Published in Oncogene on September 17, 1998
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Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev (2001) 15.97
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev (2001) 11.25
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev (2004) 9.54
Ras oncogenes: split personalities. Nat Rev Mol Cell Biol (2008) 7.91
Direct visualization of Ras proteins in spatially distinct cell surface microdomains. J Cell Biol (2003) 5.45
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet (2008) 5.07
Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev (2000) 4.24
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. J Invest Dermatol (2004) 3.80
Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell (2009) 3.47
H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. Mol Cell Biol (2000) 3.24
Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers. Mol Cell Biol (1999) 3.05
Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells. J Cell Biol (2002) 2.62
Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins. Proc Natl Acad Sci U S A (1999) 2.41
A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol (2005) 2.16
CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling. Proc Natl Acad Sci U S A (2001) 2.15
Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol (2007) 2.05
A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision. Mol Cell (2011) 2.02
Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. J Mol Signal (2010) 1.94
APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci U S A (2002) 1.89
Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Mol Cell Biol (2002) 1.88
Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis. EMBO J (2001) 1.74
Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259. Mol Cell Biol (2002) 1.63
Roles for KRAS in pancreatic tumor development and progression. Gastroenterology (2013) 1.61
MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway. Blood (2013) 1.61
Dissection of upstream regulatory components of the Rho1p effector, 1,3-beta-glucan synthase, in Saccharomyces cerevisiae. Genetics (2002) 1.57
Non-transcriptional action of oestradiol and progestin triggers DNA synthesis. EMBO J (1999) 1.54
Reovirus oncolysis: the Ras/RalGEF/p38 pathway dictates host cell permissiveness to reovirus infection. Proc Natl Acad Sci U S A (2004) 1.53
Activation of cJUN N-terminal kinase by herpes simplex virus type 1 enhances viral replication. J Virol (1999) 1.48
Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models. PLoS One (2013) 1.47
TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development. J Clin Invest (2008) 1.45
Heat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infection. PLoS One (2014) 1.45
Functions and functional domains of the GTPase Cdc42p. Mol Biol Cell (2000) 1.45
Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation. Mol Biol Cell (2005) 1.45
RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation. EMBO J (2001) 1.44
p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways. PLoS Biol (2004) 1.44
Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling. J Exp Med (2003) 1.44
Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b). Mol Cell Biol (2000) 1.41
Mechanism of the spatio-temporal regulation of Ras and Rap1. EMBO J (2003) 1.40
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. J Cell Biol (2006) 1.38
NRAS mutations are rare in colorectal cancer. Diagn Mol Pathol (2010) 1.38
The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties. EMBO J (2000) 1.38
The histidine triad superfamily of nucleotide-binding proteins. J Cell Physiol (1999) 1.38
Requirement of phospholipase D1 activity in H-RasV12-induced transformation. Proc Natl Acad Sci U S A (2005) 1.38
Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis. Mol Cancer Res (2008) 1.35
Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation. Genetics (2000) 1.33
Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade. Mol Cell Biol (2000) 1.32
Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells. Clin Exp Metastasis (2000) 1.30
Palmitoylation and plasma membrane localization of Ras2p by a nonclassical trafficking pathway in Saccharomyces cerevisiae. Mol Cell Biol (2003) 1.29
A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila. Genetics (2000) 1.29
Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf. Structure (2007) 1.26
Suppression of Ras-induced apoptosis by the Rac GTPase. Mol Cell Biol (1999) 1.26
Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice. Cancer Res (2007) 1.26
Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis. Cancer Res (2007) 1.26
Expression profiling of genes regulated by TGF-beta: differential regulation in normal and tumour cells. BMC Genomics (2007) 1.25
Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop. Mol Biol Cell (2004) 1.24
Ras-GRF1 signaling is required for normal beta-cell development and glucose homeostasis. EMBO J (2003) 1.21
The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. Mol Biol Cell (2003) 1.21
Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion. Mol Cell Biol (2004) 1.21
Smad proteins and hepatocyte growth factor control parallel regulatory pathways that converge on beta1-integrin to promote normal liver development. Mol Cell Biol (2001) 1.20
Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38. Mol Cell Biol (2002) 1.20
Kras as a key oncogene and therapeutic target in pancreatic cancer. Front Physiol (2014) 1.19
Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway. Mol Cell Biol (2001) 1.19
Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades. Mol Cell Biol (2005) 1.18
Accumulation of Fra-1 in ras-transformed cells depends on both transcriptional autoregulation and MEK-dependent posttranslational stabilization. Mol Cell Biol (2003) 1.18
Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration. J Cell Biol (2000) 1.18
Ras activity regulates cyclin E degradation by the Fbw7 pathway. Proc Natl Acad Sci U S A (2005) 1.15
Rho GTPases in platelet function. J Thromb Haemost (2013) 1.15
Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol Cell Biol (2001) 1.15
Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest. Mol Cell Biol (2001) 1.15
Negative regulation of the alpha interferon-induced antiviral response by the Ras/Raf/MEK pathway. J Virol (2006) 1.14
Antiapoptotic signaling generated by caspase-induced cleavage of RasGAP. Mol Cell Biol (2001) 1.13
Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor. J Mol Signal (2008) 1.13
FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosis. Biochim Biophys Acta (2007) 1.13
Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange. Proc Natl Acad Sci U S A (2003) 1.13
Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras. Proc Natl Acad Sci U S A (2000) 1.12
Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. Mol Cell Biol (1999) 1.12
Reovirus as a novel oncolytic agent. J Clin Invest (2000) 1.11
The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1. J Exp Med (2000) 1.11
In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I. Mol Cancer Ther (2009) 1.11
A Rac homolog functions downstream of Ras1 to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans. Eukaryot Cell (2005) 1.11
Molecular mechanism of pancreatic cancer--understanding proliferation, invasion, and metastasis. Langenbecks Arch Surg (2010) 1.10
Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9. Mol Biol Cell (2008) 1.10
K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma. Am J Pathol (2004) 1.10
Pulmonary adenocarcinoma: a renewed entity in 2011. Respirology (2012) 1.09
Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations. Invest New Drugs (2009) 1.07
Suppression of integrin activation by activated Ras or Raf does not correlate with bulk activation of ERK MAP kinase. Mol Biol Cell (2002) 1.06
DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation. J Cell Biol (2007) 1.06
Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeability. Am J Pathol (2007) 1.06
RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity. Mol Cell Biol (2010) 1.06
Association of yeast adenylyl cyclase with cyclase-associated protein CAP forms a second Ras-binding site which mediates its Ras-dependent activation. Mol Cell Biol (2000) 1.06
The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases. Mol Cell Biol (1999) 1.05
The genomics of lung adenocarcinoma: opportunities for targeted therapies. Genes Cancer (2010) 1.05
C. elegans EOR-1/PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 Mediator component. Genes Dev (2002) 1.02
Natural biology of polyomavirus middle T antigen. Microbiol Mol Biol Rev (2001) 1.02
Induction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6. Mol Cancer Res (2010) 1.01
Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras. EMBO J (2006) 1.01
K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis. PLoS One (2008) 1.01
IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling. J Biol Chem (2008) 1.00
Recent advances on tea polyphenols. Front Biosci (Elite Ed) (2012) 1.00
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene (2007) 11.85
Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science (1997) 6.50
Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc Natl Acad Sci U S A (1982) 5.39
Biological and biochemical properties of human rasH genes mutated at codon 61. Cell (1986) 5.05
p21ras is modified by a farnesyl isoprenoid. Proc Natl Acad Sci U S A (1989) 4.80
Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol Cell Biol (1995) 4.78
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature (1997) 4.66
Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. Science (1988) 4.58
Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell (1997) 4.39
GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex. J Cell Biol (1992) 4.34
Understanding Ras: 'it ain't over 'til it's over'. Trends Cell Biol (2000) 3.86
Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science (1997) 3.32
Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. J Cell Biol (1991) 3.22
Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation. Cell (1989) 3.12
Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways. Mol Cell Biol (1997) 3.09
BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell (1993) 2.92
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell (2001) 2.89
Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol (1996) 2.69
The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. J Biol Chem (1996) 2.60
Increasing complexity of the Ras signaling pathway. J Biol Chem (1998) 2.56
Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. J Cell Biol (1995) 2.56
Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation. J Biol Chem (1997) 2.55
The Ras branch of small GTPases: Ras family members don't fall far from the tree. Curr Opin Cell Biol (2000) 2.38
Critical role of Rho in cell transformation by oncogenic Ras. Oncogene (1995) 2.37
