2008) 1.28
Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae. Eukaryot Cell (2004) 1.28
The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Mol Cell Biol (2005) 1.25
Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy. BMC Genomics (2007) 1.24
Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. BMC Dev Biol (2008) 1.24
Myocardial smad4 is essential for cardiogenesis in mouse embryos. Circ Res (2007) 1.19
RSK2 mediates muscle cell differentiation through regulation of NFAT3. J Biol Chem (2007) 1.19
Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest (2010) 1.19
Vascular endothelial and endocardial progenitors differentiate as cardiomyocytes in the absence of Etsrp/Etv2 function. Development (2011) 1.17
A second calcineurin binding site on the NFAT regulatory domain. Proc Natl Acad Sci U S A (2000) 1.16
Integration of calcium and cyclic AMP signaling pathways by 14-3-3. Mol Cell Biol (2000) 1.14
Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure. Am J Physiol Heart Circ Physiol (2010) 1.13
Partitioning the heart: mechanisms of cardiac septation and valve development. Development (2012) 1.13
A potential role for nuclear factor of activated T-cells in receptor tyrosine kinase and G-protein-coupled receptor agonist-induced cell proliferation. Biochem J (2002) 1.12
Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells. Proc Natl Acad Sci U S A (2007) 1.12
Alternative splicing and expression of human and mouse NFAT genes. Genomics (2008) 1.12
Linkage analysis of left ventricular outflow tract malformations (aortic valve stenosis, coarctation of the aorta, and hypoplastic left heart syndrome). Eur J Hum Genet (2009) 1.11
VEGF and RANKL regulation of NFATc1 in heart valve development. Circ Res (2009) 1.11
Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development. Proc Natl Acad Sci U S A (2009) 1.09
Regulation of transcription factor NFAT by ADP-ribosylation. Mol Cell Biol (2008) 1.09
Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Physiol Genomics (2009) 1.06
Development of the endocardium. Pediatr Cardiol (2010) 1.04
VEGF signaling has distinct spatiotemporal roles during heart valve development. Dev Biol (2010) 1.03
Role of transcription factor NFAT in glucose and insulin homeostasis. Mol Cell Biol (2006) 1.02
NFATc1 targets cyclin A in the regulation of vascular smooth muscle cell multiplication during restenosis. J Biol Chem (2008) 1.01
Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling. Proc Natl Acad Sci U S A (2006) 1.01
Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis. J Biol Chem (2008) 1.01
Epidemiology and pathophysiology of mitral valve prolapse: new insights into disease progression, genetics, and molecular basis. Circulation (2014) 1.00
Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development. J Biol Chem (2007) 0.99
Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. Am J Physiol Heart Circ Physiol (2009) 0.99
An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation. Proc Natl Acad Sci U S A (2010) 0.99
The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p. EMBO J (2001) 0.98
NFATc1/αA: The other Face of NFAT Factors in Lymphocytes. Cell Commun Signal (2012) 0.98
Vascular endothelial growth factor receptor signaling is required for cardiac valve formation in zebrafish. Dev Dyn (2006) 0.97
Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development. Dev Biol (2010) 0.96
NFATC1 promotes epicardium-derived cell invasion into myocardium. Development (2011) 0.96
Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity. Mol Cell Biol (2011) 0.95
Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis. Development (2013) 0.95
Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. J Cell Biol (2005) 0.94
Transcriptional regulation of heart valve progenitor cells. Pediatr Cardiol (2009) 0.94
Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling. Development (2009) 0.93
Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function. J Biol Chem (2009) 0.92
NFAT as cancer target: mission possible? Biochim Biophys Acta (2014) 0.91
FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart. Dev Biol (2006) 0.91
Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev (2013) 0.90
Superoxide Dismutase 1 In Vivo Ameliorates Maternal Diabetes Mellitus-Induced Apoptosis and Heart Defects Through Restoration of Impaired Wnt Signaling. Circ Cardiovasc Genet (2015) 0.90
NFATc1 regulates lymphatic endothelial development. Mech Dev (2009) 0.89
Opposing roles of FoxP1 and Nfat3 in transcriptional control of cardiomyocyte hypertrophy. Mol Cell Biol (2011) 0.89
Human pulmonary valve endothelial cells express functional adhesion molecules for leukocytes. J Heart Valve Dis (2003) 0.88
The mitochondrial respiratory chain controls intracellular calcium signaling and NFAT activity essential for heart formation in Xenopus laevis. Mol Cell Biol (2007) 0.88
Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes. Development (2015) 0.88
Transcriptional regulation of heart valve development and disease. Cardiovasc Pathol (2010) 0.88
Myoferlin regulation by NFAT in muscle injury, regeneration and repair. J Cell Sci (2010) 0.87
Recombination signal binding protein for Ig-κJ region regulates juxtaglomerular cell phenotype by activating the myo-endocrine program and suppressing ectopic gene expression. J Am Soc Nephrol (2014) 0.87
Conserved transcriptional regulatory mechanisms in aortic valve development and disease. Arterioscler Thromb Vasc Biol (2014) 0.87
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