SMART, a simple modular architecture research tool: identification of signaling domains.

PubWeight™: 36.83‹?› | Rank: Top 0.01% | All-Time Top 10000

🔗 View Article (PMC 34487)

Published in Proc Natl Acad Sci U S A on May 26, 1998

Authors

J Schultz1, F Milpetz, P Bork, C P Ponting

Author Affiliations

1: European Molecular Biology Laboratory, Meyerhofstr.1, 69012 Heidelberg, Germany.

Articles citing this

(truncated to the top 100)

MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res (2004) 168.89

The COG database: an updated version includes eukaryotes. BMC Bioinformatics (2003) 60.98

MUSCLE: a multiple sequence alignment method with reduced time and space complexity. BMC Bioinformatics (2004) 50.89

Identifying biological themes within lists of genes with EASE. Genome Biol (2003) 31.72

Recent improvements to the SMART domain-based sequence annotation resource. Nucleic Acids Res (2002) 25.06

The InterPro database, an integrated documentation resource for protein families, domains and functional sites. Nucleic Acids Res (2001) 24.45

PANTHER: a library of protein families and subfamilies indexed by function. Genome Res (2003) 21.64

SMART 4.0: towards genomic data integration. Nucleic Acids Res (2004) 19.37

SMART: a web-based tool for the study of genetically mobile domains. Nucleic Acids Res (2000) 17.77

SMART 5: domains in the context of genomes and networks. Nucleic Acids Res (2006) 17.13

Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79

Human protein reference database as a discovery resource for proteomics. Nucleic Acids Res (2004) 9.99

SMART 6: recent updates and new developments. Nucleic Acids Res (2008) 9.80

SMART 7: recent updates to the protein domain annotation resource. Nucleic Acids Res (2011) 9.15

FunSpec: a web-based cluster interpreter for yeast. BMC Bioinformatics (2002) 8.01

Genome-wide analysis of NBS-LRR-encoding genes in Arabidopsis. Plant Cell (2003) 7.66

PANTHER: a browsable database of gene products organized by biological function, using curated protein family and subfamily classification. Nucleic Acids Res (2003) 7.21

Measuring genome evolution. Proc Natl Acad Sci U S A (1998) 6.97

Genome-wide detection of tissue-specific alternative splicing in the human transcriptome. Nucleic Acids Res (2002) 6.71

Epigenetic protein families: a new frontier for drug discovery. Nat Rev Drug Discov (2012) 6.70

Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum. J Bacteriol (2001) 6.46

Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila. Cell (2009) 6.16

Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain. Genes Dev (2004) 5.72

Selection in the evolution of gene duplications. Genome Biol (2002) 5.58

The ankyrin repeat as molecular architecture for protein recognition. Protein Sci (2004) 5.07

A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes. Genome Biol (2004) 4.94

A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. J Exp Med (2004) 4.81

Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomics. Microbiol Mol Biol Rev (2001) 4.75

AutoFACT: an automatic functional annotation and classification tool. BMC Bioinformatics (2005) 4.26

SMART: recent updates, new developments and status in 2015. Nucleic Acids Res (2014) 4.19

Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J Natl Cancer Inst (2001) 4.14

Stimulus perception in bacterial signal-transducing histidine kinases. Microbiol Mol Biol Rev (2006) 4.12

Signals, regulatory networks, and materials that build and break bacterial biofilms. Microbiol Mol Biol Rev (2009) 4.11

Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol (2004) 3.98

Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world. Plant Cell (2003) 3.80

The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens. Proc Natl Acad Sci U S A (2002) 3.72

The SRA methyl-cytosine-binding domain links DNA and histone methylation. Curr Biol (2007) 3.70

The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Mol Cell Biol (2001) 3.68

Protein subfamily assignment using the Conserved Domain Database. BMC Res Notes (2008) 3.62

A novel two-component hybrid molecule regulates vascular morphogenesis of the Arabidopsis root. Genes Dev (2000) 3.60

Systematic identification of novel protein domain families associated with nuclear functions. Genome Res (2002) 3.50

