Antiplatelet efficacy of XV459, a novel nonpeptide platelet GPIIb/IIIa antagonist: comparative platelet binding profiles with c7E3.

PubWeight™: 0.77‹?›

🔗 View Article (PMID 9732389)

Published in J Pharmacol Exp Ther on September 01, 1998

Authors

S A Mousa1, J M Bozarth, W Lorelli, M S Forsythe, M J Thoolen, A M Slee, T M Reilly, P A Friedman

Author Affiliations

1: DuPont Pharmaceuticals Co., Wilmington, Delaware, USA.

Articles by these authors

(truncated to the top 100)

Mechanism of action of DuP 721: inhibition of an early event during initiation of protein synthesis. Antimicrob Agents Chemother (1988) 3.36

The mechanism of action of DuP 721, a new antibacterial agent: effects on macromolecular synthesis. Biochem Biophys Res Commun (1988) 2.70

Antibiotics and nucleic acids. Annu Rev Biochem (1971) 2.20

Phosphoenolpyruvate-dependent sucrose phosphotransferase activity in Streptococcus mutans NCTC 10449. Infect Immun (1979) 2.02

Disintegrins: a family of integrin inhibitory proteins from viper venoms. Proc Soc Exp Biol Med (1990) 1.85

Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase. J Biol Chem (1990) 1.68

Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain. J Biol Chem (1972) 1.53

Pressor effect of naloxone in septic shock. Lancet (1981) 1.53

Early scintigraphic detection of experimental myocardial infarction in dogs with technetium-99m-glucaric acid. J Nucl Med (1991) 1.50

The pericyte as a possible osteoblast progenitor cell. Clin Orthop Relat Res (1992) 1.49

Physiological dependence on, and symptoms of withdrawal from, chlormethiazole. Br J Psychiatry (1976) 1.48

Echistatin. A potent platelet aggregation inhibitor from the venom of the viper, Echis carinatus. J Biol Chem (1988) 1.45

Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma. J Clin Invest (1996) 1.43

Investigation of a thrombin inhibitor peptide as an alternative to heparin in cardiopulmonary bypass surgery. Circulation (1993) 1.42

Real-time calcium response of cultured bone cells to fluid flow. Clin Orthop Relat Res (1995) 1.39

Long-term survival after ablation of the atrioventricular node and implantation of a permanent pacemaker in patients with atrial fibrillation. N Engl J Med (2001) 1.38

Successful treatment with pimozide of delusional parasitosis. Br J Dermatol (1978) 1.37

Intra-atrial conduction block along the mitral valve annulus during accessory pathway ablation: evidence for a left atrial "isthmus". J Cardiovasc Electrophysiol (2001) 1.36

Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin. Biochim Biophys Acta (1978) 1.36

Sucrose transport by Streptococcus mutans. Evidence for multiple transport systems. Biochim Biophys Acta (1982) 1.34

Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin. J Biol Chem (2000) 1.33

Mechanism of calcium transport stimulated by chlorothiazide in mouse distal convoluted tubule cells. J Clin Invest (1992) 1.31

A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen. J Biol Chem (1989) 1.27

In vitro evaluation of three iodine-containing compounds as antiplaque agents. Antimicrob Agents Chemother (1977) 1.23

CO2-stimulated NaCl absorption in the mouse renal cortical thick ascending limb of Henle. Evidence for synchronous Na +/H+ and Cl-/HCO3- exchange in apical plasma membranes. J Gen Physiol (1982) 1.21

Predominant microflora associated with human dental periapical abscesses. J Clin Microbiol (1982) 1.20

cDNA cloning and expression of bovine aspartyl (asparaginyl) beta-hydroxylase. J Biol Chem (1992) 1.19

Role of hypoxia and extracellular matrix-integrin binding in the modulation of angiogenic growth factors secretion by retinal pigmented epithelial cells. J Cell Biochem (1999) 1.19

Cardiovascular effects and interaction with adrenoceptors of urapidil. Arch Int Pharmacodyn Ther (1985) 1.18

In vitro evaluation of seven cationic detergents as antiplaque agents. Antimicrob Agents Chemother (1979) 1.17

Antagonists of integrin alpha v beta 3 inhibit retinal neovascularization in a murine model. Lab Invest (1996) 1.16

Parathyroid hormone-related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets. Br J Pharmacol (2001) 1.15

Effect of growth conditions on sucrose phosphotransferase activity of Streptococcus mutans. Infect Immun (1980) 1.15

Response of the kidney to furosemide. I. Effects of salt intake and renal compensation. J Lab Clin Med (1983) 1.14

Structural requirements of guanide, biguanide, and bisbiguanide agents for antiplaque activity. Antimicrob Agents Chemother (1977) 1.13