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Nature (2000) 2.37
Dbl family proteins. Biochim Biophys Acta (1997) 2.36
Altered gene products are associated with activation of cellular rasK genes in human lung and colon carcinomas. Cell (1983) 2.27
The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. EMBO J (1997) 2.19
Biological assays for Ras transformation. Methods Enzymol (1995) 2.16
Human cell hybrids: analysis of transformation and tumorigenicity. Science (1982) 2.16
The Ras signal transduction pathway. Cancer Metastasis Rev (1994) 2.13
Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc Natl Acad Sci U S A (1992) 2.10
Activation of the cellular proto-oncogene product p21Ras by addition of a myristylation signal. Science (1989) 2.04
Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis. J Biol Chem (2000) 2.02
Rho family proteins and Ras transformation: the RHOad less traveled gets congested. Oncogene (1998) 1.99
Isoprenoid modification of rab proteins terminating in CC or CXC motifs. Proc Natl Acad Sci U S A (1991) 1.99
The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation. J Biol Chem (1997) 1.98
Lck regulates Vav activation of members of the Rho family of GTPases. Mol Cell Biol (1997) 1.96
GTP binding by class II transactivator: role in nuclear import. Science (1999) 1.94
Vav2 is an activator of Cdc42, Rac1, and RhoA. J Biol Chem (2000) 1.93
Two distinct Raf domains mediate interaction with Ras. J Biol Chem (1995) 1.88
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation. Proc Natl Acad Sci U S A (1990) 1.84
Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway. J Biol Chem (1999) 1.82
Activation of ras genes in human tumors does not affect localization, modification, or nucleotide binding properties of p21. Cell (1984) 1.76
Aberrant function of the Ras signal transduction pathway in human breast cancer. Breast Cancer Res Treat (1995) 1.75
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes. J Biol Chem (1995) 1.75
rasH mutants deficient in GTP binding. Mol Cell Biol (1986) 1.73
Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc Natl Acad Sci U S A (1994) 1.67
The six amino-terminal amino acids of p60src are sufficient to cause myristylation of p21v-ras. Mol Cell Biol (1988) 1.65
Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras. Mol Cell Biol (1994) 1.60
ras-induced neuronal differentiation of PC12 cells: possible involvement of fos and jun. Mol Cell Biol (1989) 1.59
Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins. Bioessays (1995) 1.57
Emerging concepts in the Ras superfamily of GTP-binding proteins. FASEB J (1993) 1.56
Transformation by Rho exchange factor oncogenes is mediated by activation of an integrin-dependent pathway. EMBO J (1996) 1.56
Regulation of RasGRP via a phorbol ester-responsive C1 domain. Mol Cell Biol (1998) 1.55
Protein prenylation: more than just glue? Curr Opin Cell Biol (1992) 1.54
Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells. J Biol Chem (1999) 1.53
The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. Mol Cell Biol (1991) 1.52
Biological assays for cellular transformation. Methods Enzymol (1994) 1.51
Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras [corrected]. J Biol Chem (1996) 1.50
RASSF6 is a novel member of the RASSF family of tumor suppressors. Oncogene (2007) 1.48
Oncogenic Ras can induce transcriptional activation through a variety of promoter elements, including tandem c-Ets-2 binding sites. Oncogene (1994) 1.48
Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways. Mol Med (2001) 1.46
Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells. Proc Natl Acad Sci U S A (1996) 1.46
Ras and Rho regulation of the cell cycle and oncogenesis. Cancer Lett (2001) 1.45
RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. J Biol Chem (2001) 1.44
Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity. Proc Natl Acad Sci U S A (1994) 1.44
Rap1A is a substrate for cyclic AMP-dependent protein kinase in human neutrophils. J Immunol (1991) 1.43
R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells. Oncogene (1994) 1.42
Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras? Biochim Biophys Acta (1997) 1.42
Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation. J Biol Chem (1996) 1.42
Molecular basis for Rac1 recognition by guanine nucleotide exchange factors. Nat Struct Biol (2001) 1.39
Oncogenic Neu/ErbB-2 increases ets, AP-1, and NF-kappaB-dependent gene expression, and inhibiting ets activation blocks Neu-mediated cellular transformation. J Biol Chem (1996) 1.39
Identification and characterization of Src SH3 ligands from phage-displayed random peptide libraries. J Biol Chem (1994) 1.39
Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein. Mol Cell Biol (1992) 1.39
Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA. J Biol Chem (2001) 1.39
Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation. Mol Cell Biol (1999) 1.38
Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals. J Biol Chem (1999) 1.38
Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility. Cancer Metastasis Rev (2009) 1.36
Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. J Biol Chem (1996) 1.32
M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6. J Biol Chem (1999) 1.30
The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways. Oncogene (2001) 1.29
R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism. J Cell Biol (1995) 1.29