Published in Biochemistry on September 22, 1998
Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution. Science (2009) 3.48
Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. Nat Rev Neurosci (2010) 2.69
Molecular diversity and regulation of renal potassium channels. Physiol Rev (2005) 2.56
Thermosensitive TRP channel pore turret is part of the temperature activation pathway. Proc Natl Acad Sci U S A (2010) 2.15
Localization and molecular determinants of the Hanatoxin receptors on the voltage-sensing domains of a K(+) channel. J Gen Physiol (2000) 1.77
Tarantula toxins interacting with voltage sensors in potassium channels. Toxicon (2006) 1.69
Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor. Proc Natl Acad Sci U S A (2003) 1.56
K+ channel modulators for the treatment of neurological disorders and autoimmune diseases. Chem Rev (2008) 1.52
Mitochondrial ROMK channel is a molecular component of mitoK(ATP). Circ Res (2012) 1.51
Homology modeling and molecular dynamics simulation studies of an inward rectifier potassium channel. Biophys J (2000) 1.42
Activation of ATP-sensitive K+ (K(ATP)) channels by H2O2 underlies glutamate-dependent inhibition of striatal dopamine release. Proc Natl Acad Sci U S A (2003) 1.41
The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proc Natl Acad Sci U S A (2009) 1.38
Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity. Proc Natl Acad Sci U S A (2004) 1.32
Dietary K regulates ROMK channels in connecting tubule and cortical collecting duct of rat kidney. Am J Physiol Renal Physiol (2008) 1.20
Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of subtype-selective agonists and the role of G-protein-mediated signaling. J Pharmacol Exp Ther (2006) 1.19
Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity. Proc Natl Acad Sci U S A (2006) 1.19
Permeant cations and blockers modulate pH gating of ROMK channels. Biophys J (2003) 1.16
Functional expression of Kir4.1 channels in spinal cord astrocytes. Glia (2006) 1.16
Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1. Front Pharmacol (2011) 1.16
Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels. Proc Natl Acad Sci U S A (2001) 1.10
The bee venom peptide tertiapin underlines the role of I(KACh) in acetylcholine-induced atrioventricular blocks. Br J Pharmacol (2000) 1.08
Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. Br J Pharmacol (2011) 1.07
Phasic and tonic attenuation of EPSPs by inward rectifier K+ channels in rat hippocampal pyramidal cells. J Physiol (2002) 1.06
Gating of a G protein-sensitive mammalian Kir3.1 prokaryotic Kir channel chimera in planar lipid bilayers. J Biol Chem (2010) 1.00
Diverse levels of an inwardly rectifying potassium conductance generate heterogeneous neuronal behavior in a population of dorsal cochlear nucleus pyramidal neurons. J Neurophysiol (2012) 0.98
Relaxation gating of the acetylcholine-activated inward rectifier K+ current is mediated by intrinsic voltage sensitivity of the muscarinic receptor. J Physiol (2011) 0.97
The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide. Br J Pharmacol (2005) 0.93
Targeting GIRK Channels for the Development of New Therapeutic Agents. Front Pharmacol (2011) 0.93
An intersubunit salt bridge near the selectivity filter stabilizes the active state of Kir1.1. Biophys J (2009) 0.92
Inhibition of acetylcholine-activated K(+) currents by U73122 is mediated by the inhibition of PIP(2)-channel interaction. Br J Pharmacol (2001) 0.92
Differential subunit composition of the G protein-activated inward-rectifier potassium channel during cardiac development. J Clin Invest (2004) 0.90
Dynamic metabotropic control of intrinsic firing in cerebellar unipolar brush cells. J Neurophysiol (2008) 0.90
C-type natriuretic peptide and endothelium-dependent hyperpolarization in the guinea-pig carotid artery. Br J Pharmacol (2007) 0.89
Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons. J Neurosci (2010) 0.88
Nociceptin/orphanin FQ inhibits capsaicin-induced guinea-pig airway contraction through an inward-rectifier potassium channel. Br J Pharmacol (2002) 0.88
A difference in inward rectification and polyamine block and permeation between the Kir2.1 and Kir3.1/Kir3.4 K+ channels. J Physiol (2005) 0.88
High-throughput screening for small-molecule modulators of inward rectifier potassium channels. J Vis Exp (2013) 0.87
Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+ channels. Proc Natl Acad Sci U S A (2008) 0.86
Muscarinic activation of inwardly rectifying K(+) conductance reduces EPSPs in rat hippocampal CA1 pyramidal cells. J Physiol (2001) 0.85