PDZ domain binding selectivity is optimized across the mouse proteome. Science (2007) 3.47

A post-docking role for active zone protein Rim. Nat Neurosci (2001) 3.40

A census of membrane-bound and intracellular signal transduction proteins in bacteria: bacterial IQ, extroverts and introverts. BMC Microbiol (2005) 3.38

Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes. J Bacteriol (2002) 3.35

Central roles of small GTPases in the development of cell polarity in yeast and beyond. Microbiol Mol Biol Rev (2007) 3.30

Lineage-specific loss and divergence of functionally linked genes in eukaryotes. Proc Natl Acad Sci U S A (2000) 3.27

A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev (1999) 3.25

PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats. Am J Hum Genet (2002) 3.21

Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome. Genome Res (2003) 3.21

Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways. Mol Cell Biol (2001) 3.09

Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone. Am J Hum Genet (2002) 3.00

Genetic analysis of crawling and swimming locomotory patterns in C. elegans. Proc Natl Acad Sci U S A (2008) 2.92

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A (2003) 2.89

Nature of the protein universe. Proc Natl Acad Sci U S A (2009) 2.73

Conserved plant genes with similarity to mammalian de novo DNA methyltransferases. Proc Natl Acad Sci U S A (2000) 2.72

Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor. EMBO J (2000) 2.64

DUFs: families in search of function. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 2.61

The identification of functional modules from the genomic association of genes. Proc Natl Acad Sci U S A (2002) 2.59

Genome-wide identification of NBS genes in japonica rice reveals significant expansion of divergent non-TIR NBS-LRR genes. Mol Genet Genomics (2004) 2.56

Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p. EMBO J (2006) 2.52

Functional microdomains in bacterial membranes. Genes Dev (2010) 2.50

Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. EMBO J (2000) 2.49

Identification of genes controlled by the essential YycG/YycF two-component system of Staphylococcus aureus. J Bacteriol (2004) 2.49

Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription. EMBO J (1999) 2.43

The Arabidopsis pxa1 mutant is defective in an ATP-binding cassette transporter-like protein required for peroxisomal fatty acid beta-oxidation. Plant Physiol (2001) 2.33

New insights into the WalK/WalR (YycG/YycF) essential signal transduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in Staphylococcus aureus. J Bacteriol (2007) 2.30

PhyloFacts: an online structural phylogenomic encyclopedia for protein functional and structural classification. Genome Biol (2006) 2.27

Regulation of the Jak2 tyrosine kinase by its pseudokinase domain. Mol Cell Biol (2000) 2.25

Genome-wide analysis of basic/helix-loop-helix transcription factor family in rice and Arabidopsis. Plant Physiol (2006) 2.25

PartsList: a web-based system for dynamically ranking protein folds based on disparate attributes, including whole-genome expression and interaction information. Nucleic Acids Res (2001) 2.23

MADS-box gene family in rice: genome-wide identification, organization and expression profiling during reproductive development and stress. BMC Genomics (2007) 2.19

Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system. Genome Res (2001) 2.19

Genome sequence of the cellulolytic gliding bacterium Cytophaga hutchinsonii. Appl Environ Microbiol (2007) 2.15

Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2. Am J Hum Genet (2004) 2.13

Proteomic analysis of interchromatin granule clusters. Mol Biol Cell (2004) 2.12

Novel features of the polysaccharide-digesting gliding bacterium Flavobacterium johnsoniae as revealed by genome sequence analysis. Appl Environ Microbiol (2009) 2.11

Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals. BMC Bioinformatics (2003) 2.10

Complete genome sequence and analysis of Wolinella succinogenes. Proc Natl Acad Sci U S A (2003) 2.10

Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human. Nucleic Acids Res (2009) 2.09

Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling. EMBO J (2003) 2.09

Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature. Mol Cell Proteomics (2009) 2.08

High-throughput production of human proteins for crystallization: the SGC experience. J Struct Biol (2010) 2.07

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J (2002) 2.07

PDZ domains and their binding partners: structure, specificity, and modification. Cell Commun Signal (2010) 2.07

