Published in Genes Dev on July 15, 1998
Transcriptional control by the TGF-beta/Smad signaling system. EMBO J (2000) 8.49
A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. Genes Dev (1999) 5.13
TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses. EMBO J (2002) 3.80
Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation. Mol Biol Cell (1999) 3.27
Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions. Biochem J (2003) 2.89
Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease. J Med Genet (2005) 2.72
Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control. Genes Dev (2002) 2.56
Transforming growth factor beta-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth. Mol Cell Biol (2008) 2.27
Impact of cyclin E overexpression on Smad3 activity in breast cancer cell lines. Cell Cycle (2010) 2.19
MicroRNA-144 dysregulates the transforming growth factor-β signaling cascade and contributes to the development of bronchiolitis obliterans syndrome after human lung transplantation. J Heart Lung Transplant (2015) 2.18
Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. Genes Dev (2000) 2.13
Inherited human diseases of heterotopic bone formation. Nat Rev Rheumatol (2010) 1.87
TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch. EMBO J (2008) 1.74
Characterization of a bone morphogenetic protein-responsive Smad-binding element. Mol Biol Cell (2000) 1.66
Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors. J Biol Chem (2009) 1.59
Insights from a rare genetic disorder of extra-skeletal bone formation, fibrodysplasia ossificans progressiva (FOP). Bone (2008) 1.53
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J (2006) 1.47
The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling. J Cell Biol (2001) 1.44
Sequence comparison by sequence harmony identifies subtype-specific functional sites. Nucleic Acids Res (2006) 1.40
Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism. Cytokine Growth Factor Rev (2009) 1.39
Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3. EMBO J (2011) 1.27
Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity. Proc Natl Acad Sci U S A (2008) 1.22
Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif. EMBO J (2002) 1.20
Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2. Mol Cell Biol (2003) 1.19
Signal transduction in vasculogenesis and developmental angiogenesis. Int J Dev Biol (2011) 1.17
Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb. J Biol Chem (2010) 1.16
Nuclear interpretation of Dpp signaling in Drosophila. EMBO J (2001) 1.15
Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells. J Biol Chem (2009) 1.12
Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins. Nucleic Acids Res (2001) 1.04
The Smads. Genome Biol (2001) 1.03
Activin B can signal through both ALK4 and ALK7 in gonadotrope cells. Reprod Biol Endocrinol (2006) 1.00
Determining the basis of channel-tetramerization specificity by x-ray crystallography and a sequence-comparison algorithm: Family Values (FamVal). Proc Natl Acad Sci U S A (2003) 0.99
Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem Biol (2013) 0.99
Smad inhibition by the Ste20 kinase Misshapen. Proc Natl Acad Sci U S A (2011) 0.96
TGF-β signaling via TAK1 pathway: role in kidney fibrosis. Semin Nephrol (2012) 0.96
Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction. J Biol Chem (2010) 0.96
HILI inhibits TGF-β signaling by interacting with Hsp90 and promoting TβR degradation. PLoS One (2012) 0.95
Dynamic analysis of BMP-responsive smad activity in live zebrafish embryos. Dev Dyn (2011) 0.94
A p90(rsk) mutant constitutively interacting with MAP kinase uncouples MAP kinase from p34(cdc2)/cyclin B activation in Xenopus oocytes. Mol Biol Cell (1999) 0.93
TGF-β signaling and its targeting for glioma treatment. Am J Cancer Res (2015) 0.93
MEK1/2 inhibitors block basal and transforming growth factor 1beta1-stimulated JC virus multiplication. J Virol (2007) 0.90
Transforming growth factor beta receptor signaling and endocytosis are linked through a COOH terminal activation motif in the type I receptor. Mol Biol Cell (2001) 0.90
Smad signalling in the ovary. Reprod Biol Endocrinol (2006) 0.88
Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β. J Biol Chem (2013) 0.87
Changes in expression, and/or mutations in TGF-beta receptors (TGF-beta RI and TGF-beta RII) and Smad 4 in human ovarian tumors. J Cancer Res Clin Oncol (2010) 0.87
Bone morphogenetic protein 2 signals via BMPR1A to regulate murine follicle-stimulating hormone beta subunit transcription. Biol Reprod (2009) 0.85
Functional analysis of saxophone, the Drosophila gene encoding the BMP type I receptor ortholog of human ALK1/ACVRL1 and ACVR1/ALK2. Genetics (2009) 0.85
Characterization of negative feedback network motifs in the TGF-β signaling pathway. PLoS One (2013) 0.84
Inhibition of TGF-β signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and Smad3, and PPM1A. Sci Signal (2013) 0.83
Coated pit-mediated endocytosis of the type I transforming growth factor-β (TGF-β) receptor depends on a di-leucine family signal and is not required for signaling. J Biol Chem (2012) 0.83
Mutations in protein-binding hot-spots on the hub protein Smad3 differentially affect its protein interactions and Smad3-regulated gene expression. PLoS One (2011) 0.82
Molecular characterization of TGF-β type I receptor gene (Tgfbr1) in Chlamys farreri, and the association of allelic variants with growth traits. PLoS One (2012) 0.82
Diversity is in my veins: role of bone morphogenetic protein signaling during venous morphogenesis in zebrafish illustrates the heterogeneity within endothelial cells. Arterioscler Thromb Vasc Biol (2014) 0.81
The bone morphogenetic protein type Ib receptor is a major mediator of glial differentiation and cell survival in adult hippocampal progenitor cell culture. Mol Biol Cell (2004) 0.80
Tid1 is a Smad-binding protein that can modulate Smad7 activity in developing embryos. Biochem J (2006) 0.79
Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells. Am J Physiol Endocrinol Metab (2012) 0.79
