Published in Lancet on May 09, 1998
Study of Metformin With Simvastatin for Men With Prostate Carcinoma | NCT01561482
Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts. Breast Cancer Res (2005) 8.73
Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies. Lancet Oncol (2010) 3.75
Height and risk of death among men and women: aetiological implications of associations with cardiorespiratory disease and cancer mortality. J Epidemiol Community Health (2000) 3.23
Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study. Lancet Oncol (2009) 3.21
Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidence. Breast Cancer Res (2008) 3.05
Randomized controlled trial of aerobic exercise on insulin and insulin-like growth factors in breast cancer survivors: the Yale Exercise and Survivorship study. Cancer Epidemiol Biomarkers Prev (2009) 2.73
The association of breast mitogens with mammographic densities. Br J Cancer (2002) 2.25
Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link. Cancer (2009) 2.19
Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women. J Clin Oncol (2010) 2.00
IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci U S A (2007) 1.88
Insulin-like growth factor receptor inhibitors: baby or the bathwater? J Natl Cancer Inst (2012) 1.86
Randomized double-blind 2 x 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in high-risk premenopausal women. J Clin Oncol (2009) 1.85
Energy balance, host-related factors, and cancer progression. J Clin Oncol (2010) 1.85
Effect of prediagnostic alcohol consumption on survival after breast cancer in young women. Cancer Epidemiol Biomarkers Prev (2008) 1.83
Unraveling insulin-like growth factor binding protein-3 actions in human disease. Endocr Rev (2009) 1.76
Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer. J Clin Oncol (2010) 1.68
Role of insulin-like growth factor 1 receptor signalling in cancer. Br J Cancer (2005) 1.64
Mammary gland development. Wiley Interdiscip Rev Dev Biol (2013) 1.64
Future directions in cancer prevention. Nat Rev Cancer (2012) 1.62
Growth hormone, the insulin-like growth factor axis, insulin and cancer risk. Nat Rev Endocrinol (2010) 1.61
Body size and risk of luminal, HER2-overexpressing, and triple-negative breast cancer in postmenopausal women. Cancer Epidemiol Biomarkers Prev (2008) 1.53
Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells. Clin Exp Metastasis (2002) 1.53
Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma. Cancer Chemother Pharmacol (2009) 1.50
Birthweight, childhood growth and risk of breast cancer in a British cohort. Br J Cancer (2000) 1.49
A prospective study of age-specific physical activity and premenopausal breast cancer. J Natl Cancer Inst (2008) 1.48
Urinary melatonin levels and postmenopausal breast cancer risk in the Nurses' Health Study cohort. Cancer Epidemiol Biomarkers Prev (2009) 1.46
Insulin-like growth factor-I and risk of breast cancer. Lancet (1998) 1.45
Metabolic syndrome and postmenopausal breast cancer in the ORDET cohort: a nested case-control study. Nutr Metab Cardiovasc Dis (2009) 1.43
Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma. J Clin Oncol (2011) 1.43
Retracted Targeting 3-phosphoinoside-dependent kinase-1 to inhibit insulin-like growth factor-I induced AKT and p70 S6 kinase activation in breast cancer cells. PLoS One (2012) 1.41
Insulin-like growth factor-binding protein 5 (Igfbp5) compromises survival, growth, muscle development, and fertility in mice. Proc Natl Acad Sci U S A (2004) 1.41
Tallness and overweight during childhood have opposing effects on breast cancer risk. Br J Cancer (2001) 1.41
Breast cancer mortality vs. exercise and breast size in runners and walkers. PLoS One (2013) 1.40
HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924. Mol Cancer Ther (2008) 1.40
A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk. Br J Cancer (2005) 1.40
Population-based case-control study of soyfood intake and breast cancer risk in Shanghai. Br J Cancer (2001) 1.39
Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis. Breast Cancer Res (2007) 1.35
Obesity, mammography use and accuracy, and advanced breast cancer risk. J Natl Cancer Inst (2008) 1.35
Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study. Br J Cancer (2006) 1.34
Insulin-like growth factor-dependent proliferation and survival of triple-negative breast cancer cells: implications for therapy. Neoplasia (2011) 1.32
Fetal growth and subsequent risk of breast cancer: results from long term follow up of Swedish cohort. BMJ (2003) 1.28
IGF1 genotype, mean plasma level and breast cancer risk in the Hawaii/Los Angeles multiethnic cohort. Br J Cancer (2003) 1.27
Cancer and insulin-like growth factor-I. A potential mechanism linking the environment with cancer risk. BMJ (2000) 1.26
2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen. J Cell Biol (2012) 1.26
Diabetes and thyroid cancer risk in the National Institutes of Health-AARP Diet and Health Study. Thyroid (2011) 1.22
New targets for therapy in breast cancer: mammalian target of rapamycin (mTOR) antagonists. Breast Cancer Res (2004) 1.20