Adrenaline-induced hyperpolarization of mouse pancreatic islet cells is mediated by G protein-gated inwardly rectifying potassium (GIRK) channels. Pflugers Arch (2008) 0.85
T-type channels become highly permeable to sodium ions using an alternative extracellular turret region (S5-P) outside the selectivity filter. J Biol Chem (2014) 0.85
Generation of a constitutive Na+-dependent inward-rectifier current in rat adult atrial myocytes by overexpression of Kir3.4. J Physiol (2007) 0.85
Inward-rectifying potassium (Kir) channels regulate pacemaker activity in spinal nociceptive circuits during early life. J Neurosci (2013) 0.83
Multiple effects of 4-aminopyridine on feline and rabbit sinoatrial node myocytes and multicellular preparations. Pflugers Arch (2009) 0.83
Activation of GIRK channels in substantia gelatinosa neurones of the adult rat spinal cord: a possible involvement of somatostatin. J Physiol (2008) 0.82
Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis. Am J Pathol (2008) 0.82
Functional and developmental expression of a zebrafish Kir1.1 (ROMK) potassium channel homologue Kcnj1. J Physiol (2011) 0.82
Deletion of GIRK2 Subunit of GIRK Channels Alters the 5-HT1A Receptor-Mediated Signaling and Results in a Depression-Resistant Behavior. Int J Neuropsychopharmacol (2015) 0.81
Molecular basis for genistein-induced inhibition of Kir2.3 currents. Pflugers Arch (2007) 0.80
Renal proteinase-activated receptor 2, a new actor in the control of blood pressure and plasma potassium level. J Biol Chem (2013) 0.80
Regulation of rat mesencephalic GABAergic neurones through muscarinic receptors. J Physiol (2004) 0.79
Inward rectifiers and their regulation by endogenous polyamines. Front Physiol (2014) 0.79
Nociceptin inhibits vanilloid TRPV-1-mediated neurosensitization induced by fenoterol in human isolated bronchi. Naunyn Schmiedebergs Arch Pharmacol (2004) 0.79
Toxins Targeting the Kv1.3 Channel: Potential Immunomodulators for Autoimmune Diseases. Toxins (Basel) (2015) 0.78
G protein-gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites. Br J Pharmacol (2014) 0.78
A new signalling pathway for parallel fibre presynaptic type 4 metabotropic glutamate receptors (mGluR4) in the rat cerebellar cortex. J Physiol (2012) 0.78
A fluorescent screening assay for identifying modulators of GIRK channels. J Vis Exp (2012) 0.77
Kir1.1 (ROMK) and Kv7.1 (KCNQ1/KvLQT1) are essential for normal gastric acid secretion: importance of functional Kir1.1. Pflugers Arch (2014) 0.77
Inward rectifier potassium (Kir) current in dopaminergic periglomerular neurons of the mouse olfactory bulb. Front Cell Neurosci (2014) 0.76
Towards therapeutic applications of arthropod venom k(+)-channel blockers in CNS neurologic diseases involving memory acquisition and storage. J Toxicol (2012) 0.76
Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria. Front Pharmacol (2016) 0.75
Expression of a Diverse Array of Ca2+-Activated K+ Channels (SK1/3, IK1, BK) that Functionally Couple to the Mechanosensitive TRPV4 Channel in the Collecting Duct System of Kidney. PLoS One (2016) 0.75
A computational design approach for virtual screening of peptide interactions across K(+) channel families. Comput Struct Biotechnol J (2014) 0.75
Neuroadaptations of presynaptic and postsynaptic GABAB receptor function in the paraventricular nucleus in response to chronic unpredictable stress. Br J Pharmacol (2017) 0.75
Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr (2000) 11.69
miR-21-mediated tumor growth. Oncogene (2006) 9.90
Mutations in the K+ channel signature sequence. Biophys J (1994) 6.81
Comparative genomics of foot-and-mouth disease virus. J Virol (2005) 3.42
Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40. Nat Med (1999) 3.29
New tumor markers: CA125 and beyond. Int J Gynecol Cancer (2005) 2.92
Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ (2001) 2.85
Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J Immunol (1989) 2.70
North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions. J Gen Virol (1999) 2.68
The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis. EMBO J (1999) 2.67
The genome of fowlpox virus. J Virol (2000) 2.30
Prototype systems for rechargeable magnesium batteries. Nature (2000) 2.26
Involvement of Ral GTPase in v-Src-induced phospholipase D activation. Nature (1995) 2.16
Expression of chemokine receptors by subsets of neurons in the central nervous system. J Immunol (1997) 2.10
HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action. Eur J Pharm Biopharm (2000) 2.05
Umbilical cord mesenchymal stem cell transplantation in drug-induced Stevens-Johnson syndrome. J Eur Acad Dermatol Venereol (2012) 2.03
