Published in Curr Biol on January 14, 1999
The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol (2000) 10.20
Transport into and out of the nucleus. Microbiol Mol Biol Rev (2001) 6.36
Kinetic analysis of translocation through nuclear pore complexes. EMBO J (2001) 5.27
The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion. EMBO J (2002) 3.34
RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase. Mol Cell Biol (1999) 2.37
The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1. EMBO J (1999) 2.31
tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes. PLoS Biol (2006) 2.28
A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. J Cell Biol (1999) 2.27
The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins. EMBO J (2001) 2.14
The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import. J Cell Biol (2002) 2.13
Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation. EMBO J (2003) 2.06
The direction of transport through the nuclear pore can be inverted. Proc Natl Acad Sci U S A (1999) 1.99
Importin 13: a novel mediator of nuclear import and export. EMBO J (2001) 1.98
Nup358/RanBP2 attaches to the nuclear pore complex via association with Nup88 and Nup214/CAN and plays a supporting role in CRM1-mediated nuclear protein export. Mol Cell Biol (2004) 1.70
The mechanism of inhibition of Ran-dependent nuclear transport by cellular ATP depletion. J Cell Biol (2002) 1.59
Nuclear import of the ran exchange factor, RCC1, is mediated by at least two distinct mechanisms. J Cell Biol (2000) 1.50
RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. EMBO Rep (2001) 1.46
Supraphysiological nuclear export signals bind CRM1 independently of RanGTP and arrest at Nup358. EMBO J (2004) 1.44
Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer. Proc Natl Acad Sci U S A (2002) 1.40
The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import. Mol Biol Cell (2008) 1.40
Optical recording of signal-mediated protein transport through single nuclear pore complexes. Proc Natl Acad Sci U S A (1999) 1.34
HIV infection of non-dividing cells: a divisive problem. Retrovirology (2006) 1.33
The nucleoporin Nup188 controls passage of membrane proteins across the nuclear pore complex. J Cell Biol (2010) 1.33
Influence of cargo size on Ran and energy requirements for nuclear protein import. J Cell Biol (2002) 1.30
Kinetics and mechanism of DNA uptake into the cell nucleus. Proc Natl Acad Sci U S A (2001) 1.29
Nucleo-cytoplasmic partitioning of proteins in plants: implications for the regulation of environmental and developmental signalling. Curr Genet (2003) 1.28
Systematic analysis of barrier-forming FG hydrogels from Xenopus nuclear pore complexes. EMBO J (2012) 1.27
FG/FxFG as well as GLFG repeats form a selective permeability barrier with self-healing properties. EMBO J (2009) 1.22
The importin-beta binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro. J Cell Biol (2002) 1.21
Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1. Mol Cell Biol (2000) 1.18
Exportin 7 defines a novel general nuclear export pathway. EMBO J (2004) 1.17
Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. Mol Cell Biol (2005) 1.15
Charge as a selection criterion for translocation through the nuclear pore complex. PLoS Comput Biol (2010) 1.13
Nuclear import of IkappaBalpha is accomplished by a ran-independent transport pathway. Mol Cell Biol (2000) 1.12
Metastable network model of protein transport through nuclear pores. Biophys J (2004) 1.11
The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus. J Cell Biol (1999) 1.07
Looking beyond the Wnt pathway for the deep nature of β-catenin. EMBO Rep (2013) 1.06
NXT1 is necessary for the terminal step of Crm1-mediated nuclear export. J Cell Biol (2001) 1.06
An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins. J Cell Biol (2000) 1.02
In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160. J Cell Biol (2004) 1.02
The strategy for coupling the RanGTP gradient to nuclear protein export. Proc Natl Acad Sci U S A (2003) 1.00
Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity. Elife (2015) 0.98
Selective disruption of nuclear import by a functional mutant nuclear transport carrier. J Cell Biol (2000) 0.97
The importin beta binding domain modulates the avidity of importin beta for the nuclear pore complex. J Biol Chem (2010) 0.93
The 70-kD heat shock cognate protein (hsc70) facilitates the nuclear export of the import receptors. J Cell Biol (2005) 0.91
Functionalization of a nanopore: the nuclear pore complex paradigm. Biochim Biophys Acta (2009) 0.90
Avian reovirus sigmaA localizes to the nucleolus and enters the nucleus by a nonclassical energy- and carrier-independent pathway. J Virol (2009) 0.90
Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains. Mol Cell Biol (2002) 0.88
Reconstitution of nuclear protein export in isolated nuclear envelopes. J Cell Biol (2002) 0.86
Cytokine-induced nuclear translocation of signaling proteins and their analysis using the inducible translocation trap system. Cytokine (2008) 0.77
Novel regulation of CCL2 gene expression by murine LITAF and STAT6B. PLoS One (2011) 0.77
