Published in Blood on May 01, 1998
Telomeres and telomerase in cancer. Carcinogenesis (2009) 4.28
Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med (1999) 4.27
Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature (2005) 4.16
Bmi1, stem cells, and senescence regulation. J Clin Invest (2004) 3.80
Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci U S A (2003) 2.95
Telomeres shorten at equivalent rates in somatic tissues of adults. Nat Commun (2013) 2.56
A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells. Blood (2008) 2.23
Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proc Natl Acad Sci U S A (2008) 2.15
Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice. Proc Natl Acad Sci U S A (2004) 1.83
Leukocyte telomere length and the father's age enigma: implications for population health and for life course. Int J Epidemiol (2013) 1.66
Genetics of leukocyte telomere length and its role in atherosclerosis. Mutat Res (2011) 1.44
Telomere length in breast cancer patients before and after chemotherapy with or without stem cell transplantation. Br J Cancer (2001) 1.28
Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms. PLoS One (2010) 1.19
Tracking and fixed ranking of leukocyte telomere length across the adult life course. Aging Cell (2013) 1.17
Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence? J Clin Invest (2004) 1.14
Stem cell aging: survival of the laziest? Cell Cycle (2008) 1.14
Beyond average: potential for measurement of short telomeres. Aging (Albany NY) (2012) 1.12
Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart. Proc Natl Acad Sci U S A (2001) 1.10
Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle. Proc Natl Acad Sci U S A (2001) 1.10
Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells. Proc Natl Acad Sci U S A (2005) 1.07
Understanding telomere diseases through analysis of patient-derived iPS cells. Curr Opin Genet Dev (2013) 1.03
Regulation of senescence in cancer and aging. J Aging Res (2011) 0.98
Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation. J Exp Med (2014) 0.97
Making the most of a little: dosage effects in eukaryotic telomere length maintenance. Chromosome Res (2005) 0.95
Bypass of senescence, immortalization, and transformation of human hematopoietic progenitor cells. Stem Cells (2005) 0.95
Aging stem cells, latexin, and longevity. Exp Cell Res (2008) 0.94
Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans. Mol Hum Reprod (2012) 0.94
Leukocyte telomere dynamics in the elderly. Eur J Epidemiol (2013) 0.92
Understanding TERT Promoter Mutations: A Common Path to Immortality. Mol Cancer Res (2016) 0.90
The proximal promoter region of mTert is sufficient to regulate telomerase activity in ES cells and transgenic animals. Reprod Biol Endocrinol (2006) 0.90
Differentiation rather than aging of muscle stem cells abolishes their telomerase activity. Biotechnol Prog (2009) 0.90
The heritability of leucocyte telomere length dynamics. J Med Genet (2015) 0.87
Changes in gene expression associated with aging commonly originate during juvenile growth. Mech Ageing Dev (2010) 0.85
Potent antitumoral efficacy of a novel replicative adenovirus CNHK300 targeting telomerase-positive cancer cells. J Cancer Res Clin Oncol (2004) 0.84
Conditional Knockout of Telomerase Reverse Transcriptase in Mesenchymal Cells Impairs Mouse Pulmonary Fibrosis. PLoS One (2015) 0.79
Hematopoietic stem cells. Methods Enzymol (2006) 0.78
Age-related Deterioration of Hematopoietic Stem Cells. Int J Stem Cells (2008) 0.78
A second chance for telomerase reverse transcriptase in anticancer immunotherapy. Nat Rev Clin Oncol (2016) 0.77
Telomere length assessment in leukocytes presents potential diagnostic value in patients with breast cancer. Oncol Lett (2016) 0.75
The regulation of hematopoietic stem cell populations. F1000Res (2016) 0.75
p53 Mediates Failure of Human Definitive Hematopoiesis in Dyskeratosis Congenita. Stem Cell Reports (2017) 0.75
Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell (1997) 13.34
The RNA component of human telomerase. Science (1995) 9.86
Production of hybridoma growth factor by human monocytes. Eur J Immunol (1987) 7.99
Plasticity of the differentiated state. Science (1985) 6.19
Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev Biol (2000) 6.06
Cytoplasmic activation of human nuclear genes in stable heterocaryons. Cell (1983) 5.71
Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc Natl Acad Sci U S A (1997) 4.88
Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat Biotechnol (1998) 4.68
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci U S A (1994) 4.57
Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med (1999) 4.27
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci U S A (1998) 4.11
Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev (1995) 3.81
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet (1999) 3.47
Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proc Natl Acad Sci U S A (1990) 3.43
Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells. Blood (1991) 3.12
Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc Natl Acad Sci U S A (1994) 3.08
Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS (1996) 2.95
Short telomeres on human chromosome 17p. Nat Genet (1998) 2.81
Enrichment of neurons and neural precursors from human embryonic stem cells. Exp Neurol (2001) 2.63
Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. Mol Cell Biol (1997) 2.61
Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. Proc Natl Acad Sci U S A (1990) 2.59
Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood (1989) 2.44
Human endothelial cell life extension by telomerase expression. J Biol Chem (1999) 2.38
Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo. Blood (1997) 2.33
Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science (2000) 2.25
Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr Biol (2001) 2.21
Expression of Thy-1 on human hematopoietic progenitor cells. J Exp Med (1993) 2.09
Telomere length measurements using digital fluorescence microscopy. Cytometry (1999) 2.03
Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow. Stem Cells (1996) 1.97
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr Biol (2000) 1.97
Telomere length in leukocyte subpopulations of patients with aplastic anemia. Blood (2001) 1.89
Isolation in a single step of a highly enriched murine hematopoietic stem cell population with competitive long-term repopulating ability. Blood (1989) 1.84
A growth-factor dependent B-cell hybridoma. Curr Top Microbiol Immunol (1986) 1.79
Telomere length regulation in mice is linked to a novel chromosome locus. Proc Natl Acad Sci U S A (1998) 1.78
Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood (2001) 1.71
Mechanism of telomerase induction during T cell activation. Exp Cell Res (1996) 1.68
Reprogramming cell differentiation in the absence of DNA synthesis. Cell (1984) 1.66
5-Azacytidine permits gene activation in a previously noninducible cell type. Cell (1985) 1.64
The human hematopoietic stem cell in vitro and in vivo. Blood Cells (1992) 1.58
Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. Nat Genet (1999) 1.56
Lineage commitment in human hemopoiesis involves asymmetric cell division of multipotent progenitors and does not appear to be influenced by cytokines. J Cell Physiol (1993) 1.53
Autografting with cultured marrow in chronic myeloid leukemia: results of a pilot study. Blood (1994) 1.51
eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization. Circ Res (2001) 1.45
The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts. Blood (1996) 1.45
Differential regulation of primitive human hematopoietic cells in long-term cultures maintained on genetically engineered murine stromal cells. Blood (1991) 1.44
A comparison of long-term repopulating hematopoietic stem cells in fetal liver and adult bone marrow from the mouse. Exp Hematol (1996) 1.42
Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA. Mol Cell Biol (2000) 1.42
Differential roles of stromal cells, interleukin-7, and kit-ligand in the regulation of B lymphopoiesis. Blood (1992) 1.32
Immunological study of in vitro maturation of human megakaryocytes. Br J Haematol (1984) 1.32
Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Exp Cell Res (2000) 1.30
Retrovirus-mediated gene transfer to purified hemopoietic stem cells with long-term lympho-myelopoietic repopulating ability. Proc Natl Acad Sci U S A (1989) 1.29
Asymmetric cell divisions sustain long-term hematopoiesis from single-sorted human fetal liver cells. J Exp Med (1998) 1.27
Accelerated telomere shortening in hematological lineages is limited to the first year following stem cell transplantation. Blood (2001) 1.26
Biology of human umbilical cord blood-derived hematopoietic stem/progenitor cells. Stem Cells (1998) 1.26
Monoclonal antibodies against human platelet glycoprotein IIIa. Br J Haematol (1983) 1.25
Impaired steel factor responsiveness differentially affects the detection and long-term maintenance of fetal liver hematopoietic stem cells in vivo. Blood (1997) 1.24
Explanation for excessive DNA single-strand breaks and endogenous repair foci in pluripotent mouse embryonic stem cells. Exp Cell Res (2008) 1.24