The structural basis for biphasic kinetics in the folding of the WW domain from a formin-binding protein: lessons for protein design? Proc Natl Acad Sci U S A (2003) 2.05

A Plasmodium whole-genome synteny map: indels and synteny breakpoints as foci for species-specific genes. PLoS Pathog (2005) 2.05

Analysis of septins across kingdoms reveals orthology and new motifs. BMC Evol Biol (2007) 2.04

SHORT INTEGUMENTS1/SUSPENSOR1/CARPEL FACTORY, a Dicer homolog, is a maternal effect gene required for embryo development in Arabidopsis. Plant Physiol (2002) 2.04

Distribution, expression, and motif variability of ankyrin domain genes in Wolbachia pipientis. J Bacteriol (2005) 2.01

The Nod-like receptor (NLR) family: a tale of similarities and differences. PLoS One (2008) 1.99

MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family. Oncogene (2009) 1.98

Mutagenesis of the phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding site in the NH(2)-terminal domain of ezrin correlates with its altered cellular distribution. J Cell Biol (2000) 1.97

Phylogenetic analysis of the human basic helix-loop-helix proteins. Genome Biol (2002) 1.96

A post-synaptic scaffold at the origin of the animal kingdom. PLoS One (2007) 1.96

Structure and mechanism of ADP-ribose-1''-monophosphatase (Appr-1''-pase), a ubiquitous cellular processing enzyme. Protein Sci (2005) 1.95

Sodium ion cycle in bacterial pathogens: evidence from cross-genome comparisons. Microbiol Mol Biol Rev (2001) 1.95

The rhodanese/Cdc25 phosphatase superfamily. Sequence-structure-function relations. EMBO Rep (2002) 1.94

Comparative analysis of protein domain organization. Genome Res (2004) 1.94

Analysis of the myosins encoded in the recently completed Arabidopsis thaliana genome sequence. Genome Biol (2001) 1.93

Articles cited by this

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res (1994) 392.47

Predicting coiled coils from protein sequences. Science (1991) 38.18

Pfam: a comprehensive database of protein domain families based on seed alignments. Proteins (1997) 26.91

Distinguishing homologous from analogous proteins. Syst Zool (1970) 25.10

Detection of conserved segments in proteins: iterative scanning of sequence databases with alignment blocks. Proc Natl Acad Sci U S A (1994) 18.46

Analysis of compositionally biased regions in sequence databases. Methods Enzymol (1996) 17.11

A workbench for multiple alignment construction and analysis. Proteins (1991) 16.96

Maximum discrimination hidden Markov models of sequence consensus. J Comput Biol (1995) 15.75

A dynamic look at structures: WWW-Entrez and the Molecular Modeling Database. Trends Biochem Sci (1996) 9.95

Proteins regulating Ras and its relatives. Nature (1993) 9.87

PairWise and SearchWise: finding the optimal alignment in a simultaneous comparison of a protein profile against all DNA translation frames. Nucleic Acids Res (1996) 9.82

Searching protein sequence libraries: comparison of the sensitivity and selectivity of the Smith-Waterman and FASTA algorithms. Genomics (1991) 9.65

The PROSITE database, its status in 1997. Nucleic Acids Res (1997) 8.12

Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium. Cell (1997) 7.43

A candidate gene for familial Mediterranean fever. Nat Genet (1997) 7.17

PHD--an automatic mail server for protein secondary structure prediction. Comput Appl Biosci (1994) 6.71

Overview of the yeast genome. Nature (1997) 5.86

The multiplicity of domains in proteins. Annu Rev Biochem (1995) 5.26

Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs. Proc Natl Acad Sci U S A (1997) 4.40

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. J Cell Biol (1995) 4.26

Presence of an SH2 domain in the actin-binding protein tensin. Science (1991) 4.03

A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK. Nature (1996) 3.88

The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway. Trends Biochem Sci (1996) 3.57

PH domain: the first anniversary. Trends Biochem Sci (1994) 3.38

A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: identification of duplicated repeats and potential active site residues. Protein Sci (1996) 3.34

p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins. J Biol Chem (1996) 3.27

Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature (1997) 3.17

Structure and distribution of modules in extracellular proteins. Q Rev Biophys (1996) 3.10

Opitz G/BBB syndrome, a defect of midline development, is due to mutations in a new RING finger gene on Xp22. Nat Genet (1997) 3.03

Recent enhancements to the Blocks Database servers. Nucleic Acids Res (1997) 3.01

SPRY domains in ryanodine receptors (Ca(2+)-release channels). Trends Biochem Sci (1997) 2.82

The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein. Nature (1997) 2.81

Novel developments with the PRINTS protein fingerprint database. Nucleic Acids Res (1997) 2.79

Applying motif and profile searches. Methods Enzymol (1996) 2.78

Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J (1996) 2.76

The death domain: a module shared by proteins with diverse cellular functions. Trends Biochem Sci (1995) 2.70

A novel partner for the GTP-bound forms of rho and rac. FEBS Lett (1995) 2.52

Focal adhesion kinase: at the crossroads of signal transduction. J Cell Sci (1997) 2.51

A phosphotyrosine interaction domain. Cell (1995) 2.28

A duplicated catalytic motif in a new superfamily of phosphohydrolases and phospholipid synthases that includes poxvirus envelope proteins. Trends Biochem Sci (1996) 2.16

Pleckstrin's repeat performance: a novel domain in G-protein signaling? Trends Biochem Sci (1996) 2.13

The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium. Mol Cell Biol (1996) 2.06

Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin. Protein Sci (1996) 2.03

Domain insertion. Protein Eng (1994) 1.98

Cloning and expression of a gene encoding an integrin-like protein in Candida albicans. Proc Natl Acad Sci U S A (1996) 1.88

Direct binding of the platelet integrin alphaIIbbeta3 (GPIIb-IIIa) to talin. Evidence that interaction is mediated through the cytoplasmic domains of both alphaIIb and beta3. J Biol Chem (1996) 1.85

The prediction of transmembrane protein sequences and their conformation: an evaluation. Trends Biochem Sci (1990) 1.85

sn-1,2-Diacylglycerol kinase of Escherichia coli. Purification, reconstitution, and partial amino- and carboxyl-terminal analysis. J Biol Chem (1985) 1.78

The death domain motif found in Fas (Apo-1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance. FEBS Lett (1995) 1.67

An ankyrin-related gene (unc-44) is necessary for proper axonal guidance in Caenorhabditis elegans. J Cell Biol (1995) 1.55

The N-terminal domains of tensin and auxilin are phosphatase homologues. Protein Sci (1996) 1.55

Cytoplasmic signalling domains: the next generation. Trends Biochem Sci (1997) 1.52

Articles by these authors

Initial sequencing and analysis of the human genome. Nature (2001) 212.86

Prediction of deleterious human alleles. Hum Mol Genet (2001) 21.00

Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature (2000) 18.26

SMART: a web-based tool for the study of genetically mobile domains. Nucleic Acids Res (2000) 17.77

HGBASE: a database of SNPs and other variations in and around human genes. Nucleic Acids Res (2000) 11.75

BRCA1 protein products ... Functional motifs... Nat Genet (1996) 11.50

SMART: identification and annotation of domains from signalling and extracellular protein sequences. Nucleic Acids Res (1999) 11.33

Conservation of gene order: a fingerprint of proteins that physically interact. Trends Biochem Sci (1998) 9.94

Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Nature (2000) 9.82

Gene families: the taxonomy of protein paralogs and chimeras. Science (1997) 8.80

Genome phylogeny based on gene content. Nat Genet (1999) 8.12

Measuring genome evolution. Proc Natl Acad Sci U S A (1998) 6.97

IMPALA: matching a protein sequence against a collection of PSI-BLAST-constructed position-specific score matrices. Bioinformatics (1999) 6.91

Quantitative phylogenetic assessment of microbial communities in diverse environments. Science (2007) 6.35

STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene. Nucleic Acids Res (2000) 5.68