Forces, fluctuations, and self-organization in the nucleus. Mol Biol Cell (2015) 0.76
Role of Ran-regulated nuclear-cytoplasmic trafficking of pVHL in the regulation of microtubular stability-mediated HIF-1α in hypoxic cardiomyocytes. Sci Rep (2015) 0.76
CRM1 is an export receptor for leucine-rich nuclear export signals. Cell (1997) 18.60
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell (1995) 9.98
Nucleocytoplasmic transport. Science (1996) 8.76
Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding. Cell (1986) 5.59
Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity. Cell (2001) 5.33
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. EMBO J (1997) 5.08
Nuclear export of different classes of RNA is mediated by specific factors. J Cell Biol (1994) 4.99
Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins. Cell (1985) 4.98
Monomethylated cap structures facilitate RNA export from the nucleus. Cell (1990) 4.72
Identification of the RNA binding segment of human U1 A protein and definition of its binding site on U1 snRNA. EMBO J (1989) 4.69
Major determinants of the specificity of interaction between small nuclear ribonucleoproteins U1A and U2B'' and their cognate RNAs. Nature (1990) 4.67
A nuclear cap binding protein complex involved in pre-mRNA splicing. Cell (1994) 4.56
Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex. EMBO J (1997) 4.06
A cap-binding protein complex mediating U snRNA export. Nature (1995) 3.89
Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Nature (1999) 3.84
An enhancer-like sequence within the Xenopus U2 gene promoter facilitates the formation of stable transcription complexes. Nature (1985) 3.80
Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. Science (1995) 3.79
Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Nat Cell Biol (2001) 3.67
Fungal small nuclear ribonucleoproteins share properties with plant and vertebrate U-snRNPs. EMBO J (1987) 3.50
Identification of a nuclear export receptor for tRNA. Curr Biol (1998) 3.49
U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase. Mol Cell (1998) 3.39
Dual-color visualization of trans-Golgi network to plasma membrane traffic along microtubules in living cells. J Cell Sci (1999) 3.26
The trimethylguanosine cap structure of U1 snRNA is a component of a bipartite nuclear targeting signal. Cell (1990) 3.24
In vitro assembly of U1 snRNPs. EMBO J (1987) 3.18
RNA export. Cell (1995) 3.03
Nucleocytoplasmic transport: the last 200 nanometers. Cell (1998) 3.00
PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Cell (2000) 2.88
A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export. J Cell Biol (1996) 2.84
Xenopus laevis U2 snRNA genes: tandemly repeated transcription units sharing 5' and 3' flanking homology with other RNA polymerase II transcribed genes. EMBO J (1983) 2.81
A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J Cell Biol (1997) 2.74
Importin provides a link between nuclear protein import and U snRNA export. Cell (1996) 2.65
The human U1 snRNP-specific U1A protein inhibits polyadenylation of its own pre-mRNA. Cell (1993) 2.58
The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein. Nat Struct Biol (2000) 2.53
Nucleocytoplasmic transport: Ran, beta and beyond. Trends Cell Biol (2001) 2.50
A nuclear cap-binding complex facilitates association of U1 snRNP with the cap-proximal 5' splice site. Genes Dev (1996) 2.50
A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes. Nature (1987) 2.48
Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif. Cell (1994) 2.45
Diversity in the signals required for nuclear accumulation of U snRNPs and variety in the pathways of nuclear transport. J Cell Biol (1991) 2.45
The role of exportin-t in selective nuclear export of mature tRNAs. EMBO J (1998) 2.40
RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase. Mol Cell Biol (1999) 2.37
Participation of the nuclear cap binding complex in pre-mRNA 3' processing. Proc Natl Acad Sci U S A (1997) 2.31
The carboxyl terminus of vertebrate poly(A) polymerase interacts with U2AF 65 to couple 3'-end processing and splicing. Genes Dev (2000) 2.27
Functional analysis of mutant Xenopus U2 snRNAs. Cell (1989) 2.23
GTP hydrolysis by Ran is required for nuclear envelope assembly. Mol Cell (2000) 2.22
A cap binding protein that may mediate nuclear export of RNA polymerase II-transcribed RNAs. J Cell Biol (1992) 2.20
Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway. EMBO J (2001) 2.17
The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins. EMBO J (2001) 2.14
Molecular requirements for bi-directional movement of phagosomes along microtubules. J Cell Biol (1997) 2.13
The U2B'' RNP motif as a site of protein-protein interaction. EMBO J (1990) 2.12
Structure and sequence of the promoter area and of a 5' upstream demethylation site of the estrogen-regulated chicken vitellogenin ii gene. J Biol Chem (1983) 2.11
Xenopus laevis U1 snRNA genes: characterisation of transcriptionally active genes reveals major and minor repeated gene families. EMBO J (1984) 2.08
