Published in Exp Cell Res on June 15, 1998
Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi. BMC Genomics (2005) 2.66
Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. J Cell Biol (1998) 2.60
Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells. Science (2014) 2.43
An unappreciated role for RNA surveillance. Genome Biol (2004) 2.28
The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing. Mol Cell Biol (1999) 2.09
Phosphorylation regulates in vivo interaction and molecular targeting of serine/arginine-rich pre-mRNA splicing factors. J Cell Biol (1999) 2.00
Processive phosphorylation of alternative splicing factor/splicing factor 2. Proc Natl Acad Sci U S A (2003) 1.75
Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis. Cell Metab (2010) 1.75
Regulation of splicing by SR proteins and SR protein-specific kinases. Chromosoma (2013) 1.53
Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation. Structure (2009) 1.36
Detained introns are a novel, widespread class of post-transcriptionally spliced introns. Genes Dev (2015) 1.31
Conserved sequence elements associated with exon skipping. Nucleic Acids Res (2003) 1.23
Regulation and substrate specificity of the SR protein kinase Clk/Sty. Mol Cell Biol (2003) 1.20
Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. J Mol Biol (2008) 1.17
Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions. Mol Biol Cell (2001) 1.14
The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site. BMC Biochem (2006) 1.10
Chemical treatment enhances skipping of a mutated exon in the dystrophin gene. Nat Commun (2011) 1.05
Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor. J Cell Biol (2011) 1.02
Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development. Mol Cell Biol (2004) 1.01
Latent herpes simplex virus infection of sensory neurons alters neuronal gene expression. J Virol (2003) 1.01
Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1. J Mol Biol (2009) 0.99
Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy. Retrovirology (2011) 0.99
Functional coexpression of serine protein kinase SRPK1 and its substrate ASF/SF2 in Escherichia coli. Nucleic Acids Res (2000) 0.96
Digoxin suppresses HIV-1 replication by altering viral RNA processing. PLoS Pathog (2013) 0.95
Mechanism of dephosphorylation of the SR protein ASF/SF2 by protein phosphatase 1. J Mol Biol (2010) 0.94
Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation. J Biol Chem (2010) 0.92
HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models. J Clin Invest (2015) 0.88
Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. BMC Genomics (2008) 0.86
DAP-like kinase interacts with the rat homolog of Schizosaccharomyces pombe CDC5 protein, a factor involved in pre-mRNA splicing and required for G2/M phase transition. Nucleic Acids Res (2002) 0.86
Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1α and MED1 complex. Diabetes (2014) 0.85
Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function. Biochem J (2015) 0.85
spp42, identified as a classical suppressor of prp4-73, which encodes a kinase involved in pre-mRNA splicing in fission yeast, is a homologue of the splicing factor Prp8p. Genetics (1999) 0.85
SR protein kinases promote splicing of nonconsensus introns. Nat Struct Mol Biol (2015) 0.85
Splicing changes in SMA mouse motoneurons and SMN-depleted neuroblastoma cells: evidence for involvement of splicing regulatory proteins. RNA Biol (2014) 0.84
PSKH1, a novel splice factor compartment-associated serine kinase. Nucleic Acids Res (2002) 0.84
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett (2013) 0.82
Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion. Nucleic Acids Res (2013) 0.82
Identification of distant drug off-targets by direct superposition of binding pocket surfaces. PLoS One (2013) 0.78
