Phase IB trial of chimeric antidisialoganglioside antibody plus interleukin 2 for melanoma patients.

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Published in Clin Cancer Res on August 01, 1997

Authors

M R Albertini1, J A Hank, J H Schiller, M Khorsand, A A Borchert, J Gan, R Bechhofer, B Storer, R A Reisfeld, P M Sondel

Author Affiliations

1: University of Wisconsin Comprehensive Cancer Center, University of Wisconsin, Madison, Wisconsin 53792, USA.

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Separation of 7S gamma-1-globulin, 7S gamma-2-globulin and macroglobulin guinea pig antibodies. Proc Soc Exp Biol Med (1966) 2.08

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Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation. Blood (2001) 2.04

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Serologic evidence for antigens controlled by the Ir region in mice. J Exp Med (1973) 1.94

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HL-A LD (lymphocyte defined) typing: a rapid assay with primed lymphocytes. Science (1975) 1.91

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TCGF production for cloning and growth of functional human T lymphocytes. Scand J Immunol (1980) 1.50

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Chronic kidney disease following non-myeloablative hematopoietic cell transplantation. Am J Transplant (2006) 1.29

Proteases and protease inhibitors in tumor progression. Adv Exp Med Biol (1997) 1.27

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Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan. Proc Natl Acad Sci U S A (1996) 1.25

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Effectiveness of smoking cessation interventions integrated into primary care practice. Med Care (1988) 1.23

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Cell-mediated destruction of human leukemic cells by MHC identical lymphocytes: requirement for a proliferative trigger in vitro. J Immunol (1976) 1.22

Elimination of established murine colon carcinoma metastases by antibody-interleukin 2 fusion protein therapy. Cancer Res (1997) 1.22

Correlation of chondroitin sulfate proteoglycan expression on proliferating brain capillary endothelial cells with the malignant phenotype of astroglial cells. Cancer Res (1991) 1.22

Biosynthetic studies of proteoglycans in human melanoma cells with a monoclonal antibody to a core glycoprotein of chondroitin sulfate proteoglycans. J Biol Chem (1984) 1.22

Clinical and immunological effects of recombinant interleukin 2 given by repetitive weekly cycles to patients with cancer. Cancer Res (1988) 1.22