A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas

Clinical Trial ID NCT01172964

PubWeight™ 27.41‹?›

🔗 Visit the ClinicalTrials.gov page for NCT01172964

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Neural stem cell-mediated enzyme/prodrug therapy for glioma: preclinical studies. Sci Transl Med 2013 1.42
2 A preclinical evaluation of neural stem cell-based cell carrier for targeted antiglioma oncolytic virotherapy. J Natl Cancer Inst 2013 1.21
3 Pharmacokinetic study of neural stem cell-based cell carrier for oncolytic virotherapy: targeted delivery of the therapeutic payload in an orthotopic brain tumor model. Cancer Gene Ther 2012 1.08
4 Magnetic resonance imaging tracking of ferumoxytol-labeled human neural stem cells: studies leading to clinical use. Stem Cells Transl Med 2013 1.07
5 Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy. Small 2013 0.97
6 Stem cell-based therapies for cancer treatment: separating hope from hype. Nat Rev Cancer 2014 0.96
7 Stem cells as therapeutic vehicles for the treatment of high-grade gliomas. Neuro Oncol 2011 0.96
8 Glioma virus therapies between bench and bedside. Neuro Oncol 2014 0.95
9 Sui generis: gene therapy and delivery systems for the treatment of glioblastoma. Neuro Oncol 2015 0.94
10 Neural stem cell-mediated CE/CPT-11 enzyme/prodrug therapy in transgenic mouse model of intracerebellar medulloblastoma. Gene Ther 2012 0.93
11 Drug-loaded nanoparticle systems and adult stem cells: a potential marriage for the treatment of malignant glioma? Oncotarget 2013 0.93
12 Neural stem cell-mediated delivery of irinotecan-activating carboxylesterases to glioma: implications for clinical use. Stem Cells Transl Med 2013 0.92
13 Current status of gene therapy for brain tumors. Transl Res 2012 0.90
14 Intranasal delivery of neural stem/progenitor cells: a noninvasive passage to target intracerebral glioma. Stem Cells Transl Med 2012 0.87
15 Strategies in gene therapy for glioblastoma. Cancers (Basel) 2013 0.87
16 Neural stem cells: brain building blocks and beyond. Ups J Med Sci 2012 0.85
17 Formulations for Intranasal Delivery of Pharmacological Agents to Combat Brain Disease: A New Opportunity to Tackle GBM? Cancers (Basel) 2013 0.85
18 EXPLORING THE ANTITUMOR EFFECT OF VIRUS IN MALIGNANT GLIOMA. Drugs Future 2016 0.84
19 Gene therapy for malignant glioma. Mol Cell Ther 2014 0.83
20 Genetically engineered theranostic mesenchymal stem cells for the evaluation of the anticancer efficacy of enzyme/prodrug systems. J Control Release 2015 0.83
21 Contact and encirclement of glioma cells in vitro is an intrinsic behavior of a clonal human neural stem cell line. PLoS One 2012 0.82
22 Neural Stem Cells Secreting Anti-HER2 Antibody Improve Survival in a Preclinical Model of HER2 Overexpressing Breast Cancer Brain Metastases. Stem Cells 2015 0.81
23 Analysis of glioblastoma tumor coverage by oncolytic virus-loaded neural stem cells using MRI-based tracking and histological reconstruction. Cancer Gene Ther 2014 0.79
24 Antiglioma oncolytic virotherapy: unattainable goal or a success story in the making? Future Virol 2013 0.79
25 Stem Cell-Based Cell Carrier for Targeted Oncolytic Virotherapy: Translational Opportunity and Open Questions. Viruses 2015 0.78
26 Stem cell-based therapies for tumors in the brain: are we there yet? Neuro Oncol 2016 0.77
27 Gene-directed enzyme prodrug therapy. AAPS J 2014 0.77
28 MMP14 as a novel downstream target of VEGFR2 in migratory glioma-tropic neural stem cells. Stem Cell Res 2015 0.77
29 Use of genetically engineered stem cells for glioma therapy. Oncol Lett 2015 0.75
30 Neural stem/progenitor cells react to non-glial cns neoplasms. Springerplus 2015 0.75
31 Practical Issues with the Use of Stem Cells for Cancer Gene Therapy. Stem Cell Rev 2015 0.75
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