Published in Cell on May 29, 1998
Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nat Med (2001) 3.44
Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. J Gen Physiol (2001) 3.04
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J (2003) 3.02
Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner. J Neurosci (2002) 2.65
Two pacemaker channels from human heart with profoundly different activation kinetics. EMBO J (1999) 2.51
Pacemaker channel dysfunction in a patient with sinus node disease. J Clin Invest (2003) 2.14
Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis. Proc Natl Acad Sci U S A (1999) 2.07
Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. J Neurosci (2003) 1.94
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Assessing the role of Ih channels in synaptic transmission and mossy fiber LTP. Proc Natl Acad Sci U S A (2002) 1.81
Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes. EMBO J (2000) 1.73
Integrated allosteric model of voltage gating of HCN channels. J Gen Physiol (2001) 1.72
Intracellular Ca2+ oscillations drive spontaneous contractions in cardiomyocytes during early development. Proc Natl Acad Sci U S A (1999) 1.71
Hyperpolarization-activated cation channels in fast-spiking interneurons of rat hippocampus. J Physiol (2006) 1.61
The S4-S5 linker couples voltage sensing and activation of pacemaker channels. Proc Natl Acad Sci U S A (2001) 1.60
Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One (2007) 1.57
Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions. J Gen Physiol (2001) 1.55
Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node. J Physiol (2003) 1.54
Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine. J Gen Physiol (2002) 1.52
Voltage-controlled gating at the intracellular entrance to a hyperpolarization-activated cation channel. J Gen Physiol (2002) 1.52
Hyperpolarization-activated currents in presynaptic terminals of mouse cerebellar basket cells. J Physiol (2000) 1.45
Differential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1-4 suggests evolving roles in the developing rat hippocampus. Neuroscience (2001) 1.44
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Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels. J Gen Physiol (2003) 1.37
S4 movement in a mammalian HCN channel. J Gen Physiol (2003) 1.36
C-Linker of cyclic nucleotide-gated channels controls coupling of ligand binding to channel gating. J Gen Physiol (1999) 1.35
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Exploring HCN channels as novel drug targets. Nat Rev Drug Discov (2011) 1.28
Dual allosteric modulation of pacemaker (f) channels by cAMP and voltage in rabbit SA node. J Physiol (1999) 1.28
Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels. J Physiol (2006) 1.28
Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem (2011) 1.26
Calcium influx through hyperpolarization-activated cation channels (I(h) channels) contributes to activity-evoked neuronal secretion. Proc Natl Acad Sci U S A (2004) 1.21
Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity. Proc Natl Acad Sci U S A (2006) 1.19
Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents. J Gen Physiol (2006) 1.19
Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels. J Gen Physiol (2007) 1.19
Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels. J Physiol (2006) 1.17
Movements near the gate of a hyperpolarization-activated cation channel. J Gen Physiol (2003) 1.17
Modulation of a presynaptic hyperpolarization-activated cationic current (I(h)) at an excitatory synaptic terminal in the rat auditory brainstem. J Physiol (2001) 1.14
Functional expression of the hyperpolarization-activated, non-selective cation current I(f) in immortalized HL-1 cardiomyocytes. J Physiol (2002) 1.13
The electrophysiological properties of spontaneously beating pacemaker cells isolated from mouse sinoatrial node. J Physiol (2003) 1.13
How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels. Nat Chem Biol (2011) 1.12
The antiarrhythmic effect of n-3 polyunsaturated fatty acids: modulation of cardiac ion channels as a potential mechanism. J Membr Biol (2005) 1.12
Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2. Neurobiol Dis (2008) 1.12
Contribution of the hyperpolarization-activated current to the resting membrane potential of rat nodose sensory neurons. J Physiol (1999) 1.12
HCN-related channelopathies. Pflugers Arch (2010) 1.11
Tyrosine kinase inhibition differentially regulates heterologously expressed HCN channels. Pflugers Arch (2003) 1.11
The magnitudes of hyperpolarization-activated and low-voltage-activated potassium currents co-vary in neurons of the ventral cochlear nucleus. J Neurophysiol (2011) 1.10
Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels. J Physiol (2003) 1.10
Mechanism of electromechanical coupling in voltage-gated potassium channels. Front Pharmacol (2012) 1.09
KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents. Pflugers Arch (2003) 1.08
The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path. Proc Natl Acad Sci U S A (2005) 1.06
