Published in J Biol Chem on December 25, 1998
Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell (2011) 7.30
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways. Nat Rev Mol Cell Biol (2009) 3.95
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. Biochem J (2014) 3.35
The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein. Proc Natl Acad Sci U S A (2004) 3.16
Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity. Nature (2007) 3.05
Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep (2008) 2.19
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol (2004) 1.86
Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate. Proc Natl Acad Sci U S A (2006) 1.81
The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy. Genes Cancer (2010) 1.80
Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation. Nat Chem Biol (2010) 1.80
Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy. Proc Natl Acad Sci U S A (2003) 1.60
Analyses of the effects of all ubiquitin point mutants on yeast growth rate. J Mol Biol (2013) 1.59
Structural determinants for the binding of ubiquitin-like domains to the proteasome. EMBO J (2003) 1.56
Inhibition of the ubiquitin-proteasome system in Alzheimer's disease. Proc Natl Acad Sci U S A (2000) 1.52
Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J (2005) 1.48
ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus. J Virol (2008) 1.38
Protein neddylation: beyond cullin-RING ligases. Nat Rev Mol Cell Biol (2015) 1.33
NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway. Nat Struct Mol Biol (2012) 1.23
Proximity-induced activation of human Cdc34 through heterologous dimerization. Proc Natl Acad Sci U S A (2005) 1.19
Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery. ACS Chem Biol (2009) 1.16
Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes. Biochem J (2012) 1.15
Solution structure of Urm1 and its implications for the origin of protein modifiers. Proc Natl Acad Sci U S A (2006) 1.14
ElaD, a Deubiquitinating protease expressed by E. coli. PLoS One (2007) 1.11
UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation. BMC Biol (2012) 1.10
Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1. Proc Natl Acad Sci U S A (2013) 1.08
Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents. Mol Cancer Res (2012) 1.08
Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo. Biochem J (2004) 1.07
Uncovering ubiquitin and ubiquitin-like signaling networks. Chem Rev (2011) 1.06
RNF111-dependent neddylation activates DNA damage-induced ubiquitination. Mol Cell (2013) 1.05
Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy. Mol Oncol (2012) 1.05
Ubiquitylation, neddylation and the DNA damage response. Open Biol (2015) 1.04
TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes. EMBO J (2013) 1.04
Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1. Biochemistry (2008) 1.03
COP9-associated CSN5 regulates exosomal protein deubiquitination and sorting. Am J Pathol (2009) 1.01
Characterizing ubiquitination sites by peptide-based immunoaffinity enrichment. Mol Cell Proteomics (2012) 1.00
The ubiquitin-like protein HUB1 forms SDS-resistant complexes with cellular proteins in the absence of ATP. EMBO Rep (2003) 0.99
Structure and interaction of ubiquitin-associated domain of human Fas-associated factor 1. Protein Sci (2009) 0.99
Structural analysis of UBL5, a novel ubiquitin-like modifier. Protein Sci (2003) 0.97
Macromolecular juggling by ubiquitylation enzymes. BMC Biol (2013) 0.95
The Ubp6 family of deubiquitinating enzymes contains a ubiquitin-like domain: SUb. Protein Sci (1999) 0.93
Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system. Mol Cell Proteomics (2012) 0.93
Cellular strategies for making monoubiquitin signals. Crit Rev Biochem Mol Biol (2011) 0.91
Structural basis for ubiquitin recognition by a novel domain from human phospholipase A2-activating protein. J Biol Chem (2009) 0.89
Mechanistic studies on activation of ubiquitin and di-ubiquitin-like protein, FAT10, by ubiquitin-like modifier activating enzyme 6, Uba6. J Biol Chem (2012) 0.88
Creation of a pluripotent ubiquitin-conjugating enzyme. Mol Cell Biol (2001) 0.86
The molecular basis of ubiquitin-like protein NEDD8 deamidation by the bacterial effector protein Cif. Proc Natl Acad Sci U S A (2012) 0.86