Coupled ion movement underlies rectification in an inward-rectifier K+ channel. J Gen Physiol (1998) 1.94
Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain. J Biol Chem (1997) 1.86
Pacing-induced heart failure causes a reduction of delayed rectifier potassium currents along with decreases in calcium and transient outward currents in rabbit ventricle. Cardiovasc Res (2000) 1.86
The genome of Melanoplus sanguinipes entomopoxvirus. J Virol (1999) 1.84
An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1. J Virol (1993) 1.83
Double-blind placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures. Neurology (2006) 1.81
Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus. J Virol (2004) 1.79
Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene (2010) 1.78
CXCR-4 desensitization is associated with tissue localization of hemopoietic progenitor cells. J Immunol (2001) 1.77
Effects of Ca2+ on the kinetics of phosphate release in skeletal muscle. J Biol Chem (1992) 1.77
The genome of a very virulent Marek's disease virus. J Virol (2000) 1.71
The genomes of sheeppox and goatpox viruses. J Virol (2002) 1.68
DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries. J Biol Chem (1999) 1.62
Removing a barrier to computer-based outbreak and disease surveillance--the RODS Open Source Project. MMWR Morb Mortal Wkly Rep (2004) 1.60
Mechanism of IRK1 channel block by intracellular polyamines. J Gen Physiol (2000) 1.60
Altered expression of HOXA10 in endometriosis: potential role in decidualization. Mol Hum Reprod (2007) 1.57
Mechanism of inhibition of tannic acid and related compounds on the growth of intestinal bacteria. Food Chem Toxicol (1998) 1.56
The genome of canarypox virus. J Virol (2004) 1.56
Identification of a new mouse beta-chemokine, thymus-derived chemotactic agent 4, with activity on T lymphocytes and mesangial cells. J Immunol (1997) 1.53
Melatonin inhibits fatty acid-induced triglyceride accumulation in ROS17/2.8 cells: implications for osteoblast differentiation and osteoporosis. Am J Physiol Regul Integr Comp Physiol (2007) 1.53
[Effect of temperature and food on Spodoptera litura population]. Ying Yong Sheng Tai Xue Bao (2000) 1.47
A plasmid expression system for quantitative in vivo biotinylation of thioredoxin fusion proteins in Escherichia coli. Nucleic Acids Res (1998) 1.45
An African swine fever virus virulence-associated gene NL-S with similarity to the herpes simplex virus ICP34.5 gene. J Virol (1996) 1.44
An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity. EMBO J (2000) 1.43
The genome of turkey herpesvirus. J Virol (2001) 1.42
Genome of horsepox virus. J Virol (2006) 1.42
Intramuscular administration of E7-transfected dendritic cells generates the most potent E7-specific anti-tumor immunity. Gene Ther (2000) 1.41
Synthesis of a stable form of tertiapin: a high-affinity inhibitor for inward-rectifier K+ channels. Biochemistry (1999) 1.41
Lessons from a review of thyroglobulin assays in the management of thyroid cancer. Intern Med J (2008) 1.40
Laboratory investigation of ecological factors influencing the environmental presence of Burkholderia pseudomallei. Microbiol Immunol (1996) 1.40
Fifteen-year global time series of satellite-derived fine particulate matter. Environ Sci Technol (2014) 1.37
Tuning the voltage dependence of tetraethylammonium block with permeant ions in an inward-rectifier K+ channel. J Gen Physiol (1999) 1.34
Mechanism of cGMP-gated channel block by intracellular polyamines. J Gen Physiol (2000) 1.34
Pharmacokinetics of an anti-human immunodeficiency virus antisense oligodeoxynucleotide phosphorothioate (GEM 91) in HIV-infected subjects. Clin Pharmacol Ther (1995) 1.34
Genome sequence of a baculovirus pathogenic for Culex nigripalpus. J Virol (2001) 1.32
Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner. Oncogene (2009) 1.31
The genome of swinepox virus. J Virol (2002) 1.30
Cell permeable Bcl-2 binding peptides: a chemical approach to apoptosis induction in tumor cells. Cancer Res (2000) 1.30
The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development (1998) 1.29
Structure and function in rhodopsin. Separation and characterization of the correctly folded and misfolded opsins produced on expression of an opsin mutant gene containing only the native intradiscal cysteine codons. Biochemistry (1995) 1.28
Preclinical diagnosis of African swine fever in contact-exposed swine by a real-time PCR assay. J Clin Microbiol (2005) 1.27
Phylogenetic comparison of classical swine fever virus in China. Virus Res (2001) 1.26
Epidemiological model for Clostridium difficile transmission in healthcare settings. Infect Control Hosp Epidemiol (2011) 1.26
