Complementation of lymphotoxin alpha knockout mice with tumor necrosis factor-expressing transgenes rectifies defective splenic structure and function.

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Published in J Exp Med on August 17, 1998

Authors

L Alexopoulou1, M Pasparakis, G Kollias

Author Affiliations

1: Department of Molecular Genetics, Hellenic Pasteur Institute, 115 21 Athens, Greece.

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Osteochondroma in a lioness. J Am Vet Med Assoc (1976) 0.80

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