Dietary intake and breast density in high-risk women: a cross-sectional study. Breast Cancer Res (2007) 1.20
Rethinking breast cancer risk and the environment: the case for the precautionary principle. Environ Health Perspect (1998) 1.20
Is the association of birth weight with premenopausal breast cancer risk mediated through childhood growth? Br J Cancer (2004) 1.20
IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-β1 resulting in epithelial to mesenchymal transition. Cell Commun Signal (2011) 1.17
Insulin-like growth factor-I and new opportunities for cancer prevention. Lancet (1998) 1.17
Tyrosine kinase signalling in breast cancer: insulin-like growth factors and their receptors in breast cancer. Breast Cancer Res (2000) 1.16
Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. Hum Mol Genet (2010) 1.16
A review of anabolic therapies for osteoporosis. Arthritis Res Ther (2003) 1.14
Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer. Br J Cancer (2000) 1.14
The insulin-like growth factor-I receptor inhibitor figitumumab (CP-751,871) in combination with docetaxel in patients with advanced solid tumours: results of a phase Ib dose-escalation, open-label study. Br J Cancer (2010) 1.14
Long-term effectiveness of adjuvant goserelin in premenopausal women with early breast cancer. J Natl Cancer Inst (2009) 1.13
18FDG-PET predicts pharmacodynamic response to OSI-906, a dual IGF-1R/IR inhibitor, in preclinical mouse models of lung cancer. Clin Cancer Res (2011) 1.13
Insulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1. J Cell Biol (1999) 1.11
Body mass index in young adulthood and cancer mortality: a retrospective cohort study. J Epidemiol Community Health (2002) 1.09
The interaction of insulin-like growth factor-I with the N-terminal domain of IGFBP-5. EMBO J (2001) 1.08
Tomato-based food products for prostate cancer prevention: what have we learned? Cancer Metastasis Rev (2010) 1.08
Insulin resistance and hyperinsulinaemia in the development and progression of cancer. Clin Sci (Lond) (2009) 1.06
Criteria for the evaluation of large cohort studies: an application to the nurses' health study. J Natl Cancer Inst (2008) 1.06
Mesenchymal stem cell-mediated ectopic hematopoiesis alleviates aging-related phenotype in immunocompromised mice. Blood (2008) 1.05
Combined inhibition of estrogen-dependent human breast carcinoma by soy and tea bioactive components in mice. Int J Cancer (2004) 1.05
Expression of a protease-resistant insulin-like growth factor-binding protein-4 inhibits tumour growth in a murine model of breast cancer. Br J Cancer (2009) 1.05
Cigarette smoking increases copy number alterations in nonsmall-cell lung cancer. Proc Natl Acad Sci U S A (2011) 1.05
Insulin-like growth factor-1 inscribes a gene expression profile for angiogenic factors and cancer progression in breast epithelial cells. Neoplasia (2002) 1.04
The role of chronic inflammation in obesity-associated cancers. ISRN Oncol (2013) 1.04
Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro. Diabetologia (2012) 1.03
Diabetes and thyroid cancer risk: literature review. Exp Diabetes Res (2012) 1.02
Candidate mechanisms accounting for effects of physical activity on breast carcinogenesis. IUBMB Life (2009) 1.02
The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer. Breast Cancer Res (2008) 1.01
Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts. Br J Cancer (2007) 1.01
Hormone replacement therapy and physical function in healthy older men. Time to talk hormones? Endocr Rev (2012) 1.01
Insulin-like growth factor (IGF) signaling in tumorigenesis and the development of cancer drug resistance. Genes Dis (2015) 1.01
IGFBP-3, a marker of cellular senescence, is overexpressed in human papillomavirus-immortalized cervical cells and enhances IGF-1-induced mitogenesis. J Virol (2004) 1.00
The combined influence of multiple sex and growth hormones on risk of postmenopausal breast cancer: a nested case-control study. Breast Cancer Res (2011) 1.00
Insulin-like growth factor: current concepts and new developments in cancer therapy. Recent Pat Anticancer Drug Discov (2012) 1.00
Favorable prognostic value of SOCS2 and IGF-I in breast cancer. BMC Cancer (2007) 1.00
A candidate targeting molecule of insulin-like growth factor-I receptor for gastrointestinal cancers. World J Gastroenterol (2010) 0.99
I-CLIP: improved stratification of advanced hepatocellular carcinoma patients by integrating plasma IGF-1 into CLIP score. Oncology (2011) 0.98
Intestinal adaptation after massive intestinal resection. Postgrad Med J (2005) 0.98
Population-based case-control study of diabetes and breast cancer risk in Hispanic and non-Hispanic White women living in US southwestern states. Am J Epidemiol (2007) 0.98
SOX9 directly regulates IGFBP-4 in the intestinal epithelium. Am J Physiol Gastrointest Liver Physiol (2013) 0.97
PPAR-γ agonists and their effects on IGF-I receptor signaling: Implications for cancer. PPAR Res (2009) 0.96
Protein secretion is required for pregnancy-associated plasma protein-A to promote lung cancer growth in vivo. PLoS One (2012) 0.96