Metabolism and evolution of Haemophilus influenzae deduced from a whole-genome comparison with Escherichia coli. Curr Biol (1996) 5.50

Towards a structural basis of human non-synonymous single nucleotide polymorphisms. Trends Genet (2000) 5.41

Predicting protein function by genomic context: quantitative evaluation and qualitative inferences. Genome Res (2000) 5.14

EST comparison indicates 38% of human mRNAs contain possible alternative splice forms. FEBS Lett (2000) 4.96

eggNOG v2.0: extending the evolutionary genealogy of genes with enhanced non-supervised orthologous groups, species and functional annotations. Nucleic Acids Res (2009) 4.55

Differential genome display. Trends Genet (1997) 4.48

Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs. Proc Natl Acad Sci U S A (1997) 4.40

A novel class of RanGTP binding proteins. J Cell Biol (1997) 4.36

REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. RNA (2000) 4.10

The GAF domain: an evolutionary link between diverse phototransducing proteins. Trends Biochem Sci (1997) 4.10

HGVbase: a human sequence variation database emphasizing data quality and a broad spectrum of data sources. Nucleic Acids Res (2002) 4.08

The cytoplasmic helical linker domain of receptor histidine kinase and methyl-accepting proteins is common to many prokaryotic signalling proteins. FEMS Microbiol Lett (1999) 3.86

SNP frequencies in human genes an excess of rare alleles and differing modes of selection. Trends Genet (2000) 3.78

Comparison of ARM and HEAT protein repeats. J Mol Biol (2001) 3.78

Protein repeats: structures, functions, and evolution. J Struct Biol (2001) 3.67

CHROMA: consensus-based colouring of multiple alignments for publication. Bioinformatics (2001) 3.30

Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer. J Mol Biol (1999) 3.28

Automated extraction of information in molecular biology. FEBS Lett (2000) 3.28

HEAT repeats in the Huntington's disease protein. Nat Genet (1995) 3.24

The helix-hairpin-helix DNA-binding motif: a structural basis for non-sequence-specific recognition of DNA. Nucleic Acids Res (1996) 3.20

PAS: a multifunctional domain family comes to light. Curr Biol (1997) 3.20

Non-orthologous gene displacement. Trends Genet (1996) 3.12

Characterization of a novel protein-binding module--the WW domain. FEBS Lett (1995) 3.11

DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins. Trends Biochem Sci (1995) 3.06

Protein annotation: detective work for function prediction. Trends Genet (1998) 3.04

Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem (1995) 3.01

Evolution of domain families. Adv Protein Chem (2000) 2.98

Prediction of potential GPI-modification sites in proprotein sequences. J Mol Biol (1999) 2.95

Yeast chromosome III: new gene functions. EMBO J (1994) 2.85

SPRY domains in ryanodine receptors (Ca(2+)-release channels). Trends Biochem Sci (1997) 2.82

Re-annotating the Mycoplasma pneumoniae genome sequence: adding value, function and reading frames. Nucleic Acids Res (2000) 2.79

Mutations in the fukutin-related protein gene (FKRP) cause a form of congenital muscular dystrophy with secondary laminin alpha2 deficiency and abnormal glycosylation of alpha-dystroglycan. Am J Hum Genet (2001) 2.66

Gene context conservation of a higher order than operons. Trends Biochem Sci (2000) 2.66

Exploitation of gene context. Curr Opin Struct Biol (2000) 2.65

Charting the proteomes of organisms with unsequenced genomes by MALDI-quadrupole time-of-flight mass spectrometry and BLAST homology searching. Anal Chem (2001) 2.65

Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome. Nat Genet (1996) 2.53

Genome evolution. Gene fusion versus gene fission. Trends Genet (2000) 2.53

Sequence properties of GPI-anchored proteins near the omega-site: constraints for the polypeptide binding site of the putative transamidase. Protein Eng (1998) 2.46

SAM as a protein interaction domain involved in developmental regulation. Protein Sci (1997) 2.42

Homology-based method for identification of protein repeats using statistical significance estimates. J Mol Biol (2000) 2.42