Close correspondence between the action spectra for the blue light responses of the guard cell and coleoptile chloroplasts, and the spectra for blue light-dependent stomatal opening and coleoptile phototropism. Proc Natl Acad Sci U S A (1996) 1.25
Analysis of 74 kb of DNA located at the right end of the 330-kb chlorella virus PBCV-1 genome. Virology (1997) 1.24
Identification and characterization of embryonic stem cell-derived pacemaker and atrial cardiomyocytes. FASEB J (2005) 1.24
Transformation of cells overexpressing a tyrosine kinase by phospholipase D1 and D2. Biochem Biophys Res Commun (2001) 1.23
Association between v-Src and protein kinase C delta in v-Src-transformed fibroblasts. J Biol Chem (1997) 1.22
Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q. Biochemistry (1999) 1.22
Role of FOXO1A in the regulation of insulin-like growth factor-binding protein-1 in human endometrial cells: interaction with progesterone receptor. Biol Reprod (2005) 1.22
Pore block versus intrinsic gating in the mechanism of inward rectification in strongly rectifying IRK1 channels. J Gen Physiol (2000) 1.21
Kinetics of inward-rectifier K+ channel block by quaternary alkylammonium ions. dimension and properties of the inner pore. J Gen Physiol (2001) 1.21
Clothing prevents ultraviolet-B radiation-dependent photosynthesis of vitamin D3. J Clin Endocrinol Metab (1992) 1.20
An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swine. J Virol (2000) 1.19
Enhanced Photosynthesis and Stomatal Conductance of Pima Cotton (Gossypium barbadense L.) Bred for Increased Yield. Plant Physiol (1991) 1.19
The genome of camelpox virus. Virology (2002) 1.19
Screening for acute HIV infection in South Africa: finding acute and chronic disease. HIV Med (2011) 1.19
Nocardia beijingensis sp. nov., a novel isolate from soil. Int J Syst Evol Microbiol (2001) 1.19
Genome of lumpy skin disease virus. J Virol (2001) 1.17
Mutations in the genome of porcine reproductive and respiratory syndrome virus responsible for the attenuation phenotype. Arch Virol (2000) 1.17
Constitutive activation of the fucAO operon and silencing of the divergently transcribed fucPIK operon by an IS5 element in Escherichia coli mutants selected for growth on L-1,2-propanediol. J Bacteriol (1989) 1.17
Comparative sequence analysis of the South African vaccine strain and two virulent field isolates of Lumpy skin disease virus. Arch Virol (2003) 1.17
Genome of bovine herpesvirus 5. J Virol (2003) 1.16
Identification of an African swine fever virus gene with similarity to a myeloid differentiation primary response gene and a neurovirulence-associated gene of herpes simplex virus. J Virol (1992) 1.16
Thioredoxin as a fusion partner for production of soluble recombinant proteins in Escherichia coli. Methods Enzymol (2000) 1.15
The LIM-only factor LMO4 regulates expression of the BMP7 gene through an HDAC2-dependent mechanism, and controls cell proliferation and apoptosis of mammary epithelial cells. Oncogene (2007) 1.14
The organization of the Golgi complex and microtubules in skeletal muscle is fiber type-dependent. J Neurosci (1999) 1.13
African swine fever virus multigene family 360 and 530 genes affect host interferon response. J Virol (2004) 1.13
bax, but not bcl-2, influences the prognosis of human pancreatic cancer. Gut (1998) 1.12
Increasing the thermostability of staphylococcal nuclease: implications for the origin of protein thermostability. J Mol Biol (2000) 1.12
DNA delivery from an intravascular stent with a denatured collagen-polylactic-polyglycolic acid-controlled release coating: mechanisms of enhanced transfection. Gene Ther (2003) 1.12
Vasohibin 2 is transcriptionally activated and promotes angiogenesis in hepatocellular carcinoma. Oncogene (2012) 1.11
The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways. Oncogene (2011) 1.11
Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor. Mol Cell Biol (1999) 1.10
Genetic variability for stomatal conductance in Pima cotton and its relation to improvements of heat adaptation. Proc Natl Acad Sci U S A (1994) 1.10
Dynamics study on the anti-human immunodeficiency virus chemokine viral macrophage-inflammatory protein-II (VMIP-II) reveals a fully monomeric protein. Biochemistry (1999) 1.10
Ras mediates the activation of phospholipase D by v-Src. J Biol Chem (1995) 1.09
RalA requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator: involvement of metalloproteases. Oncogene (1999) 1.09
Enhanced inhibition of human immunodeficiency virus type 1 by Met-stromal-derived factor 1beta correlates with down-modulation of CXCR4. J Virol (1999) 1.08