Enzyme E2 from Chinese white shrimp inhibits replication of white spot syndrome virus and ubiquitinates its RING domain proteins. J Virol (2011) 0.84
Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells. Protein Sci (2005) 0.83
The NEDD8 modification pathway in plants. Front Plant Sci (2014) 0.83
Using the ubiquitin-modified proteome to monitor protein homeostasis function. Mol Cell Proteomics (2013) 0.82
Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast. J Mol Biol (2014) 0.81
Substrate specificity of the ubiquitin and Ubl proteases. Cell Res (2016) 0.80
The essential functions of NEDD8 are mediated via distinct surface regions, and not by polyneddylation in Schizosaccharomyces pombe. PLoS One (2011) 0.80
Minireview: ubiquitination-regulated G protein-coupled receptor signaling and trafficking. Mol Endocrinol (2013) 0.80
Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins. DNA Repair (Amst) (2015) 0.80
Residues 240-250 in the C-terminus of the Pirh2 protein complement the function of the RING domain in self-ubiquitination of the Pirh2 protein. PLoS One (2013) 0.80
Phage display to identify Nedd8-mimicking peptides as inhibitors of the Nedd8 transfer cascade. Chembiochem (2013) 0.78
The molecular determinants of NEDD8 specific recognition by human SENP8. PLoS One (2011) 0.78
Enhancing ubiquitin crystallization through surface-entropy reduction. Acta Crystallogr F Struct Biol Commun (2014) 0.78
Stress, specificity and the NEDD8 proteome. Cell Cycle (2012) 0.76
Profiling the cross reactivity of ubiquitin with the Nedd8 activating enzyme by phage display. PLoS One (2013) 0.76
Redesigning the NEDD8 pathway with a bacterial genetic screen for ubiquitin-like molecule transfer. J Mol Biol (2012) 0.75
Inhibition of NEDD8 and FAT10 ligase activities through the degrading enzyme NEDD8 ultimate buster 1: A potential anticancer approach. Oncol Lett (2016) 0.75
UBE4B: a promising regulatory molecule in neuronal death and survival. Int J Mol Sci (2012) 0.75
COP9-Signalosome deneddylase activity is enhanced by simultaneous neddylation: insights into the regulation of an enzymatic protein complex. Cell Div (2015) 0.75
A high throughput mutagenic analysis of yeast sumo structure and function. PLoS Genet (2017) 0.75
Recognition of the polyubiquitin proteolytic signal. EMBO J (2000) 10.12
Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid. Cell (1996) 6.74
Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell (1999) 6.56
Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein. Science (1997) 6.10
Image reconstructions of helical assemblies of the HIV-1 CA protein. Nature (2000) 5.60
Molecular recognition in the HIV-1 capsid/cyclophilin A complex. J Mol Biol (1997) 3.50
Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer. Cell (2001) 3.09
Structural basis for the activation of 20S proteasomes by 11S regulators. Nature (2000) 3.04
EMB30 is essential for normal cell division, cell expansion, and cell adhesion in Arabidopsis and encodes a protein that has similarity to Sec7. Cell (1994) 2.85
Structural basis for the specificity of ubiquitin C-terminal hydrolases. EMBO J (1999) 2.79
Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution. Acta Crystallogr D Biol Crystallogr (1999) 2.77
Functional heterogeneity of ubiquitin carrier proteins. J Biol Chem (1985) 2.53
Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting. Proc Natl Acad Sci U S A (1996) 2.50
Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a. J Biol Chem (1998) 2.47
In vitro assembly and recognition of Lys-63 polyubiquitin chains. J Biol Chem (2001) 2.42
A 25-kilodalton ubiquitin carrier protein (E2) catalyzes multi-ubiquitin chain synthesis via lysine 48 of ubiquitin. J Biol Chem (1990) 2.31
Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T. Biochemistry (1995) 2.31
Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution. EMBO J (1997) 2.29
Distinct functional surface regions on ubiquitin. J Biol Chem (2001) 2.18
Penicillin acylase has a single-amino-acid catalytic centre. Nature (1995) 2.18
Inhibition of the 26 S proteasome by polyubiquitin chains synthesized to have defined lengths. J Biol Chem (1997) 2.14
Ubiquitin carboxyl-terminal hydrolase acts on ubiquitin carboxyl-terminal amides. J Biol Chem (1985) 2.08
Structure of a diubiquitin conjugate and a model for interaction with ubiquitin conjugating enzyme (E2). J Biol Chem (1992) 2.08