Cdc2-like kinase 2 is a key regulator of the cell cycle via FOXO3a/p27 in glioblastoma. Oncotarget (2016) 0.77
Pharmacology of Modulators of Alternative Splicing. Pharmacol Rev (2017) 0.75
Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity. Proc Natl Acad Sci U S A (2017) 0.75
CDK13, a Kinase Involved in Pre-mRNA Splicing, Is a Component of the Perinucleolar Compartment. PLoS One (2016) 0.75
Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature (1996) 6.02
The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J (1996) 4.65
Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Nat Med (2000) 4.37
Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. J Biol Chem (1999) 2.65
A case of multicentric intranodal palisaded myofibroblastoma. Histopathology (1994) 2.09
The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus. J Virol (2000) 2.08
STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases. Mol Cell Biol (1991) 1.97
In vivo regulation of alternative pre-mRNA splicing by the Clk1 protein kinase. Mol Cell Biol (1997) 1.81
Influenza vaccination. JAMA (1983) 1.77
SARCOMA OF THE SMALL INTESTINE: REPORT OF FOUR CASES. Ann Surg (1942) 1.76
Switching from competition to sharing or cooperation at large response requirements: competition requires more responding. J Exp Anal Behav (1975) 1.68
TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. J Biol Chem (1991) 1.44
Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms. Mol Cell Biol (1992) 1.42
Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. J Mol Biol (1994) 1.41
SR protein kinases: the splice of life. Biochem Cell Biol (1999) 1.40
Abnormal capnogragh trace. Anaesthesia (2000) 1.39
Phosphorylation sites on phosphoprotein NS of vesicular stomatitis virus. J Virol (1985) 1.37
Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53. Mol Cell Biol (1999) 1.34
Should infants be screened for anaemia? A prospective study investigating the relation between haemoglobin at 8, 12, and 18 months and development at 18 months. Arch Dis Child (2001) 1.33
Primed abortive initiation of RNA synthesis by E. coli RNA polymerase on T7 DNA. Steady state kinetic studies. Nucleic Acids Res (1978) 1.31
Protein kinase activity associated with immunoprecipitates of the vesicular stomatitis virus phosphoprotein NS. Virology (1984) 1.31
Alternative splicing of STY, a nuclear dual specificity kinase. J Biol Chem (1995) 1.30
Characterization of the multidrug resistance protein expressed in cell clones stably transfected with the mouse mdr1 cDNA. Cancer Res (1989) 1.30
The stereochemical basis of template function. Eur J Biochem (1977) 1.29
Outcomes of pregnancies in women with pre-gestational diabetes mellitus and gestational diabetes mellitus; a population-based study in New South Wales, Australia, 1998-2002. Diabet Med (2008) 1.22
Differentiation and maturation of embryonal carcinoma-derived neurons in cell culture. J Neurosci (1988) 1.20
The incidence of salmonella infection in sheep in England and Wales, 1975 to 1981. Br Vet J (1983) 1.16
The effects of thioketo substitution upon uracil-adenine interactions in polyribonucleotides. Synthesis and properties of poly (2-thiouridylic acid) and poly(2,4-dithiouridylic acid). Eur J Biochem (1973) 1.13
Taming the Trojan horse: optimizing dynamic carrier cell/oncolytic virus systems for cancer biotherapy. Gene Ther (2008) 1.12
Studies of the topography of the binding site of DNA-dependent RNA polymerase from Escherichia coli for the antibiotic rifamycin SV. Eur J Biochem (1977) 1.09
Activation of NF-kappaB by double-stranded RNA (dsRNA) in the absence of protein kinase R and RNase L demonstrates the existence of two separate dsRNA-triggered antiviral programs. Mol Cell Biol (2001) 1.07