Flow cytometry for clinical estimation of circulating hematopoietic progenitors for autologous transplantation in cancer patients. Blood (1991) 1.23
DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. Mol Cell Biol (2001) 1.20
Immunoperoxidase procedures to detect monoclonal antibodies against cell surface antigens. Quantitation of binding and staining of individual cells. J Immunol Methods (1980) 1.19
Separation of functionally distinct subpopulations of primitive human hematopoietic cells using rhodamine-123. Exp Hematol (1991) 1.17
Studies of W mutant mice provide evidence for alternate mechanisms capable of activating hematopoietic stem cells. Exp Hematol (1996) 1.16
Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks. DNA Repair (Amst) (2008) 1.16
The genes for leukemia inhibitory factor and interleukin-6 are expressed in mouse blastocysts prior to the onset of hemopoiesis. Mol Cell Biol (1990) 1.16
Thy-1 expression is linked to functional properties of primitive hematopoietic progenitor cells from human umbilical cord blood. Blood (1994) 1.14
Extra-chromosomal telomeric DNA in cells from Atm(-/-) mice and patients with ataxia-telangiectasia. Hum Mol Genet (2001) 1.11
Cytokine-induced selective expansion and maturation of erythroid versus myeloid progenitors from purified cord blood precursor cells. Blood (1993) 1.10
Telomere length dynamics in normal individuals and in patients with hematopoietic stem cell-associated disorders. Ann N Y Acad Sci (2001) 1.08
Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells. Proc Natl Acad Sci U S A (2005) 1.07
The pattern of actin expression in human fibroblast x mouse muscle heterokaryons suggests that human muscle regulatory factors are produced. Cell (1986) 1.06
Polyclonal hematopoiesis with variable telomere shortening in human long-term allogeneic marrow graft recipients. Blood (2000) 1.06
Quantitative fluorescence in situ hybridization (Q-FISH). Curr Protoc Cell Biol (2001) 1.02
Differentiation properties of pure populations of human dystrophic muscle cells. Exp Cell Res (1983) 1.02
Oligoclonal expansions in the CD8(+)CD28(-) T cells largely explain the shorter telomeres detected in this subset: analysis by flow FISH. Hum Immunol (2000) 1.00
Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo. Mol Cell Biol (2000) 1.00
Accelerated telomere shortening in the human inactive X chromosome. Am J Hum Genet (1999) 0.99
Detection and isolation of the erythropoietin receptor using biotinylated erythropoietin. Blood (1990) 0.98
Retroviral gene transfer to primitive normal and leukemic hematopoietic cells using clinically applicable procedures. J Clin Invest (1992) 0.96
Measurements of telomere length on individual chromosomes by image cytometry. Methods Cell Biol (2001) 0.94
Myeloid-associated antigen 3-alpha-fucosyl-N-acetyllactosamine (FAL): location on various granulocyte membrane glycoproteins and masking upon monocytic differentiation. Eur J Immunol (1984) 0.94
Characterization of functionally distinct subpopulations of CD34+ cord blood cells in serum-free long-term cultures supplemented with hematopoietic cytokines. Blood (1993) 0.93
Telomerase activity in female and male rat germ cells undergoing meiosis and in early embryos. Biol Reprod (1997) 0.92
Production of interleukin-1 by bone marrow myeloma cells. Blood (1989) 0.92
Human embryonic stem cells: culture, differentiation, and genetic modification for regenerative medicine applications. Cancer J (2002) 0.92
An 18q- syndrome breakpoint resides between the duplicated serpins SCCA1 and SCCA2 and arises via a cryptic rearrangement with satellite III DNA. Hum Mol Genet (1999) 0.91
Differentiation-associated changes in CD44 isoform expression during normal hematopoiesis and their alteration in chronic myeloid leukemia. Blood (1995) 0.90
Successful autografting in chronic myeloid leukaemia after maintenance of marrow in culture. Bone Marrow Transplant (1989) 0.89
The synthesis and characterization of poly(γ-glutamic acid)-coated magnetite nanoparticles and their effects on antibacterial activity and cytotoxicity. Nanotechnology (2011) 0.89
Increased erythropoietin-receptor expression on CD34-positive bone marrow cells from patients with chronic myeloid leukemia. Blood (1992) 0.88
Specific capture of targeted hematopoietic cells by high gradient magnetic separation by the use of ordered wire array filters and tetrameric antibody complexes linked to a dextran iron particle. Prog Clin Biol Res (1994) 0.87
A comparison of surface marker analysis and FAB classification in acute myeloid leukemia. Blood (1983) 0.87
Characterization of primitive hematopoietic cells in normal human peripheral blood. Blood (1992) 0.86