Published in Eur J Cancer on October 01, 1997
Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis. Cancer Res (2005) 0.96
Analyses of apoptotic regulators CASP9 and DFFA at 1P36.2, reveal rare allele variants in human neuroblastoma tumours. Br J Cancer (2002) 0.95
The p42 variant of ETS1 protein rescues defective Fas-induced apoptosis in colon carcinoma cells. Proc Natl Acad Sci U S A (1999) 0.90
Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82
Variable number of tandem repeat (VNTR) markers for human gene mapping. Science (1987) 25.71
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science (1989) 11.53
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science (1995) 11.38
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science (1991) 9.89
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell (1998) 6.79
Quantum computers. Nature (2010) 6.79
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature (2000) 6.01
When is cancer pain mild, moderate or severe? Grading pain severity by its interference with function. Pain (1995) 5.97
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell (2000) 5.64
Allelotype of colorectal carcinomas. Science (1989) 5.54
The action of tetrodotoxin on electrogenic components of squid giant axons. J Gen Physiol (1965) 5.42
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet (2000) 5.26
Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science (1993) 5.22
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science (1997) 5.16
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet (1992) 5.14
Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti. DNA Res (2000) 4.94
Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science (1993) 4.63
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62
The gene for familial polyposis coli maps to the long arm of chromosome 5. Science (1987) 4.48
Hydrogen peroxide metabolism in human monocytes during differentiation in vitro. J Clin Invest (1981) 4.46
Transient regulation of protein synthesis in Escherichia coli upon shift-up of growth temperature. J Bacteriol (1978) 4.38
Nucleotide sequence of a full-length cDNA for mouse cytoskeletal beta-actin mRNA. Nucleic Acids Res (1986) 4.36
Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120. DNA Res (2001) 4.27
A primary genetic map of markers of human chromosome 10. Genomics (1988) 4.23
Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. Cancer Res (1992) 4.21
Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis. Nucleic Acids Res (2000) 4.11
Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Res (2001) 4.03
Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature (1988) 3.96
An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Nature (1998) 3.86
Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells. J Clin Invest (1998) 3.54
Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO Rep (2001) 3.47
Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology (2000) 3.42
Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci (2002) 3.28
Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat Med (1998) 3.23
Rapid confirmation of single copy lambda prophage integration by PCR. Nucleic Acids Res (1994) 3.19
Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res (2001) 3.18
A high-throughput SNP typing system for genome-wide association studies. J Hum Genet (2001) 3.18
Isolation and mapping of a polymorphic DNA sequence (pTHH22) on chromosome 9 [D9S12]. Nucleic Acids Res (1988) 3.17
IL-6 is produced by osteoblasts and induces bone resorption. J Immunol (1990) 3.14
Gene organization deduced from the complete sequence of liverwort Marchantia polymorpha mitochondrial DNA. A primitive form of plant mitochondrial genome. J Mol Biol (1992) 3.11
Molecular detection of microscopic and submicroscopic deletions associated with Miller-Dieker syndrome. Am J Hum Genet (1988) 2.97
Mapping of mutation causing Friedreich's ataxia to human chromosome 9. Nature (1988) 2.96
A tripeptide 'anticodon' deciphers stop codons in messenger RNA. Nature (2000) 2.90
Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. Lancet (1993) 2.88
Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell (1995) 2.81
A mapped set of genetic markers for human chromosome 9. Genomics (1988) 2.80
Genetic mapping of autosomal dominant Charcot-Marie-Tooth disease in a large French-Acadian kindred: identification of new linked markers on chromosome 17. Am J Hum Genet (1990) 2.77
Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet (1998) 2.77
Experimental investigation of geologically produced antineutrinos with KamLAND. Nature (2005) 2.75
A simple method for counting adherent cells: application to cultured human monocytes, macrophages and multinucleated giant cells. J Immunol Methods (1983) 2.75
Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients. Cancer Res (1992) 2.72
A primary genetic linkage map for human chromosome 12. Genomics (1987) 2.72
Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol Cell Biol (1997) 2.71
Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science (1993) 2.68
Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc Natl Acad Sci U S A (1994) 2.66
Requirement of CD9 on the egg plasma membrane for fertilization. Science (2000) 2.65
Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers. Cancer Res (1987) 2.65
Complete structure of the chloroplast genome of Arabidopsis thaliana. DNA Res (1999) 2.63
Mutations of the APC (adenomatous polyposis coli) gene. Hum Mutat (1993) 2.63
A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur J Immunol (1994) 2.62
Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice. Neuron (1996) 2.62
Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors. Mol Cell Biol (1997) 2.58
Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer. Cancer Res (1990) 2.57
Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J Neurosci (2001) 2.54
A radiation hybrid map of the rat genome containing 5,255 markers. Nat Genet (1999) 2.54
Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation. J Biol Chem (2000) 2.50
Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma: positive association a T924C polymorphism in the thromboxane A2 receptor gene. Hum Genet (2000) 2.50
p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Mol Cell (2001) 2.47
Helium-3 emission related to volcanic activity. Science (1984) 2.43
Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res (1998) 2.42
Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J (1998) 2.41
Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer. Proc Natl Acad Sci U S A (2000) 2.38
Musashi1: an evolutionally conserved marker for CNS progenitor cells including neural stem cells. Dev Neurosci (2000) 2.36
A large scale analysis of cDNA in Arabidopsis thaliana: generation of 12,028 non-redundant expressed sequence tags from normalized and size-selected cDNA libraries. DNA Res (2000) 2.33
Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps. N Engl J Med (1990) 2.32
The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein. Mol Cell Biol (1991) 2.30
Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected]. JAMA (1989) 2.29
Biochemical and genetic analysis of the effects of amylose-extender mutation in rice endosperm. Plant Physiol (2001) 2.28
Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts. Oncogene (1999) 2.27
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Oncogene (2001) 2.25
Lymphokines enhance the capacity of human monocytes to secret reactive oxygen intermediates. J Clin Invest (1982) 2.23
Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. Cell (1994) 2.20
Virus associated with S.M.O.N. in Japan. Lancet (1971) 2.19
Mutation analysis in the BRCA2 gene in primary breast cancers. Nat Genet (1996) 2.18
Novel proteins of the phosphotransferase system encoded within the rpoN operon of Escherichia coli. Enzyme IIANtr affects growth on organic nitrogen and the conditional lethality of an erats mutant. J Biol Chem (1995) 2.17
Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Nature (2000) 2.17
Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Nature (2000) 2.16
Genetic diagnosis of lymph-node metastasis in colorectal cancer. Lancet (1995) 2.15
A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis. J Med Genet (2008) 2.15
Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. Gene (1986) 2.14
International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee. Br J Cancer (2009) 2.13
Autoregulation of RNase III operon by mRNA processing. EMBO J (1989) 2.11
Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation. Nat Med (2000) 2.11
A detailed genetic map of the long arm of chromosome 11. Genomics (1990) 2.11
Response to local inflammation of IL-1 beta-converting enzyme- deficient mice. J Immunol (1997) 2.10
Coherent dynamics of a flux qubit coupled to a harmonic oscillator. Nature (2004) 2.07