Pathway alignment: application to the comparative analysis of glycolytic enzymes. Biochem J (1999) 2.40

Anopheles gambiae pilot gene discovery project: identification of mosquito innate immunity genes from expressed sequence tags generated from immune-competent cell lines. Proc Natl Acad Sci U S A (2000) 2.38

A novel RNA-binding motif in omnipotent suppressors of translation termination, ribosomal proteins and a ribosome modification enzyme? Nucleic Acids Res (1994) 2.37

XplorMed: a tool for exploring MEDLINE abstracts. Trends Biochem Sci (2001) 2.34

Wanted: subcellular localization of proteins based on sequence. Trends Cell Biol (1998) 2.30

A phosphotyrosine interaction domain. Cell (1995) 2.28

PIN domains in nonsense-mediated mRNA decay and RNAi. Curr Biol (2001) 2.26

JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta. Trends Biochem Sci (2001) 2.16

Pleckstrin's repeat performance: a novel domain in G-protein signaling? Trends Biochem Sci (1996) 2.13

A latrophilin/CL-1-like GPS domain in polycystin-1. Curr Biol (1999) 2.08

TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. Mol Cell Biol (2000) 2.07

Sequence variation and disease in the wake of the draft human genome. Hum Mol Genet (2001) 2.07

Swaposins: circular permutations within genes encoding saposin homologues. Trends Biochem Sci (1995) 2.05

On the evolution of protein folds: are similar motifs in different protein folds the result of convergence, insertion, or relics of an ancient peptide world? J Struct Biol (2001) 1.90

Homology among (betaalpha)(8) barrels: implications for the evolution of metabolic pathways. J Mol Biol (2000) 1.83

Variation and evolution of the citric-acid cycle: a genomic perspective. Trends Microbiol (1999) 1.80

Homologues of 26S proteasome subunits are regulators of transcription and translation. Protein Sci (1998) 1.79

A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases. Trends Biochem Sci (1997) 1.76

Evolution of prokaryotic gene order: genome rearrangements in closely related species. Trends Genet (2001) 1.75

Internal repeats in the BRCA2 protein sequence. Nat Genet (1996) 1.72

A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migration. Hum Mol Genet (2001) 1.70

Tracing the spread of fibronectin type III domains in bacterial glycohydrolases. J Mol Evol (1994) 1.69

Missense mutation clustering in the survival motor neuron gene: a role for a conserved tyrosine and glycine rich region of the protein in RNA metabolism? Hum Mol Genet (1997) 1.67

An adhesive domain detected in functionally diverse receptors. Trends Biochem Sci (1993) 1.65

The breast cancer gene product TSG101: a regulator of ubiquitination? J Mol Med (Berl) (1997) 1.64

Challenging times for bioinformatics. Nature (1995) 1.63

Homology-based fold predictions for Mycoplasma genitalium proteins. J Mol Biol (1998) 1.60

The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins. Structure (1999) 1.57

Evolutionarily mobile modules in proteins. Sci Am (1993) 1.57

The N-terminal domains of tensin and auxilin are phosphatase homologues. Protein Sci (1996) 1.55

Protein families in multicellular organisms. Curr Opin Struct Biol (1999) 1.53

Frameshift peptide-derived T-cell epitopes: a source of novel tumor-specific antigens. Int J Cancer (2001) 1.53

Cytoplasmic signalling domains: the next generation. Trends Biochem Sci (1997) 1.52

Quantitative assessment of protein function prediction from metagenomics shotgun sequences. Proc Natl Acad Sci U S A (2007) 1.47

The Spir actin organizers are involved in vesicle transport processes. Curr Biol (2001) 1.45

Integrin alpha- and beta 4-subunit-domain homologues in cyanobacterial proteins. Trends Biochem Sci (1999) 1.45

GRAM, a novel domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins. Trends Biochem Sci (2000) 1.40

Post-translational GPI lipid anchor modification of proteins in kingdoms of life: analysis of protein sequence data from complete genomes. Protein Eng (2001) 1.40