PubRank

Human Lipoprotein Pathophysiology - Subproject: Genetics of Familial Combined Hyperlipidemia

Clinical Trial ID NCT00005313

PubWeight™ 12.32‹?›

🔗 Visit the ClinicalTrials.gov page for NCT00005313

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications. Diabetes Care 2002 4.46
2 Detection and characterization of the heterozygote state for lipoprotein lipase deficiency. Arteriosclerosis 1989 2.14
3 Apoproteins B and A-I and coronary artery disease in humans. Arteriosclerosis 1984 1.73
4 Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk. J Clin Endocrinol Metab 2004 1.70
5 Effect of ritonavir on lipids and post-heparin lipase activities in normal subjects. AIDS 2000 1.60
6 Transcriptional activation of the lipoprotein lipase and apolipoprotein E genes accompanies differentiation in some human macrophage-like cell lines. Biochemistry 1988 1.52
7 A major insertion accounts for a significant proportion of mutations underlying human lipoprotein lipase deficiency. Proc Natl Acad Sci U S A 1989 1.41
8 Body fat distribution and dyslipidemia. Am J Med 1995 1.40
9 Human adipose tissue lipoprotein lipase: changes with feeding and relation to postheparin plasma enzyme. Am J Physiol 1985 1.38
10 Partial gene duplication involving exon-Alu interchange results in lipoprotein lipase deficiency. Am J Hum Genet 1990 1.31
11 Effect of hepatic lipase on LDL in normal men and those with coronary artery disease. Arterioscler Thromb 1993 1.24
12 Molecular basis of familial chylomicronemia: mutations in the lipoprotein lipase and apolipoprotein C-II genes. J Lipid Res 1992 1.20
13 Analysis of techniques to obtain plasma for measurement of levels of free fatty acids. J Lipid Res 1993 1.14
14 Inheritance of low density lipoprotein subclass patterns in familial combined hyperlipidemia. Arteriosclerosis 1990 1.12
15 Weight loss leads to a marked decrease in nonresting energy expenditure in ambulatory human subjects. Metabolism 1988 1.10
16 Evidence for a new pathophysiological mechanism for coronary artery disease regression: hepatic lipase-mediated changes in LDL density. Circulation 1999 1.05
17 Human lipoprotein lipase. Analysis of the catalytic triad by site-directed mutagenesis of Ser-132, Asp-156, and His-241. J Biol Chem 1992 1.04
18 Relationship between lipoprotein lipase activity and plasma sex steroid level in obese women. J Clin Invest 1988 1.04
19 Molecular genetics of apolipoproteins and coronary heart disease. Cold Spring Harb Symp Quant Biol 1986 1.03
20 Dyslipidemia of central obesity and insulin resistance. Diabetes Care 1999 1.03
21 The contribution of intraabdominal fat to gender differences in hepatic lipase activity and low/high density lipoprotein heterogeneity. J Clin Endocrinol Metab 2001 1.02
22 Characterization of low-density lipoprotein subclasses: methodologic approaches and clinical relevance. Curr Opin Lipidol 1994 1.02
23 A mutation in the promoter of the lipoprotein lipase (LPL) gene in a patient with familial combined hyperlipidemia and low LPL activity. Proc Natl Acad Sci U S A 1995 1.01
24 Large buoyant LDL-like particles in hepatic lipase deficiency. Arteriosclerosis 1989 1.01
25 Lipoprotein lipase gene expression in THP-1 cells. Biochemistry 1989 0.99
26 Defective enzyme protein in lipoprotein lipase deficiency. Eur J Clin Invest 1989 0.99
27 Genetic predictors of FCHL in four large pedigrees. Influence of ApoB level major locus predicted genotype and LDL subclass phenotype. Arterioscler Thromb 1994 0.96
28 A hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women. Arterioscler Thromb Vasc Biol 1999 0.95
29 Coexistence of abnormalities of hepatic lipase and lipoprotein lipase in a large family. Am J Hum Genet 1990 0.95
30 Conversion of plasma VLDL and IDL precursors into various LDL subpopulations using density gradient ultracentrifugation. J Lipid Res 1990 0.94
31 Common hepatic lipase gene promoter variant determines clinical response to intensive lipid-lowering treatment. Circulation 2001 0.93
32 Effect of weight loss with reduction of intra-abdominal fat on lipid metabolism in older men. J Clin Endocrinol Metab 2000 0.93
33 The LPL gene in individuals with familial combined hyperlipidemia and decreased LPL activity. Arterioscler Thromb 1994 0.92