Involvement of the carboxyl terminus of vertebrate poly(A) polymerase in U1A autoregulation and in the coupling of splicing and polyadenylation. Genes Dev (1997) 2.03
Intracellular distribution of the U1A protein depends on active transport and nuclear binding to U1 snRNA. J Cell Biol (1992) 2.01
Nuclear import of U snRNPs requires importin beta. EMBO J (1997) 2.00
TFIID is required for in vitro transcription of the human U6 gene by RNA polymerase III. EMBO J (1991) 1.97
Monospecific antibodies reveal details of U2 snRNP structure and interaction between U1 and U2 snRNPs. EMBO J (1986) 1.96
Domains of U4 and U6 snRNAs required for snRNP assembly and splicing complementation in Xenopus oocytes. EMBO J (1990) 1.96
Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly. Nat Cell Biol (2001) 1.95
An abundant U6 snRNP found in germ cells and embryos of Xenopus laevis. EMBO J (1989) 1.94
Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron (1992) 1.85
Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus. J Cell Sci (1998) 1.84
Loop I of U1 small nuclear RNA is the only essential RNA sequence for binding of specific U1 small nuclear ribonucleoprotein particle proteins. Mol Cell Biol (1988) 1.77
Transport of RNA between nucleus and cytoplasm. Semin Cell Biol (1992) 1.77
RNA-protein interactions. Cell (1991) 1.71
The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation. Mol Cell (2000) 1.71
The determinants for Sm protein binding to Xenopus U1 and U5 snRNAs are complex and non-identical. EMBO J (1993) 1.67
RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus. J Cell Biol (1996) 1.66
Estrogen induces a demethylation at the 5' end region of the chicken vitellogenin gene. Proc Natl Acad Sci U S A (1982) 1.63
Structure and expression of a Xenopus gene encoding an snRNP protein (U1 70K). EMBO J (1988) 1.62
Functional characterization of X. laevis U5 snRNA genes. EMBO J (1987) 1.62
Two rhombomeres are altered in Hoxa-1 mutant mice. Development (1993) 1.62
A complex secondary structure in U1A pre-mRNA that binds two molecules of U1A protein is required for regulation of polyadenylation. EMBO J (1993) 1.62
Roles of U4 and U6 snRNAs in the assembly of splicing complexes. EMBO J (1992) 1.60
Multiple domains of U1 snRNA, including U1 specific protein binding sites, are required for splicing. EMBO J (1990) 1.60
Nuclear retention of RNA as a mechanism for localization. RNA (1995) 1.57
A yeast cap binding protein complex (yCBC) acts at an early step in pre-mRNA splicing. Nucleic Acids Res (1996) 1.57
Genetic and physical interactions involving the yeast nuclear cap-binding complex. Mol Cell Biol (1999) 1.56
A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus. Mol Cell Biol (1996) 1.55
Formation of the 3' end on U snRNAs requires at least three sequence elements. EMBO J (1986) 1.52
RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. EMBO Rep (2001) 1.46
Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition. Genes Dev (1999) 1.46
Ribonucleoprotein particles in cellular processes. J Cell Biol (1988) 1.44
The Xenopus U2 gene PSE is a single, compact, element required for transcription initiation and 3' end formation. Nucleic Acids Res (1989) 1.43
Conserved amino acid residues within and outside of the N-terminal ribonucleoprotein motif of U1A small nuclear ribonucleoprotein involved in U1 RNA binding. J Mol Biol (1991) 1.40
A role for microtubule dynamics in phagosome movement. J Cell Sci (1998) 1.37
Crystal structure of the human nuclear cap binding complex. Mol Cell (2001) 1.32
The influence of 5' and 3' end structures on pre-mRNA metabolism. J Cell Sci Suppl (1995) 1.32
Drosophila SNF/D25 combines the functions of the two snRNP proteins U1A and U2B' that are encoded separately in human, potato, and yeast. RNA (1996) 1.31
Visualizing nuclear export of different classes of RNA by electron microscopy. RNA (1997) 1.30
Position-dependent inhibition of the cleavage step of pre-mRNA 3'-end processing by U1 snRNP. RNA (2000) 1.30
Interaction between the human nuclear cap-binding protein complex and hnRNP F. Mol Cell Biol (1997) 1.24
Conserved loop I of U5 small nuclear RNA is dispensable for both catalytic steps of pre-mRNA splicing in HeLa nuclear extracts. Mol Cell Biol (1999) 1.24
Cofractionation of the TATA-binding protein with the RNA polymerase III transcription factor TFIIIB. Nucleic Acids Res (1992) 1.23
RNA processing. Splicing in space. Nature (1995) 1.22
Properties of a U1 RNA enhancer-like sequence. Nucleic Acids Res (1987) 1.21
A weak interaction between the U2A' protein and U2 snRNA helps to stabilize their complex with the U2B" protein. Nucleic Acids Res (1991) 1.21
Isolation and fine structure organisation of an avian vitellogenin gene coding for the major estrogen-inducible mRNA. Gene (1981) 1.20
Analysis of in vitro binding of U1-A protein mutants to U1 snRNA. Nucleic Acids Res (1991) 1.17
Cloning of nucleoplasmin from Xenopus laevis oocytes and analysis of its developmental expression. Genes Dev (1987) 1.16
Interferon alpha inhibits a Src-mediated pathway necessary for Shigella-induced cytoskeletal rearrangements in epithelial cells. J Cell Biol (1998) 1.12