p21-Activated kinase 2 (PAK2) inhibits TGF-β signaling in Madin-Darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interaction. J Biol Chem (2012) 0.78
Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem (2014) 0.78
A phase I dose-escalation study to a predefined dose of a transforming growth factor-β1 monoclonal antibody (TβM1) in patients with metastatic cancer. Int J Oncol (2014) 0.77
[The head inducer Cerberus in a multivalent extracellular inhibitor]. J Soc Biol (1999) 0.77
Mechanical stretch down-regulates expression of the Smad6 gene in cultured rat mesangial cells. Clin Exp Nephrol (2012) 0.76
Structure of Drosophila Mad MH2 domain. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.76
TGF-β-activated kinase-1: New insights into the mechanism of TGF-β signaling and kidney disease. Kidney Res Clin Pract (2012) 0.75
ALK1 signaling in development and disease: new paradigms. Cell Mol Life Sci (2017) 0.75
TGF-beta signal transduction. Annu Rev Biochem (1998) 17.83
TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature (1997) 15.75
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science (1996) 11.13
The transforming growth factor-beta family. Annu Rev Cell Biol (1990) 10.62
Signaling through scaffold, anchoring, and adaptor proteins. Science (1997) 9.48
TGF beta signals through a heteromeric protein kinase receptor complex. Cell (1992) 8.12
Mechanism of activation of the TGF-beta receptor. Nature (1994) 8.10
Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev (1996) 7.43
The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev (1994) 5.65
Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature (1996) 5.30
Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature (1996) 5.21
MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell (1996) 4.70
GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. EMBO J (1995) 4.63
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J (1997) 4.48
Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature (1997) 4.41
A human Mad protein acting as a BMP-regulated transcriptional activator. Nature (1996) 4.36
A transcriptional partner for MAD proteins in TGF-beta signalling. Nature (1996) 4.26
MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell (1996) 3.87
Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature (1997) 3.66
Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics (1995) 3.45
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev (1997) 3.33
A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature (1997) 3.29
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev (1997) 3.28
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev (1998) 3.16
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature (1997) 3.12
Characterization of type I receptors for transforming growth factor-beta and activin. Science (1994) 2.94
Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components. Proc Natl Acad Sci U S A (1996) 2.84
Structural framework for the protein kinase family. Annu Rev Cell Biol (1992) 2.74
Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. Mol Cell Biol (1994) 2.59
Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily. Cell (1996) 2.56
A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes Dev (1996) 2.47
Disruption of transforming growth factor beta signaling by a mutation that prevents transphosphorylation within the receptor complex. Mol Cell Biol (1995) 2.08
Mechanism of TGFbeta receptor inhibition by FKBP12. EMBO J (1997) 2.06
Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol Cell Biol (1997) 2.05
Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development (1997) 1.91
Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms. J Biol Chem (1990) 1.86
Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth. Proc Natl Acad Sci U S A (1996) 1.67
A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity. EMBO J (1997) 1.65
Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor. Development (1996) 1.63
Bone morphogenetic proteins in the nervous system. Trends Neurosci (1997) 1.62
Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling. EMBO J (1996) 1.61
The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors. EMBO J (1998) 1.54
Smad5 induces ventral fates in Xenopus embryo. Dev Biol (1997) 1.49
Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo. EMBO J (1995) 1.45
Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers. Cancer Res (1996) 1.41
Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase. Proc Natl Acad Sci U S A (1997) 1.34
Transcriptional regulation by transforming growth factor beta of the expression of retinoic acid and retinoid X receptor genes in osteoblastic cells is mediated through AP-1. J Biol Chem (1996) 1.00
Activins and the receptor serine kinase superfamily. Recent Prog Horm Res (1995) 0.88
TGFbeta signaling in growth control, cancer, and heritable disorders. Cell (2000) 12.38
Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem (1986) 10.00
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell (1994) 9.48
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol (2000) 9.16
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature (1995) 9.03
Transcriptional control by the TGF-beta/Smad signaling system. EMBO J (2000) 8.49
TGF beta signals through a heteromeric protein kinase receptor complex. Cell (1992) 8.12
Mechanism of activation of the TGF-beta receptor. Nature (1994) 8.10
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature (1996) 6.67
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature (2001) 6.62
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell (1999) 6.59
The galvanization of biology: a growing appreciation for the roles of zinc. Science (1996) 5.67
TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J Clin Invest (1999) 5.30
Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature (1996) 5.21
A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. Genes Dev (1999) 5.13
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev (1995) 4.94
CREB-binding protein/p300 are transcriptional coactivators of p65. Proc Natl Acad Sci U S A (1997) 4.71
GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. EMBO J (1995) 4.63
Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature (1997) 4.41
A human Mad protein acting as a BMP-regulated transcriptional activator. Nature (1996) 4.36
YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro. Nature (1991) 4.30
Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways. EMBO J (1994) 4.23
Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol (2001) 4.22
Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev (1995) 4.19
Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature (2000) 4.01
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling. Cell (1998) 3.86
Type beta transforming growth factor is an inhibitor of myogenic differentiation. Proc Natl Acad Sci U S A (1986) 3.83
A molecular variant of angiotensinogen associated with preeclampsia. Nat Genet (1993) 3.78
Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation. Cell (1994) 3.74
TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat Cell Biol (2001) 3.69
Structural basis of IAP recognition by Smac/DIABLO. Nature (2001) 3.66
Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell (1990) 3.61
Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. Nature (1999) 3.59
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J Biol Chem (1992) 3.57
Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature (2000) 3.54
The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors. Cell (1987) 3.52
Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. Cell (1993) 3.51
Betaglycan presents ligand to the TGF beta signaling receptor. Cell (1993) 3.48
Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Cell (1999) 3.47
Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes Dev (1997) 3.45
The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature (1993) 3.45
The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1. J Virol (2000) 3.43
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev (1997) 3.33
A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature (1997) 3.29
Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. Science (1993) 3.28
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev (1997) 3.28
Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta. J Biol Chem (1987) 3.25
Ubiquitin-dependent degradation of TGF-beta-activated smad2. Nat Cell Biol (1999) 3.25
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. Nature (1999) 3.16
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev (1998) 3.16
OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell (2000) 3.12
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature (1997) 3.12
Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1. Nature (1995) 3.11
Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1. Proc Natl Acad Sci U S A (1993) 3.09
A Smad transcriptional corepressor. Cell (1999) 3.07
Structural basis of caspase-7 inhibition by XIAP. Cell (2001) 2.99
A new malformation syndrome of long palpebral fissures, large ears, depressed nasal tip, and skeletal anomalies associated with postnatal dwarfism and mental retardation. J Pediatr (1981) 2.97
Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Nature (1999) 2.95
Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300. Genes Dev (1995) 2.93
A single mutation affects both N-acetylglucosaminyltransferase and glucuronosyltransferase activities in a Chinese hamster ovary cell mutant defective in heparan sulfate biosynthesis. Proc Natl Acad Sci U S A (1992) 2.92
The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Mol Cell (2001) 2.87
The TGF-beta family of growth and differentiation factors. Cell (1987) 2.86
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci U S A (2001) 2.83
Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol Cell Biol (1995) 2.80
SMADs: mediators and regulators of TGF-beta signaling. Curr Opin Genet Dev (1998) 2.76
Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Nat Genet (2001) 2.75
Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system. Cell (1991) 2.73
Regulation of cell adhesion receptors by transforming growth factor-beta. Concomitant regulation of integrins that share a common beta 1 subunit. J Biol Chem (1989) 2.71
The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor. J Biol Chem (1982) 2.62
Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol (1999) 2.61
Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. Mol Cell Biol (1994) 2.59
Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev (1997) 2.59
Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program. Proc Natl Acad Sci U S A (2001) 2.55
Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination. Nat Genet (2000) 2.53
Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15. Nature (1997) 2.51
The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction. Cell (1989) 2.49
Template-switching during DNA synthesis by Thermus aquaticus DNA polymerase I. Nucleic Acids Res (1995) 2.46
Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells. J Biol Chem (1983) 2.42
Cell adhesion protein receptors as targets for transforming growth factor-beta action. Cell (1987) 2.41
Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors. Cell (1992) 2.40
Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases. Cell (1998) 2.40
Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding. Cell (2001) 2.39
Predicting clopidogrel response using DNA samples linked to an electronic health record. Clin Pharmacol Ther (2011) 2.36
The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev (1997) 2.35
Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism. Hum Mol Genet (1999) 2.32
Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4. J Biol Chem (1997) 2.32
The end of the (cell) line: methods for the study of apoptosis in vitro. Methods Cell Biol (1995) 2.32
Transforming growth factor-beta inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor. J Biol Chem (1989) 2.29
Type beta transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts. Proc Natl Acad Sci U S A (1985) 2.28
Transforming growth factor beta regulates the expression and structure of extracellular matrix chondroitin/dermatan sulfate proteoglycans. J Biol Chem (1988) 2.28