Steady state kinetic studies of initiation of RNA synthesis on T7 DNA in the presence of rifampicin. Nucleic Acids Res (1977) 1.07
Seminaplasmin is a potent inhibitor of E. coli RNA polymerase in vivo. Nature (1979) 1.04
The enzymatic synthesis of poly 4-thiouridylic acid by polynucleotide phosphorylase from Escherichia coli. Biochim Biophys Acta (1970) 1.04
A pyrimidine nucleoside in the syn conformation: molecular and crystal structure of 4-thiouridine-hydrate. J Mol Biol (1970) 1.02
Human elongation factor 1 beta: cDNA and derived amino acid sequence. Biochem Biophys Res Commun (1991) 1.02
In vitro in corporation of 2'-deoxyadenosine and 3'-deoxyadenosine into yeast tRNA Phe using t-RNA nucleotidyl transferase, and properties of tRNA Phe -C-C-2'dA and tRNA Phe -C-C-3'dA. Biochem Biophys Res Commun (1973) 1.01
Proteins of vesicular stomatitis virus. V. Identification of a precursor to the phosphoprotein of Piry virus. J Virol (1979) 1.00
[On the synthesis and properties of 4-thiouridylyl-(3'-5')-4-thiouridine, 4-thiouridylyl-(3'-5')-uridine and uridylyl-(3'-5')-4-thiouridine]. Biochim Biophys Acta (1968) 1.00
Cost effectiveness of vaccination against pneumococcal pneumonia. N Engl J Med (1980) 1.00
Oncolytic activity of vesicular stomatitis virus in primary adult T-cell leukemia. Oncogene (2006) 0.99
Myelin-associated glycoprotein, a cell adhesion molecule of oligodendrocytes, is phosphorylated in brain. Mol Cell Biol (1988) 0.99
Different host-cell shutoff strategies related to the matrix protein lead to persistence of vesicular stomatitis virus mutants on fibroblast cells. Virus Res (2001) 0.98
Cloning and sequence analysis of a cDNA encoding poly-ubiquitin in human ovarian granulosa cells. Biochem Biophys Res Commun (1987) 0.97
Salmonella infection in horses in England and Wales, 1973 to 1979. Vet Rec (1981) 0.97
The modification of DNA-dependent RNA polymerase from Escherichia coli by an alkylating derivative of rifamycin SV. Eur J Biochem (1975) 0.97
The interactions of 2-thiopyrimidine bases with hydroxymercurybenzene sulfonate. Eur J Biochem (1973) 0.97
Affinity labeling of E. coli RNA polymerase with substrate and template analogues. Biochem Biophys Res Commun (1973) 0.96
Preparation in vitro of a 2-thiocytidine-containing yeast tRNA Phe -A 73 -C 74 -S 2 C 75 -A 76 and its interaction wiith p-hydroxymercuribenzoate. Eur J Biochem (1973) 0.95
Gene expression and cDNA cloning identified a major basic protein constituent of bovine seminal plasma as bovine monocyte-chemoattractant protein-1 (MCP-1). DNA Cell Biol (1991) 0.94
Synthesis and properties of a new fluorescent polynucleotide, poly(1,N6-ethenoadenylic acid). Biochim Biophys Acta (1973) 0.94
Amino acid sequence of seminalplasmin, an antimicrobial protein from bull semen. EMBO J (1983) 0.94
Demonstration of ignition radiation temperatures in indirect-drive inertial confinement fusion hohlraums. Phys Rev Lett (2011) 0.93
Identification of protein S 1 at the messenger RNA binding site of the Escherichia coli ribosome. Biochem Biophys Res Commun (1974) 0.93
Detection and verification of quantitative trait loci for resistance to Dothistroma needle blight in Pinus radiata. Theor Appl Genet (2004) 0.93
Hierarchical patterns of correlated mating in Acacia melanoxylon. Genetics (1991) 0.92
A new polynucleotide complex poly(s 2 C)-poly(I). Eur J Biochem (1972) 0.92
The synthesis of the alternating copolymer poly(r(A-s4U)) by RNA polymerase of Escherichia coli. Eur J Biochem (1971) 0.91
Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41. Biochem Biophys Res Commun (1992) 0.91
Salmonellosis in horses and wild birds. Vet Rec (1980) 0.90
The interferon system: a review with emphasis on the role of PKR in growth control. Cancer Invest (1995) 0.90
Control of zoonoses in Britain: past, present, and future. Br Med J (Clin Res Ed) (1983) 0.90