The implantable cardioverter defibrillator. Lancet (2001) 1.12

Vitamin K-dependent carboxylase. Stoichiometry of carboxylation and vitamin K 2,3-epoxide formation. J Biol Chem (1981) 1.10

Some characteristics of a vitamin K-dependent carboxylating system from rat liver microsomes. Biochem Biophys Res Commun (1976) 1.10

Selective alpha v beta 3 integrin blockade potently limits neointimal hyperplasia and lumen stenosis following deep coronary arterial stent injury: evidence for the functional importance of integrin alpha v beta 3 and osteopontin expression during neointima formation. Cardiovasc Res (1997) 1.10

Detection of hepatic phenylalanine 4-hydroxylase in classical phenylketonuria. Proc Natl Acad Sci U S A (1973) 1.08

Effects of antidiuretic hormone on cellular conductive pathways in mouse medullary thick ascending limbs of Henle: I. ADH increases transcellular conductance pathways. J Membr Biol (1984) 1.08

Phosphoenolpyruvate-dependent sucrose phosphotransferase activity in five serotypes of Streptococcus mutans. Infect Immun (1979) 1.08

Occurrence of beta-hydroxylated asparagine residues in non-vitamin K-dependent proteins containing epidermal growth factor-like domains. Proc Natl Acad Sci U S A (1987) 1.08

Opposing actions of angiotensin-(1-7) and angiotensin II in the brain of transgenic hypertensive rats. Hypertension (1995) 1.06

Warfarin inhibition of vitamin K 2,3-epoxide reductase in rat liver microsomes. Biochemistry (1983) 1.06

Effect of converting enzyme inhibition and angiotensin receptor blockade on the vasoconstriction mediated by alpha 1-and alpha 2-adrenoceptor stimulation in pithed normotensive rats. Naunyn Schmiedebergs Arch Pharmacol (1982) 1.06

Activation of latent Ca2+ channels in renal epithelial cells by parathyroid hormone. Nature (1990) 1.05

Sodium-calcium interactions in the renal proximal convoluted tubule of the rabbit. Am J Physiol (1981) 1.05

Bovine liver aspartyl beta-hydroxylase. Purification and characterization. J Biol Chem (1991) 1.03

Monoclonal antibodies directed against basic fibroblast growth factor which inhibit its biological activity in vitro and in vivo. Biochem Biophys Res Commun (1989) 1.03

A nonpeptide integrin antagonist can inhibit epithelial cell ingestion of Streptococcus pyogenes by blocking formation of integrin alpha 5beta 1-fibronectin-M1 protein complexes. Proc Natl Acad Sci U S A (2000) 1.02

Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque. J Med Chem (1984) 1.01

Comparative in vitro efficacy of different platelet glycoprotein IIb/IIIa antagonists on platelet-mediated clot strength induced by tissue factor with use of thromboelastography: differentiation among glycoprotein IIb/IIIa antagonists. Arterioscler Thromb Vasc Biol (2000) 1.01

Monosymptomatic hypochondriacal Psychosis: Presentation and Treatment. Proc R Soc Med (1977) 1.01

The amino acid sequence of antistasin. A potent inhibitor of factor Xa reveals a repeated internal structure. J Biol Chem (1988) 1.00

Is sinus node modification appropriate for inappropriate sinus tachycardia with features of postural orthostatic tachycardia syndrome? Pacing Clin Electrophysiol (2001) 1.00

The hollow fiber assay: continued characterization with novel approaches. Anticancer Res (2000) 1.00

Introduction of antisense oligonucleotides into cells by permeabilization with streptolysin O. Biotechniques (1993) 1.00

Partial purification and characterization of bovine liver aspartyl beta-hydroxylase. J Biol Chem (1990) 1.00

A saturable high affinity binding site for transcobalamin II-vitamin B12 complexes in human placental membrane preparations. J Clin Invest (1977) 1.00

Immunomagnetic separation, primary culture, and characterization of cortical thick ascending limb plus distal convoluted tubule cells from mouse kidney. In Vitro Cell Dev Biol (1991) 1.00

Carbonic anhydrase histochemistry in rabbit and mouse kidneys. Anat Rec (1982) 1.00

On the mechanism of parathyroid hormone stimulation of calcium uptake by mouse distal convoluted tubule cells. J Clin Invest (1992) 1.00

A spectrum of partially carboxylated prothrombins in the plasmas of coumarin-treated patients. Biochim Biophys Acta (1977) 0.99

Sodium entry mechanisms in distal convoluted tubule cells. Am J Physiol (1995) 0.99

Multiple sclerosis masquerading as a mass lesion. Neuroradiology (1992) 0.98

Antistasin, a leech-derived inhibitor of factor Xa. Kinetic analysis of enzyme inhibition and identification of the reactive site. J Biol Chem (1989) 0.98

