Published in Angew Chem Int Ed Engl on May 01, 1978
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Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation. Proc Natl Acad Sci U S A (1979) 1.47
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell (2003) 2.85
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Molecular analysis of the c-myc locus in normal tissue and in avian leukosis virus-induced lymphomas. J Virol (1982) 1.70
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Prostacyclin: a potentially valuable agent for preserving myocardial tissue in acute myocardial ischemia. Science (1978) 1.62
Identification of lipoxin A4 and its relationship to the sulfidopeptide leukotrienes C4, D4, and E4 in the bronchoalveolar lavage fluids obtained from patients with selected pulmonary diseases. Am Rev Respir Dis (1990) 1.58
Structure and distribution of the Notch protein in developing Drosophila. Genes Dev (1989) 1.55
Regional, cellular, and ultrastructural distribution of N-methyl-D-aspartate receptor subunit 1 in monkey hippocampus. Proc Natl Acad Sci U S A (1994) 1.55
Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane A2, a stable analog of thromboxane A2. Proc Natl Acad Sci U S A (1980) 1.52
Cardiac and renal prostaglandin I2. Biosynthesis and biological effects in isolated perfused rabbit tissues. J Clin Invest (1978) 1.48
Studies on the protective effect of prostacyclin in acute myocardial ischemia. Eur J Pharmacol (1979) 1.47
Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation. Proc Natl Acad Sci U S A (1979) 1.47
Selective binding site for [3H]prostacyclin on platelets. J Clin Invest (1979) 1.47
Chemical self-replication of palindromic duplex DNA. Nature (1994) 1.46
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Conformation of a water-soluble derivative of taxol in water by 2D-NMR spectroscopy. Chem Biol (1994) 1.44
Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly. Mol Pharmacol (2006) 1.36
Identification of a novel small molecule HIF-1alpha translation inhibitor. Clin Cancer Res (2009) 1.33
Characterization of a binding site for chemically synthesized lipo-oligosaccharidic NodRm factors in particulate fractions prepared from roots. Plant J (1995) 1.29
The enediyne antibiotics. J Med Chem (1996) 1.29
The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels. Chem Biol (1995) 1.28
Taxoids: new weapons against cancer. Sci Am (1996) 1.23
Selective oxidation at carbon adjacent to aromatic systems with IBX. J Am Chem Soc (2001) 1.22
The characterization and localization of the glutamate receptor subunit GluR1 in the rat brain. J Neurosci (1991) 1.21
The chemistry and biology of epothilones--the wheel keeps turning. ChemMedChem (2007) 1.21
Lipoxin A4 inhibits leukotriene B4-induced inflammation in the hamster cheek pouch. Acta Physiol Scand (1989) 1.16
Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11. Angew Chem Int Ed Engl (2009) 1.14
The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. Biochemistry (1999) 1.10
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Total syntheses of anominine and tubingensin A. J Am Chem Soc (2012) 1.06
Chronic ingestion of ethanol up-regulates NMDAR1 receptor subunit immunoreactivity in rat hippocampus. J Neurochem (1994) 1.06
Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. Biochemistry (1999) 1.06
Total Synthesis of Tovophyllin B. Tetrahedron Lett (2009) 1.03
Sequence-selective carbohydrate-DNA interaction: dimeric and monomeric forms of the calicheamicin oligosaccharide interfere with transcription factor function. Proc Natl Acad Sci U S A (1996) 1.03
Lipoxins stimulate prostacyclin generation by human endothelial cells. FEBS Lett (1989) 1.03
Responsiveness of platelets and coronary arteries from different species to synthetic thromboxane and prostaglandin endoperoxide analogues. Br J Pharmacol (1983) 1.03
Addressing the stereochemistry of complex organic molecules by density functional theory-NMR: vannusal B in retrospective. J Am Chem Soc (2011) 1.02
Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors. Bioorg Med Chem Lett (2011) 1.01
PGI2-specific antibodies administered in vivo suggest against a role for endogenous PGI2 as a circulating vasodepressor hormone in the normotensive and spontaneously hypertensive rat. Prostaglandins (1980) 0.99
Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP. Clin Cancer Res (2012) 0.97
Prostaglandin synthesis by fetal rat bone in vitro: evidence for a role of prostacyclin. Prostaglandins (1979) 0.97
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Stimulation of renin release from rabbit renal cortex by arachidonic acid and prostaglandin endoperoxides. Circ Res (1976) 0.96
Stereospecific 1,2-migrations in carbohydrates. Stereocontrolled synthesis of .alpha.- and .beta.-2-deoxyglycosides. J Am Chem Soc (1986) 0.96
Proteomic signature of fatty acid biosynthesis inhibition available for in vivo mechanism-of-action studies. Antimicrob Agents Chemother (2011) 0.95
Enhanced formation of PGI2, a potent hypotensive substance, by aortic rings and homogenates of the spontaneously hypertensive rat. Prostaglandins (1978) 0.93