Paracrine overexpression of insulin-like growth factor-1 enhances mammary tumorigenesis in vivo. Am J Pathol (2008) 0.96
Antitumorigenic actions of growth hormone-releasing hormone antagonists. Proc Natl Acad Sci U S A (2000) 0.96
Phosphorylation of the mutant K303R estrogen receptor alpha at serine 305 affects aromatase inhibitor sensitivity. Oncogene (2010) 0.95
Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density. BMC Med Genomics (2010) 0.95
An update on the health effects of tomato lycopene. Annu Rev Food Sci Technol (2010) 0.95
Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent. Hum Genet (2008) 0.94
IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients. BMC Med (2010) 0.94
Insights into the beneficial effect of caloric/ dietary restriction for a healthy and prolonged life. Front Physiol (2012) 0.94
A twenty-first century cancer epidemic caused by obesity: the involvement of insulin, diabetes, and insulin-like growth factors. Int J Endocrinol (2013) 0.93
Dietary carbohydrates, fiber, and breast cancer risk in Chinese women. Am J Clin Nutr (2008) 0.93
An association between air pollution and mortality in six U.S. cities. N Engl J Med (1993) 38.84
Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol (1985) 26.13
Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol (1992) 17.17
Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am J Respir Crit Care Med (1995) 15.80
Observations on recent increase in mortality from asthma. Br Med J (1968) 14.82
Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med (2001) 14.48
Design and serendipity in establishing a large cohort with wide dietary intake distributions : the National Institutes of Health-American Association of Retired Persons Diet and Health Study. Am J Epidemiol (2001) 11.17
The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med (1995) 11.08
Body weight and mortality among women. N Engl J Med (1995) 11.04
OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage (2008) 10.99
Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. Int J Epidemiol (1989) 10.98
Validation of questionnaire information on risk factors and disease outcomes in a prospective cohort study of women. Am J Epidemiol (1986) 10.84
Validity of self-reported waist and hip circumferences in men and women. Epidemiology (1990) 10.57
Reproducibility and validity of a self-administered physical activity questionnaire. Int J Epidemiol (1994) 9.90
Reproducibility and validity of food intake measurements from a semiquantitative food frequency questionnaire. J Am Diet Assoc (1993) 9.90
Aspirin and the risk of colorectal cancer in women. N Engl J Med (1995) 9.59
Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements. Am J Epidemiol (1999) 9.34
Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med (2000) 9.05
Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. N Engl J Med (1990) 8.98
No hiding place: on the discomforts of researching the contemporary policy process. J Soc Policy (1990) 8.97
Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study. N Engl J Med (1991) 8.66
Prospective study of alcohol consumption and risk of coronary disease in men. Lancet (1991) 8.64
Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med (1996) 8.57
Test of the National Death Index. Am J Epidemiol (1984) 8.46
Dietary fat intake and the risk of coronary heart disease in women. N Engl J Med (1997) 8.43
Misinterpretation and misuse of the kappa statistic. Am J Epidemiol (1987) 8.29
Evidence based policymaking. BMJ (1995) 8.08
Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet (1991) 7.87
A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. Arch Ophthalmol (1993) 7.73
Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med (1995) 7.62
OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage (2010) 7.52
A meta-analysis of physical activity in the prevention of coronary heart disease. Am J Epidemiol (1990) 7.24
Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care (1994) 7.11
Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA (1998) 7.09
Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med (2001) 7.07
Guidelines for healthy weight. N Engl J Med (1999) 7.03
Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire. Am J Clin Nutr (1999) 7.02
Plasma organochlorine levels and the risk of breast cancer. N Engl J Med (1997) 7.02
Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. JAMA (1997) 6.92
Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science (1998) 6.50
The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med (2001) 6.37
Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med (1993) 6.37
Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men. Arch Intern Med (2001) 6.23
Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med (1999) 6.21
Abdominal adiposity and coronary heart disease in women. JAMA (1998) 6.21
Dietary fiber and the risk of colorectal cancer and adenoma in women. N Engl J Med (1999) 6.17
A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. N Engl J Med (1991) 6.13
A prospective study of family history and the risk of colorectal cancer. N Engl J Med (1994) 6.12