Production of antibodies to rat liver phenylalanine hydroxylase. Cross-reactivity with other pterin-dependent hydroxylases. Mol Pharmacol (1972) 0.98

The vitamin K-dependent synthesis of gamma-carboxyglutamic acid by bone microsomes. J Biol Chem (1978) 0.97

Nager acrofacial dysostosis: male-to-male transmission in 2 families. Am J Med Genet (1991) 0.97

Nifedipine serum concentrations following sublingual and oral doses. Int J Clin Pharmacol Ther Toxicol (1986) 0.96

Production of idiotypic and anti-idiotypic antibodies by BALB/c mice in response to immunizations with glucagon, vasopressin, or insulin: supporting evidence for the network concept. J Immunol (1986) 0.96

Relationship between phosphatidylinositol turnover and Ca++ mobilization induced by alpha-1 adrenoceptor stimulation in the rat aorta. J Pharmacol Exp Ther (1987) 0.96

Vitamin K-dependent gamma-carboxyglutamic acid formation by kidney microsomes in vitro. Biochem Biophys Res Commun (1976) 0.96

Interaction of anthelmintic benzimidazoles with Ascaris suum embryonic tubulin. Biochim Biophys Acta (1980) 0.95

In vitro antiplaque activity of octenidine dihydrochloride (WIN 41464-2) against preformed plaques of selected oral plaque-forming microorganisms. Antimicrob Agents Chemother (1983) 0.95

The Mitrofanoff principle for continent urinary diversion. Br J Urol (1989) 0.94

Are routine arrhythmia inductions necessary in patients with pectoral implantable cardioverter defibrillators? J Cardiovasc Electrophysiol (2000) 0.94

Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line. Cancer Res (1990) 0.94

Isolation, characterization, and cDNA cloning of a vampire bat salivary plasminogen activator. J Biol Chem (1989) 0.94

Discovery of an orally active series of isoxazoline glycoprotein IIb/IIIa antagonists. J Med Chem (1997) 0.94

Hemodynamic characterization of pinacidil in rats. Comparison with hydralazine. Pharmacology (1983) 0.94

A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases. Proc Natl Acad Sci U S A (1994) 0.93

Selective medium for isolation of Eikenella corrodens from periodontal lesions. J Clin Microbiol (1978) 0.93

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling. Oncogene (2010) 0.93

Invertebrate aspartyl/asparaginyl beta-hydroxylase: potential modification of endogenous epidermal growth factor-like modules. Biochem Biophys Res Commun (1992) 0.93

The contractions induced in rat and guinea-pig aortic strips by the alpha 2-adrenoceptor selective agonists B-HT 920 and UK 14,304 are mediated by alpha 1-adrenoceptors. Eur J Pharmacol (1984) 0.92

Inhibitors of 2-ketoglutarate-dependent dioxygenases block aspartyl beta-hydroxylation of recombinant human factor IX in several mammalian expression systems. J Biol Chem (1989) 0.92

Nature of the molecular defect in phenylketonuria and hyperphenylalaninaemia. Nature (1972) 0.92

Hemodynamic and natriuretic effects of bumetanide and furosemide in the cat. J Pharmacol Exp Ther (1977) 0.92

Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha 1D isoform by parathyroid hormone. Proc Natl Acad Sci U S A (1995) 0.91

Some characteristics of partially purified human liver phenylalanine hydroxylase. Biochim Biophys Acta (1973) 0.91

Chemical synthesis of echistatin, a potent inhibitor of platelet aggregation from Echis carinatus: synthesis and biological activity of selected analogs. Proc Natl Acad Sci U S A (1989) 0.91

Aspartyl beta-hydroxylase: in vitro hydroxylation of a synthetic peptide based on the structure of the first growth factor-like domain of human factor IX. Proc Natl Acad Sci U S A (1989) 0.91

Site-directed mutagenesis of residues in a conserved region of bovine aspartyl (asparaginyl) beta-hydroxylase: evidence that histidine 675 has a role in binding Fe2+. Biochemistry (1996) 0.90

Oxazolidinones mechanism of action: inhibition of the first peptide bond formation. J Biol Chem (2001) 0.90

Obligate mitogen-activated protein kinase activation in parathyroid hormone stimulation of calcium transport but not calcium signaling. Endocrinology (2000) 0.90

Deviating central hypotensive activity of urapidil in the cat. J Pharm Pharmacol (1985) 0.89

Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 1. The "B" group. J Med Chem (1989) 0.89

Effect of captopril on sympathetic neurotransmission in pithed normotensive rats. Eur J Pharmacol (1983) 0.89