34 Bile acid metabolism in hereditary forms of hypertriglyceridemia: evidence for an increased synthesis rate in monogenic familial hypertriglyceridemia. Proc Natl Acad Sci U S A 1987 0.92
35 Adipose tissue fatty acid composition in humans with lipoprotein lipase deficiency. J Investig Med 2001 0.92
36 Changes in LDL density across the menopausal transition. J Investig Med 2000 0.91
37 Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia. Arterioscler Thromb Vasc Biol 2001 0.90
38 In vivo evidence of a role for hepatic lipase in human apoB-containing lipoprotein metabolism, independent of its lipolytic activity. J Lipid Res 2000 0.90
39 Plasma triglyceride and LDL heterogeneity in familial combined hyperlipidemia. Arterioscler Thromb 1993 0.89
40 LDL physical and chemical properties in familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol 1995 0.89
41 Linkage of low-density lipoprotein size to the lipoprotein lipase gene in heterozygous lipoprotein lipase deficiency. Am J Hum Genet 1999 0.89
42 Lipoprotein heterogeneity in end-stage renal disease. Kidney Int 1993 0.89
43 PLTP activity in premenopausal women. Relationship with lipoprotein lipase, HDL, LDL, body fat, and insulin resistance. J Lipid Res 2000 0.88
44 Bacterial lipopolysaccharide reduces macrophage lipoprotein lipase levels: an effect that is independent of tumor necrosis factor. J Lipid Res 1988 0.88
45 Evidence against linkage of familial combined hyperlipidemia to the apolipoprotein AI-CIII-AIV gene complex. Arterioscler Thromb Vasc Biol 1998 0.87
46 Primary lipoprotein lipase deficiency. Adv Exp Med Biol 1986 0.84
47 Relationship of insulin sensitivity and ApoB levels to intra-abdominal fat in subjects with familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol 2001 0.83
48 Regulatory mutations in the human lipoprotein lipase gene in patients with familial combined hyperlipidemia and coronary artery disease. J Lipid Res 1996 0.83
49 Host and environmental effects on plasma apolipoprotein B. Int J Clin Lab Res 1993 0.81
50 A missense mutation Pro157 Arg in lipoprotein lipase (LPLNijmegen) resulting in loss of catalytic activity. Eur J Biochem 1992 0.80
51 Prevention of raised low-density lipoprotein cholesterol in a patient with familial hypercholesterolaemia and lipoprotein lipase deficiency. Lancet 1993 0.79
52 Obesity and common genetic metabolic disorders. Ann Intern Med 1985 0.79
53 Lipoprotein and apolipoprotein abnormalities in familial combined hyperlipidemia: a 20-year prospective study. Atherosclerosis 2001 0.79
54 Low-density and high-density lipoprotein subspecies and risk for premature coronary artery disease. Am J Med 1999 0.78
55 Hepatic lipase as a focal point for the development and treatment of coronary artery disease. J Investig Med 2001 0.77
56 Lack of evidence for linkage between low-density lipoprotein subclass phenotypes and the apolipoprotein B locus in familial combined hyperlipidemia. Genet Epidemiol 1991 0.77
57 Low density lipoprotein metabolism in familial combined hyperlipidemia and familial hypercholesterolemia: kinetic analysis using an integrated model. Metabolism 1986 0.77
58 Evidence for kinetic heterogeneity among human low density lipoproteins. Metabolism 1986 0.77
59 Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity. Hum Mutat 1996 0.76
60 Use of niacin, statins, and resins in patients with combined hyperlipidemia. Am J Cardiol 1998 0.76
61 Relationships between LDL density and kinetic heterogeneity in subjects with normolipidemia and familial combined hyperlipidemia using density gradient ultracentrifugation. J Lipid Res 1989 0.75
62 The effects of diuretics and adrenergic-blocking agents on plasma lipids. West J Med 1986 0.75
63 Are all obese patients at risk for cardiovascular disease? Int J Obes 1984 0.75
64 Individuality, hyperlipidemia, and premature coronary artery disease. World Rev Nutr Diet 1990 0.75
65 Chylomicronemia induced by cimetidine. Gastroenterology 1985 0.75
66 Association of apolipoprotein B gene variants with plasma apoB and low density lipoprotein (LDL) cholesterol levels. Hum Genet 1992 0.75
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