Structure of tetraubiquitin shows how multiubiquitin chains can be formed. J Mol Biol (1994) 1.76
Structure of the C-terminal domain of FliG, a component of the rotor in the bacterial flagellar motor. Nature (1999) 1.76
The hydrophobic effect contributes to polyubiquitin chain recognition. Biochemistry (1998) 1.68
Structure and function of ubiquitin conjugating enzyme E2-25K: the tail is a core-dependent activity element. Biochemistry (1997) 1.66
Energetics of the calcium-transporting ATPase. J Biol Chem (1984) 1.60
Specificity of the ubiquitin isopeptidase in the PA700 regulatory complex of 26 S proteasomes. J Biol Chem (1997) 1.56
Structure of the proteasome activator REGalpha (PA28alpha). Nature (1997) 1.56
Identification of an activation region in the proteasome activator REGalpha. Proc Natl Acad Sci U S A (1998) 1.54
Inhibition of the ubiquitin-proteasome system in Alzheimer's disease. Proc Natl Acad Sci U S A (2000) 1.52
Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme. J Biol Chem (1996) 1.47
Characterization of recombinant REGalpha, REGbeta, and REGgamma proteasome activators. J Biol Chem (1997) 1.47
Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin. J Biol Chem (1986) 1.43
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein. Protein Sci (1997) 1.36
A HECT domain E3 enzyme assembles novel polyubiquitin chains. J Biol Chem (2001) 1.30
Efforts toward expansion of the genetic alphabet: replication of DNA with three base pairs. J Am Chem Soc (2001) 1.29
Structure of a new crystal form of tetraubiquitin. Acta Crystallogr D Biol Crystallogr (2001) 1.28
Crystal structure of human uroporphyrinogen decarboxylase. EMBO J (1998) 1.26
Comparison of the NMR and X-ray structures of the HIV-1 matrix protein: evidence for conformational changes during viral assembly. Protein Sci (1996) 1.26
Crystal structure of human uroporphyrinogen III synthase. EMBO J (2001) 1.23
Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes. J Androl (2001) 1.22
Chemical structure of sterols that activate oocyte meiosis. Nature (1995) 1.22
A locus involved in the regulation of replication in plasmid pSC101. Mol Microbiol (1994) 1.15
Molecular identification and characterization of the Arabidopsis AtADF1, AtADFS and AtADF6 genes. Plant Mol Biol (2001) 1.14
Analysis of chromosomal and organellar DNA of somatic hybrids between Triticum aestiuvm and Haynaldia villosa Schur. Mol Genet Genomics (2001) 1.13
Evidence for a quantum phase transition in Pr2-xCe(x)CuO4-delta from transport measurements. Phys Rev Lett (2004) 1.09
Construct for high-level expression and low misincorporation of lysine for arginine during expression of pET-encoded eukaryotic proteins in Escherichia coli. Biotechniques (1999) 1.06
Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 A resolution. J Biol Chem (1998) 1.06
E2/E3-mediated assembly of lysine 29-linked polyubiquitin chains. J Biol Chem (1999) 1.05
Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex. Biochemistry (1997) 1.05
Characterization and crystallization of human uroporphyrinogen decarboxylase. Protein Sci (1997) 1.02
Isolation of a cDNA encoding a mammalian multiubiquitinating enzyme (E225K) and overexpression of the functional enzyme in Escherichia coli. J Biol Chem (1991) 0.98
Inactivation of arginyl-tRNA protein transferase by a bifunctional arsenoxide: identification of residues proximal to the arsenoxide site. Biochemistry (1995) 0.98
Binding of phenylarsenoxide to Arg-tRNA protein transferase is independent of vicinal thiols. Biochemistry (1995) 0.96
Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation. Proc Natl Acad Sci U S A (1995) 0.95
Expression, purification and crystallization of penicillin G acylase from Escherichia coli ATCC 11105. Protein Eng (1990) 0.95
Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase. J Biol Chem (2001) 0.95
Mechanism of ubiquitin conjugating enzyme E2-230K: catalysis involving a thiol relay? Biochemistry (1996) 0.94
Arsenite inhibits two steps in the ubiquitin-dependent proteolytic pathway. J Biol Chem (1989) 0.94
Slow dissociation of ATP from the calcium ATPase. J Biol Chem (1982) 0.94
The impact of starch-powdered gloves on the formation of adhesions in rats. Eur J Surg (1994) 0.93
Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani. EMBO J (1999) 0.93