Expression of endogenous NMDAR1 transcripts without receptor protein suggests post-transcriptional control in PC12 cells. J Biol Chem (1993) 0.93
The action of lipoxin-A on glomerular microcirculatory dynamics in the rat. Biochem Biophys Res Commun (1987) 0.93
Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: studies on stereospecificity of inhibition and mode of action. J Immunol (1987) 0.92
Prostaglandin I2 as a potentiator of acute inflammation in rats. Prostaglandins (1978) 0.92
Effects of prostacyclin and albumin on platelet loss during in vitro simulation of extracorporeal circulation. Blood (1979) 0.92
Preservation of ischemic myocardium by pinane thromboxane A2. Am J Physiol (1980) 0.92
Rapid and easy preparation of prostacyclin. Lancet (1977) 0.92
Sulfated blood group Lewis(a). A superior oligosaccharide ligand for human E-selectin. J Biol Chem (1994) 0.90
Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells. Biochem Pharmacol (2007) 0.90
Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study. J Med Chem (2007) 0.90
Studies of the mechanisms involved in the fate of prostacyclin (PGI2) and 6-keto-PGF1alpha in the pulmonary circulation. Prostaglandins (1978) 0.90
Inhibition of protein kinases by balanol: specificity within the serine/threonine protein kinase subfamily. Mol Pharmacol (1999) 0.89
Protein chemical characterization and immunocytochemical localization of the NMDA receptor subunit NMDA R1. J Biol Chem (1993) 0.89
Mechanism of coronary vasoconstriction induced by carbocyclic thromboxane A2. Am J Physiol (1981) 0.88
Further studies of the binding specificity of the leukocyte adhesion molecule, L-selectin, towards sulphated oligosaccharides--suggestion of a link between the selectin- and the integrin-mediated lymphocyte adhesion systems. Glycobiology (1995) 0.88
Diversity-oriented organic synthesis and proteomics. New frontiers for chemistry & biology. Chem Biol (2002) 0.87
Carbocyclic thromboxane A2: aggrevation of myocardial ischemia by a new synthetic thromboxane A2 analog. Prostaglandins (1981) 0.87
Origins of selectivity in pericyclic reaction cascades for the synthesis of gambogin and lateriflorone. Org Lett (2006) 0.86
Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A. Proc Natl Acad Sci U S A (1993) 0.85
Prostaglandin I2 has more potent hypotensive properties than prostaglandin E2 in the normal and spontaneously hypertensive rat. Prostaglandins (1978) 0.85
6,9-thiaprostacyclin. A stable and biologically potent analogue of prostacyclin (PGI2) J Am Chem Soc (1977) 0.85
Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies. Chem Res Toxicol (2006) 0.85
Design and synthesis of a rapamycin-based high affinity binding FKBP12 ligand. Chem Biol (1995) 0.84
New synthetic technology for the construction of oxocenes. J Am Chem Soc (1986) 0.84
Effect of prostacyclin on perfusion pressure, electrical activity, rate and force of contraction in isolated rat and rabbit hearts. Life Sci (1978) 0.84
Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. Chem Biol (1995) 0.84
Lipoxins A4 and B4: comparison of icosanoids having bronchoconstrictor and vasodilator actions but lacking platelet aggregatory activity. Proc Natl Acad Sci U S A (1988) 0.83
Protective effects of a novel thromboxane analog in lethal traumatic shock. Prostaglandins Med (1979) 0.83
The discovery of indoxacarb: oxadiazines as a new class of pyrazoline-type insecticides. Pest Manag Sci (2001) 0.83
The synthesis and biology of fluorinated prostacyclins. CRC Crit Rev Biochem (1984) 0.83
Azaspiracid substituent at C1 is relevant to in vitro toxicity. Chem Res Toxicol (2008) 0.83
The effects of lipoxin A and lipoxin B on functional responses of human granulocytes. Biochem Biophys Res Commun (1987) 0.82
Nodule-inducing activity of synthetic Sinorhizobium meliloti nodulation factors and related lipo-chitooligosaccharides on alfalfa. Importance of the acyl chain structure. Plant Physiol (1999) 0.82
In vivo arrhythmogenicity of the marine biotoxin azaspiracid-2 in rats. Arch Toxicol (2013) 0.82
Antitumor efficacy of 26-fluoroepothilone B against human prostate cancer xenografts. Cancer Chemother Pharmacol (2001) 0.82
Solid-phase combinatorial synthesis using MicroKan reactors, Rf tagging, and directed sorting. Biotechnol Bioeng (2000) 0.82
The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1. Cell Physiol Biochem (2007) 0.81
Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorg Med Chem Lett (2013) 0.81
Azaspiracids modulate intracellular pH levels in human lymphocytes. Biochem Biophys Res Commun (2006) 0.81
Thromboxane synthetase inhibitors differentially antagonize thromboxane receptors in vascular smooth muscle. Naunyn Schmiedebergs Arch Pharmacol (1981) 0.81
The beta-D-glucose scaffold as a beta-turn mimetic. Acc Chem Res (2009) 0.81
Origins of regioselectivity of Diels-Alder reactions for the synthesis of bisanthraquinone antibiotic BE-43472B. J Org Chem (2010) 0.80
Ca2+ mobilization with leukotriene A4 and epoxytetraenes in human neutrophils. Biochem Pharmacol (1990) 0.80
The oxide anion accelerated retro-diels-alder reaction. Chemistry (1997) 0.80
In vivo release and turnover of secreted platelet antiheparin proteins in rhesus monkey (Macaca mulatta). Blood (1980) 0.80