Characterization of a monoclonal antibody specific for prostatic secretory protein of 94 amino acids (PSP94) and development of a two-site binding enzyme immunoassay for PSP94. Clin Chim Acta (1990) 0.90
Differential phosphorylation of myelin-associated glycoprotein isoforms in cell culture. J Neurochem (1990) 0.90
Dual specificity kinases--a new family of signal transducers. Cancer Metastasis Rev (1994) 0.89
Phosphorylation and disruption of intermediate filament proteins in oligodendrocyte precursor cultures treated with calyculin A. J Neurosci Res (1993) 0.89
Oncolytic viruses: programmable tumour hunters. Curr Gene Ther (2002) 0.89
SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds. Cell Death Dis (2011) 0.89
Abelson-transformed fibroblasts contain nuclear phosphotyrosyl-proteins which preferentially bind to murine DNA. Nature (1987) 0.89
Proteins at the mRNA binding site of the Escherichia coli ribosome. FEBS Lett (1975) 0.88
Lineage-specific transformation after differentiation of multipotential murine stem cells containing a human oncogene. Mol Cell Biol (1986) 0.88
Discontinuation of epidural analgesia late in labour for reducing the adverse delivery outcomes associated with epidural analgesia. Cochrane Database Syst Rev (2004) 0.88
[Selective phosphorylation of nucleosides]. Chem Ber (1968) 0.88
[The chemical synthesis of 2,4-dithiothymine nucleosides]. Chem Ber (1970) 0.87
Tyrosine phosphorylation of biliary glycoprotein, a cell adhesion molecule related to carcinoembryonic antigen. Biochim Biophys Acta (1992) 0.87
Synthesis and physicochemical properties of two analogs of poly(dA): poly(2-aminopurine-9-beta-D-deoxyribonucleotide) and poly 2-amino-deoxyadenylic acid. Nucleic Acids Res (1982) 0.87
The effects of thioketo substitution upon uracil-adenine interactions in polyribonucleotides. Synthesis and properties of the alternating polynucleotides poly(r(A-s2U)) and poly(r(A-s2s4U)). Eur J Biochem (1975) 0.87
Substrate specificity of CTP synthetase from Escherichia coli. Eur J Biochem (1982) 0.86
Poly(4-thiouridylic acid) as messenger RNA and its application for photoaffinity labelling of the ribosomal mRNA binding site. Eur J Biochem (1977) 0.86
Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells. Biol Chem Hoppe Seyler (1989) 0.86
[Methylation of dinucleoside phosphates with diazomethane]. Biochim Biophys Acta (1967) 0.86
The effect of thioketo substitution on uracil-2-aminopurine and uracil-2, 6-diaminopurine interactions in polynucleotides. Biochim Biophys Acta (1976) 0.85
Chemical deglycosylation on a micro-scale of membrane glycoproteins with retention of phosphoryl-protein linkages. J Neurosci Res (1989) 0.84
Antibody response to keyhole limpet hemocyanin (KLH) treatment in patients with superficial bladder carcinoma. Anticancer Res (1996) 0.84
Synthesis and properties of poly(s 2 C), a new poly(C) analog. Eur J Biochem (1971) 0.84
The origin and genetic diversity of Pinus radiata in Australia. Theor Appl Genet (1987) 0.84
Enzymatic synthesis of DNA with 4-thio-thymidine triphosphate as substitute for dTTP. Eur J Biochem (1967) 0.84
Abelson transformed fibroblasts lacking the EGF receptor are not tumourigenic in nude mice. EMBO J (1986) 0.84
A genetic linkage map for Pinus radiata based on RFLP, RAPD, and microsatellite markers. Theor Appl Genet (1996) 0.84
The murine PKR tumor suppressor gene is rearranged in a lymphocytic leukemia. Exp Cell Res (1998) 0.83
[Methylation of inosine and uridylyl-(3'-5')inosine with dimethylsulfate]. Biochim Biophys Acta (1967) 0.83
Induction of interferon by polyribonucleotides containing thiopyrimidines. Nucleic Acids Res (1976) 0.83
Characterization of a new bioactive protein from bovine seminal fluid. Biochem Biophys Res Commun (1991) 0.82