A novel, arsenite-sensitive E2 of the ubiquitin pathway: purification and properties. Biochemistry (1989) 0.93
Functional consequences of naturally occurring mutations in human uroporphyrinogen decarboxylase. Blood (2001) 0.91
Molecular confirmation of oysters as the vector for hepatitis A in a 2005 multistate outbreak. J Food Prot (2007) 0.91
Can we predict body height from segmental bone length measurements? A study of 3,647 children. J Pediatr Orthop (1998) 0.90
Several mammalian ubiquitin carrier proteins, but not E2(20K), are related to the 20-kDa yeast E2, RAD6. Biochem Biophys Res Commun (1990) 0.89
Healthcare-associated hepatitis C virus transmission among patients in an abdominal organ transplant center. Transpl Infect Dis (2009) 0.88
Exposure to L-ascorbic acid or alpha-tocopherol facilitates the development of porcine denuded oocytes from metaphase I to metaphase II and prevents cumulus cells from fragmentation. Reprod Domest Anim (2004) 0.87
A new look at the sequential development of elbow-ossification centers in children. J Pediatr Orthop (1998) 0.86
Dynamics of ubiquitin conjugation during erythroid differentiation in vitro. J Biol Chem (1995) 0.86
Defining polyubiquitin chain topology. Nat Struct Biol (2001) 0.86
Molecular cloning and expression of an N-acetylgalactosamine-4-O-sulfotransferase that transfers sulfate to terminal and non-terminal beta 1,4-linked N-acetylgalactosamine. J Biol Chem (2001) 0.85
Inhibition of ubiquitin-protein ligase (E3) by mono- and bifunctional phenylarsenoxides. Evidence for essential vicinal thiols and a proximal nucleophile. J Biol Chem (1992) 0.85
Effects of radiation on wound healing. J Environ Pathol Toxicol Oncol (1998) 0.84
Superovulation, fertilization and in vitro embryo development in mice after administration of an inhibin-neutralizing antiserum. Reproduction (2001) 0.84
Structural diversity in metal ion chelation and the structure of uroporphyrinogen III synthase. Biochem Soc Trans (2002) 0.84
What factors determine the severity of hepatitis A-related acute liver failure? J Viral Hepat (2010) 0.84
Effects of antioxidants and PAF receptor antagonist in intestinal shock in the rat. Circ Shock (1994) 0.83
Core domain mutation (S86Y) selectively inactivates polyubiquitin chain synthesis catalyzed by E2-25K. Biochemistry (1998) 0.83
Development of brain-derived neurotrophic factor and neurotrophin-3 immunoreactivity in the lower auditory brainstem of the postnatal gerbil. Eur J Neurosci (2001) 0.83
The proteasome 11S regulator subunit REG alpha (PA28 alpha) is a heptamer. Protein Sci (1997) 0.83
Expression of aquaporins 7 and 8 in the developing rat testis. Andrologia (2001) 0.82
Atrial natriuretic peptide inhibits the actions of FSH and forskolin in meiotic maturation of pig oocytes via different signalling pathways. J Mol Endocrinol (2005) 0.82
Opening doors into the proteasome. Nat Struct Biol (2000) 0.81
Evaluation of viral heterogeneity using next-generation sequencing, end-point limiting-dilution and mass spectrometry. In Silico Biol (2012) 0.81
Functional heterogeneity of ubiquitin carrier proteins. Prog Clin Biol Res (1985) 0.81
Dihydroorotate dehydrogenase from Clostridium oroticum is a class 1B enzyme and utilizes a concerted mechanism of catalysis. Biochemistry (2000) 0.80
Induction of specific transplantation tolerance across xenogeneic barriers in the T-independent immune compartment. Nat Med (1998) 0.80
A reactive nucleophile proximal to vicinal thiols is an evolutionarily conserved feature in the mechanism of Arg aminoacyl-tRNA protein transferase. Arch Biochem Biophys (1992) 0.80
Protein kinase C, rather than protein kinase A is involved in follicle-stimulating hormone-mediated meiotic resumption of mouse cumulus cell-enclosed oocytes in hypoxanthine-supplemented medium. Mol Cell Endocrinol (2001) 0.79
Construction of a primary RH panel of Italian ryegrass genome via UV-induced protoplast fusion. Plant Biol (Stuttg) (2006) 0.79
Single nucleotide polymorphisms of the interleukin-33 (IL-33) gene are associated with ankylosing spondylitis in Chinese individuals: a case-control pilot study. Scand J Rheumatol (2014) 0.78
Formation of stable anhydrides from CoA transferase and hydroxamic acids. J Biol Chem (1979) 0.78
Correlates of consistent condom use among female entertainment workers in Shanghai, China: a repeated measures analysis. Int J STD AIDS (2013) 0.78