Controlling potassium channel activities: Interplay between the membrane and intracellular factors. Proc Natl Acad Sci U S A (2001) 1.05
An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision. J Neurosci (2012) 1.03
A homology model of the pore region of HCN channels. Biophys J (2005) 1.02
Statistical limits to the identification of ion channel domains by sequence similarity. J Gen Physiol (2006) 1.02
Countervailing modulation of Ih by neuropeptide Y and corticotrophin-releasing factor in basolateral amygdala as a possible mechanism for their effects on stress-related behaviors. J Neurosci (2010) 1.02
Is neuronal death required for seizure-induced epileptogenesis in the immature brain? Prog Brain Res (2002) 1.02
Voltage-dependent gating of single wild-type and S4 mutant KAT1 inward rectifier potassium channels. J Gen Physiol (1998) 1.01
Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes. Biochim Biophys Acta (2009) 1.01
Structural changes during HCN channel gating defined by high affinity metal bridges. J Gen Physiol (2012) 1.00
The fast and slow ups and downs of HCN channel regulation. Channels (Austin) (2011) 1.00
HCN-encoded pacemaker channels: from physiology and biophysics to bioengineering. J Membr Biol (2007) 1.00
Cortical HCN channels: function, trafficking and plasticity. J Physiol (2014) 0.99
Caveolin-3 associates with and affects the function of hyperpolarization-activated cyclic nucleotide-gated channel 4. Biochemistry (2008) 0.99
Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels. J Biol Chem (2009) 0.99
High-pass filtering of input signals by the Ih current in a non-spiking neuron, the retinal rod bipolar cell. PLoS One (2007) 0.99
Cyclic nucleotide-regulated cation channels. J Biol Chem (2008) 0.99
Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate. J Gen Physiol (2012) 0.99
Cloning and functional expression of rat ether-à-go-go-like K+ channel genes. J Physiol (1998) 0.98
Energetics of cyclic AMP binding to HCN channel C terminus reveal negative cooperativity. J Biol Chem (2011) 0.97
Modulation of the hyperpolarization-activated cation current of rat thalamic relay neurones by intracellular pH. J Physiol (1999) 0.97
The Yin and Yang of the H-Channel and Its Role in Epilepsy. Epilepsy Curr (2004) 0.96
Functional expression and regulation of the hyperpolarization activated non-selective cation current in embryonic stem cell-derived cardiomyocytes. J Physiol (2000) 0.96
Determinants of activation kinetics in mammalian hyperpolarization-activated cation channels. J Physiol (2001) 0.96
Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531. Am J Physiol Cell Physiol (2007) 0.95
Calcium influx through If channels in rat ventricular myocytes. Am J Physiol Cell Physiol (2006) 0.93
Functional characterisation and subcellular localisation of HCN1 channels in rabbit retinal rod photoreceptors. J Physiol (2002) 0.93
Intrinsic physiological properties of the five types of mouse ganglion-cell photoreceptors. J Neurophysiol (2013) 0.93
HCN channels in the heart: lessons from mouse mutants. Br J Pharmacol (2012) 0.93
Hyperpolarization activated cyclic-nucleotide gated (HCN) channels in developing neuronal networks. Prog Neurobiol (2008) 0.93
Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits. PLoS One (2012) 0.92
HCN channels expressed in the inner ear are necessary for normal balance function. J Neurosci (2011) 0.92
Postnatal development of dendritic synaptic integration in rat neocortical pyramidal neurons. J Neurophysiol (2009) 0.92
Dual Regulation of Voltage-Sensitive Ion Channels by PIP(2). Front Pharmacol (2012) 0.91
Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP. J Biol Chem (2012) 0.91
Effects of surface water on protein dynamics studied by a novel coarse-grained normal mode approach. Biophys J (2008) 0.90
Action of internal pronase on the f-channel kinetics in the rabbit SA node. J Physiol (1999) 0.90
Ancient gene transfer from algae to animals: mechanisms and evolutionary significance. BMC Evol Biol (2012) 0.90
Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells. J Comp Neurol (2011) 0.89
Molecular mechanism underlying phosphatidylinositol 4,5-bisphosphate-induced inhibition of SpIH channels. J Biol Chem (2011) 0.89
Pore topology of the hyperpolarization-activated cyclic nucleotide-gated channel from sea urchin sperm. Biophys J (2002) 0.89
Use-dependent inhibition of hHCN4 by ivabradine and relationship with reduction in pacemaker activity. Br J Pharmacol (2006) 0.88
Calcium-dependent binding of HCN1 channel protein to hair cell stereociliary tip link protein protocadherin 15 CD3. J Biol Chem (2008) 0.88
K+ channel regulator KCR1 suppresses heart rhythm by modulating the pacemaker current If. PLoS One (2008) 0.87
Unlocking the mechanisms of HCN channel gating with locked-open and locked-closed channels. J Gen Physiol (2012) 0.87
Genomic biomarkers of SUDEP in brain and heart. Epilepsy Behav (2013) 0.87
Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy. Neurobiol Dis (2007) 0.86
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