Safety and Efficacy Study of Five-fraction Stereotactic Body Radiation Therapy to Locally Advanced Pancreatic Cancer

Clinical Trial ID NCT02704156

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cancer statistics, 2012. CA Cancer J Clin 2012 87.38
2 Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012 35.24
3 Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA 2007 14.54
4 Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 1985 7.14
5 Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National Cancer Database. J Am Coll Surg 1999 5.58
6 Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res 2009 4.58
7 Analysis of fluorouracil-based adjuvant chemotherapy and radiation after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas: results of a large, prospectively collected database at the Johns Hopkins Hospital. J Clin Oncol 2008 3.51
8 Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial. JAMA 2013 3.46
9 Adjuvant radiotherapy and chemotherapy for pancreatic carcinoma: the Mayo Clinic experience (1975-2005). J Clin Oncol 2008 3.15
10 Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J Immunother 2010 3.06
11 External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing. Cancer Res 2004 2.91
12 Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas. J Clin Oncol 1997 2.75
13 Genomic analyses identify molecular subtypes of pancreatic cancer. Nature 2016 2.70
14 Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers. Nat Med 2019 2.66
15 Pancreaticoduodenectomy with vascular resection: margin status and survival duration. J Gastrointest Surg 2004 2.62
16 Long-term results of partial pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-year experience. World J Surg 2003 2.26
17 Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 2004 2.20
18 The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy in Pancreatic Cancer Models by Altering Ribonucleotide Reductase Subunit-1 (RRM1). Clin Cancer Res 2015 2.03
19 Phase-II study on stereotactic radiotherapy of locally advanced pancreatic carcinoma. Radiother Oncol 2005 2.01
20 Oncogenic KRAS signalling in pancreatic cancer. Br J Cancer 2014 1.71
21 Adjuvant 5-fluorouracil and folinic acid vs observation for pancreatic cancer: composite data from the ESPAC-1 and -3(v1) trials. Br J Cancer 2009 1.69
22 Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies. Cancer Res 2012 1.59
23 KRAS as a Therapeutic Target. Clin Cancer Res 2015 1.11
24 Evidence and research in rectal cancer. Radiother Oncol 2008 1.00
25 Neoadjuvant therapy for pancreatic cancer: the Duke experience. Surg Oncol Clin N Am 2004 0.94
26 Neoadjuvant therapy for pancreatic cancer: a current review. J Surg Oncol 2010 0.86
27 Stereotactic body radiation therapy in pancreatic cancer: the new frontier. Expert Rev Anticancer Ther 2014 0.81
28 Emerging role of stereotactic body radiotherapy in the treatment of pancreatic cancer. Expert Rev Anticancer Ther 2013 0.81
29 Single- versus multifraction stereotactic body radiation therapy for pancreatic adenocarcinoma: outcomes and toxicity. Int J Radiat Oncol Biol Phys 2014 0.81
30 Neoadjuvant chemoradiation in patients with pancreatic adenocarcinoma. HPB (Oxford) 2006 0.79
31 [The role of radiation therapy in treatment of pancreatic cancer from the viewpoint of radio-oncologists]. Radiologe 2009 0.77
32 Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Nat Med 2019 0.75
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